Zhen Xin An Shen Tang

Sedate the Heart and Calm the Spirit Decoction · 镇心安神汤

Also known as: Zizyphus & Polygonum Stem Combination

A modern formula designed for stubborn insomnia and sleep disturbances. It uses heavy mineral substances to settle an agitated mind while nourishing Heart Blood and calming emotional tension. Particularly suited for people who have difficulty falling asleep, wake frequently, or experience restless sleep due to emotional stress, anxiety, or underlying deficiency of Qi and Blood.

Origin Modern clinical formula (contemporary TCM hospital practice, c. 1985) — Modern era, c. 1985 CE
Composition 7 herbs
Long Gu
King
Long Gu
Mu Li ke
King
Mu Li ke
Dan Shen
Deputy
Dan Shen
Suan Zao Ren
Deputy
Suan Zao Ren
Ye Jiao Teng
Assistant
Ye Jiao Teng
He Huan Pi
Assistant
He Huan Pi
Fu Shen
Assistant
Fu Shen
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhen Xin An Shen Tang is designed to correct these specific patterns.

Why Zhen Xin An Shen Tang addresses this pattern

When Heart Blood is insufficient, the spirit (Shen) loses its residence and becomes restless, leading to insomnia, palpitations, and anxiety. Zhen Xin An Shen Tang addresses this through Suan Zao Ren and Ye Jiao Teng, which directly nourish Heart Blood, while Dan Shen ensures the Blood circulates properly to the Heart. Fu Shen supports Spleen function to sustain Blood production. The heavy minerals Long Gu and Mu Li anchor the spirit that has become unmoored due to insufficient Blood, providing symptomatic relief while the nourishing herbs rebuild the foundation.

A practitioner would look for one or more of these signs

Insomnia

Difficulty falling asleep or staying asleep

Palpitations

Heart palpitations, especially at night

Anxiety

Anxiety and restlessness

Excessive Sweating

Vivid or excessive dreaming

Poor Memory

Poor memory and forgetfulness

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Zhen Xin An Shen Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, sleep depends on the spirit (Shen) returning to the Heart at night. The Heart houses the spirit, and Blood is the material foundation that anchors it. When Heart Blood is depleted, or when rising Yang agitates the mind, the spirit cannot settle and insomnia results. Chronic insomnia often involves multiple layers: underlying Blood deficiency, emotional constraint generating Liver Qi stagnation, and eventually rising Yang or Blood stasis as the condition becomes entrenched. The longer the insomnia persists, the more these factors compound each other.

Why Zhen Xin An Shen Tang Helps

Zhen Xin An Shen Tang addresses chronic insomnia on multiple levels simultaneously. Long Gu and Mu Li provide the heavy anchoring force needed to pull the agitated spirit back into the Heart, offering relatively quick symptomatic relief. Dan Shen moves Blood and clears Heart Heat, breaking the cycle of stasis that develops with long-standing insomnia. Suan Zao Ren and Ye Jiao Teng rebuild the Heart Blood that has been depleted, addressing the root cause. He Huan Pi resolves the emotional tension that so commonly accompanies and perpetuates sleep difficulties. This multi-layered approach explains why the formula was reported effective in treating 157 cases of severe sleeping disorders in clinical trials.

Also commonly used for

Palpitations

Functional palpitations, especially at night

Depression

Mild depression with insomnia and emotional constraint

Excessive Sweating

Excessive or disturbing dreams

Neurasthenia

Neurasthenia with sleep disturbance and emotional instability

Menopausal Symptoms

Menopausal insomnia and emotional disturbance

What This Formula Does

Every TCM formula has a specific set of actions — here's what Zhen Xin An Shen Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Zhen Xin An Shen Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Zhen Xin An Shen Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Zhen Xin An Shen Tang works at the root level.

This formula addresses insomnia that arises from a combination of Heart Blood insufficiency and unanchored Yang. In TCM theory, the Heart houses the Shen (the mind or spirit), and the Shen can only rest peacefully at night when it is properly nourished by Blood and anchored within the Heart. When Heart Blood becomes deficient — through prolonged worry, overwork, chronic illness, or aging — the Shen loses its material foundation and becomes restless, like a boat without a mooring. This leads to difficulty falling asleep, light or easily disrupted sleep, excessive dreaming, and anxiety.

At the same time, when Yin and Blood are insufficient, Yang is no longer properly counterbalanced. The Liver, which stores Blood and anchors the Ethereal Soul (Hun), can develop Yang rising when its Blood is depleted. This ascending, unanchored Yang further agitates the Shen above, creating a vicious cycle: the more restless the spirit, the more the Yang floats upward, and the worse the sleep becomes. The overall picture is one of Yin-Yang disharmony — Yang stays active when it should be quiet, and Yin cannot draw it back down into rest. Clinically, this manifests as trouble falling asleep, waking easily or too early, being unable to return to sleep, or in severe cases, complete sleeplessness through the night.

Zhen Xin An Shen Tang works by addressing both sides of this mechanism: it weighs down and anchors the floating Yang with heavy mineral substances, while simultaneously nourishing Heart Blood and calming the spirit through plant-based sedating herbs. By restoring the proper relationship between Yin and Yang, the Shen can settle back into the Heart and sleep is restored.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Predominantly astringent, salty, and sweet — astringent and salty to anchor and settle the spirit, sweet to gently nourish Heart Blood.

Target Organs

Channels Entered

Ingredients

7 herbs

The herbs that make up Zhen Xin An Shen Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Long Gu

Long Gu

Dragon bones

Dosage 30g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Liver
Preparation Decoct first for 30 minutes (先煎)

Role in Zhen Xin An Shen Tang

Heavy mineral substance that settles the Heart, calms the spirit, and anchors floating Yang. Used raw (Sheng) for its spirit-calming and Liver-pacifying effects. Its heavy, descending nature directly addresses the restless, unanchored spirit that characterizes severe insomnia.
Mu Li ke

Mu Li ke

Oyster shells

Dosage 30g
Temperature Cold
Taste Salty
Organ Affinity Urinary Bladder, Gallbladder, Kidneys, Liver
Preparation Decoct first for 30 minutes (先煎)

Role in Zhen Xin An Shen Tang

Works alongside Long Gu to heavily sedate and anchor the spirit. Nourishes Yin and subdues rising Yang, calms the Liver, and resolves restlessness. Together with Long Gu, the pair forms the core anchoring strategy of the formula.
Deputies — Assists and enhances the King
Dan Shen

Dan Shen

Red sage roots

Dosage 30g
Temperature Cool
Taste Bitter
Organ Affinity Heart, Liver

Role in Zhen Xin An Shen Tang

Invigorates Blood and clears Heat from the Heart. Addresses blood stasis that may underlie chronic insomnia. Also soothes irritability and restlessness. Its blood-moving action ensures that Heart Blood circulates properly so the spirit has a stable residence.
Suan Zao Ren

Suan Zao Ren

Jujube seeds

Dosage 30g
Temperature Neutral
Taste Sour, Sweet
Organ Affinity Gallbladder, Heart, Liver

Role in Zhen Xin An Shen Tang

Nourishes Heart Blood and Liver Yin while calming the spirit. The core nourishing component that addresses the underlying Blood deficiency. Dry-fried (Chao) to enhance its spirit-calming properties. Works from the nourishing side to complement the heavy anchoring of Long Gu and Mu Li.
Assistants — Supports or moderates other herbs
Ye Jiao Teng

Ye Jiao Teng

Fleeceflower stems

Dosage 30g
Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Heart, Liver

Role in Zhen Xin An Shen Tang

Nourishes Heart Blood and calms the spirit. Its name literally means 'vine of night exchange,' reflecting its traditional use for promoting sleep. Also unblocks the channels, helping the formula's effects reach throughout the body.
He Huan Pi

He Huan Pi

Silktree albizia barks

Dosage 15g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Liver

Role in Zhen Xin An Shen Tang

Calms the spirit and relieves emotional constraint. Specifically addresses insomnia arising from emotional disturbance, depression, or unresolved feelings. Harmonizes the Liver and resolves Qi stagnation that may be disturbing sleep.
Fu Shen

Fu Shen

Host-wood Poria

Dosage 15g
Temperature Neutral
Taste Sweet
Organ Affinity Spleen, Heart

Role in Zhen Xin An Shen Tang

Calms the Heart and settles the spirit while gently strengthening the Spleen. Fu Shen (Poria with hostwood) is specifically chosen over regular Fu Ling for its superior spirit-calming properties. Supports the middle burner to ensure adequate Qi and Blood production.

Why This Combination Works

How the herbs in Zhen Xin An Shen Tang complement each other

Overall strategy

Zhen Xin An Shen Tang combines heavy, descending mineral substances with Blood-nourishing and spirit-calming herbs to treat insomnia from both the root (Blood deficiency, emotional strain) and the branch (restless, unanchored spirit and rising Yang). The formula addresses the common clinical scenario where the spirit lacks a stable anchor due to depleted Heart Blood and emotional disturbance.

King herbs

Sheng Long Gu and Sheng Mu Li are the King pair, used raw and in heavy doses (30g each). Their mineral weight physically and energetically pulls the agitated spirit downward, anchoring it in the Heart. Long Gu settles anxiety by calming the Liver and preventing Yang from floating upward. Mu Li nourishes Yin and subdues excess Yang, complementing Long Gu's anchoring effect. Together, they provide the immediate, powerful sedating action needed for severe insomnia.

Deputy herbs

Dan Shen and Chao Suan Zao Ren serve as Deputies. Dan Shen invigorates Heart Blood and clears Heart Heat, addressing both blood stasis and irritability that accompany chronic sleeplessness. Suan Zao Ren nourishes Heart and Liver Blood, providing the nutritive foundation the spirit needs. These two Deputies ensure the formula does not merely suppress symptoms but also addresses the underlying deficiency and stagnation.

Assistant herbs

Ye Jiao Teng (reinforcing assistant) nourishes Heart Blood and promotes sleep, amplifying the Blood-nourishing strategy of Suan Zao Ren. He Huan Pi (reinforcing assistant) specifically targets emotional constraint and depression-related insomnia, soothing the Liver and relieving pent-up feelings. Fu Shen (reinforcing assistant) calms the spirit through its affinity for the Heart while gently supporting the Spleen, ensuring the digestive system can produce the Blood and Qi the Heart needs.

Notable synergies

The Long Gu-Mu Li pair is one of the most established synergies in TCM for calming the spirit and subduing Yang. Dan Shen paired with Suan Zao Ren addresses insomnia from both the circulation and nourishment angles. He Huan Pi combined with Ye Jiao Teng is a classic pairing for emotionally driven insomnia, with He Huan Pi resolving the emotional root and Ye Jiao Teng nourishing the Heart Blood that emotional strain depletes.

How to Prepare

Traditional preparation instructions for Zhen Xin An Shen Tang

Soak all herbs in water for 30 minutes before cooking. Decoct Sheng Long Gu and Sheng Mu Li first for 30 minutes, then add the remaining herbs and continue to decoct for another 20-30 minutes. Strain and combine two decoctions to yield approximately 300-450 mL total. The first decoction should be taken one hour before bedtime, and the second decoction taken 30 minutes after the midday meal the following day. After taking the medicine, rest quietly with closed eyes for 1-2 hours.

Common Modifications

How practitioners adapt Zhen Xin An Shen Tang for specific situations

Added
Huang Qi

Zhi Huang Qi 30g, tonifies Qi and supports Blood production

Dang Gui

Dang Gui Shen 10g, nourishes and invigorates Blood

Long Yan Rou

Long Yan Rou 10g, nourishes Heart Blood and calms the spirit

When insomnia is accompanied by marked fatigue, pale complexion, and weak pulse indicating Qi and Blood deficiency, adding Qi and Blood tonics addresses the root depletion that prevents the spirit from settling.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Zhen Xin An Shen Tang should not be used or requires extra caution

Avoid

Insomnia caused by Phlegm-Heat disturbing the Heart. The formula lacks herbs that clear Phlegm or drain Fire, making it unsuitable for excess-type patterns involving thick, greasy tongue coating, a feeling of chest oppression, nausea, or bitter taste from Phlegm-Fire.

Avoid

Insomnia caused by Stomach disharmony (food stagnation or rebellious Stomach Qi). Symptoms like fullness, bloating, acid reflux, or heavy meals disrupting sleep require a different treatment approach.

Avoid

Insomnia caused by excess Liver Fire or vigorous Heart Fire. While the formula can subdue mild Yang rising, pronounced Fire signs (severe irritability, red face, bitter taste, constipation, dark urine) require formulas that clear Fire more directly.

Caution

Patients with significant Spleen Qi deficiency or loose stools should use with caution. The heavy mineral substances (Long Gu, Mu Li) and the cool nature of Dan Shen may burden a weak digestive system if used long-term without modification.

Caution

Patients on anticoagulant or antiplatelet therapy should use with caution due to the blood-invigorating properties of Dan Shen (Salvia root), which may potentiate bleeding risk.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe in pregnancy at standard doses, but should be used with practitioner supervision. Dan Shen (Salvia root) invigorates Blood and has mild blood-moving properties, which warrants caution in pregnancy, particularly during the first trimester or in patients with a history of miscarriage. The mineral substances Long Gu and Mu Li are considered safe. He Huan Pi and Shou Wu Teng (Ye Jiao Teng) have no specific pregnancy contraindications but lack extensive safety data in pregnant populations. A qualified practitioner should assess the individual case before prescribing.

Breastfeeding

No specific contraindications are established for breastfeeding. The herbs in this formula are generally mild and are not known to have toxic metabolites that transfer significantly into breast milk. Dan Shen (Salvia root) and the mineral substances Long Gu and Mu Li are not associated with adverse effects on lactation or nursing infants. However, formal safety studies in breastfeeding populations are lacking. As a precaution, practitioners typically use moderate doses and monitor both mother and infant for any changes. If the infant shows unusual drowsiness, irritability, or feeding changes, the formula should be discontinued and a practitioner consulted.

Children

This formula is primarily designed for adult insomnia and is not commonly prescribed for young children. For adolescents (approximately 12 years and older) experiencing insomnia from emotional stress or anxiety, it may be considered at reduced doses (typically one-third to one-half of the adult dose), with practitioner guidance. The heavy mineral ingredients Long Gu and Mu Li should be used cautiously in children with weak digestion. For children under 12, other approaches to insomnia (such as Gan Mai Da Zao Tang for restlessness) are generally preferred. Any pediatric use should be supervised by a qualified practitioner.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Zhen Xin An Shen Tang

Dan Shen (Salvia root) is the primary herb of pharmacological concern for drug interactions. Dan Shen contains tanshinones and salvianolic acids that inhibit platelet aggregation and may potentiate the effects of anticoagulant medications (warfarin, heparin) and antiplatelet drugs (aspirin, clopidogrel), increasing the risk of bleeding. Dan Shen has also been shown to affect cytochrome P450 enzymes (particularly CYP3A4), which could alter the metabolism of many pharmaceutical drugs. Patients taking warfarin should have their INR monitored closely if using this formula.

Long Gu and Mu Li (mineral/shell substances) are rich in calcium carbonate and may interfere with the absorption of certain antibiotics (tetracyclines, fluoroquinolones), thyroid medications (levothyroxine), and iron supplements if taken concurrently. A gap of at least two hours between taking this formula and these medications is advisable.

Suan Zao Ren (Ziziphus seed) has documented sedative and anxiolytic properties that may have additive effects with benzodiazepines, barbiturates, and other CNS depressants, potentially causing excessive drowsiness. Patients using prescription sleep aids or anti-anxiety medications should be monitored for over-sedation.

Usage Guidance

Practical advice for getting the most out of Zhen Xin An Shen Tang

Best time to take

First decoction taken one hour before bedtime; second decoction taken after lunch the following day. Rest quietly for 1-2 hours after the evening dose.

Typical duration

Typically taken for 2-4 weeks as an initial course, then reassessed by a practitioner based on sleep improvement.

Dietary advice

Avoid stimulating foods and beverages while taking this formula, particularly coffee, strong tea, alcohol, and chocolate, as these can counteract its calming, spirit-settling effects. Spicy, greasy, and heavily fried foods should also be minimized, as they can generate internal Heat and Phlegm that disturb the Shen. Favor light, easily digestible meals in the evening — porridge, steamed vegetables, and calming foods such as lily bulb (bai he), lotus seed (lian zi), and longan fruit (long yan rou) are traditionally recommended to support sleep. Eating the final meal at least two to three hours before bedtime allows the Stomach to settle and supports the natural descent of Yang Qi into rest.

Zhen Xin An Shen Tang originates from Modern clinical formula (contemporary TCM hospital practice, c. 1985) Modern era, c. 1985 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Zhen Xin An Shen Tang and its clinical use

Because Zhen Xin An Shen Tang is a modern clinical formula rather than a classical prescription from the ancient texts, there are no classical quotes attributed to it directly. However, its design draws on foundational principles from the classical literature on insomnia:

The Ling Shu (Spiritual Pivot), in its discussion of sleep physiology, states: 「卫气不得入于阴,常留于阳。留于阳则阳气满……不得入于阴则阴气虚,故目不瞑」"When the defensive Qi cannot enter the Yin [aspect], it stays constantly in the Yang. When it stays in Yang, Yang Qi becomes excessive… when it cannot enter Yin, the Yin Qi is depleted, and so the eyes cannot close [in sleep]." This passage establishes the core principle that insomnia arises from a disharmony between Yin and Yang, which Zhen Xin An Shen Tang addresses through anchoring Yang and nourishing Heart Blood.

The Jin Gui Yao Lue (Essential Prescriptions of the Golden Cabinet) states: 「虚劳虚烦不得眠,酸枣仁汤主之」"For deficiency-taxation with vexation and inability to sleep, Suan Zao Ren Tang governs." This classical precedent for using Suan Zao Ren as the key spirit-calming herb in deficiency-type insomnia directly informs the inclusion of fried Suan Zao Ren in Zhen Xin An Shen Tang.

Historical Context

How Zhen Xin An Shen Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Zhen Xin An Shen Tang is a modern clinical formula, not a classical prescription from the traditional canon. It was developed in the mid-1980s by contemporary Chinese hospital practitioners and was first reported in clinical literature around 1985. The formula was designed specifically to treat neurotic insomnia — a condition of increasing prevalence in modern urban China — and it was tested on 157 patients with severe sleeping disorders, including those for whom conventional sleeping pills had lost effectiveness.

Although the formula itself is modern, every herb in it has deep classical roots. The pairing of Long Gu (Dragon Bone) and Mu Li (Oyster Shell) as heavy, anchoring substances to calm the spirit dates back to the Shang Han Lun, where Zhang Zhongjing used them in formulas like Gui Zhi Jia Long Gu Mu Li Tang. The use of Suan Zao Ren for insomnia from deficiency traces to the Jin Gui Yao Lue's Suan Zao Ren Tang. He Huan Pi (Silk Tree Bark) appears in the Shen Nong Ben Cao Jing for resolving depression and calming the spirit, and Dan Shen's use for clearing Heart Heat and soothing restlessness is well established in classical materia medica. The formula represents a pragmatic modern synthesis of these time-tested strategies, optimized for clinical convenience and targeted at a specific modern disease presentation.