Formula

Zhi Sou San

Platycodon & Schizonepeta Formula | 止嗽散

Also known as:

Stop Coughing Powder , Zhi Sou Tang

Properties

Cough-relieving and wheezing-calming formulas · Slightly Warm

Key Ingredients

Zi Wan, Bai Bu

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A gentle classical formula used to relieve persistent coughing after a cold, especially when the throat feels itchy and phlegm is difficult to bring up. It works by soothing the lungs, helping clear residual Wind from the body, and restoring normal respiratory function without being too harsh or drying.

Formula Category

Main Actions

  • Resolves Phlegm and Stops Cough
  • Diffuses Lung Qi
  • Disperses Wind
  • Benefits the Throat

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhi Sou San is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Zhi Sou San addresses this pattern

When Wind-Cold invades the Lungs, it disrupts the Lungs' ability to properly disperse and descend Qi. This leads to coughing, throat itchiness, and Phlegm that is difficult to expectorate. Zhi Sou San is especially suited for the later stage of this pattern, when the bulk of the exterior symptoms (strong chills, body aches, headache) have already resolved but the cough persists because residual Wind is still lodged in the Lung system. The King herbs Zi Wan and Bai Bu directly moisten the Lungs and stop the cough, while the Deputy pair Jie Geng and Bai Qian restore normal Lung Qi circulation. Jing Jie gently clears the remaining Wind so the pathogen cannot linger further. The formula's balanced, mild nature is specifically designed for the Lungs' delicate constitution, which cannot tolerate overly harsh treatment.

A practitioner would look for one or more of these signs

Hypochondrial Pain That Is Worse On Coughing And Breathing

Persistent cough that lingers after a cold

Itchy Throat

Ticklish, itchy sensation in the throat triggering the cough

Difficult Expectoration

Phlegm that is hard to bring up, often thin and white

Mild Chills

Slight aversion to wind or mild chills, suggesting residual exterior pathogen

Thin White Tongue Coating

Thin white tongue coating indicating lingering Wind-Cold

How It Addresses the Root Cause

This formula addresses coughing caused by Wind lingering in the Lungs after a common cold or respiratory infection. In TCM, the Lungs are considered the most "delicate" organ (娇脏, jiāo zàng) — they sit at the top of the body, open to the nose and throat, and are directly exposed to the outside environment. This makes them the first organ attacked by external pathogens like Wind-Cold.

When Wind-Cold invades, the body's initial response is a typical cold — chills, sneezing, congestion. Usually this resolves with rest or treatment. But sometimes the pathogen is not fully expelled. It lingers in the Lungs, even after most cold symptoms have cleared. The remaining trace of Wind disrupts the Lung's ability to perform its two key functions: descending (sending Qi and fluids downward) and dispersing (spreading defensive Qi outward to the body surface). When these functions are disrupted, Qi rises rebelliously instead of descending, producing coughing. Fluids that should be circulated smoothly accumulate as Phlegm, causing a sensation of phlegm stuck in the throat. The lingering Wind also irritates the throat, producing an itchy, tickling sensation that triggers repeated coughing fits.

The hallmark of this pattern is that the person is past the worst of their cold but still coughing persistently — perhaps with a slightly itchy throat, thin white phlegm that is hard to expectorate, and maybe a very mild sensation of Wind aversion. The tongue coating is thin and white, and the pulse is floating and moderate. Because the remaining pathogen is mild, the treatment must also be mild — strong exterior-releasing or aggressively cooling medicines would either overshoot the problem or trap the pathogen further. Cheng Guopeng compared this to a minor intruder at the gate: you simply open the door and usher him out gently.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly acrid (pungent) and bitter with mild sweetness — acrid to open and disperse, bitter to direct Qi downward, sweet to harmonize and moisten.

Target Organs
Lungs Spleen
Channels Entered
Lung

Formula Origin

Yi Xue Xin Wu (Medical Revelations, 医学心悟) by Cheng Guopeng (程国彭)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Zhi Sou San

Detailed information about each herb in Zhi Sou San and their roles

Kings
Deputies
Assistants
Envoys
Zi Wan
Zi Wan

Tatarian aster root

Dosage: 9 - 15g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs
Parts Used Root (根 gēn)
Role in Zhi Sou San

Warms and moistens the Lungs to dissolve Phlegm and stop coughing. Its nature is warm without being hot and moistening without being cloying, making it effective for both acute and chronic coughs. As a King herb it directly targets the core symptom of persistent cough.

Bai Bu
Bai Bu

Stemona root

Dosage: 9 - 12g

Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Zhi Sou San

Moistens the Lungs and stops coughing. Like Zi Wan, it is warm but not hot and moist but not cloying, making it suitable for coughs of all types. Together with Zi Wan it forms the core cough-relieving pair of this formula, effective for both new and chronic coughs.

Jie Geng
Jie Geng

Balloon flower root

Dosage: 9 - 15g

Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs
Parts Used Root (根 gēn)
Role in Zhi Sou San

Opens and disseminates Lung Qi upward and outward, promoting the expulsion of Phlegm. Its ascending action complements Bai Qian's descending action, together restoring the Lungs' natural rhythm of dispersing and descending.

Bai Qian
Bai Qian

Willowleaf swallowwort rhizome

Dosage: 9 - 12g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs
Parts Used Rhizome (根茎 gēn jīng)
Role in Zhi Sou San

Directs Lung Qi downward and resolves Phlegm. Its descending action works in tandem with Jie Geng's ascending action, and together they restore the Lungs' normal up-and-down Qi movement, reinforcing the cough-stopping effect of the King herbs.

Jing Jie
Jing Jie

Schizonepeta

Dosage: 6 - 10g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver
Parts Used Whole plant / Aerial parts (全草 quán cǎo)
Role in Zhi Sou San

Gently disperses residual Wind from the exterior and soothes an itchy throat. Although the formula's main focus is not strong exterior-releasing, this mild dispersing action is essential to expel lingering Wind pathogen so the Lung Qi can fully recover.

Chen Pi
Chen Pi

Tangerine peel

Dosage: 6 - 10g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Lungs, Spleen
Parts Used Peel / Rind (皮 pí / 果皮 guǒ pí)
Role in Zhi Sou San

Regulates Qi flow and dries Dampness to transform Phlegm. It supports the Spleen's role in fluid metabolism to prevent further Phlegm production, and its Qi-moving action helps the Lungs function smoothly.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Zhi Sou San

Harmonizes all the other herbs in the formula, moderates their actions, and soothes the throat. Combined with Jie Geng and Jing Jie, it also benefits the throat and helps stop coughing.

Modern Research (2 studies)

  • Clinical Effects and Safety of Zhi Sou San for Cough: A Meta-Analysis of Randomized Trials (2017)
  • Zhisou Powder Suppresses Airway Inflammation in Post-Infectious Cough Model Mice via TRPA1/TRPV1 Channels (Preclinical, 2024)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

After meals and/or before bedtime, as specified in the original text. If taken as a decoction, twice daily (morning and evening) after meals.

Typical Duration

Acute use: 3–10 days for post-cold lingering cough; reassess if cough persists beyond 2 weeks.

Dietary Advice

Avoid cold, raw, and icy foods and drinks, which can further impair the Lung's dispersing function and congeal Phlegm. Limit greasy, fried, and heavily sweetened foods, which generate Dampness and Phlegm. Avoid sour and astringent foods (such as vinegar-heavy dishes or unripe fruits) which can contract Lung Qi and trap the pathogen. Warm, lightly cooked foods are preferred. Pear soup with a small amount of ginger can complement the formula's action. The classical text specifies taking the powder after meals or before bed, and using ginger tea (生姜汤) to wash it down if there are initial Wind-Cold symptoms.

Modern Usage

Zhi Sou San is the name of a traditional Chinese medicine formula. It is classified as a release-exterior formula and has the effects of dispersing Wind, ventilating the Lungs, stopping cough, and transforming Phlegm. It is primarily used to treat coughs caused by external Wind invasion, with symptoms such as coughing with an itchy throat, difficulty expectorating phlegm, mild aversion to wind, slight fever, a thin white tongue coating, and a floating, moderate pulse.

Clinically, it is used to treat upper respiratory tract infections, bronchitis, whooping cough, and other conditions where the external pathogen has not been fully expelled, leading to Lung Qi Stagnation.

Special Populations

Pregnancy

Generally considered low risk, but caution is advisable. Jing Jie (Schizonepeta) has mild blood-moving properties in some classical descriptions, and Jie Geng (Platycodon) has an upward-directing action on Qi. While none of the seven herbs are classified as strongly contraindicated in pregnancy, the formula should only be used during pregnancy under the guidance of a qualified practitioner, at appropriate dosages, and only for as long as needed to resolve the cough. Avoid prolonged use without supervision.

Breastfeeding

No specific safety concerns have been identified for breastfeeding. All seven herbs are mild in nature and widely used in clinical practice. Gan Cao (Licorice) is present in a small dose and unlikely to affect lactation at standard formula dosages. The formula may be used during breastfeeding when indicated, but as with any herbal medicine, use should be supervised by a qualified practitioner and limited to the duration necessary to resolve the cough.

Pediatric Use

Zhi Sou San is widely used in pediatric practice in China for post-cold coughs. All seven herbs are mild and well tolerated by children. Dosages should be reduced according to age and body weight — typically one-third to one-half of the adult dose for children aged 3-7, and two-thirds for children aged 8-14. The original powder form (mixed with warm water) can be convenient for younger children. As with adults, the formula is not suitable for children with Yin-deficient or Lung-Heat type coughs. Always consult a qualified practitioner for pediatric use.

Drug Interactions

Gan Cao (Licorice root) in this formula, though used in a small dose, may interact with certain medications:

  • Corticosteroids: Glycyrrhizin in licorice can potentiate the effects of corticosteroids by inhibiting cortisol metabolism, potentially increasing the risk of side effects such as fluid retention or hypokalemia.
  • Antihypertensives and diuretics: Licorice can cause sodium retention and potassium loss, potentially counteracting blood pressure medications or worsening potassium depletion from loop or thiazide diuretics.
  • Digoxin: The hypokalemia risk from licorice could increase the toxicity of cardiac glycosides like digoxin.

At the small dose used in Zhi Sou San (approximately 6g in decoction), these interactions are unlikely to be clinically significant with short-term use, but caution is warranted in patients on the above medications, especially with prolonged use.

Contraindications

Avoid

Yin deficiency with consumptive cough (阴虚劳嗽). The formula has a slightly warm, drying tendency that can further damage Yin fluids and worsen dry, unproductive coughs from Lung Yin depletion.

Caution

Lung Heat cough with thick yellow phlegm, fever, and a red tongue with yellow coating. The formula's warm nature is unsuitable for pronounced Heat patterns and should not be used unmodified.

Caution

Cough with profuse blood-streaked sputum from Lung Heat or Yin-deficient Fire flaring. The warm dispersing herbs may aggravate bleeding by moving Blood recklessly.

Caution

Strong exterior Wind-Cold with high fever, severe chills, body aches, and a tight pulse. The formula's exterior-releasing action is mild and insufficient for acute, severe external invasion — a dedicated exterior-releasing formula is more appropriate.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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