You Gui Yin

Right-Restoring Drink · 右歸飲

Also known as: You Gui Yin, Right-Returning Decoction, Restore the Right Decoction

A classical warming formula designed to strengthen Kidney Yang and replenish vital essence. It is commonly used for people who feel cold easily, experience lower back or knee weakness, fatigue, and general low vitality due to insufficient warmth in the body's deepest reserves. The formula gently warms while also nourishing the body's foundational substance, following the principle of 'seeking Yang within Yin.'

Origin Jǐng Yuè Quán Shū (景岳全書, The Complete Works of Jing-Yue) by Zhang Jing-Yue, Volume 51 — Míng dynasty, 1624 CE
Composition 8 herbs
Shu Di huang
King
Shu Di huang
Lai Fu Zi
Deputy
Lai Fu Zi
Rou Gui
Deputy
Rou Gui
Shan Yao
Assistant
Shan Yao
Shan Zhu Yu
Assistant
Shan Zhu Yu
Gou Qi Zi
Assistant
Gou Qi Zi
Du Zhong
Assistant
Du Zhong
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. You Gui Yin is designed to correct these specific patterns.

Why You Gui Yin addresses this pattern

Kidney Yang deficiency is the primary pattern this formula addresses. When the warming function of the Kidney declines, the body loses its ability to warm the limbs and lower back, maintain strong bones and sinews, and support reproductive vitality. The Ming Men (Life Gate) fire grows dim, leaving the person cold, fatigued, and weak. You Gui Yin directly restores Kidney Yang through Fu Zi and Rou Gui while using Shu Di Huang and the other nourishing herbs to rebuild the essence foundation that sustains Yang long-term. Du Zhong targets the characteristic lumbar weakness, while Shan Zhu Yu astringes the weakened Kidney to prevent further loss of essence.

A practitioner would look for one or more of these signs

Cold Limbs

Cold hands and feet due to insufficient Yang warmth

Lower Back Pain

Aching, cold, and weak lower back and knees

Eye Fatigue

Persistent tiredness and low vitality

Frequent Pale Urination

Frequent, clear, copious urination especially at night

Loose Stools

Loose stools or early morning diarrhea

Impotence

Impotence or decreased libido

Edema

Swelling of the limbs, especially the lower extremities

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider You Gui Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, reproductive capacity is fundamentally governed by the Kidney system. The Kidney stores essence (Jing), which is the material basis of fertility, including egg quality, sperm production, and the ability to conceive and sustain pregnancy. Kidney Yang provides the warming force needed to activate this essence and create the conditions for conception. In women, the uterus (called the 'Palace of the Child') depends on Kidney Yang warmth through the Chong and Ren meridians. When Yang is deficient, the uterus becomes 'cold,' leading to irregular periods, scanty flow, and difficulty conceiving. In men, Kidney Yang and essence deficiency manifests as low sperm count, poor motility, impotence, or premature ejaculation.

Why You Gui Yin Helps

You Gui Yin directly warms the Kidney Yang through Fu Zi and Rou Gui, restoring the warmth needed for the reproductive system to function. At the same time, Shu Di Huang and Gou Qi Zi nourish the essence and Blood that serve as the raw material for reproductive capacity. Shan Zhu Yu astringes the Kidney to prevent further essence leakage. Du Zhong supports the Kidney and has been traditionally associated with calming a restless fetus and supporting pregnancy. The formula's 'seeking Yang within Yin' approach is particularly well-suited for fertility, because both the warming fire (Yang) and the nourishing substance (Yin/essence) must be present for successful conception.

Also commonly used for

Impotence

Erectile dysfunction from Kidney Yang decline

Chronic Diarrhea

Chronic diarrhea due to Spleen and Kidney Yang deficiency

Chronic Bronchitis

Chronic cough and wheezing from Kidney failing to grasp Qi

Osteoporosis

Bone weakness due to Kidney deficiency

Edema

Chronic edema from Yang deficiency fluid metabolism failure

Frequent Urination

Frequent, pale urination including nocturia

Allergic Sinusitis

Chronic allergic rhinitis with clear watery discharge due to Kidney and Lung Yang deficiency

What This Formula Does

Every TCM formula has a specific set of actions — here's what You Gui Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, You Gui Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that You Gui Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how You Gui Yin works at the root level.

This formula addresses the core problem of Kidney Yang Deficiency with Ming Men (Life Gate) Fire decline. In TCM theory, the Ming Men is the root of all Yang in the body. It sits between the two Kidneys and acts as the body's fundamental warming and activating force. When this fire weakens, the body loses its ability to warm itself, move fluids, support digestion, and sustain vitality.

The immediate consequences are pervasive cold and weakness: the low back and knees become sore and weak (the Kidneys govern the bones and lumbar region); the limbs feel cold because Yang can no longer reach the extremities; fatigue sets in because there is insufficient driving force for the body's functions; digestion falters because Kidney Yang normally warms the Spleen to help it transform food ("Fire fails to generate Earth"); and the stools become loose while urination becomes frequent and pale. In more severe cases, the weakened Ming Men fire can no longer anchor Yang in the lower body, causing it to float upward, which produces paradoxical symptoms of apparent Heat (flushed face, restlessness) layered over a fundamentally cold constitution. This is the "true Cold, false Heat" pattern Zhang Jing-Yue specifically mentions in his instructions.

The formula's strategy follows Zhang Jing-Yue's principle of "seeking Yang within Yin" (阴中求阳). Because Yin and Yang are interdependent, you cannot effectively restore Yang by warming alone. You must also nourish the Yin-Essence substrate from which Yang arises. By combining strong Yang-warming herbs with rich Yin-nourishing substances, the formula rekindles Ming Men fire on a stable foundation of replenished Essence, producing a lasting and balanced restoration rather than a brief, unsustainable burst of warmth.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sweet and warm — sweet to nourish and tonify Essence and Qi, with pungent warmth from Cinnamon and Aconite to invigorate Yang and dispel Cold.

Channels Entered

Ingredients

8 herbs

The herbs that make up You Gui Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Shu Di huang

Shu Di huang

Prepared rehmannia

Dosage 6 - 60g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver

Role in You Gui Yin

The chief herb of the formula, Shu Di Huang richly nourishes Kidney Yin and replenishes essence and Blood. As the heaviest-dosed herb, it provides the material foundation upon which Yang can be restored, embodying the principle of 'seeking Yang within Yin.' Without adequate Yin substance, Yang has no root to anchor to.
Deputies — Assists and enhances the King
Lai Fu Zi

Lai Fu Zi

Radish seeds

Dosage 3 - 9g
Temperature Neutral
Taste Pungent, Sweet
Organ Affinity Lungs, Spleen, Stomach
Preparation Decoct first for 30-60 minutes (先煎) to reduce toxicity

Role in You Gui Yin

Powerfully warms and restores Kidney Yang and Ming Men (Life Gate) fire. It rescues depleted Yang, disperses interior Cold, and provides the formula's strongest warming force to counteract the pattern of Yang deficiency with internal Cold predominance.
Rou Gui

Rou Gui

Cinnamon bark

Dosage 3 - 6g
Temperature Hot
Taste Pungent, Sweet
Organ Affinity Heart, Kidneys, Liver, Spleen
Preparation Add in last 5 minutes of decoction (后下)

Role in You Gui Yin

Warms the Kidney Yang and Ming Men fire, supplements declining fire at its source, and guides floating Yang back to its origin. Works synergistically with Fu Zi to warm Yang, while also promoting Qi and Blood circulation to ensure the nourishing herbs are properly distributed.
Assistants — Supports or moderates other herbs
Shan Yao

Shan Yao

Yam

Dosage 6 - 12g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Lungs, Spleen
Preparation Dry-fried (炒)

Role in You Gui Yin

Tonifies the Spleen and Kidney simultaneously. By strengthening the Spleen (the postnatal root), it supports the body's ability to generate Qi and Blood, which in turn nourishes the Kidney. This addresses the interdependence between the prenatal and postnatal foundations of the body.
Shan Zhu Yu

Shan Zhu Yu

Cornelian cherries

Dosage 3 - 6g
Temperature Warm
Taste Sour
Organ Affinity Kidneys, Liver

Role in You Gui Yin

Tonifies and astringes the Liver and Kidney, securing essence and preventing leakage of vital substances. Its sour and warm nature helps contain the Kidney essence that might otherwise be lost due to Yang deficiency, complementing the nourishing action of Shu Di Huang.
Gou Qi Zi

Gou Qi Zi

Goji berries

Dosage 6 - 12g
Temperature Neutral
Taste Sweet
Organ Affinity Kidneys, Liver

Role in You Gui Yin

Nourishes the Liver and Kidney, replenishes essence, and supports Blood. Its gentle, sweet nature complements Shu Di Huang in building the Yin and essence foundation without being overly cloying, while also benefiting the Liver to ensure smooth distribution of Blood.
Du Zhong

Du Zhong

Eucommia bark

Dosage 6 - 12g
Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver
Preparation Prepared with ginger juice (姜制)

Role in You Gui Yin

Tonifies the Liver and Kidney, strengthens sinews and bones, and supports the lower back. It directly addresses the symptom of lumbar weakness and pain that is characteristic of Kidney Yang deficiency, while also having a mild Yang-warming quality that supports the formula's overall warming strategy.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Liquorice

Dosage 3 - 6g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in You Gui Yin

Harmonizes all the other herbs in the formula and tonifies the Middle Jiao (Spleen and Stomach). By strengthening the digestive system, it ensures the rich, nourishing herbs in the formula can be properly absorbed. Its moderating quality prevents the warming herbs from being overly harsh.

Why This Combination Works

How the herbs in You Gui Yin complement each other

Overall strategy

You Gui Yin addresses Kidney Yang deficiency by warming and restoring the Ming Men (Life Gate) fire while simultaneously nourishing the Yin essence that serves as Yang's material foundation. This embodies Zhang Jing-Yue's famous therapeutic principle: 'Those who are skilled at tonifying Yang must seek Yang within Yin, so that Yang, assisted by Yin, has an inexhaustible source of transformation.' The formula uses a moderate number of Yang-warming herbs anchored by a generous base of Yin-nourishing substances.

King herbs

Shu Di Huang is the sole King herb, used at the highest dosage (up to 60g in severe cases). It richly nourishes Kidney Yin and replenishes essence and Blood. This may seem surprising in a Yang-warming formula, but it reflects Zhang Jing-Yue's insight that Yang cannot be restored without first providing it a substantial Yin foundation to take root in. Without this base, warming herbs alone would produce temporary heat that quickly dissipates.

Deputy herbs

Zhi Fu Zi and Rou Gui form the warming core of the formula. Fu Zi is the strongest Yang-restoring herb in Chinese medicine, powerfully warming the Ming Men and dispelling deep Cold. Rou Gui reinforces this warming action while also guiding the body's floating, rootless Yang back down to its source in the Kidney. Together they provide the 'fire' that the formula aims to restore.

Assistant herbs

Four herbs serve as assistants, each reinforcing the formula from a different angle. Shan Yao tonifies both the Spleen and Kidney, supporting digestion so the body can absorb these rich tonics (reinforcing assistant). Shan Zhu Yu astringes the Kidney and Liver, preventing the leakage of vital essence (reinforcing assistant). Gou Qi Zi nourishes Liver and Kidney Yin, further building the essence foundation (reinforcing assistant). Du Zhong strengthens the lower back and bones, directly targeting a key symptom of Kidney Yang deficiency (reinforcing assistant).

Envoy herbs

Zhi Gan Cao serves as the envoy, harmonizing all the other ingredients and protecting the Spleen and Stomach. The rich, heavy nature of Shu Di Huang can tax digestion, so Zhi Gan Cao helps ensure the Middle Jiao can process the formula effectively.

Notable synergies

The Fu Zi and Rou Gui pairing creates a powerful Yang-warming effect greater than either herb alone: Fu Zi restores Yang with raw power while Rou Gui guides that warmth to the Kidney source. The Shu Di Huang with Fu Zi/Rou Gui pairing is the formula's defining dynamic: Yin-nourishing substance paired with Yang-warming fire, perfectly expressing 'seeking Yang within Yin.' Shan Zhu Yu and Gou Qi Zi together address both Liver and Kidney, preventing essence leakage while replenishing what has been lost.

How to Prepare

Traditional preparation instructions for You Gui Yin

Add all herbs to approximately 400 mL of water. Bring to a boil, then reduce heat and simmer until the liquid is reduced to approximately 250 mL. Strain and drink warm on an empty stomach.

Rou Gui (Cinnamon Bark) may be added in the last 5 minutes of decoction or infused separately in the hot strained liquid, as prolonged boiling can reduce its aromatic, warming properties. Zhi Fu Zi (Prepared Aconite) should be decocted first for 30 to 60 minutes before adding other herbs to reduce its toxicity.

Common Modifications

How practitioners adapt You Gui Yin for specific situations

Added
Ren Shen

9-15g, powerfully tonifies the primal Qi

Bai Zhu

9-12g, strengthens the Spleen to support Qi generation

When Yang deficiency is complicated by severe Qi collapse, manifesting as fainting, cold sweating, or breathlessness, Ren Shen and Bai Zhu are essential to rescue and rebuild Qi alongside the Yang-warming herbs.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where You Gui Yin should not be used or requires extra caution

Avoid

Yin Deficiency with vigorous Empty Heat (signs such as night sweats, five-palm heat, red tongue with no coating, rapid pulse). This formula's warming herbs would further damage Yin and intensify Heat.

Avoid

Damp-Heat conditions, particularly in the lower burner (urinary tract infections, prostatitis with burning urination, thick yellow vaginal discharge). The rich, warm, cloying herbs would trap and worsen Damp-Heat.

Avoid

Impotence or sexual dysfunction caused by Damp-Heat or Liver Fire rather than Kidney Yang Deficiency. Warming tonics are contraindicated when the root cause is excess Heat.

Avoid

Exterior pathogenic invasion (common cold, flu). Tonifying formulas should not be used while an external pathogen is still present, as they can trap the pathogen inside the body.

Caution

Weak digestion with significant Spleen Qi Deficiency. The heavy, cloying nature of Shu Di Huang (prepared Rehmannia) can be difficult to digest and may cause bloating or loose stools. If used, the formula should be modified with digestive aids.

Caution

Pre-existing internal Heat or true Excess Heat patterns. The warming properties of Fu Zi (prepared Aconite) and Rou Gui (Cinnamon Bark) could aggravate Heat symptoms.

Caution

Hypertension. Fu Zi (prepared Aconite) and Rou Gui (Cinnamon Bark) are strongly warming and may raise blood pressure. Use with careful monitoring if at all.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Zhi Fu Zi (prepared Aconite) is a potent warming herb with potential toxicity concerns, and Rou Gui (Cinnamon Bark) promotes blood circulation and warmth in the lower abdomen, both of which raise theoretical concerns about uterine stimulation. While the formula is not strictly classified as an abortifacient, the combination of these two strongly warming herbs means it should only be used during pregnancy under close supervision by a qualified practitioner when the pattern clearly calls for it. Du Zhong (Eucommia Bark), on the other hand, is traditionally considered safe and even beneficial for calming a restless fetus. Overall classification: use only when clearly indicated, with practitioner supervision.

Breastfeeding

Limited safety data exists for use during breastfeeding. Zhi Fu Zi (prepared Aconite) contains aconitine alkaloids, which, even after proper processing to reduce toxicity, raise theoretical concerns about transfer into breast milk. Rou Gui (Cinnamon Bark) is generally considered safe in culinary doses but is used here in medicinal quantities. The formula's overall warming nature could theoretically affect milk composition or the nursing infant's constitution (potentially causing irritability or Heat signs in the infant). Caution is advised, and the formula should only be used during breastfeeding if clearly needed and under practitioner guidance. An alternative with milder warming herbs may be preferred.

Children

You Gui Yin is not commonly used in pediatric practice. Kidney Yang Deficiency severe enough to warrant this formula is uncommon in children, who generally have robust Yang. If prescribed for a child (for example, in cases of congenital Kidney deficiency, enuresis, or failure to thrive with clear Yang Deficiency signs), dosages should be substantially reduced, typically to one-third to one-half of the adult dose depending on the child's age and weight. Zhi Fu Zi (prepared Aconite) requires particular caution in children due to its potential toxicity. Use should be limited to short courses under close practitioner supervision. Not generally suitable for children under age 3.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with You Gui Yin

CYP450 enzyme interactions: A preclinical study found that You Gui Yin can induce CYP2C9, CYP2C19, and CYP3A4 liver enzymes. This means the formula could potentially speed up the breakdown of many common medications metabolized by these enzymes, reducing their effectiveness. Important drug classes affected include:

  • Warfarin and other anticoagulants (CYP2C9 substrate): reduced anticoagulant effect, increasing clot risk
  • Proton pump inhibitors such as omeprazole (CYP2C19 substrate): reduced acid-suppression
  • Benzodiazepines such as midazolam (CYP3A4 substrate): reduced sedative effect
  • Many statins, calcium channel blockers, and immunosuppressants (CYP3A4 substrates)

Zhi Gan Cao (Licorice root): Contains glycyrrhizin, which can cause potassium loss and sodium retention. May interact with corticosteroids (additive potassium depletion), digoxin (increased toxicity risk from low potassium), diuretics, and antihypertensive medications.

Zhi Fu Zi (prepared Aconite): Contains residual aconitine alkaloids even after processing. Theoretical concern for interactions with antiarrhythmic drugs and cardiac glycosides. Should not be combined with drugs that slow heart conduction.

Usage Guidance

Practical advice for getting the most out of You Gui Yin

Best time to take

On an empty stomach with warm water, ideally in the morning and evening. The original text specifies '食远温服' (take warm, away from meals).

Typical duration

Medium-term use: typically 2–8 weeks, reassessed regularly by a practitioner. Chronic Yang Deficiency may require longer courses with periodic breaks.

Dietary advice

Favor warm, cooked, easy-to-digest foods that support Kidney Yang and Spleen function: lamb, venison, bone broths, walnuts, black beans, chestnuts, leeks, ginger, and cinnamon. Warm porridge (congee) with warming spices is ideal. Avoid cold and raw foods (salads, iced drinks, raw fish, chilled fruit), as they further damage the Yang the formula is trying to restore. Also avoid greasy, heavy, or excessively rich foods that can overwhelm the Spleen and impair absorption of the formula's heavy tonic herbs, particularly Shu Di Huang. Limit dairy and excessively sweet or damp-producing foods.

You Gui Yin originates from Jǐng Yuè Quán Shū (景岳全書, The Complete Works of Jing-Yue) by Zhang Jing-Yue, Volume 51 Míng dynasty, 1624 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described You Gui Yin and its clinical use

《景岳全书·新方八阵·补阵》(Jǐng Yuè Quán Shū, Complete Works of Jing-Yue, 'Supplementing Formation'):

「此益火之剂也,凡命门之阳衰阴胜者,宜此方加减主之。此方与大补元煎出入互用。如治阴盛格阳,真寒假热等证,宜加泽泻二钱,煎成用凉水浸冷服之尤妙。」

"This is a formula for supplementing Fire. Whenever the Yang of the Ming Men (Life Gate) is declining and Yin is predominating, this formula should be used with appropriate modifications. This formula can be used interchangeably with Da Bu Yuan Jian (Major Origin-Supplementing Decoction). For treating Yin excess repelling Yang, or true Cold with false Heat patterns, add Ze Xie (Alisma) two qian; after cooking, soak the decoction in cold water and take it cold for best results."


《景岳全书》加减法 (Modification guidelines from the original text):

「如气虚血脱,或厥或昏,或汗或运,或虚狂,或短气者,必大加人参、白术。」

"If there is Qi Deficiency with Blood collapse, or fainting, or loss of consciousness, or sweating, or dizziness, or manic agitation from deficiency, or shortness of breath, one must add large amounts of Ren Shen (Ginseng) and Bai Zhu (Atractylodes)."

Historical Context

How You Gui Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

You Gui Yin (Right-Restoring Beverage) was created by the Ming Dynasty physician Zhang Jie-Bin (张介宾, 1563–1640), better known by his courtesy name Zhang Jing-Yue (张景岳). It first appeared in his magnum opus, the Jǐng Yuè Quán Shū (《景岳全书》, Complete Works of Jing-Yue), published in the early 17th century. Zhang was the leading figure of the Warm Supplementation school (温补学派), which championed the importance of nourishing the body's foundational Yang and Yin rather than relying on harsh cooling and draining treatments that were fashionable at the time.

The formula is part of Zhang's systematic reworking of the classic Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill) framework. He took the "three supplementing" herbs from Liu Wei Di Huang Wan (Shu Di Huang, Shan Yao, Shan Zhu Yu), removed the "three draining" herbs (Fu Ling, Ze Xie, Mu Dan Pi), and added warming herbs (Fu Zi, Rou Gui, Du Zhong) plus Gou Qi Zi and Zhi Gan Cao. This created a purely supplementing formula without any draining action. The name "You Gui" (Right-Restoring) refers to the right Kidney, which in the Nán Jīng (Classic of Difficulties) tradition was identified with the Ming Men and Yang. Its counterpart, Zuo Gui Yin (Left-Restoring Beverage), nourishes the left Kidney (Yin). Together they form a matched pair addressing the two sides of Kidney deficiency.

According to one historical account, Zhang Jing-Yue's patient population included wealthy aristocrats seeking pure tonification, which influenced his preference for formulas without draining components. The formula later evolved into You Gui Wan (Right-Restoring Pill), which adds Lu Jiao Jiao (Deer Antler Glue), Tu Si Zi (Dodder Seed), and Dang Gui (Angelica), creating an even stronger version for chronic use in pill form.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of You Gui Yin

1

Effect of You-Gui Yin on the Activities of Seven Cytochrome P450 Isozymes in Rats (Preclinical pharmacokinetic study, 2020)

He F, et al. Evidence-Based Complementary and Alternative Medicine, 2020, Article ID 7091821.

This animal study investigated how You Gui Yin affects liver drug-metabolizing enzymes. At high doses, the formula induced the activity of CYP2C9, CYP2C19, and CYP3A4, meaning it could speed up the metabolism of drugs processed by these enzymes and potentially reduce their effectiveness. No significant effects were found on CYP1A2, CYP2B6, CYP2C8, or CYP2D6.

PubMed
2

You-Gui-Yin Improved Reproductive Dysfunction of Male Rats with Chronic Kidney Disease via Regulating the HIF1α-STAT5 Pathway (Preclinical study, 2020)

Li ZH, Wu C, Ke H, Xue Q, Tang Q, Li J, Feng S, Xu XY. Journal of Ethnopharmacology, 2020, 246:112240.

This animal study tested You Gui Yin's effect on reproductive dysfunction caused by chronic kidney disease. The formula significantly slowed kidney disease progression, improved hormone levels and sexual function, and reduced sperm abnormalities in the treated rats. The mechanism involved regulation of the HIF1α-EPO-STAT5 signaling pathway in the kidney and testis.

PubMed
3

Network Pharmacology-Based and Molecular Docking-Based Analysis of You-Gui-Yin for the Treatment of Osteonecrosis of the Femoral Head (Computational study, 2023)

Wang Y, et al. Medicine, 2023, 102(43):e35829.

This computational pharmacology study explored how You Gui Yin may work against steroid-induced osteonecrosis of the femoral head (a condition where bone tissue in the hip dies due to poor blood supply). The analysis identified multiple active compounds and biological targets, suggesting the formula works through multiple pathways including anti-inflammatory (IL-17), anti-hypoxia (HIF-1), and tissue repair (MAPK) signaling.

PubMed
4

N-Butanol Extract of Modified You-Gui-Yin Attenuates Osteoclastogenesis and Ameliorates Osteoporosis by Inhibiting RANKL-Mediated NF-κB Signaling (Preclinical study, 2022)

Zeng Q, Xu R, Ling H, Zhao S, Wang X, Yuan W, Gu M, Xu T, Wang P, Ruan H, Jin H, Qu H, Ye F, Chen J. Frontiers in Endocrinology, 2022, 13:925848.

Using an ovariectomized mouse model of postmenopausal osteoporosis, this study found that a modified You Gui Yin extract protected against bone loss. It worked by inhibiting the formation of osteoclasts (cells that break down bone) through suppression of the NF-κB signaling pathway, offering a potential mechanism for the formula's traditional use in treating bone weakness.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.