Tao He Cheng Qi Tang

Peach Pit Qi-Guiding Decoction · 桃核承氣湯

Also known as: Tao Ren Cheng Qi Tang (桃仁承气汤), Peach Kernel Order the Qi Decoction

A classical formula used to break up blood stasis and clear heat from the lower abdomen. It is commonly applied for lower abdominal pain with a sense of tightness and fullness, dark-coloured menstrual blood or stools, restlessness, and nighttime fevers caused by stagnant blood binding with heat in the lower body.

Origin Shang Han Lun (傷寒論) by Zhang Zhongjing — Eastern Hàn dynasty, ~200 CE
Composition 5 herbs
Tao Ren
King
Tao Ren
Da Huang
King
Da Huang
Gui Zhi
Deputy
Gui Zhi
Mang Xiao
Deputy
Mang Xiao
Gan Cao
Envoy
Gan Cao
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Tao He Cheng Qi Tang is designed to correct these specific patterns.

Why Tao He Cheng Qi Tang addresses this pattern

This is the primary pattern this formula was designed for, described in the Shang Han Lun as "heat binding in the Bladder" (a classical term for the lower abdomen). When pathological heat combines with stagnant blood in the lower body, the blood congeals and accumulates. The formula addresses this by using Tao Ren and Da Huang as its core pair to break up blood stasis and drive heat downward, while Gui Zhi warms and opens the vessels to mobilize stagnant blood. Mang Xiao softens hardened accumulations. The result is that bound heat and stagnant blood are expelled through the bowels, relieving the pressure and congestion in the lower abdomen.

A practitioner would look for one or more of these signs

Lower Abdominal Pain

Acute, tight, distending pain in the lower abdomen that worsens with pressure

Restlessness

Agitation or manic-like restless behaviour (described classically as 'acting as if mad')

High Fever

Fever that worsens at night, a hallmark of blood-level heat

Constipation

Dark or black stools indicating blood stasis in the intestines

Amenorrhea

Painful periods with dark, clotted menstrual blood

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Tao He Cheng Qi Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Blood Stasis in the Lower Jiao Blood Stagnation with Heat

TCM Interpretation

In TCM, painful periods are fundamentally a problem of obstruction: when blood does not flow smoothly through the uterus and its channels, pain results. Among the various causes of this obstruction, one of the most intense is when stagnant blood binds together with heat in the lower abdomen. The heat thickens and congeals the blood, while the stagnant blood traps heat, creating a self-reinforcing cycle. This manifests as severe cramping that worsens with pressure, menstrual blood that is dark purple with clots, and often accompanying signs of heat such as irritability, thirst, or nighttime fevers.

Why Tao He Cheng Qi Tang Helps

Tao He Cheng Qi Tang directly targets the mechanism of heat-bound blood stasis. Tao Ren (Peach Kernel) is one of the strongest blood stasis-breaking herbs and has a particular affinity for the lower abdomen. Da Huang (Rhubarb) drives the expelled stasis and heat downward through the bowels, providing rapid relief. Gui Zhi (Cinnamon Twig) warms and opens the blood vessels to restore circulation, while Mang Xiao softens any hardened accumulations. This combined action clears the obstruction causing the pain. The formula is best suited for excess-type dysmenorrhea with clear heat signs, rather than pain from cold or deficiency.

Also commonly used for

Intestinal Obstruction

Bowel obstruction with signs of blood stasis and heat

Trauma

Post-traumatic agitation, nighttime restlessness, and delirium after head injury

Retained Placenta

Postpartum retention of placental tissue with blood stasis

Urinary Stones

Urinary tract calculi with blood stasis and heat signs

Cerebral Hemorrhage

Acute cerebrovascular bleeding with stasis and heat pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Tao He Cheng Qi Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Tao He Cheng Qi Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Tao He Cheng Qi Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Tao He Cheng Qi Tang works at the root level.

This formula addresses a condition the Shāng Hán Lùn calls "Blood accumulation in the Lower Burner" (下焦蓄血证, xià jiāo xù xuè zhèng). The underlying disease logic works like this:

An illness that initially attacked the body's surface (a Tài Yáng-level disorder) fails to resolve completely. Instead of being expelled outward, pathogenic Heat follows the channels inward and downward, becoming trapped in the lower abdomen, in the region around the Bladder, uterus, and intestines. This Heat meets the Blood that circulates in this area and causes it to congeal and stagnate. Once Blood stops moving freely, it and the Heat reinforce each other in a vicious cycle: the Heat "cooks" the Blood into a thicker, stagnant mass, while the stagnant Blood traps the Heat and prevents it from being cleared. This is called "mutual binding of stasis and Heat" (瘀热互结). The resulting pattern shows tightness and urgent pain in the lower abdomen (because stagnant Blood physically obstructs the area), fever that worsens at night (because Blood belongs to Yin and its pathology intensifies during Yin hours), and mental agitation or manic-like behavior (because the blocked Heat and stagnant Blood disturb the Spirit housed in the Heart). Urination remains normal, which distinguishes this from fluid accumulation. The formula resolves this by simultaneously breaking up the stagnant Blood and purging the bound Heat downward through the bowels, restoring normal Blood circulation and clearing the trapped Heat from below.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter and salty with a mild pungent note. Bitter to drain Heat and move stasis downward, salty to soften hardness and break accumulation, pungent to open the vessels and disperse congealed Blood.

Channels Entered

Ingredients

5 herbs

The herbs that make up Tao He Cheng Qi Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Tao Ren

Tao Ren

Peach kernel

Dosage 9 - 12g
Temperature Neutral
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Large Intestine

Role in Tao He Cheng Qi Tang

Breaks up blood stasis and disperses blood accumulation in the lower abdomen. As the primary blood-moving herb, it directly addresses the core pathomechanism of static blood binding in the lower body.
Da Huang

Da Huang

Rhubarb root and rhizome

Dosage 9 - 12g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium

Role in Tao He Cheng Qi Tang

Purges heat downward and expels blood stasis through the bowels. Works together with Tao Ren to flush accumulated stagnant blood and heat from the lower body via the intestinal tract.
Deputies — Assists and enhances the King
Gui Zhi

Gui Zhi

Cinnamon twig

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder

Role in Tao He Cheng Qi Tang

Warms and unblocks the blood vessels, assisting the movement of stagnant blood. Its warm, pungent nature prevents the cold properties of Da Huang and Mang Xiao from congealing the blood further, ensuring the formula disperses rather than stagnates.
Mang Xiao

Mang Xiao

Mirabilite (Glauber's salt)

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Stomach, Large Intestine
Preparation Dissolve in the strained decoction (冲服); do not decoct with the other herbs

Role in Tao He Cheng Qi Tang

Softens hardness and clears heat. Its salty, cold nature helps to dissolve hard accumulations of stagnant blood while assisting Da Huang in purging heat downward.
Envoy — Directs the formula to its target
Gan Cao

Gan Cao

Licorice root

Dosage 3 - 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Tao He Cheng Qi Tang

Harmonizes the formula and moderates the harsh, drastic actions of Da Huang and Mang Xiao, protecting the Stomach and preventing excessive purging.

Why This Combination Works

How the herbs in Tao He Cheng Qi Tang complement each other

Overall strategy

The formula is built on the framework of Tiao Wei Cheng Qi Tang (Da Huang, Mang Xiao, Gan Cao), a purgative base for clearing interior heat, with the addition of Tao Ren to break up blood stasis and Gui Zhi to warm and move the blood vessels. This combination allows the formula to simultaneously purge heat and expel stagnant blood from the lower body.

King herbs

Tao Ren (Peach Kernel) directly enters the blood level and powerfully breaks up blood stasis, making it the primary agent against the core problem of accumulated static blood. Da Huang (Rhubarb) purges heat downward and itself has blood stasis-dispelling properties. Together, they form a potent pairing that drives stagnant blood and bound heat out of the lower abdomen via the bowels.

Deputy herbs

Gui Zhi (Cinnamon Twig) warms and opens the blood vessels, assisting blood circulation so that stagnant blood can be mobilized. Its warm, dispersing nature also counterbalances the cold properties of Da Huang and Mang Xiao, preventing the formula from becoming too cold and potentially causing the blood to congeal further. Mang Xiao (Mirabilite) softens hard accumulations and clears heat, reinforcing Da Huang's purgative and heat-clearing actions while helping to dissolve congealed blood masses.

Envoy herbs

Zhi Gan Cao (Honey-prepared Licorice) serves a dual role: it harmonizes the actions of all the other herbs in the formula and moderates the drastic purgative force of Da Huang and Mang Xiao. This prevents excessive purging that could injure the digestive system, ensuring the formula achieves only a gentle loosening of the bowels.

Notable synergies

The Tao Ren and Da Huang pairing is the formula's engine: Tao Ren breaks up blood stasis while Da Huang provides the downward-driving force to expel it. The Gui Zhi and Tao Ren combination is also significant. Gui Zhi moves through the blood vessels and promotes circulation, while Tao Ren breaks up existing clots. Together they ensure blood is both mobilized and dispersed. The interplay between the warming Gui Zhi and the cooling Da Huang and Mang Xiao creates a balanced formula that clears heat without freezing the blood, reflecting the classical principle of preventing cold from causing further stagnation in a blood stasis condition.

How to Prepare

Traditional preparation instructions for Tao He Cheng Qi Tang

Decoct the first four ingredients (Tao Ren, Da Huang, Gui Zhi, and Zhi Gan Cao) in approximately 1400 ml of water, reducing to about 500 ml. Strain and remove the dregs. Add Mang Xiao (Mirabilite) to the strained decoction and return briefly to the heat, bringing it to a gentle simmer. Remove from heat immediately. Take warm on an empty stomach (before meals), approximately 150-170 ml per dose, three times daily. The expected effect is mild, loose stools ("should produce gentle purging"). Discontinue once stools become smooth and symptoms improve.

Common Modifications

How practitioners adapt Tao He Cheng Qi Tang for specific situations

Added
Dang Gui

9g, nourishes and moves blood

Chi Shao

9g, cools blood and disperses stasis

Chuan Xiong

6g, moves blood and Qi in the pelvic region

Niu Xi

9g, directs blood downward and unblocks menstruation

Adding Si Wu Tang components strengthens the blood-moving effect while providing some nourishment to prevent excessive depletion, and Niu Xi directs the formula's action to the lower body and uterus.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Tao He Cheng Qi Tang should not be used or requires extra caution

Avoid

Pregnancy. This formula contains Tao Ren (Peach Kernel) and Da Huang (Rhubarb), both of which strongly move Blood and can stimulate uterine contractions. Mang Xiao (Mirabilite) also has purgative action. Together these pose serious risk of miscarriage or premature labor.

Avoid

Active hemorrhage or bleeding disorders. As a formula that powerfully breaks Blood stasis and purges downward, it can worsen uncontrolled bleeding.

Avoid

Unresolved exterior pattern (exterior symptoms still present). The original Shang Han Lun text explicitly states: if exterior symptoms have not yet resolved, the exterior must be treated first before using this formula.

Caution

Qi or Blood deficiency without true excess. This is a strongly attacking formula (攻下剂) unsuitable for patients with constitutional weakness, pale complexion, or deficiency-type conditions.

Caution

Elderly or physically frail patients. The formula's purgative and Blood-breaking actions can be too aggressive. If use is necessary, dosages should be reduced and the patient closely monitored.

Caution

Menorrhagia or excessive menstrual bleeding. Although used for Blood stasis in gynecology, it should not be given when there is already heavy or uncontrolled menstrual flow, as its Blood-moving action could worsen bleeding.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated. This formula must not be used during pregnancy. Tao Ren (Peach Kernel) is a powerful Blood-moving herb that can stimulate uterine contractions. Da Huang (Rhubarb) has strong purgative action and is classified as pregnancy-prohibited in the Chinese Pharmacopoeia, with animal studies suggesting reproductive toxicity at doses close to clinical range. Mang Xiao (Mirabilite) also promotes purgation. The combined Blood-breaking and downward-draining actions of the formula create a significant risk of miscarriage, premature labor, or fetal harm. Classical sources explicitly state: 因本方为破血下瘀之剂,故孕妇禁用 ("As this formula breaks Blood and purges stasis, it is prohibited in pregnancy").

Breastfeeding

Use with caution during breastfeeding. Da Huang (Rhubarb) contains anthraquinone compounds (such as emodin and rhein) that can pass into breast milk and may cause loose stools or diarrhea in the nursing infant. Mang Xiao (Mirabilite) also has strong purgative properties. While not absolutely contraindicated like in pregnancy, this formula should only be used during breastfeeding when clearly necessary and under professional supervision, ideally for the shortest possible duration. If the infant develops diarrhea or signs of gastrointestinal upset, the formula should be discontinued immediately.

Children

This formula is generally not suitable for young children due to its strongly purgative and Blood-breaking nature. In adolescents (roughly age 12 and older) with clear signs of Heat-bound Blood stasis, it may be considered under close professional supervision with significant dosage reduction, typically to one-third to one-half of the adult dose depending on the child's age and body weight. The formula should only be used short-term (1 to 3 doses), and bowel movements should be carefully monitored. Classical sources note that the formula's force is potent and it should only be used temporarily, not for prolonged courses. It is not appropriate for children with weak constitutions.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Tao He Cheng Qi Tang

Anticoagulants and antiplatelet drugs (warfarin, heparin, aspirin, clopidogrel): Tao Ren (Peach Kernel) and Da Huang (Rhubarb) both have demonstrated antiplatelet and antithrombotic effects. Using this formula alongside blood-thinning medications may increase bleeding risk. Close monitoring of coagulation parameters (INR, PT) is advisable if concurrent use is necessary.

Cardiac glycosides (digoxin): Da Huang and Mang Xiao can cause significant fluid and electrolyte loss through purgation, particularly potassium depletion. Hypokalemia increases the risk of digoxin toxicity. Electrolytes should be monitored.

Diuretics (especially loop and thiazide diuretics): The purgative action of this formula combined with diuretic medications may lead to excessive fluid loss, dehydration, and electrolyte imbalance.

Gan Cao (Licorice root) in this formula may interact with corticosteroids (additive potassium-depleting effects), antihypertensives (licorice can promote sodium retention and raise blood pressure), and hypoglycemic agents (potential interference with blood sugar regulation), though at the relatively low dose used here (6g) these interactions are less likely to be clinically significant.

Usage Guidance

Practical advice for getting the most out of Tao He Cheng Qi Tang

Best time to take

On an empty stomach, before meals (the classical text specifies 先食温服, 'take warm before eating'), typically 30 to 60 minutes before meals, divided into 2 to 3 doses per day.

Typical duration

Acute use: 1 to 5 days. This is a strongly attacking formula meant for short-term use only. Once symptoms improve (bowels move, abdominal tightness eases, mental agitation calms), the formula should be discontinued.

Dietary advice

While taking this formula, avoid cold and raw foods, icy drinks, and greasy or heavy foods, as these can impede the formula's ability to move Blood and clear Heat. Spicy, hot, and stimulating foods (alcohol, chili, fried foods) should also be limited, as they can aggravate Heat. Light, easily digestible, warm foods are preferable. The classical instructions specify taking the formula before meals (先食温服), meaning on an empty stomach, to maximize its therapeutic action in the lower abdomen.

Tao He Cheng Qi Tang originates from Shang Han Lun (傷寒論) by Zhang Zhongjing Eastern Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Tao He Cheng Qi Tang and its clinical use

《伤寒论》第106条 (Shāng Hán Lùn, Clause 106):

「太阳病不解,热结膀胱,其人如狂,血自下,下者愈。其外不解者,尚未可攻,当先解其外。外解已,但少腹急结者,乃可攻之,宜桃核承气汤。」

"When a Tài Yáng disease has not resolved and Heat binds in the Bladder, the person becomes manic-like [rú kuáng]. If Blood descends spontaneously, the condition resolves. If the exterior has not yet resolved, one must not attack [the interior] but should first resolve the exterior. Once the exterior is resolved and only tightness and urgency in the lower abdomen remain, one may attack it. Táo Hé Chéng Qì Tāng is appropriate."

柯琴 Kē Qín,《伤寒来苏集·伤寒附翼》(Shāng Hán Lái Sū Jí, Shāng Hán Fù Yì):

「气者血之用,气行则血濡,气结则血蓄,气壅不濡,是血亦病矣……治病必求其本,气留不行,故君大黄之走而不守者,以行其逆气;甘草之甘平者,以调和其正气;血结而不行,故用芒硝之咸以软之;桂枝之辛以散之;桃仁之苦以泄之。」

"Qi is the function of Blood. When Qi flows, Blood is nourished; when Qi stagnates, Blood accumulates... In treating disease one must seek the root. Qi is blocked and cannot flow, therefore Da Huang is made sovereign to move the rebellious Qi. Gan Cao harmonizes the upright Qi. Blood is congealed and cannot flow, so Mang Xiao's salty nature softens it, Gui Zhi's acrid nature disperses it, and Tao Ren's bitter nature drains it."

Historical Context

How Tao He Cheng Qi Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Táo Hé Chéng Qì Tāng was created by Zhāng Zhòngjǐng (张仲景) and first recorded in the Shāng Hán Lùn (Treatise on Cold Damage, c. 200–210 CE), Clause 106. The formula's name literally means "Peach Kernel Decoction to Order the Qi," reflecting its dual strategy of breaking Blood stasis (represented by Tao Ren, originally called Tao He in the Shén Nóng Běn Cǎo Jīng) while using the downward-purging mechanism of the Chéng Qì ("Order the Qi") family to expel Heat and restore proper Qi movement. Its base is essentially Tiáo Wèi Chéng Qì Tāng (Regulate the Stomach and Order the Qi Decoction) with the addition of Tao Ren and Gui Zhi.

The formula sits within a classical triad of Blood stasis formulas of increasing strength: Guì Zhī Fú Líng Wán (mildest, for chronic Blood stasis), Táo Hé Chéng Qì Tāng (moderate, for Heat-bound Blood stasis), and Dǐ Dāng Tāng (most aggressive, using leeches and gadflies for severe, entrenched stasis). The name shift from "Tao He" to "Tao Ren" Cheng Qi Tang began in the Ming dynasty, when physicians like Huángfǔ Zhōng started using the latter name. Later physicians, including the prominent Shāng Hán Lùn commentator Kē Qín (Qing dynasty), praised the formula for gynecological applications, noting it was excellent for menstrual irregularity, painful periods, and amenorrhea. In modern times, the formula's applications have expanded well beyond its original Blood-accumulation indication to include traumatic brain injury, acute pelvic inflammatory disease, endometriosis, intestinal obstruction, and other conditions sharing the core pathomechanism of Heat-bound Blood stasis.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Tao He Cheng Qi Tang

1

Neuroprotective effects of Tao-Ren-Cheng-Qi Tang against embolic stroke in rats (Animal study, 2017)

Hsu LW, Shiao WC, Chang NC, et al. Chinese Medicine, 2017, 12:7

This animal study examined whether the formula combined with aspirin could protect against brain damage from stroke. Rats with induced cerebral artery blockage were treated for 30 days. The formula reduced brain infarct volume and improved neurological outcomes by reducing cell death, lowering TNF-alpha and p-JNK expression, and reducing harmful free radical formation.

Link
2

Metabolic insight into the neuroprotective effect of THCQ decoction on intracerebral hemorrhage rats using untargeted metabolomics (Animal study, 2021)

Yang RP, Cai DK, Chen YX, et al. Frontiers in Pharmacology, 2021, 12:636457

This preclinical study used metabolomics to investigate how the formula protects against secondary brain injury after intracerebral hemorrhage in rats. The researchers identified 27 potential biomarkers affected by the formula, mainly involved in amino acid metabolism, lipid metabolism-related oxidative stress, and energy metabolism. The results suggest the formula significantly reduces hemorrhage-induced brain damage through multiple metabolic pathways.

Link
3

Deciphering the pharmacological mechanisms of Taohe-Chengqi decoction extract against renal fibrosis through integrating network pharmacology and experimental validation (Preclinical study, 2020)

Zhou S, Ai Z, Li W, et al. Frontiers in Pharmacology, 2020, 11:425

This study combined computational network pharmacology with in vitro and in vivo experiments to explore how the formula works against kidney fibrosis. The formula demonstrated the ability to improve renal interstitial fibrosis through multiple pharmacological targets, supporting its traditional use for conditions involving Blood stasis in the Lower Burner.

Link
4

Anti-colon cancer targets and molecular mechanisms of Tao-He-Cheng-Qi Formula (Network pharmacology study, 2022)

Zhang Z, et al. Evidence-Based Complementary and Alternative Medicine, 2022

Using network pharmacology approaches, this study explored the formula's potential anti-tumor mechanisms against colon cancer. The analysis identified multiple molecular targets and pathways through which the formula may exert anti-cancer effects, including regulation of apoptosis-related proteins. The study provides a theoretical basis for the formula's broader applications but requires clinical validation.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.