Huang Lian Tang

Coptis Decoction · 黄连汤

A classical formula for digestive problems involving a mix of Heat above and Cold below. It is used when someone experiences upper abdominal or chest discomfort with a sensation of heat, nausea or vomiting, along with abdominal pain and possibly diarrhea caused by cold in the stomach and intestines. The formula works by clearing Heat from the upper body while warming the middle and lower digestive tract, restoring normal digestive function.

Origin Shang Han Lun (傷寒論) by Zhang Zhongjing — Eastern Hàn dynasty, ~200 CE
Composition 7 herbs
Huang Lian
King
Huang Lian
Gui Zhi
Deputy
Gui Zhi
Gan Jiang
Deputy
Gan Jiang
Ban Xia
Assistant
Ban Xia
Ren Shen
Assistant
Ren Shen
Da Zao
Envoy
Da Zao
Gan Cao
Envoy
Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Huang Lian Tang is designed to correct these specific patterns.

Why Huang Lian Tang addresses this pattern

This is the primary pattern Huang Lian Tang was designed for. When an external pathogenic factor invades and disrupts the middle burner, the normal communication between the upper and lower body breaks down. Yang (warmth) floats upward and transforms into Heat in the chest, while Yin (cold) sinks downward, leaving the Stomach and intestines cold. The Spleen and Stomach, which normally act as a pivot to coordinate ascending and descending Qi, lose their regulatory function. Huang Lian directly clears the Heat trapped above, while Gui Zhi and Gan Jiang warm the Cold below. Ban Xia redirects rebellious Qi downward, and Ren Shen with Zhi Gan Cao and Da Zao restore the middle burner's strength to resume its pivoting function. The formula restores the proper top-to-bottom flow so that Heat no longer accumulates above and Cold no longer stagnates below.

A practitioner would look for one or more of these signs

Abdominal Pain

Abdominal pain from Cold in the intestines, often around or below the navel

Nausea

Nausea and desire to vomit from Heat rebelling upward

Epigastric Fullness And Pain Relieved By Vomiting

Vomiting due to disrupted descending of Stomach Qi

Chest Congestion

A sensation of heat and stuffiness in the chest

Diarrhea

Loose stools or diarrhea with borborygmus from intestinal Cold

Irritability

Restlessness and irritability from Heat disturbing the chest

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Huang Lian Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Upper Heat and Lower Cold Cold and Heat Complex in the Middle Burner

TCM Interpretation

TCM understands chronic gastritis as a condition where the Spleen and Stomach have been damaged over time, often by irregular eating, emotional stress, or the lingering effects of external pathogens. In the pattern that Huang Lian Tang addresses, the Stomach lining generates Heat (manifesting as a burning sensation, acid reflux, or a bitter taste), while the deeper digestive function has become Cold and weak (manifesting as loose stools, cold abdominal pain, and poor appetite). The middle burner's ability to properly separate the clear from the turbid has broken down, so the patient simultaneously has signs of both excess Heat and deficiency Cold.

Why Huang Lian Tang Helps

Huang Lian Tang is well suited to chronic gastritis with this specific mixed presentation. Huang Lian directly clears inflammatory Heat from the Stomach lining, which corresponds to the burning, acid-reflux component of the condition. Gan Jiang and Gui Zhi warm the deeper intestinal function and relieve the cold-type abdominal pain. Ban Xia settles the Stomach to stop nausea and acid regurgitation, while Ren Shen, Zhi Gan Cao, and Da Zao strengthen the overall digestive capacity. Clinical studies have shown a total effective rate of over 90% in treating atrophic gastritis with modified Huang Lian Tang.

Also commonly used for

Gastroenteritis

Acute or chronic gastroenteritis with vomiting and diarrhea

Nausea

Persistent nausea and vomiting, including alcohol-induced

Abdominal Pain

Functional abdominal pain with cold-heat complex

Severe Heart Palpitations

Palpitations and cardiac arrhythmia with digestive symptoms

Insomnia

Insomnia accompanied by gastrointestinal disturbance

Irritable Bowel Syndrome

IBS with alternating patterns of cold and heat signs

Cholecystitis

Gallbladder inflammation with nausea, vomiting and abdominal pain

What This Formula Does

Every TCM formula has a specific set of actions — here's what Huang Lian Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Huang Lian Tang is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Huang Lian Tang works at the root level.

Huang Lian Tang addresses a condition where Cold and Heat have become separated and trapped in different parts of the body, disrupting the normal up-and-down circulation of Qi in the digestive system. The classical text describes this as "Heat in the chest" and "pathogenic Qi in the Stomach" occurring simultaneously.

In a healthy body, the Heart's warm Yang descends to warm the lower regions, while the Spleen and Stomach's clear Qi rises upward. When an external pathogen invades and disrupts the middle, this exchange breaks down. Heat becomes trapped in the upper body (the chest area), while Cold lodges in the Stomach and intestines below. The middle burner (Spleen and Stomach), which normally serves as the pivot for ascending and descending Qi, loses its coordinating function. Because Cold blocks the Stomach from descending turbid Qi downward, that Qi rebels upward, causing nausea and vomiting. Meanwhile, the Cold in the abdomen impairs the Spleen's transforming function, causing abdominal pain and potentially loose stools.

This is not simply a matter of Heat or Cold alone, but a pathological split where each occupies a different region: the upper body is too hot and the lower body is too cold, with the Spleen and Stomach caught in between. This is what classical physicians call "upper Heat, lower Cold" (上热下寒), a condition of disrupted Yin-Yang communication. The formula works precisely because it addresses both problems at once, clearing the Heat above while warming the Cold below, and crucially restoring the middle pivot so that normal ascending and descending can resume.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Neutral

Taste Profile

Predominantly bitter and acrid with underlying sweetness. The bitter taste (from Huang Lian) clears Heat and directs downward; the acrid taste (from Gui Zhi, Gan Jiang, Ban Xia) opens, disperses, and warms; the sweetness (from Ren Shen, Zhi Gan Cao, Da Zao) harmonizes and supplements the middle.

Ingredients

7 herbs

The herbs that make up Huang Lian Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Huang Lian

Huang Lian

Coptis rhizome

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Huang Lian Tang

Bitter and cold, Huang Lian clears Heat from the chest and upper body, directly addressing the core pathomechanism of Heat above. At the full dose of 9g (matching the warming herbs), it powerfully cools Heart and Stomach Fire, stops irritability, and harmonizes the Stomach.
Deputies — Assists and enhances the King
Gui Zhi

Gui Zhi

Cinnamon twig

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder

Role in Huang Lian Tang

Acrid and warm, Gui Zhi warms the Yang, disperses Cold from the Stomach and intestines, and directs counterflow Qi downward. It pairs with Huang Lian in a classic acrid-warm and bitter-cold combination that restores the normal ascending-descending axis of Qi in the middle burner.
Gan Jiang

Gan Jiang

Dried ginger rhizome

Dosage 6 - 9g
Temperature Hot
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Spleen, Lungs, Stomach

Role in Huang Lian Tang

Acrid and hot, Gan Jiang warms the middle burner, dispels Cold from the Stomach and intestines, and alleviates abdominal pain due to Cold. Working alongside Gui Zhi, it ensures the lower Cold is addressed with sufficient warming power.
Assistants — Supports or moderates other herbs
Ban Xia

Ban Xia

Pinellia rhizome

Dosage 6 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs
Preparation Washed (洗)

Role in Huang Lian Tang

Acrid and warm, Ban Xia harmonizes the Stomach, redirects rebellious Qi downward, and stops vomiting. It also dries Dampness and dissolves Phlegm, addressing the turbid fluids that accumulate when the middle burner's transport function is impaired.
Ren Shen

Ren Shen

Ginseng root

Dosage 3 - 6g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys

Role in Huang Lian Tang

Sweet and warm, Ren Shen tonifies the Qi of the middle burner, strengthening the Spleen and Stomach so they can resume their pivotal role in ascending the clear and descending the turbid. It supports the body's ability to expel the pathogenic factors.
Envoys — Directs the formula to its target
Da Zao

Da Zao

Jujube fruit

Dosage 4 - 12 pieces
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Preparation Split open (擘)

Role in Huang Lian Tang

Sweet and neutral, Da Zao nourishes the Spleen and Stomach, tonifies Qi and Blood, and moderates the harsh properties of the other herbs, helping them work in concert rather than in conflict.
Gan Cao

Gan Cao

Licorice root

Dosage 6 - 9g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Huang Lian Tang

Sweet and neutral, honey-prepared Gan Cao tonifies the Spleen, relaxes spasms to relieve abdominal pain, and harmonizes all the herbs in the formula. It bridges the cold and warm components, preventing them from clashing.

Why This Combination Works

How the herbs in Huang Lian Tang complement each other

Overall strategy

This formula addresses a situation where Heat is trapped in the upper body (chest) while Cold occupies the middle and lower digestive tract, causing the normal ascending and descending movements of Qi to break down. The prescription strategy is to simultaneously clear Heat above and warm Cold below, while restoring the Spleen and Stomach's central pivoting function through a carefully balanced combination of bitter-cold and acrid-warm herbs.

King herbs

Huang Lian (Coptis) is the sole King herb, used at a substantial dose equal to the warming herbs. Its bitter, cold nature directly clears the Heat lodged in the chest, calms irritability, and settles the Stomach. It targets the "upward" half of the pathomechanism, preventing Heat from forcing Qi to rebel upward and cause vomiting.

Deputy herbs

Gui Zhi (Cinnamon Twig) and Gan Jiang (Dried Ginger) together form the warming counterbalance. Gui Zhi warms Yang and promotes the downward movement of Qi, directly opposing the counterflow that causes nausea and vomiting. Gan Jiang warms the Stomach and intestines, dispersing the Cold that causes abdominal pain and diarrhea. Together with Huang Lian, they create the core "acrid-opening, bitter-descending" dynamic that restores the middle burner's function.

Assistant herbs

Ban Xia (Pinellia) is a reinforcing assistant that powerfully descends Stomach Qi and stops vomiting. It also dries pathological fluids that accumulate when digestion stalls. Ren Shen (Ginseng) is also a reinforcing assistant, tonifying Spleen and Stomach Qi so the digestive system can regain its strength to process food normally and resume its role as the body's central pivot.

Envoy herbs

Zhi Gan Cao (prepared Licorice) and Da Zao (Jujube) tonify the middle, ease abdominal spasms and pain, and harmonize the formula's contrasting cold and warm elements. They ensure the bitter-cold Huang Lian and acrid-warm Gui Zhi and Gan Jiang work together smoothly rather than in opposition.

Notable synergies

The Huang Lian and Gui Zhi pairing is the formula's signature. One is bitter-cold and descends, the other is acrid-warm and promotes circulation. Together they perform a function similar to the classical Jiao Tai Wan (Coptis-Cinnamon pill), restoring communication between the upper and lower parts of the body. The Gan Jiang and Ban Xia pairing reinforces the warming and drying action in the middle burner, effectively resolving both Cold and pathological fluids simultaneously.

How to Prepare

Traditional preparation instructions for Huang Lian Tang

Combine all seven ingredients with approximately 2 litres (one dou) of water. Bring to a boil and simmer until the liquid is reduced to approximately 1.2 litres (six sheng). Strain off the dregs and serve warm. The classical instructions call for five doses per day: three during the daytime and two at night, approximately 200ml per dose. This frequent small-dose schedule is particularly suited to patients with nausea and vomiting who may not tolerate large volumes at once.

Common Modifications

How practitioners adapt Huang Lian Tang for specific situations

Added
Ge Gen

12 - 15g, raises clear Yang and stops diarrhea

When diarrhea is a leading symptom, Ge Gen lifts the Spleen's ascending function and firms the stools, complementing the formula's warming and harmonizing actions.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Huang Lian Tang should not be used or requires extra caution

Avoid

Pure Heat patterns without Cold: this formula contains warm and hot herbs (Gui Zhi, Gan Jiang) and is designed for mixed Cold-Heat conditions. Using it for uniform Heat patterns (e.g. Stomach Fire alone, Yang Ming excess Heat) would worsen the condition.

Avoid

Known allergy or hypersensitivity to any of the component herbs, particularly Huang Lian (Coptis).

Avoid

Pure Cold patterns without Heat: patients with predominantly Cold conditions (e.g. Spleen-Kidney Yang deficiency without any Heat signs) should not use this formula, as the bitter-cold Huang Lian would further damage Yang.

Caution

Yin deficiency with Empty Heat: the warming herbs in this formula (Gui Zhi, Gan Jiang) can further consume Yin in patients whose Heat arises from Yin deficiency rather than from a true mixed Cold-Heat condition.

Caution

Prolonged use without reassessment: the formula is designed for an active Cold-Heat imbalance. Extended use of the bitter-cold Huang Lian may damage Spleen Yang and digestive function over time.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Gui Zhi (Cinnamon Twig) is warm and moves Qi and Blood, which theoretically could stimulate uterine activity if used in high doses. Ban Xia (Pinellia) is traditionally listed as a cautionary herb during pregnancy due to its acrid, descending nature, though the processed form (Fa Ban Xia/Qing Ban Xia) used in clinical practice carries lower risk than the raw form. This formula is not specifically contraindicated as an abortifacient, but given these two components, it should only be used during pregnancy under close supervision by a qualified practitioner when the clinical benefit clearly outweighs the potential risk.

Breastfeeding

No specific contraindication during breastfeeding has been established for this formula. However, berberine (the primary alkaloid in Huang Lian) can transfer into breast milk and has been associated with displacement of bilirubin from albumin binding sites, which could theoretically pose a risk of jaundice in neonates. Gui Zhi and Gan Jiang are warming herbs generally considered compatible with breastfeeding in moderate doses. If the nursing infant is a newborn (especially if premature or jaundiced), use with particular caution due to the berberine content. Consult a qualified practitioner before using while breastfeeding.

Children

This formula can be adapted for pediatric use with appropriate dosage reduction. A general guideline is to reduce the adult dose proportionally: children aged 6–12 may use approximately one-half to two-thirds the adult dose, children aged 2–6 approximately one-quarter to one-third, and children under 2 should only receive this formula under close practitioner supervision. Huang Lian is very bitter and may cause difficulty with compliance in young children; mixing with a small amount of honey (for children over 1 year of age) or jujube water may help. Huang Lian (Coptis) contains berberine, which should not be given to neonates or jaundiced infants due to its ability to displace bilirubin. Ban Xia (Pinellia) should always be used in its properly processed form for children.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Huang Lian Tang

Huang Lian (Coptis/berberine) interactions: Berberine, the principal alkaloid in Huang Lian, inhibits CYP2D6, CYP2C9, and CYP3A4 enzymes. This may increase blood levels of drugs metabolized by these pathways, including many common medications such as warfarin (CYP2C9), certain statins, and some antidepressants. Berberine also has documented hypoglycemic effects and may potentiate the action of oral antidiabetic drugs (metformin, sulfonylureas) or insulin, increasing the risk of hypoglycemia. Its effect on cardiac ion channels (potassium channel blockade, QTc prolongation) means caution is warranted when combined with antiarrhythmic drugs or other QTc-prolonging medications. Berberine can also displace bilirubin from albumin and should not be combined with medications that have similar effects in jaundiced patients.

Gan Cao (Licorice/glycyrrhizin) interactions: The glycyrrhizin in Zhi Gan Cao can cause pseudoaldosteronism (sodium retention, potassium loss, and elevated blood pressure). This may interfere with antihypertensive medications, potassium-sparing diuretics, and digoxin (hypokalemia increases digoxin toxicity). It may also interact with corticosteroids by potentiating their effects. Patients on these medications should use this formula with caution.

Gui Zhi (Cinnamon Twig): Contains cinnamaldehyde, which has mild anticoagulant properties. Use with caution alongside anticoagulant or antiplatelet drugs (warfarin, heparin, aspirin, clopidogrel).

Usage Guidance

Practical advice for getting the most out of Huang Lian Tang

Best time to take

The original text instructs taking it warm, three times during the day and twice at night (昼三夜二), suggesting frequent small doses throughout a 24-hour period. In modern practice, take 30 minutes before meals or between meals, 2–3 times daily.

Typical duration

Acute use: 3–7 days for acute gastritis, vomiting, or abdominal pain episodes. May be extended to 2–4 weeks for chronic conditions (e.g. chronic gastritis, reflux esophagitis), with reassessment by a practitioner.

Dietary advice

While taking this formula, avoid extremes in diet that could worsen either the Heat or Cold component. Avoid greasy, fried, and heavily spiced foods, which generate Dampness and Heat and burden the Stomach. Also avoid excessively cold or raw foods (ice water, raw salads, chilled fruit), which can aggravate the Cold in the Stomach and abdomen. Alcohol should be minimized as it generates Damp-Heat. Favor warm, easily digestible foods such as congee (rice porridge), cooked vegetables, and mild soups. Small, frequent meals are preferable to large ones, as the Spleen and Stomach are already compromised in this pattern.

Huang Lian Tang originates from Shang Han Lun (傷寒論) by Zhang Zhongjing Eastern Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Huang Lian Tang and its clinical use

Shang Han Lun (伤寒论), Clause 173:

「伤寒,胸中有热,胃中有邪气,腹中痛,欲呕吐者,黄连汤主之。」

"In Cold Damage, when there is Heat in the chest, pathogenic Qi in the Stomach, abdominal pain, and the desire to vomit, Huang Lian Tang governs."


Yu Jia Yan (喻嘉言), Yi Men Fa Lü (医门法律):

「以桂枝易柴胡,以黄连易黄芩,以干姜代生姜,寒热并用,补散兼行,和法之最佳者。」

"Cinnamon Twig replaces Bupleurum, Coptis replaces Scutellaria, dried Ginger replaces fresh Ginger. Cold and Heat are used together, supplementing and dispersing act in tandem. This is the finest example of the harmonizing method."


Formula Verse (方歌):

「黄连汤内用干姜,半夏人参甘草藏,更用桂枝兼大枣,寒热平调呕痛忘。」

"In Huang Lian Tang, dried Ginger is used; Pinellia, Ginseng, and Licorice are within. Add Cinnamon Twig and Jujube dates; Cold and Heat are leveled, and vomiting and pain are forgotten."

Historical Context

How Huang Lian Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Huang Lian Tang originates from Clause 173 of the Shang Han Lun (Treatise on Cold Damage), written by Zhang Zhongjing during the late Eastern Han Dynasty (circa 200 CE). Structurally, it is closely related to Ban Xia Xie Xin Tang (Pinellia Decoction to Drain the Epigastrium), differing by replacing Huang Qin (Scutellaria) with Gui Zhi (Cinnamon Twig) and increasing the dosage of Huang Lian from one liang to three liang. Some commentators also view it as a modification of Xiao Chai Hu Tang, with Huang Lian replacing Huang Qin, Gui Zhi replacing Chai Hu, and dried Ginger replacing fresh Ginger.

The Qing Dynasty physician Yu Jia Yan (喻嘉言, 1585–1664), one of the three great physicians of the early Qing period, creatively adapted the formula as "Jin Tui Huang Lian Tang" (Progressive and Regressive Coptis Decoction) for treating guan ge (a condition of simultaneous vomiting and urinary blockage), modifying the preparation and administration method rather than the composition itself. This adaptation for ascending and descending Yin and Yang became one of Yu's celebrated clinical contributions.

In 2018, Huang Lian Tang was officially included in the first batch of 100 Classical Famous Formulas (古代经典名方目录) published by China's State Administration of Traditional Chinese Medicine, recognizing its enduring clinical value. Literature surveys have identified at least 54 historical texts that record the formula with compositions essentially identical to the original, including the Shang Han Lun Tiao Bian, Jing Yue Quan Shu, and Shan Bu Ming Yi Fang Lun. Some texts, such as the Yi Xue Ru Men and Ji Yang Gang Mu, added Sheng Jiang (fresh Ginger) and Shao Yao (Peony) while removing Da Zao, representing minor historical variants.