Gui Zhi Er Yue Bi Yi Tang

Two-Part Cinnamon Twig and One-Part Yue Bi Decoction · 桂枝二越婢一湯

Also known as: Gui Zhi Yue Bi Tang (桂枝越婢湯), Gui Zhi Er Yue Pi Yi Tang (桂枝二越脾一湯)

A classical formula from the Shang Han Lun used for mild colds or lingering infections where there is fever that is more prominent than chills, with a weak pulse. It gently opens the body's surface to release trapped pathogens while clearing mild internal heat, making it suitable for people whose constitution is too weak for stronger sweating formulas.

Origin Shang Han Lun (傷寒論) by Zhang Zhongjing, Clause 27 — Hàn dynasty, ~200 CE
Composition 7 herbs
Gui Zhi
King
Gui Zhi
Ma Huang
Deputy
Ma Huang
Shi Gao
Deputy
Shi Gao
Bai Shao
Assistant
Bai Shao
Sheng Jiang
Assistant
Sheng Jiang
Da Zao
Envoy
Da Zao
Gan Cao
Envoy
Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gui Zhi Er Yue Bi Yi Tang is designed to correct these specific patterns.

Why Gui Zhi Er Yue Bi Yi Tang addresses this pattern

This formula is designed for a Tai Yang exterior pattern where Wind-Cold has lingered and partially transformed into Heat. The patient still has exterior signs (fever with chills), but fever predominates over chills, indicating that Heat is building internally while cold pathogen remains at the surface. The pulse is weak, showing that the patient's constitution is insufficient to mount a strong sweating response. Gui Zhi and Ma Huang work together to gently release the remaining exterior Cold, while Shi Gao targets the emerging interior Heat. The entire formula uses small doses, functioning as what Zhang Zhongjing called a "light formula" for patients who cannot tolerate aggressive sweating methods like Da Qing Long Tang.

A practitioner would look for one or more of these signs

Fever

Fever more prominent than chills (热多寒少)

Chills

Mild chills or aversion to cold

Weak Pulse

Pulse that is faint and weak (脉微弱)

Headaches

Mild headache from exterior constraint

Thirst

Slight thirst from emerging internal Heat

Eye Fatigue

General weakness and fatigue

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Gui Zhi Er Yue Bi Yi Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Wind-Cold

TCM Interpretation

In TCM, the common cold is understood as an invasion of Wind-Cold or Wind-Heat into the body's surface layer. When a cold lingers without fully resolving, the trapped pathogen can begin to generate internal Heat through constraint. This creates a mixed picture: the exterior cold has not been fully expelled, but the body's struggle against it has produced Heat on the inside. The patient experiences fever that is more prominent than chills, and their pulse is weak because their Qi and fluids have been gradually consumed by the prolonged illness. This is distinct from a straightforward Wind-Heat cold because the chills are still present, and from a typical Wind-Cold cold because Heat symptoms have appeared.

Why Gui Zhi Er Yue Bi Yi Tang Helps

Gui Zhi Er Yue Bi Yi Tang addresses this lingering cold by working on two levels simultaneously. Gui Zhi gently opens the muscle layer to allow the remaining Wind-Cold pathogen to escape, while Shi Gao clears the internal Heat that has built up from the prolonged constraint. Ma Huang supports the exterior-releasing action at a low dose, and Bai Shao preserves the patient's fluids to prevent further depletion. The small overall dosage is deliberately calibrated for patients whose constitutions cannot handle stronger sweating formulas, making it appropriate for those recurring low-grade fevers and chills that do not respond to simple exterior-releasing treatments.

Also commonly used for

Influenza

Mild cases with lingering low-grade fever

Allergic Sinusitis

With concurrent mild heat signs

Bronchitis

Early-stage with exterior symptoms and mild heat

Chronic Nephritis

With exterior pattern and mild edema

Rheumatoid Arthritis

Wind-Cold-Heat mixed type joint symptoms

What This Formula Does

Every TCM formula has a specific set of actions — here's what Gui Zhi Er Yue Bi Yi Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Gui Zhi Er Yue Bi Yi Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Gui Zhi Er Yue Bi Yi Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Gui Zhi Er Yue Bi Yi Tang works at the root level.

This formula addresses a specific transitional state where an external Wind-Cold invasion of the Tai Yang (Greater Yang) level is beginning to generate internal Heat, but the condition remains mild and the patient's constitution is relatively weak.

The core disease logic works like this: a person catches a cold (Wind-Cold pathogen enters the body's surface). Normally, the body's defensive Qi would either expel the pathogen through sweating or the pathogen would be cleared as the immune response resolves. But in this case, neither has happened completely. The exterior pathogen lingers, and over time, the body's struggle against it begins generating Heat on the interior. The patient shows fever that is more prominent than the chills ("heat is greater, cold is lesser"), suggesting that while some surface Cold remains, the illness is trending inward toward Heat. However, this interior Heat is still mild, not a full-blown high fever of the Yang Ming (Bright Yang) stage. Think of it as a cold that is starting to "turn hot" but has not yet fully transformed.

Crucially, the patient's Qi and fluids are somewhat depleted. The pulse is not strong and bounding but rather soft and weak, indicating the body lacks the resources for a vigorous fight against the pathogen. This means aggressive sweating (as with Ma Huang Tang or Da Qing Long Tang) would be dangerous, as it could further drain the body's reserves. What is needed is a gentle, dual-action approach: mildly open the surface to let the remaining Cold pathogen out, while simultaneously cooling the budding interior Heat before it deepens. This is the precise clinical niche that Gui Zhi Er Yue Bi Yi Tang fills.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly pungent and sweet with a mild sour note. The pungent herbs (Gui Zhi, Ma Huang, Sheng Jiang) gently open the surface, the sweet herbs (Gan Cao, Da Zao) tonify the middle and protect fluids, and the sour Bai Shao restrains excessive dispersal while nourishing Yin.

Channels Entered

Lung Bladder Stomach Spleen

Ingredients

7 herbs

The herbs that make up Gui Zhi Er Yue Bi Yi Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Gui Zhi

Gui Zhi

Cinnamon twigs

Dosage 6 - 9g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Lungs, Spleen

Role in Gui Zhi Er Yue Bi Yi Tang

Releases the muscle layer, disperses Wind-Cold from the exterior, and warms the channels. As the primary herb of the Gui Zhi Tang component, it harmonizes the protective and nutritive layers and leads the formula's exterior-releasing action.
Deputies — Assists and enhances the King
Ma Huang

Ma Huang

Ephedra

Dosage 3 - 6g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Urinary Bladder, Lungs
Preparation Decocted first for 1-2 boilings, skim off foam (先煎去沫)

Role in Gui Zhi Er Yue Bi Yi Tang

Opens the pores to promote mild sweating and release exterior pathogens. As the key herb from the Yue Bi Tang component, it works with Gui Zhi to enhance exterior resolution. At this small dose and paired with Shi Gao, its sweating action is restrained to produce only a gentle sweat.
Shi Gao

Shi Gao

Gypsum

Dosage 9 - 15g
Temperature Cold
Taste Pungent, Sweet
Organ Affinity Lungs, Stomach
Preparation Crush and wrap in cloth before decocting (碎,绵裹)

Role in Gui Zhi Er Yue Bi Yi Tang

Clears internal Heat that has formed from constrained exterior pathogens beginning to transform. Its cold, sweet nature moderates the warming properties of Gui Zhi and Ma Huang, and helps preserve body fluids. This is the key herb that distinguishes this formula from the Gui Zhi Ma Huang Ge Ban Tang series.
Assistants — Supports or moderates other herbs
Bai Shao

Bai Shao

White peony roots

Dosage 6 - 9g
Temperature Neutral
Taste Bitter, Sour
Organ Affinity Liver, Spleen

Role in Gui Zhi Er Yue Bi Yi Tang

Nourishes the nutritive (Ying) layer and constrains Yin to prevent excessive sweating. It balances the dispersing nature of Gui Zhi and Ma Huang, and its sour-collecting quality helps preserve fluids in a patient who is already constitutionally weak.
Sheng Jiang

Sheng Jiang

Fresh ginger

Dosage 6 - 9g
Temperature Warm
Taste Pungent
Organ Affinity Lungs, Spleen, Stomach

Role in Gui Zhi Er Yue Bi Yi Tang

Assists Gui Zhi in releasing the exterior and warming the Stomach to support digestion. Pairs with Da Zao to harmonize the protective (Wei) and nutritive (Ying) layers.
Envoys — Directs the formula to its target
Da Zao

Da Zao

Jujube dates

Dosage 4 pieces
Temperature Warm
Taste Sweet
Organ Affinity Spleen, Stomach

Role in Gui Zhi Er Yue Bi Yi Tang

Nourishes the Spleen and Stomach to support the production of Qi and Blood. Together with Sheng Jiang, it harmonizes the formula and protects the Middle Burner from the dispersing action of the exterior-releasing herbs.
Gan Cao

Gan Cao

Liquorice

Dosage 3 - 6g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Gui Zhi Er Yue Bi Yi Tang

Harmonizes all the ingredients, tonifies the Middle Burner Qi, and moderates the pungent-dispersing herbs. Supports the sweet-sour fluid-generating combination with Bai Shao and Da Zao.

Why This Combination Works

How the herbs in Gui Zhi Er Yue Bi Yi Tang complement each other

Overall strategy

This formula addresses a situation where exterior Wind-Cold remains unresolved but has begun to partially transform into interior Heat, producing more fever than chills in a constitutionally weak patient. The strategy is to gently release the exterior while simultaneously clearing the emerging internal Heat, using small doses to avoid damaging the patient's already depleted fluids and Qi. The classical commentators describe this as "producing a mild sweat within the principle of not sweating" (微发于不发之中).

King herbs

Gui Zhi is the King herb, anchoring the Gui Zhi Tang component that forms two-thirds of this combination. It releases the muscle layer to dispel Wind-Cold, warms the channels, and harmonizes the protective and nutritive layers. Its warm, pungent-sweet nature is the primary force for resolving the remaining exterior pattern.

Deputy herbs

Ma Huang and Shi Gao serve as Deputies from the Yue Bi Tang component. Ma Huang opens the pores and assists the exterior-releasing action, while Shi Gao clears the interior Heat with its cold, sweet nature. Together they form a complementary pair: Ma Huang's pungent warmth promotes sweating from the outside, while Shi Gao's cool sweetness clears Heat from the inside and prevents Ma Huang from being overly dispersing. The dosage of Shi Gao slightly exceeds that of Ma Huang, ensuring that the formula's overall direction leans toward clearing Heat rather than aggressive sweating.

Assistant herbs

Bai Shao is a restraining Assistant that prevents the pungent-warm herbs from over-dispersing and depleting Yin fluids. Its sour-collecting nature draws inward to protect the nutritive layer and complements Gui Zhi's outward dispersal. Sheng Jiang is a reinforcing Assistant that supports Gui Zhi in warming the exterior and aids the Stomach in receiving the other herbs.

Envoy herbs

Da Zao and Zhi Gan Cao harmonize the formula and protect the Middle Burner. They nourish Spleen Qi and generate fluids, ensuring that the mild sweating action does not further injure a patient whose pulse is already weak. Zhi Gan Cao also moderates the combined effects of the pungent and cold herbs, preventing their properties from clashing.

Notable synergies

The Gui Zhi and Bai Shao pairing is central to regulating the balance between dispersing and collecting, ensuring the exterior is opened without draining the interior. The Ma Huang and Shi Gao pairing achieves a controlled, mild diaphoresis with simultaneous Heat-clearing, producing what classical commentators call a "pungent-cool" effect despite both herbs originating from warm and cold categories respectively. The Sheng Jiang and Da Zao pairing anchors the Stomach and harmonizes the nutritive and protective layers.

How to Prepare

Traditional preparation instructions for Gui Zhi Er Yue Bi Yi Tang

Combine all seven ingredients with approximately 1000 ml (5 sheng) of water. First cook the Ma Huang (Ephedra) for one to two boilings and skim off the foam from the surface. Then add the remaining herbs and continue to decoil until approximately 400 ml (2 sheng) remains. Strain out the dregs and take one warm dose of approximately 200 ml (1 sheng).

The original text notes: "This should be prepared by combining two parts Gui Zhi Tang with one part Yue Bi Tang. Now combined into a single formula." The Shi Gao (Gypsum) should be crushed and wrapped in cloth (绵裹) before decocting to prevent sediment in the liquid.

Common Modifications

How practitioners adapt Gui Zhi Er Yue Bi Yi Tang for specific situations

Added
Xuan Shen

9-12g, to clear heat and relieve toxic swelling in the throat

Ma Bo

3-6g, to clear heat and benefit the throat

Xuan Shen and Ma Bo target throat heat and toxin, addressing the sore throat that develops when exterior constraint generates ascending heat in the Lung channel.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Gui Zhi Er Yue Bi Yi Tang should not be used or requires extra caution

Avoid

Patients with severe Yang deficiency and a very weak, faint pulse. The original Shang Han Lun text itself warns that when the pulse is faint and weak ('this means absence of Yang'), one should not promote sweating even with this mild formula.

Avoid

Patients with a strong exterior Cold pattern (Tai Yang Cold Damage with floating, tight pulse, no sweating, and severe body aches). This formula is too mild for a full exterior excess condition and would be ineffective. Ma Huang Tang or Da Qing Long Tang would be more appropriate.

Avoid

Patients with pronounced interior Heat at the Yang Ming stage (high fever, profuse sweating, great thirst, surging pulse). The amount of Shi Gao in this formula is far too small to address established Yang Ming Heat. Bai Hu Tang would be more suitable.

Caution

Patients with significant fluid depletion or Yin deficiency. The formula still contains warm, dispersing herbs (Gui Zhi, Ma Huang, Sheng Jiang) that can further damage fluids if Yin is already substantially depleted.

Caution

Patients who are profusely sweating. The presence of Ma Huang and Gui Zhi, even in small doses, can worsen fluid loss. Gui Zhi Tang alone with its astringent Bai Shao would be safer.

Caution

Habitual alcohol drinkers (jiu ke). As with all Gui Zhi Tang-based formulas, the sweet nature of the formula can provoke nausea and vomiting in those with pre-existing Damp-Heat from alcohol.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Ma Huang (Ephedra) in this formula, even in small doses, has dispersing and stimulating properties that could theoretically affect the fetus. While the dosage of Ma Huang is very small (only about 2.3g in the classical formula, roughly 1/8 of the standard Yue Bi Tang dose), pregnant women should still consult a qualified practitioner before use. Gui Zhi (Cinnamon Twig) is generally considered safe in pregnancy at moderate doses and is even included in pregnancy formulas in the Jin Gui Yao Lue. The primary concern here is the Ma Huang component. If a pregnant patient presents with this exact pattern, a practitioner may consider removing or further reducing the Ma Huang.

Breastfeeding

Generally considered low risk during breastfeeding due to the very small herb dosages involved. Ma Huang (Ephedra) is the primary ingredient of concern, as ephedrine alkaloids can pass into breast milk and may cause irritability or sleep disturbance in nursing infants. However, the dose of Ma Huang in this formula is extremely small (approximately 2.3g), which substantially reduces this risk. Gui Zhi, Bai Shao, Gan Cao, Sheng Jiang, Da Zao, and Shi Gao are all generally considered compatible with breastfeeding at standard doses. A breastfeeding mother should use this formula only under practitioner guidance and for the shortest duration necessary.

Children

This formula is suitable for children, and there is historical precedent for its pediatric use. Dr. Liu Duzhou famously used a modified version of this formula to treat a 10-year-old girl with lingering Wind-Cold that had partially transformed to Heat. For children, dosages should be reduced proportionally based on age and weight: roughly 1/3 of the adult dose for children aged 3-6, and 1/2 the adult dose for children aged 7-12. The classical doses are already very small, so further reduction requires careful calculation. The formula's gentle nature (a mild sweating formula, not a vigorous one) makes it well-suited to the delicate constitutions of children, who are more susceptible to fluid loss from over-sweating. Monitor the child after administration and stop once mild perspiration appears.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Gui Zhi Er Yue Bi Yi Tang

Gan Cao (Licorice Root): Glycyrrhizin in Gan Cao may interact with corticosteroids (potentiating their effects), antihypertensives (causing sodium and water retention that counteracts blood pressure medications), diuretics (increasing potassium loss and risk of hypokalemia), and cardiac glycosides such as digoxin (hypokalemia increases digoxin toxicity). Though the dose in this formula is very small (approximately 2.3g), these interactions should be noted for patients on long-term pharmaceutical therapy.

Ma Huang (Ephedra): Ephedrine alkaloids in Ma Huang can interact with MAO inhibitors (risk of hypertensive crisis), sympathomimetic drugs and decongestants (additive cardiovascular stimulation), beta-blockers (opposing effects), and cardiac glycosides. Ma Huang may also reduce the effectiveness of antihypertensive medications. Again, the dose is extremely small in this formula, but caution is warranted, particularly for patients with cardiovascular conditions or those taking stimulant medications.

Gui Zhi (Cinnamon Twig): Cinnamaldehyde compounds may have mild anticoagulant properties and could theoretically potentiate warfarin or other blood thinners, though this effect at the doses used in this formula is clinically insignificant.

Usage Guidance

Practical advice for getting the most out of Gui Zhi Er Yue Bi Yi Tang

Best time to take

Warm, between meals. Traditionally taken as a single warm dose of the decoction, with warm rice porridge sipped afterward to assist gentle sweating. Can be taken morning and evening if symptoms persist.

Typical duration

Acute use: 1-3 days. This is a formula for a mild, transitional exterior condition and should resolve symptoms quickly. If no improvement after 2-3 doses, reassess the pattern.

Dietary advice

While taking this formula, avoid cold, raw, and greasy foods, as these impair the Spleen and Stomach's ability to support the body's fight against the exterior pathogen. Cold foods and iced drinks are particularly counterproductive since the formula is trying to gently warm and open the surface. Avoid alcohol, as the Shang Han Lun explicitly warns that Gui Zhi Tang-based formulas are inappropriate for habitual drinkers (jiu ke). Light, warm, easily digestible foods such as rice porridge (congee) are ideal. Classically, after taking Gui Zhi Tang and its derivatives, patients are advised to sip warm rice porridge to support the stomach and assist the formula in generating a mild sweat.

Gui Zhi Er Yue Bi Yi Tang originates from Shang Han Lun (傷寒論) by Zhang Zhongjing, Clause 27 Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Gui Zhi Er Yue Bi Yi Tang and its clinical use

Shang Han Lun, Clause 27 (《伤寒论》第27条):

太阳病,发热恶寒,热多寒少,脉微弱者,此无阳也,不可发汗,宜桂枝二越婢一汤。

"In Tai Yang disease with heat effusion and aversion to cold, where heat is greater and cold is lesser, and the pulse is faint and weak, this indicates an absence of Yang. One cannot promote sweating. Gui Zhi Er Yue Bi Yi Tang is appropriate."

This clause has been one of the most debated in the entire Shang Han Lun. The apparent contradiction between prescribing a sweat-promoting formula while saying "one cannot promote sweating" has generated centuries of scholarly discussion. Many commentators, including Cao Yingfu and Zhang Xugu, argue that the sentence "yi Gui Zhi Er Yue Bi Yi Tang" should follow "re duo han shao" (heat is greater, cold is lesser), with the warning about not sweating being a separate caveat about patients whose pulse is truly faint and weak.


Yi Zong Jin Jian (《医宗金鉴》):

The Qing dynasty compendium noted that this formula is essentially a modified Da Qing Long Tang, with Bai Shao replacing Xing Ren. By using Bai Shao (sour and collecting, entering the Yin) instead of Xing Ren (which would further disperse), the formula shifts from vigorous sweating to gentle regulation. The commentary states that the Shi Gao is not meant to clear strong interior Heat, but rather to "assist Ma Huang and Gui Zhi in harmonizing the Ying and Wei with its cooling nature."


You Yi (尤怡), Shang Han Guan Zhu Ji (《伤寒贯珠集》):

You Yi offered one of the most influential commentaries on this formula and its sister prescriptions, noting that among the three combined formulas (Gui Zhi Ma Huang Ge Ban Tang, Gui Zhi Er Ma Huang Yi Tang, and this formula), Gui Zhi Er Yue Bi Yi Tang is unique in adding Shi Gao. He explained that even without overt Heat signs, Shi Gao is included because the patient's fluids are insufficient and cannot withstand the warm nature of Gui Zhi alone. The small amount of sweet-cold Shi Gao "subtly transforms the pungent-warm character" of the formula while also "nourishing fluids."

Historical Context

How Gui Zhi Er Yue Bi Yi Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Gui Zhi Er Yue Bi Yi Tang originates from Clause 27 of Zhang Zhongjing's Shang Han Lun (Treatise on Cold Damage), composed during the late Eastern Han dynasty (circa 200 CE). It is one of three famous "combined formulas" (合方) in the Tai Yang disease section, alongside Gui Zhi Ma Huang Ge Ban Tang (Cinnamon Twig and Ephedra Half-and-Half Decoction) and Gui Zhi Er Ma Huang Yi Tang (Two Parts Cinnamon Twig, One Part Ephedra Decoction). All three demonstrate Zhang Zhongjing's remarkably precise approach to dosage: by combining two established formulas in specific ratios and using very small amounts, he created gentle prescriptions for patients who were too weak for standard sweating formulas but still needed exterior resolution.

Clause 27 has generated more scholarly controversy than almost any other clause related to these combined formulas. The crux of the debate centers on the phrase "此无阳也,不可发汗" ("this means absence of Yang, one cannot promote sweating"), which seems to contradict the prescription that follows. Qing dynasty commentator Zhang Xugu proposed reading the clause as an inverted sentence (倒装文法), where the formula recommendation belongs with "heat greater, cold lesser" and the sweating prohibition is a separate warning for pulse-weak patients. Cao Yingfu supported this interpretation. The Gui Lin edition of the Shang Han Lun attempted to resolve the confusion by adding "脉浮大者" ("when the pulse is floating and large") as the specific indication for the formula, separating it from the weak-pulse warning.

The noted Qing physician You Yi (尤怡), in his Shang Han Guan Zhu Ji, provided one of the most influential analyses of all three combined formulas, arguing that Gui Zhi Tang serves as the foundation of each because it simultaneously supports the body's righteous Qi while dispersing pathogenic factors. The Yi Zong Jin Jian (1742) offered the insight that this formula is essentially a gentler reformulation of Da Qing Long Tang, with Bai Shao replacing Xing Ren to shift the action from aggressive dispersal to gentle harmonization.