Ai Fu Nuan Gong Wan

Mugwort and Cyperus Pill to Warm the Uterus · 艾附暖宮丸

Also known as: Ai Fu Nuan Gong Wan, Mugwort and Cyperus Combination, Mugwort and Cyperus Warm the Palace Pills

A classical formula designed for women experiencing menstrual problems related to a cold uterus and insufficient Blood. It warms the reproductive organs, nourishes Blood, and regulates Qi flow, making it commonly used for delayed or painful periods with scanty flow, lower abdominal coldness, and difficulty conceiving due to a cold constitution.

Origin Rén Zhāi Zhí Zhǐ Fāng Lùn (仁斋直指方论, with Appendix 附遗) by Yáng Shìyíng (杨士瀛) — Southern Sòng dynasty, 1264 CE
Composition 10 herbs
Ai Ye
King
Ai Ye
Xiang Fu
King
Xiang Fu
Wu Zhu Yu
Deputy
Wu Zhu Yu
Rou Gui
Deputy
Rou Gui
Dang Gui
Deputy
Dang Gui
Chuan Xiong
Assistant
Chuan Xiong
Bai Shao
Assistant
Bai Shao
Di Huang
Assistant
Di Huang
+2
more
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ai Fu Nuan Gong Wan is designed to correct these specific patterns.

Why Ai Fu Nuan Gong Wan addresses this pattern

This is the primary pattern this formula was designed to treat. When Blood is insufficient and Cold lodges in the uterus (a condition often called 'uterine Cold' or Gong Han), the reproductive organs lack both warmth and nourishment. The Si Wu Tang base (Dang Gui, Chuan Xiong, Bai Shao, Di Huang) plus Huang Qi replenishes Blood and Qi, while Ai Ye, Wu Zhu Yu, and Rou Gui directly warm the uterus and expel Cold. Xu Duan supports the Kidney foundation that governs reproduction. The formula addresses both the deficiency (not enough Blood) and the excess (Cold pathogen lodged in the uterus) simultaneously.

A practitioner would look for one or more of these signs

Amenorrhea

Menstrual cramps that feel cold and improve with warmth or a heating pad

Scanty Menstruation

Light menstrual flow with pale or dark blood and possible clots

Late Menstruation

Menstrual cycle consistently arriving late

Thin Vaginal Discharge

Thin, watery, white vaginal discharge

Infertility

Difficulty conceiving due to a cold uterine environment

Swollen Complexion

Pale, yellowish facial complexion indicating Blood deficiency

Lower Back Pain

Aching soreness in the lower back and knees

Eye Fatigue

Tiredness and lack of strength

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Ai Fu Nuan Gong Wan when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

TCM understands menstrual pain (dysmenorrhea) through the principle 'where there is no free flow, there is pain' (不通则痛). In the cold-deficiency type, Cold lodges in the uterus and constricts the channels, preventing Blood from flowing smoothly during menstruation. At the same time, insufficient Blood means the uterus is poorly nourished, making it more vulnerable to Cold invasion. The Chong and Ren channels (the two extraordinary channels that govern menstruation and reproduction) become obstructed by Cold, producing cramping pain that characteristically improves with warmth. The pale, scanty menstrual flow with clots reflects both the Blood deficiency and the Cold-induced stagnation.

Why Ai Fu Nuan Gong Wan Helps

Ai Fu Nuan Gong Wan tackles cold-type menstrual pain from multiple angles. Ai Ye and Xiang Fu (the formula's namesake pair) warm the uterus while simultaneously moving Qi to relieve cramping. Wu Zhu Yu and Rou Gui add deeper warming power that penetrates to the channels. The embedded Si Wu Tang (Dang Gui, Chuan Xiong, Bai Shao, Di Huang) rebuilds the Blood that is deficient, while Huang Qi supports Qi to drive Blood production. Modern pharmacological research suggests the formula's herbs can raise pain thresholds, relax uterine smooth muscle, and improve pelvic blood flow. For best results, it is typically started 3 to 5 days before the expected period.

Also commonly used for

Thin Vaginal Discharge

Thin, watery, white leucorrhoea

Endometriosis

When presenting with cold-type pain patterns

Polycystic Ovary Syndrome

When accompanied by cold constitution and Blood deficiency

Miscarriage

Recurrent miscarriage associated with uterine cold and deficiency

Chronic Pelvic Pain

Cold-type chronic lower abdominal pain in women

What This Formula Does

Every TCM formula has a specific set of actions — here's what Ai Fu Nuan Gong Wan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Ai Fu Nuan Gong Wan is primarily used to support these areas of health:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Ai Fu Nuan Gong Wan works at the root level.

Ai Fu Nuan Gong Wan addresses a condition rooted in two overlapping problems: Blood deficiency with Qi stagnation, and Deficiency Cold settling in the Lower Jiao (the body's lower region, including the Uterus). When the body lacks sufficient Blood, the Uterus and its associated channels (particularly the Chong and Ren vessels that govern menstruation and fertility) become under-nourished. At the same time, when the warming Qi of the Kidneys and Spleen is insufficient, Cold accumulates in the lower abdomen. Cold, by its nature, constricts and slows things down. It causes Blood to congeal and Qi to stagnate, much like how water freezes and stops flowing in winter.

This combination produces a characteristic pattern: menstrual periods arrive late because there is not enough Blood to fill the Uterus on time, and whatever Blood does come is scant, pale, and often contains dark clots (the congealed Blood). The lower abdomen feels cold and aches with a dull, cramping pain that improves with warmth, such as a hot water bottle. Over time, this Cold, stagnant environment in the Uterus becomes inhospitable for conception, which is why the classical texts describe this pattern as a cause of prolonged infertility. The Liver, which stores Blood and governs the smooth flow of Qi, is also affected: when Liver Qi stagnates alongside the Cold, it further impedes the free circulation of Blood through the menstrual channels.

The formula's strategy directly mirrors this pathology. It simultaneously warms the Uterus to dispel Cold and restore movement, nourishes and moves Blood to replenish what is lacking and break up stasis, and regulates Qi to ensure smooth circulation. By addressing both the root (deficiency of Blood and warmth) and the manifestation (Cold congealing and Qi stagnation causing pain and menstrual irregularity), the formula restores the warm, well-nourished uterine environment needed for normal menstruation and fertility.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly acrid (pungent) and sweet, with mild bitter undertones. The pungent flavour warms and moves, the sweet flavour nourishes and tonifies, and the slight bitterness helps descend and consolidate.

Channels Entered

Liver Spleen Kidney Ren Mai (任脉) Conception Vessel Chong Mai (冲脉) Penetrating Vessel

Ingredients

10 herbs

The herbs that make up Ai Fu Nuan Gong Wan, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Kings — Main ingredient driving the formula
Ai Ye

Ai Ye

Silvery wormwood leaves

Dosage 9 - 12g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Spleen, Kidneys, Liver
Preparation Used in charred form (Ai Ye Tan)

Role in Ai Fu Nuan Gong Wan

Charred Mugwort leaf warms the channels and uterus, dispels Cold, and stops bleeding. As a King herb it directly addresses uterine Cold, the central pathomechanism of this formula.
Xiang Fu

Xiang Fu

Coco-grass rhizomes

Dosage 12 - 18g
Temperature Neutral
Taste Bitter, Pungent, Sweet
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)
Preparation Processed with vinegar (Cu Zhi Xiang Fu) to enhance its ability to enter the Liver channel and relieve pain

Role in Ai Fu Nuan Gong Wan

Vinegar-processed Cyperus is the foremost Qi-regulating herb in gynaecology. It spreads Liver Qi, relieves pain, and regulates menstruation. Used in the largest dose, it ensures Qi moves freely so Blood can follow.
Deputies — Assists and enhances the King
Wu Zhu Yu

Wu Zhu Yu

Evodia fruits

Dosage 3 - 6g
Temperature Hot
Taste Bitter, Pungent
Organ Affinity Spleen, Stomach, Kidneys, Liver
Preparation Used in prepared form (Zhi Wu Zhu Yu)

Role in Ai Fu Nuan Gong Wan

Prepared Evodia fruit warms the interior, dispels Cold, and descends rebellious Qi. It reinforces the King herbs' warming action on the lower abdomen and uterus, and helps relieve pain caused by Cold stagnation.
Rou Gui

Rou Gui

Cinnamon bark

Dosage 1.5 - 3g
Temperature Hot
Taste Pungent, Sweet
Organ Affinity Heart, Kidneys, Liver, Spleen

Role in Ai Fu Nuan Gong Wan

Cinnamon bark powerfully warms Kidney Yang, warms the channels, and promotes Blood circulation. It assists the King herbs in dispelling deep-seated Cold from the lower Jiao and uterus.
Dang Gui

Dang Gui

Dong quai

Dosage 9 - 12g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Liver, Spleen

Role in Ai Fu Nuan Gong Wan

Angelica root nourishes and invigorates Blood, regulates menstruation, and relieves pain. As a key gynaecological herb, it addresses the Blood deficiency underlying the pattern and helps move stagnant Blood.
Assistants — Supports or moderates other herbs
Chuan Xiong

Chuan Xiong

Szechuan lovage roots

Dosage 6 - 9g
Temperature Warm
Taste Pungent
Organ Affinity Gallbladder, Liver, Pericardium

Role in Ai Fu Nuan Gong Wan

Szechuan Lovage rhizome invigorates Blood and promotes Qi movement. It works synergistically with Dang Gui to move Blood, and is said to 'treat the Qi within the Blood', preventing stasis from the nourishing herbs.
Bai Shao

Bai Shao

White peony roots

Dosage 6 - 9g
Temperature Neutral
Taste Bitter, Sour
Organ Affinity Liver, Spleen
Preparation Wine-fried (Jiu Chao Bai Shao)

Role in Ai Fu Nuan Gong Wan

White Peony root nourishes Blood, softens the Liver, and relieves pain through its astringent and antispasmodic qualities. Wine-frying enhances its Blood-moving capacity.
Di Huang

Di Huang

Unprepared Rehmannia

Dosage 3 - 9g
Temperature Cold
Taste Sweet
Organ Affinity Heart, Kidneys, Liver

Role in Ai Fu Nuan Gong Wan

Rehmannia root nourishes Blood and Yin, providing a material foundation for Blood replenishment. It works with the other Si Wu Tang herbs to rebuild the Blood that is deficient in this pattern.
Huang Qi

Huang Qi

Milkvetch roots

Dosage 6 - 9g
Temperature Warm
Taste Sweet
Organ Affinity Lungs, Spleen
Preparation Honey-prepared (Zhi Huang Qi)

Role in Ai Fu Nuan Gong Wan

Honey-prepared Astragalus tonifies Spleen Qi to support Blood production. Since Qi is the commander of Blood, strengthening Qi ensures new Blood can be generated and properly circulated.
Xu Duan

Xu Duan

Japanese teasel roots

Dosage 6 - 9g
Temperature Warm
Taste Bitter, Sour
Organ Affinity Kidneys, Liver

Role in Ai Fu Nuan Gong Wan

Japanese Teasel root tonifies the Liver and Kidneys, strengthens the sinews and bones, and promotes Blood circulation. It stabilizes the Chong and Ren channels, supporting fertility and addressing lower back pain.

Why This Combination Works

How the herbs in Ai Fu Nuan Gong Wan complement each other

Overall strategy

This formula simultaneously warms the uterus to dispel Cold and nourishes Blood to address deficiency, while moving Qi to relieve pain. The prescription logic treats the root cause (Cold in the uterus with Blood deficiency) and the branch symptom (Qi stagnation causing pain) at the same time.

King herbs

Ai Ye (charred Mugwort) and Xiang Fu (vinegar-processed Cyperus) form a classic pair that gives the formula its name. Ai Ye directly warms the uterus and channels, targeting the core problem of uterine Cold. Xiang Fu, used in the largest dose, is widely regarded as the most important Qi-regulating herb in gynaecology. Together they warm the uterus and move Qi, ensuring that Blood can circulate freely through the reproductive organs.

Deputy herbs

Wu Zhu Yu and Rou Gui reinforce the warming action, driving Cold from the lower abdomen and boosting Kidney Yang. Dang Gui serves double duty as both a Blood nourisher and Blood mover, directly supporting menstrual regulation. These three herbs amplify the Kings' ability to warm and nourish simultaneously.

Assistant herbs

Chuan Xiong, Bai Shao, and Di Huang join Dang Gui to form Si Wu Tang (Four Substance Decoction), the classical Blood-nourishing base formula embedded within this prescription. This ensures a solid foundation of Blood replenishment. Huang Qi tonifies Spleen Qi to fuel Blood production (a reinforcing assistant), since Qi generates Blood. Xu Duan strengthens the Liver and Kidneys and stabilises the Chong and Ren channels, addressing the lower back pain and supporting fertility (also a reinforcing assistant).

Notable synergies

The Si Wu Tang grouping (Dang Gui, Chuan Xiong, Bai Shao, Di Huang) provides comprehensive Blood nourishment while preventing stasis. The Ai Ye and Xiang Fu pairing is the signature combination: Ai Ye warms while Xiang Fu moves, so warmth reaches everywhere it is needed without causing stagnation. Rou Gui and Wu Zhu Yu together create strong interior warming that penetrates to the deepest level of the lower Jiao.

How to Prepare

Traditional preparation instructions for Ai Fu Nuan Gong Wan

The classical method calls for grinding all ten ingredients into a fine powder, then forming pills with rice vinegar paste, approximately the size of a Chinese parasol tree seed (about 5mm). Take 50 to 70 pills on an empty stomach with dilute vinegar water.

The modern Chinese Pharmacopoeia version is prepared as honey pills: the ten herbs are ground into fine powder, sieved, and mixed evenly. For every 100g of powder, 110 to 130g of refined honey is added to form either small honey pills or large honey pills (9g each). The standard modern dosage is 9g per dose (one large pill or equivalent), taken orally 2 to 3 times daily. For treating menstrual pain, begin taking the pills 3 to 5 days before the expected period and continue for one week.

Common Modifications

How practitioners adapt Ai Fu Nuan Gong Wan for specific situations

Added
Yan Hu Suo

9 - 12g, to strongly invigorate Blood and relieve pain

Hong Hua

6 - 9g, to break up Blood stasis

Shan Zha

9 - 12g, to invigorate Blood and dissolve clots

When menstrual pain is accompanied by significant dark clots and stabbing pain, Blood stasis is prominent. Adding these herbs strengthens the formula's ability to break up stagnant Blood and relieve pain.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Ai Fu Nuan Gong Wan should not be used or requires extra caution

Avoid

Pregnancy. This formula contains several warming and Blood-moving herbs (Ai Ye, Rou Gui, Chuan Xiong, Dang Gui, Wu Zhu Yu) that can stimulate uterine activity. It is classified as prohibited during pregnancy in the Chinese Pharmacopoeia and on official product labelling.

Avoid

Heat-type or excess-type (实证/热证) dysmenorrhea or menstrual disorders. If the pain worsens with pressure (拒按), or there is distending pain in the chest and flanks, this warming formula is not appropriate and may worsen the condition.

Caution

Active common cold or influenza. The warming and tonifying nature of this formula can trap pathogenic factors inside the body if taken during an external invasion.

Caution

Sudden onset of menstrual irregularity in someone with previously normal cycles, irregular vaginal bleeding, vaginal discharge with itching, or red-coloured discharge. These symptoms may indicate conditions requiring proper medical diagnosis before treatment.

Caution

Yin deficiency with Heat signs. Because the formula is predominantly warm and drying, it may worsen symptoms in patients with underlying Yin deficiency such as night sweats, hot flashes, dry mouth, and a red tongue with scanty coating.

Avoid

Known allergy to any ingredient in the formula. Those with an allergic constitution should use with caution.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Official Chinese Pharmacopoeia labelling and product inserts (e.g. Tongrentang) explicitly state: 孕妇禁用 (prohibited for pregnant women). The formula contains multiple herbs that can stimulate uterine activity: - Ai Ye (Mugwort Leaf, used here as charcoal) warms the channels and moves Blood - Chuan Xiong (Sichuan Lovage) is a strong Blood-moving herb - Dang Gui (Chinese Angelica) promotes Blood circulation and can stimulate uterine contractions - Rou Gui (Cinnamon Bark) strongly warms and moves Blood - Wu Zhu Yu (Evodia Fruit) disperses Cold and descends Qi The combined warming and Blood-invigorating action of these herbs poses a risk of uterine stimulation. If there is a desire for fertility, the formula should be used only before conception and under the guidance of a qualified practitioner, and must be stopped once pregnancy is confirmed.

Breastfeeding

There is no specific prohibition for breastfeeding in the standard product labelling, and the official drug insert states adverse reactions are "unclear" (尚不明确). However, caution is advised because: - The formula contains Wu Zhu Yu (Evodia) and Rou Gui (Cinnamon Bark), both of which are strongly warming and pungent. Their active compounds may transfer into breast milk and potentially affect the nursing infant. - Dang Gui and Chuan Xiong are Blood-moving herbs whose constituents (e.g. ligustilide, ferulic acid) may also pass into breast milk. - No formal lactation safety studies have been conducted on this formula. Breastfeeding women should consult a qualified practitioner before use. If the formula is needed, the infant should be monitored for any signs of digestive upset or irritability.

Children

Ai Fu Nuan Gong Wan is a gynaecological formula designed specifically for adult women with menstrual disorders and uterine Cold. It is not intended for use in children. - Pre-menarchal girls have no clinical indication for this formula. - For adolescent girls who have begun menstruation and present with clear Cold-deficiency dysmenorrhea, use should only be considered under the guidance of a qualified practitioner, with reduced dosage (typically one-third to one-half of the adult dose, adjusted by body weight and age). - The formula's warming nature and Blood-moving properties require extra caution in young patients whose constitutions are still developing.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Ai Fu Nuan Gong Wan

Anticoagulants and antiplatelet drugs (e.g. warfarin, heparin, aspirin, clopidogrel): This formula contains Dang Gui (Angelica sinensis), Chuan Xiong (Ligusticum chuanxiong), and Rou Gui (Cinnamomum cassia), all of which have documented Blood-moving and blood-flow-promoting pharmacological effects. Dang Gui and Rou Gui have been specifically identified as Chinese medicinal substances that can enhance the anticoagulant effect of warfarin. Concurrent use may increase the risk of bleeding. Patients on anticoagulant therapy should avoid this formula or have their INR closely monitored.

Hypoglycaemic agents: Huang Qi (Astragalus) has demonstrated blood-glucose-lowering effects in pharmacological studies. Diabetic patients on insulin or oral hypoglycaemics should be aware of the potential for additive blood sugar reduction.

Hormonal medications (oral contraceptives, hormone replacement therapy): Xiang Fu (Cyperus) has been shown to possess estrogen-like activity in pharmacological studies. Concurrent use with hormonal medications may result in unpredictable interactions with hormone levels. Consultation with a healthcare provider is recommended.

Usage Guidance

Practical advice for getting the most out of Ai Fu Nuan Gong Wan

Best time to take

30 minutes before meals or 1 hour after meals, 2-3 times daily, swallowed with warm water. May optionally be taken with warm rice wine (黄酒) to enhance the warming and channel-entering effect.

Typical duration

For dysmenorrhea: start 3-5 days before the expected period and continue for 1 week per cycle, reassessed over 2-3 menstrual cycles. For general menstrual irregularity or infertility due to Cold: often taken for 4-8 weeks with reassessment by a practitioner. If no improvement after 2 weeks, seek medical consultation.

Dietary advice

Avoid cold and raw foods (ice cream, cold drinks, salads, raw fruit) during the course of treatment, as these counteract the formula's warming action. Spicy and strongly greasy/fried foods should also be limited, as they can generate pathological Heat or disrupt digestion. Favour warm, nourishing foods that support Blood and warmth: cooked whole grains, bone broth, lamb or chicken soup, ginger tea, jujube dates (Da Zao), longan fruit, and lightly cooked vegetables. The classical source text specifically recommends avoiding raw and cold foods while taking this formula. Emotional regulation is also advised: try to avoid excessive anger, frustration, or emotional stress, as these cause Liver Qi stagnation, which the formula is also working to resolve.

Ai Fu Nuan Gong Wan originates from Rén Zhāi Zhí Zhǐ Fāng Lùn (仁斋直指方论, with Appendix 附遗) by Yáng Shìyíng (杨士瀛) Southern Sòng dynasty, 1264 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Ai Fu Nuan Gong Wan and its clinical use

《医林纂要》(Yī Lín Zuǎn Yào):

「四物以荣肝血,艾、附以暖子宫,醋以敛之,使不妄行。要以温养子珠,而为生物之本。」

Translation: "The Four Substances [Si Wu Tang ingredients] nourish the Liver Blood; Mugwort and Cyperus warm the Uterus; vinegar astringes [the formula's action], preventing it from moving recklessly. The key is to warmly nourish the 'pearl of the womb' [the ovum/reproductive essence], making it the foundation for generating new life."


Classical indication from 《仁斋直指方论》(Rén Zhāi Zhí Zhǐ Fāng Lùn):

「妇人子宫虚冷,带下白浊,面色萎黄,四肢疼痛,倦怠无力,饮食减少,月经不调,血无颜色,肚腹时痛,久无子息。」

Translation: "For women with Deficiency Cold of the Uterus, manifesting as white turbid vaginal discharge, a sallow complexion, aching limbs, fatigue and weakness, poor appetite, irregular menstruation, pale menstrual blood, intermittent abdominal pain, and prolonged infertility."

Historical Context

How Ai Fu Nuan Gong Wan evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Ai Fu Nuan Gong Wan originates from the 《仁斋直指方论》(Rén Zhāi Zhí Zhǐ Fāng Lùn), a comprehensive medical text from the Song Dynasty compiled by Yang Shiying (杨士瀛). The formula's name is self-descriptive: "Ai" (Mugwort) and "Fu" (Cyperus/Xiang Fu) are the two principal herbs, and "Nuan Gong" means "warm the palace" (a classical term for the Uterus). The formula was designed specifically for women with Cold-deficient wombs who suffered from infertility, menstrual pain, and vaginal discharge.

Over the centuries, the formula appeared in numerous later texts with modifications. Versions are recorded in the 《古今医鉴》(Gǔ Jīn Yī Jiàn), 《回春》(Huí Chūn), 《女科切要》(Nǚ Kē Qiè Yào), and 《沈氏尊生书》(Shěn Shì Zūn Shēng Shū), each with slight compositional differences. The renowned modern Shanghai gynaecology specialist Zhu Xiaonan (朱小南) created a modified decoction version (加减艾附暖宫丸) based on the Shen Shi Zun Sheng Shu formulation, adding Mu Xiang, Wu Yao, and Chuan Lian Zi to strengthen the Qi-regulating and pain-relieving action for dysmenorrhea with Chong and Ren channel Qi stagnation. Today, Ai Fu Nuan Gong Wan is one of the most widely used over-the-counter Chinese patent medicines for menstrual disorders in China, produced by major manufacturers including Beijing Tongrentang, and listed in the Chinese Pharmacopoeia.