English: Anemarrhena rhizomes

Chinese: 知母

Parts used: Dried rhizome

TCM category: Herbs that clear Heat and purge Fire and/or clear Summer Heat

TCM nature: Cold

TCM taste(s): BitterSweet

Organ affinity: Kidney Lung Stomach

Scientific name: Anemarrhena asphodeloides

Use of Zhi Mu (anemarrhena rhizomes) in TCM

Please note that you should never self-prescribe TCM ingredients. A TCM ingredient is almost never eaten on its own but as part of a formula containing several ingredients that act together. Please consult a professional TCM practitioner, they will be best able to guide you.

Preparation: Slice the root and dry it in a moisture-free room.

Dosage: 6 - 12 grams

Main actions according to TCM*: Clears Heat and Fire from the Qi level. Clears Heat and Fire from the Lung and Stomach. Clears Heat and tonifies the Yin.

Primary conditions or symptoms for which Zhi Mu may be prescribed by TCM doctors*: Fever Dry mouth Dry cough Constipation Night sweats Hypersexuality Bleeding gums

Contraindications*: This herb should not be used by those with Spleen Deficiency with loose stools and/ or diarrhea. It should also be avoided for Yin Deficiency Heat (because it clears Excess) and should only be used for Wind-Heat conditions.

Common TCM formulas in which Zhi Mu is used*

Zhi Bo Di Huang Wan

Source date: 1584 AD

Number of ingredients: 8 herbs

Formula key actions: Tonifies Yin. Drains Fire.

Zhi Mu is a king ingredient in Zhi Bo Di Huang Wan. Like the name indicates, it means it has more power than other ingredients in the formula.

In Zhi Bo Di Huang Wan, Zhi Mu is bitter and cooling. It removes excess Heat from the body.

Read more about Zhi Bo Di Huang Wan

Qing Wen Bai Du Yin

Source date: 1794 AD

Number of ingredients: 14 herbs

Formula key actions: Drains Fire. Resolves Toxicity. Dries Dampness.

Conditions targeted*: MeningitisEncephalitis B and others

Zhi Mu is a king ingredient in Qing Wen Bai Du Yin. Like the name indicates, it means it has more power than other ingredients in the formula.

In Qing Wen Bai Du Yin, Zhi Mu clears Heat from the Qi level according to the Four Level Theory

Read more about Qing Wen Bai Du Yin

San Zhong Kui Jian Tang

Source date: 1336 AD

Number of ingredients: 17 herbs

Formula key actions: Clears Heat and resolves Toxicity. Reduces swelling. Induces ulceration. Moves the Blood and dispels stasis .

Conditions targeted*: GoiterScrofula and others

Zhi Mu is a king ingredient in San Zhong Kui Jian Tang. Like the name indicates, it means it has more power than other ingredients in the formula.

In San Zhong Kui Jian Tang, Zhi Mu clears Heat while also protecting Yin that is susceptible to damage from the Heat
accumulation and the bitter, drying herbs in the formula. The combination of Anemarrhena rhizome, Platycodon root and Snake gourd root is very effect in performing this task. 

It, together with the other bitter and downward herbs, also directs Fire to descend and cease its attack on the upper body, and sweeps Phlegm-Heat downward. 

Read more about San Zhong Kui Jian Tang

Gui Zhi Shao Yao Zhi Mu Tang

Source date: 220 AD

Number of ingredients: 9 herbs

Formula key actions: Clears Heat and inflammations. Unblocks the flow of Yang Qi and promotes movement (in areas with painful obstruction). Clears Wind and Damp. Relieves pain.

Conditions targeted*: Rheumatoid arthritisConnective tissue disorders and others

Zhi Mu is a deputy ingredient in Gui Zhi Shao Yao Zhi Mu Tang. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Gui Zhi Shao Yao Zhi Mu Tang, Zhi Mu works together with White peony root (Bai Shao) - another deputy herb here - to clear Heat and prevent injury to the Yin by recurrent painful obstruction.

The combination of Cinnamon twigs (the key herb here) and White peony root is a common one that harmonizes the functions of the protective and nutritive Qi.

The less common pairing of Anemarrhena rhizome with Cinnamon twigs effectively prevents Heat from stagnating in the joints.

Read more about Gui Zhi Shao Yao Zhi Mu Tang

Yu Nu Jian

Source date: 1624 AD

Number of ingredients: 5 herbs

Formula key actions: Drains Heat from the Stomach. Nourishes Yin.

Conditions targeted*: StomatitisGlossitis and others

Zhi Mu is a deputy ingredient in Yu Nu Jian. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Yu Nu Jian, Zhi Mu helps the king herb Shi Gao (Gypsum) clear Heat from the Stomach and also nourishes the Yin.

Read more about Yu Nu Jian

Qing Hao Bie Jia Tang

Source date: 1798 AD

Number of ingredients: 5 herbs

Formula key actions: Nourishes the Yin. Clears Heat.

Conditions targeted*: Chronic pyelonephritisPulmonary tuberculosis and others

Zhi Mu is a deputy ingredient in Qing Hao Bie Jia Tang. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Qing Hao Bie Jia Tang, Zhi Mu nourishes the Yin and clears Heat from Deficiency.

Read more about Qing Hao Bie Jia Tang

Bai Hu Tang

Source date: 220 AD

Number of ingredients: 4 herbs

Formula key actions: Clears Qi-level Heat. Drains Stomach Fire. Generates fluids. Alleviates thirst.

Conditions targeted*: MeningitisScarlet fever and others

Zhi Mu is a deputy ingredient in Bai Hu Tang. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Bai Hu Tang, Zhi Mu clears Heat from the Lungs and Stomach to alleviate irritability, moistens Dryness, and enriches the Yin

Read more about Bai Hu Tang

Da Bu Yin Wan

Source date: 1481 AD

Number of ingredients: 4 herbs

Formula key actions: Enriches the Yin. Directs fire downward.

Conditions targeted*: TuberculosisBronchiectasis and others

Zhi Mu is a deputy ingredient in Da Bu Yin Wan. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Da Bu Yin Wan, Zhi Mu clears Heat, enriches the Lungs, and generates Fluids

Read more about Da Bu Yin Wan

Da Yuan Yin

Source date: 1642 AD

Number of ingredients: 7 herbs

Formula key actions: Opens the membrane source by thrusting out pathogens. Clears away filth. Transforms turbidity.

Conditions targeted*: MalariaInfluenza and others

Zhi Mu is a deputy ingredient in Da Yuan Yin. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Da Yuan Yin, Zhi Mu clears Heat, nourishes the Yin, and prevents Heat from injuring the Yin and Body Fluids.

Read more about Da Yuan Yin

Xin Yi Qing Fei Yin

Source date: 1617

Number of ingredients: 10 herbs

Formula key actions: Spreads Lung Qi. Clears Heat. Unblocks the orifices (specifically the nose) .

Conditions targeted*: Nasal polypsSinusitis and others

Zhi Mu is a deputy ingredient in Xin Yi Qing Fei Yin. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Xin Yi Qing Fei Yin, Zhi Mu clear Toxic-Heat

Read more about Xin Yi Qing Fei Yin

Xiao Feng San

Source date: 1617 AD

Number of ingredients: 13 herbs

Formula key actions: Disperses Wind. Eliminates Dampness. Clears Heat. Cools the Blood.

Conditions targeted*: UrticariaEczema and others

Zhi Mu is a deputy ingredient in Xiao Feng San. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Xiao Feng San, Zhi Mu clears Fire from the Qi Level. It helps drain the Heat from the Interior and prevents the condition from advancing to a deeper level.

Read more about Xiao Feng San

Yu Nu Tang

Source date: 1624 AD

Number of ingredients: 4 herbs

Formula key actions: Drains heat from the Stomach. Nourishes the Yin.

Conditions targeted*: StomatitisGlossitis and others

Zhi Mu is a deputy ingredient in Yu Nu Tang. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Yu Nu Tang, Zhi Mu helps Gypsum clear Heat from the Stomach and also nourishes the Yin.

Read more about Yu Nu Tang

Qing Gu San

Source date: 1602 AD

Number of ingredients: 8 herbs

Formula key actions: Clears Heat from Deficiency. Alleviates steaming bone disorder.

Conditions targeted*: TuberculosisPostwound fevers and others

Zhi Mu is a deputy ingredient in Qing Gu San. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Qing Gu San, Zhi Mu enriches the Yin and clears Heat from Kidney Yin Deficiency.

This is a principal substance for clearing Heat from Yin Deficiency and are especially useful in alleviating steaming bone disorder with sweating.

Read more about Qing Gu San

Er Xian Tang

Source date: 1950 AD

Number of ingredients: 6 herbs

Formula key actions: Nourishes Yin and tonifies Yang of the Kidneys. Clears Empty Heat. Regulates the Directing and Penetrating Vessels.

Conditions targeted*: Perimenopausal syndromeEssential hypertension and others

Zhi Mu is an assistant ingredient in Er Xian Tang. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

Read more about Er Xian Tang

Zhu Ye Cheng Liu Tang

Source date: 1613 AD

Number of ingredients: 11 herbs

Formula key actions: Releases the Exterior. Vents rashes. Clears. Generates Body Fluids.

Conditions targeted*: MeaslesChickenpox and others

Zhi Mu is an assistant ingredient in Zhu Ye Cheng Liu Tang. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Zhu Ye Cheng Liu Tang, Zhi Mu drains Heat from the Interior, generates Body Fluids, and thereby facilitate the venting of Toxin from the Nutritive and Protective Qi aspects.

Read more about Zhu Ye Cheng Liu Tang

Hua Ban Tang

Source date: 1798 AD

Number of ingredients: 6 herbs

Formula key actions: Clears Qi-level Heat. Cools the Blood.

Conditions targeted*: Macular rash and others

Zhi Mu is an assistant ingredient in Hua Ban Tang. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Hua Ban Tang, Zhi Mu drain Heat from the Qi-Level

Read more about Hua Ban Tang

Qin Jiao Bie Jia San

Source date: Yuan dynasty

Number of ingredients: 6 herbs

Formula key actions: Enriches the Yin. Nourishes the Blood. Clears Heat. Alleviates steaming bone disorder .

Conditions targeted*: TuberculosisFevers of unkonw origin and others

Zhi Mu is an assistant ingredient in Qin Jiao Bie Jia San. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Qin Jiao Bie Jia San, Zhi Mu drains Heat and enriches the Yin. 

Read more about Qin Jiao Bie Jia San

Qing Shu Yi Qi Tang

Source date: 1852 AD

Number of ingredients: 10 herbs

Formula key actions: Clears summerheat. Augments the Qi. Nourishes the Yin. Generates Body Fluids.

Conditions targeted*: HyperthermiaHeat stroke and others

Zhi Mu is an assistant ingredient in Qing Shu Yi Qi Tang. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Qing Shu Yi Qi Tang, Zhi Mu clears Heat and resolve irritability and thirst.

Read more about Qing Shu Yi Qi Tang

Ren Shen Ge Jie San

Source date: 1047 AD

Number of ingredients: 8 herbs

Formula key actions: Tonifies the Qi. Augments the Kidneys. Stops coughing. Arrests wheezing.

Conditions targeted*: Bronchial asthmaEmphysema and others

Zhi Mu is an assistant ingredient in Ren Shen Ge Jie San. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Ren Shen Ge Jie San, Zhi Mu serves the dual purpose of draining Heat from the Lungs and Kidneys without damaging the Yin.

Read more about Ren Shen Ge Jie San

Suan Zao Ren Tang

Source date: 220 AD

Number of ingredients: 5 herbs

Formula key actions: Nourishes the Blood. Calms the Mind and eliminates irritability . Clears Heat.

Conditions targeted*: InsomniaSleep walking and others

Zhi Mu is an assistant ingredient in Suan Zao Ren Tang. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Suan Zao Ren Tang, Zhi Mu is bitter, sweet, and cooling. It drains Heat to preserve the Yin and thus, by protecting the Stomach from Dryness, indirectly enriches the Body Fluids.

Read more about Suan Zao Ren Tang

Key TCM concepts behind Zhi Mu's properties

In Traditional Chinese Medicine (TCM), Zhi Mu belongs to the 'Herbs that clear Heat and purge Fire and/or clear Summer Heat' category. Herbs in this category are used to clear inflammatory and infectious conditions, referred to as 'Internal Heat' in TCM. This is why most of the herbs in this category will have both antibacterial and antiviral properties. In TCM one has too much 'Internal Heat' in their body as a result of a deficiency of 'Yin' (which is Cold in nature, see our explanation on Yin and Yang) or, more commonly, an Excess of Yang (Hot in nature). Herbs that clear Heat and purge Fire treat the latter and as such tend to be Cold or Neutral in nature.

As suggested by its category Zhi Mu is Cold in nature. This means that Zhi Mu typically helps people who have too much 'Heat' in their body. Balance between Yin and Yang is a key health concept in TCM. Those who have too much Heat in their body are said to either have a Yang Excess (because Yang is Hot in nature) or a Yin deficiency (Yin is Cold in Nature). Depending on your condition Zhi Mu can help restore a harmonious balance between Yin and Yang.

Zhi Mu also tastes Bitter and Sweet. The so-called 'Five Phases' theory in Chinese Medicine states that the taste of TCM ingredients is a key determinant of their action in the body. Bitter ingredients like Zhi Mu tends to have a cleansing action on the body by clearing Heat, drying Dampness and promoting elimination via urination or bowel movements. On the other hand Sweet ingredients tend to slow down acute reactions and detoxify the body. They also have a tonic effect because they replenish Qi and Blood.

The tastes of ingredients in TCM also determine what Organs and Meridians they target. As such Zhi Mu is thought to target the Kidney, the Lung and the Stomach. According to TCM, the Kidneys do not only regulate the urinary system but also play a key role in the reproductive system and the growth and aging process of the body. In addition to performing respiration, the Lungs are thought in TCM to be a key part of the production chain for Qi and the Body Fluids that nourish the body. The Stomach is responsible for receiving and ripening ingested food and fluids. It is also tasked with descending the digested elements downwards to the Small Intestine.

Research on Zhi Mu

Diabetic mice treated with Anemarrhena asphodeloides (AA) had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance.1

Steroidal saponins of Anemarrhena asphodeloides prevented ovariectomy-induced bone loss in rats through the promotion of bone formation.2

Sources:

1. T Miura, H Ichiki, N Iwamoto, M Kato et al. (2001). Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside. Biological and Pharmaceutical Bulletin, 24(9): 1009-1011. DOI: https://doi.org/10.1248/bpb.24.1009

2. H Nian, L Qin, W Chen, Q Zhang, H Zheng et al. (2006). Protective effect of steroidal saponins from rhizome of Anemarrhena asphodeloides on ovariectomy-induced bone loss in rats. Acta Pharmacologica Sinica, 27:728–734. DOI: https://doi.org/10.1111/j.1745-7254.2006.00328.x