Herb Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)

Yu Li Ren

Chinese Dwarf Cherry Seed · 郁李仁

Prunus humilis Bge., Prunus japonica Thunb., Prunus pedunculata Maxim. · Semen Pruni

Also known as: Xiao Li Ren (小李仁)

Images shown are for educational purposes only

Yu Li Ren (bush cherry seed) is a gentle, oil-rich seed used in Chinese medicine primarily to relieve constipation by moistening and lubricating the intestines. It also helps reduce water retention and swelling by promoting urination. Because it works by adding moisture rather than forcefully purging, it is well suited for dry-type constipation, though it should be avoided by pregnant women and people who are already fluid-depleted.

TCM Properties

Temperature

Neutral

Taste

Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)

Channels entered

Spleen, Large Intestine, Small Intestine

Parts used

Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)

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What This Herb Does

Every herb has a specific set of actions — here's what Yu Li Ren does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Yu Li Ren is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Yu Li Ren performs to restore balance in the body:

How these actions work

'Moistens the intestines and unblocks the bowels' means Yu Li Ren lubricates the intestinal tract to ease the passage of stool. It is rich in natural oils, making it physically slippery and moistening. Unlike harsh purgatives, it works gently by adding moisture and oil to dry, hard stools. It also moves Qi within the Large Intestine, which helps when constipation is caused not only by dryness but also by Qi stagnation making the intestines sluggish. This makes it suitable for chronic constipation in elderly patients, after childbirth, or in anyone whose body fluids have become depleted, leaving the intestines too dry to function normally.

'Promotes urination and reduces edema' means Yu Li Ren helps the body expel excess fluid through urination. When fluid accumulates in the tissues (causing swelling in the face, limbs, or abdomen), this herb can help open the waterways and drain that excess fluid downward and out. This action was already recorded in the Shen Nong Ben Cao Jing, which noted it treats abdominal water swelling and facial or limb edema. It is particularly useful when edema is accompanied by difficulty urinating and abdominal fullness.

'Descends Qi and relieves distension' refers to the herb's bitter and pungent tastes, which give it a natural downward-directing quality. When Qi in the abdomen becomes stuck or rebellious (moving upward or sideways instead of flowing smoothly downward), it causes bloating, fullness, and discomfort. Yu Li Ren helps push Qi downward, relieving that sense of pressure and distension in the belly. This also supports its laxative effect, since proper downward Qi movement is essential for normal bowel function.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Yu Li Ren is used to help correct these specific patterns.

Why Yu Li Ren addresses this pattern

Intestinal Dryness occurs when the body's fluids are insufficient to moisten the Large Intestine, leading to dry, hard stools that are difficult to pass. Yu Li Ren directly addresses this with its oil-rich, lubricating nature. Its sweet taste gently nourishes, while its pungent quality disperses and moves stagnation. Because it enters the Large Intestine and Small Intestine channels, it delivers its moistening action precisely where it is needed. Unlike purely nourishing laxatives, Yu Li Ren also descends Qi, which helps the intestines resume their normal downward peristaltic movement. This dual action of moistening plus Qi-moving makes it especially effective when constipation involves both dryness and Qi stagnation in the bowels.

A practitioner would look for one or more of these signs

Constipation

Dry, hard stools that are difficult to pass

Abdominal Pain

Abdominal distension and fullness

Dry Mouth

Dry mouth with reduced body fluids

Commonly Used For

These are conditions where Yu Li Ren is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

Arises from: Intestinal Dryness Large Intestine Qi Stagnation

TCM Interpretation

TCM understands constipation not as a single disease but as a symptom arising from several possible imbalances. When body fluids become depleted (from aging, blood loss after childbirth, chronic illness, or prolonged febrile disease), the intestines lose their natural lubrication, and stools become dry and hard. This is Intestinal Dryness. In other cases, the Qi that drives the intestines' downward peristaltic movement becomes stuck or weak, leading to a sluggish, obstructed bowel even when the stools are not extremely dry. The Spleen plays a central role, since it governs the transformation and transport of fluids and Qi to the intestines. When Spleen Qi is insufficient or stagnant, both fluid distribution and Qi movement to the Large Intestine suffer.

Why Yu Li Ren Helps

Yu Li Ren is well suited for constipation because it addresses both common mechanisms at once. Its rich oil content directly lubricates the intestinal lining, softening dry stools and easing their passage. Simultaneously, its pungent and bitter tastes move Qi downward in the Large Intestine, restoring the natural peristaltic drive. Because it enters the Spleen and Large Intestine channels, it works on both the source of fluid distribution and the site of stool formation. Compared to harsher purgatives, Yu Li Ren acts as a moderate laxative, making it appropriate for elderly patients, postpartum women, and anyone with depleted body fluids who cannot tolerate aggressive purging.

Also commonly used for

Abdominal Pain

Bloating and distension from Qi stagnation in the intestines

Oliguria

Scanty urination accompanying fluid retention

Ascites

Mild ascites with abdominal fullness (as an adjunct herb)

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Neutral

Taste

Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)

Channels Entered

Spleen Large Intestine Small Intestine

Parts Used

Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)

Dosage & Preparation

These are general dosage guidelines for Yu Li Ren — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

6-10g

Maximum dosage

Do not exceed 10g per day in standard clinical use. The Chinese Pharmacopoeia lists 6-10g as the therapeutic range, and the amygdalin content makes doses above 10g potentially unsafe due to cyanide generation risk.

Dosage notes

Use 6g for mild constipation or gentle bowel regulation; 10g for more pronounced intestinal dryness with difficult stools or for promoting urination in edema. The herb should be crushed (捣碎) just before adding to a decoction to release the oils and active compounds. Dry-frying (炒) reduces the oil content and softens the purgative effect, making it more suitable for edema treatment or for patients who are weak. After taking Yu Li Ren, some abdominal cramping may occur before bowel movement, which is a normal response and not a sign of adverse reaction. As a short-term remedy, prolonged use is discouraged because the purgative action depletes body fluids over time, potentially worsening the underlying constipation.

Preparation

Crush the seeds (捣碎) immediately before adding to the decoction. This is important because the whole seed coat is difficult for the decoction liquid to penetrate, and crushing exposes the oil-rich interior to allow proper extraction of active compounds. Classical processing from the Lei Gong Pao Zhi Lun involves first blanching in hot water, removing the skin and pointed tip, soaking overnight in raw honey, draining, and drying in the shade before grinding to a paste.

Processing Methods

In TCM, the same herb can be prepared in different ways to change its effects — here's how processing alters what Yu Li Ren does

Processing method

The seeds are dry-fried (without additional substances) in a pan over low heat until they turn yellowish and become aromatic.

How it changes properties

Dry-frying reduces the oil content, which lessens the strong laxative (purgative) effect. The overall thermal nature remains neutral. The diuretic and water-moving properties are relatively preserved while the risk of causing loose stools or abdominal pain is reduced.

When to use this form

Preferred when the primary goal is to promote urination and reduce edema rather than to purge the bowels. Also better suited for weaker patients who cannot tolerate the raw form's stronger laxative action.

Common Herb Pairs

These ingredients are traditionally combined with Yu Li Ren for enhanced therapeutic effect

Huo Ma Ren
Huo Ma Ren 1:1 (e.g. Yu Li Ren 9g : Huo Ma Ren 9g)

Both herbs moisten the intestines and relieve constipation, but they work through complementary mechanisms. Huo Ma Ren nourishes and gently lubricates with a milder action, while Yu Li Ren adds stronger Qi-moving and sliding power. Together they provide both nourishing moisture and active propulsion for stubborn dry stools.

When to use: Chronic constipation from intestinal dryness, especially in elderly patients or those with depleted fluids who need effective but not overly harsh bowel relief.

Bai Zi Ren
Bai Zi Ren 1:1 to 1:5 (e.g. Yu Li Ren 3g : Bai Zi Ren 15g, as in Wu Ren Wan)

Bai Zi Ren moistens the intestines while also calming the spirit and nourishing the Heart. Yu Li Ren adds stronger laxative and Qi-descending action. Together they address constipation that is accompanied by restlessness, insomnia, or anxiety from Blood and fluid deficiency.

When to use: Constipation with concurrent anxiety, insomnia, or palpitations, as commonly seen in elderly patients or those recovering from illness with both fluid depletion and unsettled spirit.

Sang Bai Pi
Sang Bai Pi 1:1 (e.g. Yu Li Ren 9g : Sang Bai Pi 9g)

Sang Bai Pi descends Lung Qi and promotes urination from above, while Yu Li Ren promotes urination and moves water from the intestinal level. Together they open the waterways from both the Lung and the intestines, producing a stronger diuretic and edema-reducing effect.

When to use: Edema with chest fullness, shortness of breath, and difficult urination, as seen in the classical Yu Li Ren Tang from the Sheng Ji Zong Lu.

Xing Ren
Xing Ren 1:1 (e.g. Yu Li Ren 6g : Xing Ren 6g)

Xing Ren descends Lung Qi and moistens the intestines from the Lung-Large Intestine paired channel relationship, while Yu Li Ren directly lubricates the intestines and moves Qi stagnation within them. Together they combine upper (Lung) and lower (Large Intestine) Qi-descending for comprehensive bowel relief.

When to use: Constipation where Lung Qi is not descending properly, often with cough or chest tightness alongside dry stools. This is a core pairing within Wu Ren Wan.

Key Formulas

These well-known formulas feature Yu Li Ren in a prominent role

Wu Ren Wan 五仁丸 Assistant

Wu Ren Wan (Five Seed Pill) is the most iconic formula for moist laxation, combining five oil-rich seeds to treat constipation from intestinal dryness. Yu Li Ren serves as an assistant, contributing its stronger sliding and Qi-descending action to complement the gentler moistening of the other seeds. This formula perfectly showcases Yu Li Ren's core intestine-moistening function.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Huo Ma Ren
Yu Li Ren vs Huo Ma Ren

Both moisten the intestines to relieve constipation, but Huo Ma Ren is gentler, more nourishing, and better suited for deficiency conditions such as postpartum or post-illness weakness. Yu Li Ren has a stronger laxative action and additionally promotes urination to reduce edema, making it more appropriate when constipation is accompanied by water retention or when a more powerful effect is needed. However, Yu Li Ren can deplete fluids more readily and is less suitable for very weak patients.

Tao Ren
Yu Li Ren vs Tao Ren

Both are oil-rich seeds that moisten the intestines. However, Tao Ren's primary strength is invigorating Blood and dispelling Blood stasis, with intestinal moistening as a secondary benefit. Yu Li Ren does not significantly move Blood but excels at Qi-descending and promoting urination. Choose Tao Ren when constipation is accompanied by Blood stasis signs; choose Yu Li Ren when constipation features Qi stagnation and fluid retention.

Bai Zi Ren
Yu Li Ren vs Bai Zi Ren

Both moisten the intestines for dry-type constipation. Bai Zi Ren is milder and also nourishes the Heart, calms the spirit, and addresses insomnia and anxiety. Yu Li Ren is a stronger laxative that also promotes urination. Bai Zi Ren is preferred for gentle, long-term use in patients with Heart Blood deficiency; Yu Li Ren is preferred when a more immediate laxative effect is needed or when edema accompanies the constipation.

Identity & Adulterants

Related species and common adulterations to be aware of when sourcing Yu Li Ren

In some southwestern provinces (Sichuan, Guangxi, Yunnan, Guizhou, Gansu, Hubei), the seeds of the common edible plum (Prunus salicina, Li) or apricot-plum hybrids are sometimes sold as Yu Li Ren. These are flat and oval, resembling almonds, and differ in taste and therapeutic properties from authentic Yu Li Ren. In Gansu province, Rui He (蕤核, the seed of Prinsepia uniflora) has sometimes been labelled as Yu Li Ren, but it is a different medicinal substance with distinct properties. Authentic Xiao Li Ren (small kernel) is ovoid, 5-8mm long, with a pointed tip and rounded base, yellowish-white to light brown surface, and thin seed coat. Da Li Ren is similar but larger (6-10mm) with a yellowish-brown surface. Both should show the characteristic linear hilum at the pointed end and a dark chalaza at the round end with longitudinal vascular bundle markings.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Yu Li Ren

Slightly toxic

Yu Li Ren contains amygdalin (approximately 1.8-2.3% depending on the source species), a cyanogenic glycoside also found in bitter almonds, peach pits, and other Rosaceae seeds. When ingested, amygdalin can be hydrolyzed by gut enzymes into hydrogen cyanide (HCN), benzaldehyde, and glucose. At standard medicinal doses (6-10g), the amount of HCN produced is too small to cause toxicity. Overdose symptoms include: bitter taste in the mouth, excessive salivation, nausea, vomiting, abdominal pain, diarrhea, dizziness, headache, and respiratory difficulty. In severe poisoning: loss of consciousness, jaw clenching, convulsions, blood pressure drop, pupil dilation, and potentially fatal respiratory paralysis. The Chinese Pharmacopoeia requires a minimum 2.0% amygdalin content for quality assurance. Proper dosage control (not exceeding 10g) and the traditional practice of crushing just before decoction help ensure safety. The saponin components in Yu Li Ren can also cause hemolysis at very high doses.

Contraindications

Situations where Yu Li Ren should not be used or requires extra caution

Caution

Pregnancy: Yu Li Ren has downward-directing and bowel-moving properties that could potentially stimulate uterine contractions. The Chinese Pharmacopoeia explicitly states pregnant women should use with caution.

Caution

Yin deficiency with fluid depletion (阴虚液亏): Yu Li Ren's purgative action can further deplete body fluids and worsen dryness. Classical sources warn that after purgation, fluid loss may make constipation even more severe.

Avoid

Chronic loose stools or diarrhea: the herb's laxative properties will aggravate pre-existing loose bowel movements. The De Pei Ben Cao states it is prohibited for those whose stools are already unformed.

Caution

Spleen and Stomach deficiency with weakness: in patients with compromised digestive function, the downward-draining nature of this herb may further weaken the Spleen's transporting function.

Avoid

Excessive dosage: the herb contains amygdalin, which can be hydrolyzed in the gut to produce hydrogen cyanide (HCN). Overdose may cause nausea, vomiting, abdominal pain, dizziness, respiratory difficulty, and in severe cases respiratory failure.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. The Chinese Pharmacopoeia explicitly states "孕妇慎用" (pregnant women should use with caution). Yu Li Ren's strong downward-directing and bowel-purging properties may theoretically stimulate uterine activity through reflex mechanisms from intestinal stimulation. Additionally, the amygdalin content poses a theoretical concern for fetal exposure to trace amounts of hydrogen cyanide, though this has not been studied directly. Avoid use unless specifically prescribed by a qualified practitioner who has determined the benefits outweigh the risks.

Breastfeeding

Safety during breastfeeding has not been well studied. The amygdalin content raises theoretical concerns about trace amounts of cyanide metabolites potentially passing into breast milk. Classical texts do not specifically address breastfeeding, though the famous Qian Yi case involved a nursing mother who was prescribed Yu Li Ren in wine for an acute condition. At standard medicinal doses and for short-term use, significant risk is considered low, but caution is advisable. Nursing mothers should use this herb only under professional guidance.

Children

Yu Li Ren can be used in children but requires careful dosage reduction appropriate to age and body weight. Classical formulas such as Yu Li Ren Wan from the Xiao Er Yao Zheng Zhi Jue (Qian Yi) demonstrate historical paediatric use for constipation and urinary difficulty in infants, combined with Da Huang and Hua Shi in very small pill form. Due to the amygdalin content and the laxative potency, doses should be conservative, generally not exceeding one-third to one-half of the adult dose depending on the child's age. Always use under qualified practitioner supervision. Not recommended for very young infants without specific clinical indication.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Yu Li Ren

Sedatives and anaesthetics: Yu Li Ren should not be combined with benzodiazepine-class sedative-hypnotic drugs or anaesthetic agents. The combination may increase the risk of respiratory centre depression, potentially compromising breathing function and placing additional burden on the liver.

Anticoagulants: Yu Li Ren has traditional blood-moving (破血) properties. Caution is warranted when used alongside anticoagulant or antiplatelet medications (such as warfarin or aspirin), as the combined effect could theoretically increase bleeding risk, though clinical data are lacking.

Cyanogenic compound interactions: Because Yu Li Ren contains amygdalin, concurrent consumption of other amygdalin-containing foods (bitter almonds, apricot kernels, peach kernels) could additively increase hydrogen cyanide exposure. Patients should avoid large amounts of these foods while taking Yu Li Ren.

Dietary Advice

Foods and dietary considerations when taking Yu Li Ren

Avoid consuming other cyanogenic glycoside-rich foods while taking Yu Li Ren, including bitter almonds, raw apricot kernels, peach kernels, and raw cassava. Classical sources also advise avoiding beef and horse meat (忌牛、马肉) when using this herb. Since Yu Li Ren is a downward-draining, fluid-moving herb, supporting the body's fluid balance by staying well-hydrated and including moistening foods (soups, porridge, pears, honey) is advisable. Avoid excessively cold, raw, or greasy foods that could further burden the digestive system.

Botanical Description

Physical characteristics and morphology of the Yu Li Ren source plant

Yu Li Ren comes from several related deciduous shrubs in the Rosaceae (rose) family, primarily Prunus humilis (European plum cherry / Ou Li), Prunus japonica (Japanese bush cherry / Yu Li), and Prunus pedunculata (long-stalked flat peach / Chang Bing Bian Tao). All are low-growing shrubs reaching about 1 to 1.5 metres in height.

Prunus japonica (Yu Li) has greyish-brown bark with irregular vertical striations and smooth yellowish-brown young branches. Its leaves are alternate, typically long-ovate or oval, 3 to 7 cm long, with sharp double-serrated margins. Pale pink or nearly white flowers bloom before or alongside the leaves in spring, appearing in clusters of 1 to 3. The fruit is a small, nearly spherical drupe that ripens to dark red, resembling a miniature cherry. Prunus humilis (Ou Li) is similar in stature with more abundant branching, slightly narrower oblong or elliptic-lanceolate leaves, and bright red, glossy spherical fruits. Both species grow wild on sunny hillsides, roadsides, and among low scrub in northern China.

The medicinal part is the dried mature seed (kernel) extracted from inside the hard pit. Seeds from P. humilis and P. japonica are smaller and called "Xiao Li Ren" (small plum kernel), while those from P. pedunculata are larger and called "Da Li Ren" (large plum kernel). The small type is traditionally considered more authentic.

Sourcing & Harvesting

Where Yu Li Ren is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Summer to autumn, when the fruits are fully ripe. Classical texts specify the sixth lunar month (approximately July). Mature fruits are collected, the flesh and hard shell removed, and the seeds extracted and dried.

Primary growing regions

The source plants of Yu Li Ren are native to northern China. Prunus humilis (Ou Li) and Prunus japonica (Yu Li) are mainly distributed in Liaoning, Jilin, Heilongjiang, eastern Inner Mongolia, Hebei, Shandong, and Shanxi provinces. Prunus pedunculata (Chang Bing Bian Tao) is primarily found in Inner Mongolia. Historically, the Ben Cao Pin Hui Jing Yao (Ming dynasty) recorded the daodi (terroir) region as Xi Zhou (隰州, modern Linfen area in Shanxi). In modern commerce, key production areas for Xiao Li Ren (small kernel) include Haicheng, Gaiping, Fengcheng, and Liaoyang in Liaoning, and eastern Inner Mongolia. Da Li Ren (large kernel) is mainly produced in Inner Mongolia, Hebei, Shandong, Liaoning, and Jilin.

Quality indicators

Good quality Yu Li Ren seeds are plump, full, and uniform in size, with an intact seed coat. The surface should be yellowish-white to light brown in colour. The cross-section reveals two white, oil-rich cotyledons. The aroma should be faint and the taste slightly bitter. Seeds should not appear oily on the surface (which indicates oxidation and rancidity). Xiao Li Ren (small kernel, from Prunus humilis or P. japonica) is traditionally considered superior to Da Li Ren (large kernel, from P. pedunculata). Avoid seeds that are broken, shrivelled, darkened, or have a rancid smell.

Classical Texts

Key passages from the classical Chinese medical texts that describe Yu Li Ren and its therapeutic uses

Shen Nong Ben Cao Jing (《神农本草经》)

Original: 郁核,味酸,平。主大腹水肿,面、目、四肢浮肿,利小便水道。
Translation: Yu He (Yu Li Ren): sour in flavour, neutral in nature. It treats abdominal distension with water swelling, facial and limb edema, and promotes urination through the water pathways.

Ben Cao Gang Mu (《本草纲目》, Li Shizhen)

Original: 郁李仁甘苦而润,其性降,故能下气利水。
Translation: Yu Li Ren is sweet, bitter, and moist; its nature is descending, hence it can direct Qi downward and promote water metabolism.

Ben Cao Jing Shu (《本草经疏》)

Original: 郁李仁,性专降下,善导大肠燥结,利周身水气,然而下后多令人津液亏损,燥结愈甚,乃治标救急之药。
Translation: Yu Li Ren specialises in descending and directing downward. It excels at guiding out dry, bound stool from the Large Intestine and promoting water movement throughout the body. However, after purgation it often causes depletion of body fluids, making dryness and constipation even worse. It is therefore a remedy for urgent, symptomatic relief rather than a long-term treatment.

Ben Cao Xin Bian (《本草新编》)

Original: 郁李仁,入肝、胆二经,去头风之痛。又入肺,止鼻渊之流涕。消浮肿,利小便,通关格,破血润燥,又其余技。
Translation: Yu Li Ren enters the Liver and Gallbladder channels, relieving headache from wind. It also enters the Lung, stopping nasal discharge. Reducing swelling, promoting urination, opening blocked passages, invigorating blood, and moistening dryness are among its additional abilities.

Historical Context

The history and evolution of Yu Li Ren's use in Chinese medicine over the centuries

Yu Li Ren was first recorded in the Shen Nong Ben Cao Jing under the name "Yu He" (郁核), classified as a lower-grade (下品) medicinal. Li Shizhen explained the etymology of the name "Yu" (郁): it derives from the character "栯" found in the Shan Hai Jing, meaning fragrant or aromatic, because both the flowers and fruits of the plant are fragrant. Other historical names include Jue Li (爵李), Que Li (雀李), and Che Xia Li (车下李, "plum under the cart"), all referencing the small size of the fruit.

One of the most celebrated clinical stories involving Yu Li Ren comes from the Song dynasty physician Qian Yi (钱乙), as recorded in the official Song History and later cited by Li Shizhen in the Ben Cao Gang Mu. A nursing woman had been ill from fright. After recovery, her eyes remained stuck open and she could not close them. Qian Yi prescribed Yu Li Ren cooked in wine, instructing her to drink until intoxicated. The treatment worked. His reasoning was that the eyes connect internally to the Liver and Gallbladder; fright had caused Qi to bind in these channels, keeping the eyes open. Yu Li Ren dissolves bound Qi, and the wine guided the herb's action upward into the Gallbladder channel. Once the knotted Qi was released, the eyes could close again.

Classical sources consistently characterise Yu Li Ren as a descending, draining remedy best suited for acute relief rather than ongoing use. The Ben Cao Jing Shu specifically warns that while it effectively unblocks the bowels, repeated use can deplete fluids and paradoxically worsen constipation. This placed it in the category of remedies to be used strategically and short-term. The herb was included in the national list of substances that are both food and medicine by China's health authorities, reflecting its relatively mild profile at standard doses.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Yu Li Ren

1

Amygdalin: A pharmacological and toxicological review (Review, 2020)

He XY, Wu LJ, Wang WX, Xie PJ, Chen YH, Wang F. Journal of Ethnopharmacology, 2020, 254:112717.

A comprehensive review of 110 in vitro and in vivo studies on amygdalin, the main bioactive glycoside in Yu Li Ren. The analysis found that amygdalin demonstrated anti-tumour, anti-fibrotic, anti-inflammatory, analgesic, immunomodulatory, anti-atherosclerosis, digestive-protective, and blood glucose-lowering activities. The review also systematically addressed toxicity concerns related to hydrogen cyanide release.

DOI
2

Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review (Review, 2019)

Shi J, Chen Q, Xu M, Xia Q, Zheng T, Teng J, Li M, Fan L. Cancer Medicine, 2019, 8(6):3004-3011.

This review examined amygdalin's anti-tumour effects in solid tumours including lung cancer, bladder cancer, and renal cell carcinoma. The mechanisms included cell cycle interference, apoptosis induction, cytotoxicity, and immune function regulation. The authors noted that further research is needed regarding optimal dosage, combination therapy, and reduction of adverse effects before clinical application.

DOI
3

Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds (Review, 2021)

Molecules, 2021, 26(8):2288.

A review examining the sources, toxicity, and anticancer properties of amygdalin. While in vitro studies showed promising anticancer activity across multiple cell lines, the clinical evidence remained inconclusive. The review highlighted that high-dose oral amygdalin exposure produces cyanide toxicity, and that toxicity depends partly on gut microbiota composition, which varies between individuals.

PubMed

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.