Xie Xin Tang

Drain the Epigastrium Decoction · 泻心汤

Also known as: San Huang Xie Xin Tang (三黄泻心汤, Three-Yellow Drain the Epigastrium Decoction), San Huang Tang (三黄汤, Three-Yellow Decoction), Da Huang Huang Lian Xie Xin Tang (大黄黄连泻心汤)

A powerful three-herb formula used to clear intense internal Heat from all three Burners of the body. It is classically used for bleeding caused by Heat forcing the Blood out of its vessels (such as nosebleeds or vomiting blood), as well as for conditions like mouth sores, red swollen eyes, irritability, and constipation driven by excess Fire.

Origin Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing — Eastern Hàn dynasty, ~200 CE
Composition 3 herbs
Da Huang
King
Da Huang
Huang Lian
Deputy
Huang Lian
Huang Qin
Deputy
Huang Qin
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xie Xin Tang is designed to correct these specific patterns.

Why Xie Xin Tang addresses this pattern

When Fire blazes in the Heart, it produces intense restlessness, insomnia, a flushed red face, mouth and tongue sores, and a sensation of heat in the chest. Xie Xin Tang addresses this by using Huang Lian to directly drain Heart Fire, supported by Huang Qin clearing the Upper Burner and Da Huang pulling the accumulated Heat downward and out through the bowels. The formula's name literally means 'Drain the Heart,' reflecting this core indication. By extinguishing Fire at its root rather than gently nourishing Yin, the formula is appropriate for excess-type Heart Fire rather than deficiency Heat.

A practitioner would look for one or more of these signs

Irritability

Intense restlessness and agitation

Insomnia

Difficulty sleeping due to internal Heat

Mouth Ulcers

Painful sores on the tongue or mouth

Red Face

Flushed complexion from excess Heat

Constipation

Dry stool from Heat drying the intestines

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Xie Xin Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Blood Heat

TCM Interpretation

In TCM, nosebleeds are most commonly attributed to Heat in the Blood, particularly when the Fire from the Stomach, Liver, or Heart channels flares upward. Since the nose is the opening of the Lungs and is traversed by the Stomach and Large Intestine channels, excess Heat in these organs can damage the delicate vessels in the nasal passages. The bleeding is typically sudden, with bright red blood, and is often accompanied by a red face, irritability, thirst, constipation, and a red tongue with yellow coating.

Why Xie Xin Tang Helps

Xie Xin Tang directly addresses the root cause by powerfully draining Fire from all three Burners. Da Huang pulls the Heat downward through the bowels, reversing the upward surge of Fire that drives blood out of the nasal vessels. Huang Lian cools the Heart and Stomach Fire, while Huang Qin clears Heat from the Upper Burner where the Lung and head vessels are affected. Historical case records describe this formula stopping severe epistaxis associated with hypertension, with documented blood pressure reduction following treatment.

Also commonly used for

Hematemesis

Upper GI bleeding from Blood Heat

Mouth Ulcers

Recurrent oral ulcers from accumulated Heat

Viral Conjunctivitis

Acute red, swollen, painful eyes

Constipation

From excess internal Heat

Jaundice

Damp-Heat type jaundice

Acne

Inflammatory acne from Blood Heat or Damp-Heat

Hemorrhoids

With bleeding and Heat signs

Insomnia

From Heart Fire with restlessness

What This Formula Does

Every TCM formula has a specific set of actions — here's what Xie Xin Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Xie Xin Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Xie Xin Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Xie Xin Tang works at the root level.

Xie Xin Tang addresses a pattern of intense, excess Fire blazing in the interior, particularly concentrated in the Heart and Stomach systems but affecting all three Burners (upper, middle, and lower). In this condition, excessive Heat accumulates internally due to factors such as emotional stress, overconsumption of rich and spicy food, or the progression of febrile illness. This Heat becomes so intense that it essentially 'overflows' the body's normal containment, scorching the Blood vessels and forcing Blood to move chaotically outside its proper pathways. The classical term for this is "Fire driving Blood to move recklessly" (迫血妄行). The result is bleeding from the upper body: vomiting blood or nosebleeds.

The Heat also rises and accumulates in the area below the heart (the epigastrium), creating a sensation of fullness and obstruction (痞). Because all three herbs in the formula are bitter and cold, they can directly purge this Fire from the three Burners simultaneously. The Qing dynasty physician Tang Rongchuan insightfully noted that although the formula is named "Drain the Heart," it actually works by draining the Stomach. When Stomach Qi descends properly, Heart Fire is conducted downward, and the Heat in the Stomach no longer surges upward. Once Qi flows downward in its natural direction, Blood also returns to its proper course and the bleeding stops.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cold

Taste Profile

Predominantly bitter throughout, with a strongly cold and draining character. The bitter taste drives Heat downward and dries Dampness.

Ingredients

3 herbs

The herbs that make up Xie Xin Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
King — Main ingredient driving the formula
Da Huang

Da Huang

Rhubarb root and rhizome

Dosage 6 - 12g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium

Role in Xie Xin Tang

The chief herb in the formula. Da Huang is bitter and cold, and powerfully drains Fire downward through the bowels. It clears Heat from all three Burners using a strategy of 'purging instead of clearing' (以泻代清), directing pathogenic Heat out via the stool. Crucially, it also cools the Blood to stop bleeding while simultaneously moving Blood to prevent stasis, so that bleeding stops without old blood accumulating.
Deputies — Assists and enhances the King
Huang Lian

Huang Lian

Coptis rhizome

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen

Role in Xie Xin Tang

Huang Lian is intensely bitter and cold, and is the primary herb for draining Heart Fire and clearing Heat from the Middle Burner. It supports Da Huang by directly cooling the pathogenic Fire that is forcing Blood out of its vessels. Its affinity for the Heart and Stomach makes it especially effective for irritability, restlessness, and epigastric Heat.
Huang Qin

Huang Qin

Baical skullcap root

Dosage 3 - 6g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Xie Xin Tang

Huang Qin is bitter and cold, and clears Heat primarily from the Upper Burner (Lungs) and Liver/Gallbladder. Together with Huang Lian, it ensures that Fire is cleared across all three Burners. Huang Qin also has a recognized ability to cool the Blood and stop bleeding, reinforcing the hemostatic action of the formula.

Why This Combination Works

How the herbs in Xie Xin Tang complement each other

Overall strategy

Xie Xin Tang addresses a state of intense, excess Fire blazing through the body's three Burners, which can force Blood out of its vessels or produce symptoms like mouth sores, red eyes, irritability, and constipation. The formula uses three powerfully bitter and cold herbs to drain this Fire comprehensively from top to bottom, employing a strategy of 'purging to clear' rather than gentle cooling.

King herbs

Da Huang (Rhubarb) serves as King because it has the strongest downward-directing action. At double the dosage of the other two herbs, it forcefully drains accumulated Heat downward through the intestines. This 'pulling the firewood from under the cauldron' approach reduces the upward surge of Fire that causes bleeding, while Da Huang's Blood-moving quality ensures that blood clots do not form even as bleeding stops.

Deputy herbs

Huang Lian and Huang Qin jointly serve as Deputies. Huang Lian targets the Heart and Middle Burner, directly draining the Fire that causes restlessness, insomnia, and epigastric distress. Huang Qin targets the Upper Burner and Liver/Gallbladder, clearing Heat from the Lungs and head. Together they ensure that Fire is addressed at every level, while both herbs share a bitter, drying quality that also resolves Damp-Heat.

Notable synergies

The three herbs are all yellow in colour and bitter-cold in nature, earning the formula its alternate name 'Three Yellows Drain the Heart Decoction' (San Huang Xie Xin Tang). Their combined bitter-cold nature creates a powerful synergy that directly extinguishes Fire. As the classical commentary notes, Huang Qin drains Fire from the Upper Burner, Huang Lian from the Middle Burner, and Da Huang from the Lower Burner, achieving comprehensive three-Burner coverage. Despite its name ('Drain the Heart'), the formula's primary site of action is actually the Stomach and intestines. As the Qing-dynasty physician Tang Rongchuan explained, draining the Stomach allows Heart Fire to be led downward, so that Qi descends normally and Blood no longer surges upward recklessly.

How to Prepare

Traditional preparation instructions for Xie Xin Tang

In the Jin Gui Yao Lue version: Take the three herbs and decoct in approximately 600 ml (3 sheng) of water. Reduce to approximately 200 ml (1 sheng) over moderate heat. Strain and take the entire dose in a single sitting (顿服, dùn fú). This full decoction method extracts the thick, bitter flavour of the herbs, producing a stronger effect that penetrates the Blood level to stop bleeding.

Note: In the Shang Han Lun, the same ingredients (listed as Da Huang Huang Lian Xie Xin Tang) are prepared differently: the herbs are steeped in freshly boiled water (麻沸汤) rather than decocted. This lighter extraction targets the Qi level and is used for Heat-type epigastric fullness (热痞) rather than bleeding. The two preparation methods yield different clinical effects from the same ingredients.

Common Modifications

How practitioners adapt Xie Xin Tang for specific situations

Added
Shu Di Huang

12-15g, cools Blood and stops bleeding

Bai Mao Gen

15-30g, cools Blood and promotes urination to drain Heat

Sheng Di Huang reinforces the Blood-cooling action and nourishes Yin to counter the drying effect of the bitter-cold herbs. Bai Mao Gen provides additional hemostatic action while opening an additional route for Heat to exit via the urine.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Xie Xin Tang should not be used or requires extra caution

Avoid

Yang deficiency bleeding (阳虚失血): where bleeding is caused by Spleen Yang failing to hold Blood rather than by excess Heat. Using this intensely cold formula would further damage Yang and worsen the condition.

Avoid

Spleen deficiency failing to control Blood (脾不统血): bleeding accompanied by fatigue, pale complexion, loose stools, and a weak pulse indicates deficiency, not excess Heat. This formula will injure the Spleen further.

Avoid

Patients with pre-existing Spleen and Stomach Cold deficiency (脾胃虚寒): the entirely bitter-cold composition of all three herbs can severely damage digestive function in those who are already constitutionally cold.

Caution

Yin deficiency with Empty Heat: the bitter-cold and draining nature of this formula can further deplete Yin fluids. Yin-nourishing formulas are more appropriate for this pattern.

Caution

Prolonged or excessive use: even in appropriate Heat-excess conditions, extended use risks damaging Stomach and Spleen Qi. The formula is designed for short-term, acute application.

Caution

Patients taking anticoagulant medications such as warfarin: Da Huang (Rhubarb) has anticoagulant and laxative properties, and Huang Lian's berberine may compete for plasma protein binding sites, potentially increasing bleeding risk.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Da Huang (Rhubarb) is classified as a pregnancy-prohibited herb due to its strong purgative and Blood-moving properties, which can stimulate uterine contractions and potentially cause miscarriage. Huang Lian and Huang Qin are extremely bitter and cold, which in combination can injure fetal Qi. The formula's entirely cold and draining nature makes it unsuitable for the gestational state, where preservation of Qi and Blood is essential.

Breastfeeding

Use with significant caution during breastfeeding. Da Huang (Rhubarb) contains anthraquinone compounds (such as emodin and rhein) that can pass into breast milk and may cause loose stools or diarrhea in the nursing infant. Huang Lian's berberine alkaloids may also transfer to breast milk. The formula's strongly cold nature could potentially affect the infant's immature digestive system. If use is deemed necessary for an acute Heat condition, treatment should be kept as brief as possible and the infant monitored for digestive disturbance.

Children

This formula should be used with great caution in children, and only for clearly diagnosed excess Heat patterns confirmed by a qualified practitioner. Children's Spleen and Stomach systems are inherently immature and more vulnerable to the harsh, bitter-cold nature of all three ingredients. Dosages should be reduced substantially: typically one-third to one-half of the adult dose for children over 6 years, and one-quarter for younger children, though precise adjustment depends on the child's age, weight, and constitution. Treatment duration should be kept as brief as possible. Da Huang in particular can cause significant diarrhea in children. This formula is generally not appropriate for infants or toddlers.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Xie Xin Tang

Anticoagulants and antiplatelet drugs (warfarin, heparin, aspirin, clopidogrel): Da Huang (Rhubarb) has demonstrated anticoagulant and antiplatelet activity. Huang Lian's berberine has a high plasma protein binding rate and may compete with warfarin for binding sites, potentially increasing free warfarin concentration and anticoagulant effect. Concurrent use may significantly increase bleeding risk. Coagulation parameters (INR/PT) should be closely monitored.

Antihypertensive medications: SHXXT has been studied for blood pressure-lowering effects. Concurrent use with antihypertensive drugs may result in additive hypotensive effects, requiring blood pressure monitoring and possible dose adjustment.

Hypoglycemic agents (metformin, sulfonylureas, insulin): Berberine from Huang Lian has well-documented blood sugar-lowering effects and may potentiate the action of diabetic medications, increasing the risk of hypoglycemia.

Digoxin and cardiac glycosides: Da Huang may alter intestinal transit time and electrolyte balance (through its purgative action), potentially affecting the absorption and toxicity of digoxin. Potassium depletion from diarrhea can increase sensitivity to cardiac glycosides.

CYP450 substrates: Components of this formula, particularly berberine, have been shown to inhibit several CYP450 enzymes (including CYP3A4 and CYP2D6), which could alter the metabolism of numerous pharmaceutical drugs processed through these pathways.

Usage Guidance

Practical advice for getting the most out of Xie Xin Tang

Best time to take

Classically taken as a single dose (顿服) on an empty stomach for acute bleeding. For other Heat conditions, take 30-60 minutes after meals to reduce gastrointestinal irritation, divided into 2 doses per day.

Typical duration

Acute use only: typically 1-3 days, rarely exceeding 5-7 days. Discontinue once bleeding stops or Heat signs resolve.

Dietary advice

While taking this formula, avoid foods that generate internal Heat: alcohol, deep-fried foods, heavily spiced dishes, lamb, and excessive red meat. Avoid overly greasy or rich foods that burden the Stomach and generate Dampness-Heat. Favor light, cooling foods such as mung bean soup, cucumber, watermelon, pear, winter melon, and congee made from plain rice. Since the formula is strongly cold and purgative, also avoid excessively raw or cold foods that might compound the digestive impact, particularly if there is any underlying Spleen weakness. Drink adequate warm water to support the body's process of clearing Heat.

Xie Xin Tang originates from Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing Eastern Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Xie Xin Tang and its clinical use

Jin Gui Yao Lue (《金匮要略》), Chapter on Palpitations, Vomiting Blood, Epistaxis, Lower Body Bleeding, and Chest Fullness with Blood Stasis:

「心气不足,吐血、衄血,泻心汤主之。」
"When the Heart Qi is unsettled [original text reads 不足, likely a scribal error for 不定 meaning 'unstable'], with vomiting of blood and nosebleeds, Xie Xin Tang governs."

Yi Zong Jin Jian (《医宗金鉴》):

「心气'不足'二字,当是'有余'二字。若是不足,如何用此方治之,必是传写之讹。心气有余,热盛也,热盛而伤阳络,迫血妄行,为吐、为衄。故以大黄、黄连、黄芩大苦大寒直泻三焦之热,热去而吐衄自止矣。」
"The words 'Heart Qi insufficiency' should read 'Heart Qi excess.' If it were insufficiency, how could this formula be used? It must be a copying error. Heart Qi excess means Heat is exuberant. When Heat is exuberant, it injures the Yang collaterals and drives the Blood to move recklessly, causing vomiting of blood and nosebleeds. Therefore, Da Huang, Huang Lian, and Huang Qin, being greatly bitter and greatly cold, directly drain the Heat of the Three Burners. Once Heat is gone, the bleeding stops naturally."

Jin Gui Yao Lue Qian Zhu (《金匮要略浅注》):

「此为吐衄之神方也。妙在以芩、连之苦寒泄心之邪热,即所以补心之不足;尤妙在大黄之通,止其血,而不使其稍停余瘀。」
"This is a divine formula for vomiting blood and nosebleeds. Its brilliance lies in using the bitter-cold nature of Huang Qin and Huang Lian to drain pathogenic Heat from the Heart, which is itself a way of supplementing the Heart's insufficiency. Even more brilliant is how Da Huang, through its unblocking action, stops the bleeding without allowing any residual Blood stasis to remain."

Historical Context

How Xie Xin Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Xie Xin Tang originates from Zhang Zhongjing's Jin Gui Yao Lue (Essentials from the Golden Cabinet), composed in the Eastern Han dynasty (circa 200 CE). The formula appears in the chapter on palpitations, vomiting blood, and nosebleeds. It is also known by several alternative names: San Huang Xie Xin Tang (Three Yellows Drain the Heart Decoction), San Huang Tang (from the Sheng Ji Zong Lu), and Da Huang Huang Lian Xie Xin Tang (from the Lei Zheng Huo Ren Shu). These names reflect the fact that all three herbs are yellow in color.

A notable scholarly controversy surrounds this formula. The original Jin Gui Yao Lue text says "心气不足" (Heart Qi insufficiency), yet the formula consists entirely of draining, bitter-cold herbs that would be completely inappropriate for deficiency. The Yi Zong Jin Jian argued this must be a scribal error for "有余" (excess). The Qian Jin Yao Fang of Sun Simiao records the phrase as "心气不定" (Heart Qi unsettled/restless), and modern textual scholarship largely agrees that "不足" was a copying error for "不定," meaning restlessness and agitation. The formula has been celebrated across the centuries as a "divine formula for vomiting blood and nosebleeds" (吐衄神方), and by the Song dynasty, the Tai Ping Hui Min He Ji Ju Fang expanded its indications to cover accumulated Heat of all three Burners.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Xie Xin Tang

1

Review: SHXXT Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamic and Pharmacokinetic Levels (2016)

Wu J, Hu Y, Xiang L, Li S, Yuan Y, Chen X, Zhang Y, Huang W, Meng X, Wang P. Frontiers in Pharmacology, 2016, 7, 448.

This review examined how the three constituent herbs of San Huang Xie Xin Tang work synergistically at both the pharmacological and pharmacokinetic levels. The analysis found that the formula's active compounds target key inflammatory pathways including NF-kB, MAPK, and JAK/STAT, and that the herbs mutually enhance each other's bioavailability through effects on intestinal transporters.

PubMed
2

Retrospective Cohort Study: SHXXT Use Reduces Mortality Rate among Breast Cancer Patients (2023)

Winardi D et al. Cancers, 2023, 15(4), 1213.

Using Taiwan's National Health Insurance database, this study compared 5,387 breast cancer patients taking SHXXT and its constituent herbs with 5,387 matched controls. The study found that use of SHXXT and its constituents was associated with reduced mortality, potentially through the formula's anti-inflammatory and immunomodulatory effects.

PubMed
3

Preclinical Study: SHXXT Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury via Inhibition of Oxidative Stress-Induced Apoptosis (2012)

Lo YC, Shih YT, Tseng YT, Hsu HT. Evidence-Based Complementary and Alternative Medicine, 2012, 2012, 915051.

This in vitro study demonstrated that SHXXT and its component baicalin significantly protected rat ventricular cells from hypoxia/reoxygenation injury. The formula reduced reactive oxygen species, inhibited apoptotic pathways (decreased Bax, increased Bcl-2, reduced caspase-3), and preserved endothelial nitric oxide synthase expression.

PubMed
4

Preclinical Study: Neuroprotective Effects of SHXXT in MPP+/MPTP Models of Parkinson's Disease In Vitro and In Vivo (2012)

Lo YC, Shih YT, Tseng YT, Hsu HT. Evidence-Based Complementary and Alternative Medicine, 2012, 2012, 501032.

This study investigated SHXXT in both cell culture and animal models of Parkinson's disease. The formula significantly increased the survival of dopaminergic neurons, reduced apoptotic signaling, and attenuated oxidative stress markers, suggesting neuroprotective potential through antioxidant and anti-inflammatory mechanisms.

PubMed
5

Preclinical Study: Anti-atherogenic Effect of SHXXT in Cultured Human Aortic Smooth Muscle Cells (2011)

Wang YS, Lin RT, Cheng HY, Yang SF, Chou WW, Juo SH. Journal of Ethnopharmacology, 2011, 133(2), 442-447.

This study showed that SHXXT significantly reduced the proliferation and migration of human aortic smooth muscle cells (key features of atherosclerosis). It also decreased inflammatory biomarkers including reactive oxygen species, COX-2, IL-1 beta, IL-6, IL-8, and MCP-1 in lipopolysaccharide-stimulated cells.

PubMed

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.