Gua Lou Xie Bai Bai Jiu Tang

Trichosanthes Fruit, Chinese Chive, and Wine Decoction · 瓜蒌薤白白酒湯

Also known as: Gua Lou Xie Bai Bai Jiu Tang (瓜蒌薤白白酒汤), Kua Lou Xie Bai Bai Jiu Tang (栝楼薤白白酒汤), Trichosanthes, Allium, and Wine Decoction

A classical three-ingredient formula for chest tightness, oppressive chest pain (sometimes radiating to the back), shortness of breath, and wheezing caused by weakened warmth in the chest area combined with phlegm accumulation. It is the foundational prescription in the Gua Lou Xie Bai family of formulas, widely used in modern practice as a base for treating angina and other chest-related conditions.

Origin Jin Gui Yao Lue (金匮要略), Chapter 9: Chest Impediment, Heart Pain, and Shortness of Breath (胸痹心痛短气病脉证治第九) — Eastern Hàn dynasty, ~200 CE
Composition 3 herbs
Gua Lou
King
Gua Lou
Xie Bai
Deputy
Xie Bai
Bai Ji
Assistant
Bai Ji
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gua Lou Xie Bai Bai Jiu Tang is designed to correct these specific patterns.

Why Gua Lou Xie Bai Bai Jiu Tang addresses this pattern

This formula is the foundational prescription for chest impediment (Xiong Bi) caused by deficient chest Yang with phlegm obstruction and Qi stagnation. When Yang in the upper body is too weak to transform and transport fluids, those fluids congeal into phlegm. The phlegm then blocks Qi circulation in the chest, causing pain, pressure, and breathing difficulty. Gua Lou expels the phlegm and opens the chest while Xie Bai warms chest Yang and disperses the knotted obstruction. Bai Jiu reinforces the upward-directing and Yang-warming actions. The formula simultaneously addresses both the root cause (weak chest Yang) and the presenting pathology (phlegm-Qi stagnation).

A practitioner would look for one or more of these signs

Chest Pain

Dull, oppressive chest pain, sometimes radiating to the upper back

Shortness Of Breath

Short, laboured breathing that feels insufficient

Wheezing

Wheezing and panting respiration

Hypochondrial Pain That Is Worse On Coughing And Breathing

Coughing with expectoration of clear or white sputum

White Greasy Tongue Coating

White, greasy tongue coating indicating phlegm-damp

Feeling Of Oppression Of The Chest

Feeling of fullness and stuffiness in the chest

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Gua Lou Xie Bai Bai Jiu Tang when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, angina pectoris falls under the category of 'chest impediment' (Xiong Bi) and 'heart pain' (Xin Tong). The Jin Gui Yao Lue established that the fundamental mechanism is 'Yang faint, Yin taut' (Yang Wei Yin Xian), meaning the Yang of the upper body is too weak while Yin-Cold pathogenic influences become excessive. When chest Yang cannot warm and move Qi and Blood effectively, fluids stagnate and congeal into phlegm-turbidity. This phlegm further obstructs the chest, creating the characteristic squeezing, oppressive pain that can radiate to the back. Cold weather, emotional stress, or physical exertion can worsen the condition by further taxing the weakened Yang.

Why Gua Lou Xie Bai Bai Jiu Tang Helps

Gua Lou Xie Bai Bai Jiu Tang directly addresses the phlegm obstruction and Yang deficiency that TCM sees as the core mechanism of many angina presentations. Gua Lou opens the chest and clears the phlegm-turbidity, restoring space for Qi to flow. Xie Bai warms chest Yang and disperses the cold congelation, relieving pain. Bai Jiu carries these actions upward to the chest and promotes Blood circulation. A meta-analysis of 12 clinical studies (1,166 patients) found that this formula, used alongside conventional treatment, improved clinical outcomes in coronary heart disease angina patients, including better blood lipid profiles and improved blood viscosity compared to Western medicine alone.

Also commonly used for

Coronary Artery Disease

Atherosclerotic heart disease with chest oppression and pain

Costochondritis

Non-suppurative costochondritis with chest wall pain

Intercostal Neuralgia

Intercostal nerve pain with chest and rib discomfort

Chest Pain

Chronic chest pain of unclear origin fitting the pattern

What This Formula Does

Every TCM formula has a specific set of actions — here's what Gua Lou Xie Bai Bai Jiu Tang does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Gua Lou Xie Bai Bai Jiu Tang is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Gua Lou Xie Bai Bai Jiu Tang performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Gua Lou Xie Bai Bai Jiu Tang works at the root level.

This formula addresses chest painful obstruction (Xiong Bi, 胸痹), a condition whose core pathomechanism the Jin Gui Yao Lue summarizes in four characters: "Yang feeble, Yin wiry" (阳微阴弦). The chest is the seat of Heart and Lung Yang, and in health, this Yang Qi fills the upper body like sunlight filling an open sky. When chest Yang becomes weak or insufficient, it loses the power to keep turbid, cold, heavy substances in check. Yin pathogens (phlegm, cold, dampness) then rise upward and accumulate where they should not, blocking the free flow of Qi in the chest.

Once phlegm congeals and Qi stagnates in the chest, the result is a constellation of symptoms: a heavy, suffocating sensation of chest pain that may radiate through to the back, difficulty breathing, coughing with expectoration, and shortness of breath. The tongue shows a white, greasy coating (reflecting phlegm), and the pulse is deep and wiry or tight (reflecting cold obstruction and Qi blockage). The essential disease logic is that Yang deficiency is the root (the reason phlegm could accumulate in the first place), while phlegm obstruction and Qi stagnation are the branches (the immediate cause of pain and dysfunction). The treatment principle therefore addresses both: unblock and restore chest Yang, while simultaneously dispersing phlegm and moving stagnant Qi.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly pungent and bitter with a sweet undertone — pungent to disperse and move Qi, bitter to direct downward and clear Phlegm, sweet from the wine to harmonize and carry the formula upward.

Ingredients

3 herbs

The herbs that make up Gua Lou Xie Bai Bai Jiu Tang, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Gua Lou

Gua Lou

Snake gourds

Dosage 12 - 24g
Temperature Cold
Taste Sweet
Organ Affinity Large Intestine, Lungs, Stomach
Preparation Crush before decocting (捣碎)

Role in Gua Lou Xie Bai Bai Jiu Tang

Opens the chest, loosens Qi, expels phlegm, and dissipates nodulation. As the primary herb, it directly addresses the core pathology of phlegm obstruction in the chest by clearing phlegm and widening the chest cavity.
Deputy — Assists and enhances the King
Xie Bai

Xie Bai

Long-stamen onion bulbs

Dosage 9 - 12g
Temperature Warm
Taste Bitter, Pungent
Organ Affinity Large Intestine, Lungs, Stomach

Role in Gua Lou Xie Bai Bai Jiu Tang

Warms and unblocks chest Yang, moves Qi, and dissipates knotted obstruction to relieve pain. It complements Gua Lou by addressing the Yang deficiency aspect of chest impediment, restoring the warm, activating function of chest Yang.
Assistant — Supports or moderates other herbs
Bai Ji

Bai Ji

Bletilla rhizomes

Dosage 30 - 60ml
Temperature Cold
Taste Bitter, Sweet
Organ Affinity Stomach, Liver, Lungs
Preparation Added to the decoction. Modern practice substitutes Huang Jiu (yellow rice wine) or rice vinegar in an appropriate amount.

Role in Gua Lou Xie Bai Bai Jiu Tang

Its warm, ascending, and dispersing nature carries the other herbs upward to the chest, invigorates Qi and Blood movement, and reinforces the Yang-warming and obstruction-opening actions of Xie Bai. In antiquity, 'Bai Jiu' referred to a low-alcohol rice wine (similar to modern Huang Jiu or even rice vinegar), not modern distilled spirits.

Why This Combination Works

How the herbs in Gua Lou Xie Bai Bai Jiu Tang complement each other

Overall strategy

Chest impediment arises when chest Yang is weak and phlegm-damp congeals, obstructing Qi flow in the upper body. This formula uses a small number of precisely chosen ingredients to warm and unblock chest Yang while expelling phlegm and restoring Qi circulation.

King herb

Gua Lou Shi (Trichosanthes fruit) is the King. Sweet in taste and cold in nature, it enters the Lung, Stomach, and Large Intestine channels. Its primary role here is to open the chest, loosen congealed Qi, expel phlegm, and dissipate nodulation. It directly addresses the phlegm accumulation that is the 'branch' (biao) of the disease.

Deputy herb

Xie Bai (Chinese chive bulb) is the Deputy. Pungent, bitter, and warm, it warms and unblocks chest Yang, moves Qi, and relieves pain from obstruction. While Gua Lou clears the phlegm, Xie Bai tackles the Yang deficiency and Qi stagnation that are the 'root' (ben). Together, one removes phlegm while the other restores Yang flow, creating a complementary pair that forms the core of all Gua Lou Xie Bai family formulas.

Assistant herb

Bai Jiu (white rice wine) serves as a reinforcing assistant. Warm, pungent, and ascending in nature, it carries the medicinal effects upward to the chest, invigorates Blood movement, and enhances Xie Bai's Yang-warming and Qi-moving actions. It also helps activate the channels and collaterals in the chest region.

Notable synergies

The pairing of Gua Lou and Xie Bai is the signature combination for chest impediment. Gua Lou resolves phlegm and opens the chest from the 'Yin' side (clearing turbid accumulation), while Xie Bai opens from the 'Yang' side (warming and moving Qi). Together they address both the root Yang deficiency and the branch phlegm obstruction simultaneously. Bai Jiu amplifies this synergy by acting as a vehicle that directs both herbs to the chest and speeds up their dispersing action.

How to Prepare

Traditional preparation instructions for Gua Lou Xie Bai Bai Jiu Tang

The original method from the Jin Gui Yao Lue instructs: combine all three ingredients and cook together, reducing to roughly two cups (about 400 ml), then divide into two doses and take warm.

In modern practice, the two herbal ingredients (Gua Lou Shi and Xie Bai) are decocted in water first, yielding approximately 300 ml of liquid. This is divided into two servings, and 30 to 60 ml of Huang Jiu (yellow rice wine) is stirred in at the time of each serving. For patients who cannot tolerate alcohol, rice vinegar (approximately 20 to 30 ml per dose) may be substituted. Some classical commentators considered rice vinegar the closest equivalent to the ancient 'Bai Jiu.'

Common Modifications

How practitioners adapt Gua Lou Xie Bai Bai Jiu Tang for specific situations

Added
Ban Xia

9-12g, to powerfully dry dampness, expel phlegm, and direct counterflow Qi downward

This is the classic escalation to Gua Lou Xie Bai Ban Xia Tang for more severe chest impediment. Ban Xia's strong phlegm-drying and Qi-descending actions address the worsened phlegm obstruction that prevents lying flat and causes intense radiating pain.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Gua Lou Xie Bai Bai Jiu Tang should not be used or requires extra caution

Avoid

Chest pain due to Yin deficiency with Empty Heat. This formula's warm, Yang-unblocking nature can further damage Yin and worsen Heat signs such as dry mouth, night sweats, and a red tongue with little coating.

Caution

Chest pain due to Heart Blood stasis without Phlegm obstruction or Yang deficiency. Pure Blood stasis patterns require Blood-moving formulas rather than Phlegm-dispersing, Yang-unblocking ones.

Caution

Severe Qi or Yang deficiency (collapse). While this formula treats mild Yang deficiency causing Phlegm accumulation, it is primarily a Qi-moving, Phlegm-expelling formula and does not strongly tonify. Severe deficiency requires supplementation with tonifying formulas such as Ren Shen Tang.

Caution

Alcohol sensitivity or intolerance. The formula traditionally requires Bai Jiu (rice wine) as a key ingredient. For those who cannot tolerate alcohol, rice vinegar can be substituted, or the wine can be omitted, though this reduces the formula's ascending, Yang-moving action.

Caution

Active gastrointestinal bleeding or hemorrhagic conditions. Gua Lou (Trichosanthes fruit) has a lubricating, downward-moving quality, and the wine component promotes Blood movement, which could aggravate bleeding.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Gua Lou (Trichosanthes fruit) has a downward-draining, slippery quality that may be inappropriate in pregnancy, and the formula contains alcohol (Bai Jiu), which should be avoided. The formula is also primarily Qi-moving and dispersing in nature, which is generally used cautiously during pregnancy. Not absolutely contraindicated, but a qualified practitioner should assess the risk-benefit ratio carefully, and the alcohol component should be removed or minimized.

Breastfeeding

Generally considered compatible with breastfeeding with appropriate caution. The three ingredients (Trichosanthes fruit, Chinese chive bulb, rice wine) are food-grade substances with long histories of dietary use. The primary concern is the alcohol component (Bai Jiu), which transfers into breast milk. If used during breastfeeding, the alcohol should be minimized or omitted, or the mother should wait several hours after taking the formula before nursing. There are no known toxic constituents in Gua Lou or Xie Bai that would pose specific risks to the nursing infant.

Children

This formula is rarely used in pediatric practice because chest painful obstruction (Xiong Bi) is predominantly an adult condition associated with aging and Yang decline. If used in adolescents for appropriate indications, dosages should be reduced to approximately one-third to one-half of the adult dose depending on age and body weight. The alcohol component (Bai Jiu) should be omitted entirely for children and replaced with additional water in the decoction. Not suitable for young children under 6 years of age.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Gua Lou Xie Bai Bai Jiu Tang

Anticoagulants and Antiplatelet Agents: Pharmacological research indicates that this formula has platelet aggregation-inhibiting properties. Concurrent use with warfarin, heparin, aspirin, clopidogrel, or other blood-thinning medications may have an additive anticoagulant effect, potentially increasing bleeding risk. Close monitoring of coagulation parameters is advised.

Alcohol-Interacting Medications: The formula traditionally contains Bai Jiu (rice wine). Medications that interact with alcohol, including metronidazole, certain cephalosporins (disulfiram-like reaction), sedatives, and benzodiazepines, may have enhanced or altered effects when taken alongside the wine-containing decoction.

Antihypertensives: The vasodilatory effects of the formula (expanding coronary arteries and increasing coronary blood flow) may have an additive effect with calcium channel blockers, nitrates, or other vasodilators, potentially causing excessive blood pressure lowering. Dose adjustments may be needed.

Usage Guidance

Practical advice for getting the most out of Gua Lou Xie Bai Bai Jiu Tang

Best time to take

Warm, divided into two doses, taken between meals (mid-morning and mid-afternoon) or 30 minutes after meals to avoid aggravating the stomach.

Typical duration

Acute chest pain episodes: 3-7 days; chronic chest painful obstruction: 2-4 weeks with regular reassessment by a practitioner.

Dietary advice

Avoid cold, raw, and greasy foods while taking this formula, as these can worsen Phlegm accumulation and impair chest Yang. Rich, fatty, or deep-fried foods and dairy products should be limited. Cold drinks and iced foods are particularly counterproductive since the formula is working to warm and open the chest. Favor warm, lightly cooked foods that are easy to digest. Moderate amounts of ginger, scallion, and warming spices support the formula's Yang-unblocking action. Avoid overeating, as a full stomach worsens Qi stagnation in the chest.

Gua Lou Xie Bai Bai Jiu Tang originates from Jin Gui Yao Lue (金匮要略), Chapter 9: Chest Impediment, Heart Pain, and Shortness of Breath (胸痹心痛短气病脉证治第九) Eastern Hàn dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Gua Lou Xie Bai Bai Jiu Tang and its clinical use

Jin Gui Yao Lue (《金匮要略》), Chapter 9: Xiong Bi Xin Tong Duan Qi Bing Mai Zheng Zhi (胸痹心痛短气病脉证治)

Original: 「胸痹之病,喘息咳唾,胸背痛,短气,寸口脉沉而迟,关上小紧数,栝蒌薤白白酒汤主之。」

Translation: "In the disease of chest painful obstruction, with panting, coughing and spitting, pain in the chest and back, shortness of breath, the cun pulse is deep and slow, the guan pulse is slightly tight and rapid — Gua Lou Xie Bai Bai Jiu Tang governs."


Jin Gui Yao Lue (《金匮要略》), Chapter 9 — Opening passage on pathomechanism:

Original: 「夫脉当取太过不及,阳微阴弦,即胸痹而痛。所以然者,责其极虚也。今阳虚知在上焦,所以胸痹心痛者,以其阴弦故也。」

Translation: "When reading the pulse, one should assess excess and deficiency. When Yang is feeble and Yin is wiry, chest painful obstruction with pain results. The reason is extreme deficiency. Yang deficiency is in the Upper Burner; the cause of chest obstruction and heart pain lies in the wiry Yin [pulse]."


Gu Fang Xuan Zhu (《古方选注》) — Commentary on the formula:

Original: 「君以薤白,滑利通阳;臣以栝楼实,润下通阴;佐以白酒,熟谷之气上行药性,助其通经活络,而痹自开。」

Translation: "The sovereign Xie Bai, slippery and freeing, unblocks Yang; the minister Gua Lou Shi, moistening and descending, opens the Yin aspect; the assistant Bai Jiu, carrying the ascending nature of fermented grain, assists the medicine in freeing the channels and collaterals, so that the obstruction naturally opens."

Historical Context

How Gua Lou Xie Bai Bai Jiu Tang evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Gua Lou Xie Bai Bai Jiu Tang originates from Zhang Zhongjing's Jin Gui Yao Lue (Synopsis of the Golden Chamber), written in the late Eastern Han Dynasty (c. 200 CE). It appears in Chapter 9, "Xiong Bi Xin Tong Duan Qi Bing" (Chest Painful Obstruction, Heart Pain, and Shortness of Breath), and is considered the foundational formula for treating chest Bi. Zhang Zhongjing built a graded series of formulas around the core pairing of Gua Lou and Xie Bai: this formula is the mildest, for the basic pattern; Gua Lou Xie Bai Ban Xia Tang adds Ban Xia for more severe phlegm causing inability to lie flat; and Zhi Shi Xie Bai Gui Zhi Tang adds Zhi Shi, Hou Po, and Gui Zhi for the most severe cases with Qi rushing upward and fullness extending below the ribs.

The "Bai Jiu" (white wine) in the original text is not modern distilled spirits but rather a low-alcohol fermented grain wine, closer to what is now called huang jiu (rice wine) or even a milky fermented rice drink (lao zao). This distinction has been noted by scholars throughout history. Qing Dynasty physician Wang Qingren, in his Yi Lin Gai Cuo (Corrections of Errors in the Medical Forest), mentioned this formula specifically for chest pain radiating to the back. The Gu Fang Xuan Zhu (Selected Commentaries on Ancient Formulas) provided an influential analysis of the formula's herb roles. In modern China, the Gua Lou-Xie Bai pairing remains the most commonly used herbal combination for coronary heart disease with phlegm obstruction, and National Master of Chinese Medicine Yan Zhenghua famously built his entire chest Bi treatment system around modifications of these three formulas.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Gua Lou Xie Bai Bai Jiu Tang

1

Network Pharmacology Analysis of Gua Lou Xie Bai Gui Zhi Tang in Coronary Heart Disease Treatment (2022, Network Pharmacology Study)

Guo Y, et al. Medicine. 2022; 101(29):e29662.

This network pharmacology study analyzed the mechanism of a Gua Lou-Xie Bai based formula in treating coronary heart disease. It identified 100 intersection targets between the formula and coronary heart disease, with key targets including IL-6, TNF, and VEGFA. Pathway analysis showed involvement of HIF-1, TNF, PI3K-Akt, and calcium signaling pathways, supporting a multi-component, multi-target mechanism.

PubMed
2

Gualou Xiebai Banxia Decoction Combined with Xuefu Zhuyu Decoction on Myocardial Apoptosis in Miniature Swine CHD Model (2015, Animal Study)

Yan AG, Liu JX, Li XZ, Dong XX, Li HK. Zhongguo Zhong Yao Za Zhi. 2015; 40(11):2174-9.

In a miniature swine model of phlegm and blood stasis type coronary heart disease, the combination of Gua Lou Xie Bai Ban Xia Tang and Xue Fu Zhu Yu Tang showed significant protective effects against myocardial apoptosis, upregulating Bcl-2 protein expression and downregulating Bax, Caspase-3, and Caspase-9 expression.

PubMed
3

Banxia Gualou Xiebai Tang and Qishen Yiqi Dropping Pills for Post-PCI CHD Patients (2025, Retrospective Comparative Study)

Fan M, Du L, Jiang W, Ding T, Yang X, Peng Z. International Journal of General Medicine. 2025; 18:1685-1695.

A retrospective study of 100 post-PCI coronary heart disease patients compared standard treatment alone versus standard treatment plus Banxia Gualou Xiebai Tang and Qishen Yiqi Dropping Pills. The combined TCM group showed a total effective rate of 92.0% versus 76.0% in controls, with significant improvements in cardiac function, TCM syndrome scores, blood lipids, and hemorheological parameters.

Link

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.