Dang Gui Di Huang Yin

Angelica and Rehmannia Drink · 當歸地黃飲

Also known as: Dang Gui Di Huang Yin Zi

A classical formula designed to nourish the Kidney and strengthen the lower back. It is commonly used for people experiencing lower back and knee pain, weakness, or soreness caused by Kidney deficiency, and is particularly suited for women with menstrual irregularities related to Blood and Kidney insufficiency.

Origin Jǐng Yuè Quán Shū (《景岳全书》, Complete Works of Zhang Jingyue), Volume 51, by Zhang Jiebin — Míng dynasty, ~1624 CE
Composition 7 herbs
Shu Di Huang
King
Shu Di Huang
Dang Gui
King
Dang Gui
Shan Zhu Yu
Deputy
Shan Zhu Yu
Shan Yao
Deputy
Shan Yao
Du Zhong
Assistant
Du Zhong
Niu Xi
Envoy
Niu Xi
Gan Cao
Envoy
Gan Cao
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Dang Gui Di Huang Yin is designed to correct these specific patterns.

Why Dang Gui Di Huang Yin addresses this pattern

Kidney Yin deficiency leads to insufficient Essence to nourish the lumbar region, sinews, and bones. Shu Di Huang directly replenishes Kidney Yin and Essence, while Shan Zhu Yu astringes and holds the Essence in the Kidneys. Shan Yao supports the Spleen to ensure ongoing production of postnatal Essence. Dang Gui supplements Blood (which shares a common source with Essence), and the combination resolves the root deficiency that causes lower back weakness and soreness.

A practitioner would look for one or more of these signs

Lower Back Pain

Dull, chronic aching in the lower back, worse with fatigue

Knee Pain

Weak, sore knees that feel unsupported

Tinnitus

Ringing in the ears from Kidney deficiency

Dizziness

Lightheadedness from insufficient Essence reaching the head

Eye Fatigue

General tiredness and weak constitution

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Dang Gui Di Huang Yin when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In TCM, the lower back is considered the 'mansion of the Kidney' (腰为肾之府). Chronic lower back pain that presents as a deep, dull ache (rather than sharp or stabbing) is frequently attributed to Kidney deficiency. When Kidney Yin and Essence are depleted, the bones, marrow, and surrounding sinews of the lumbar spine lose their source of nourishment, leading to weakness, soreness, and vulnerability to strain. This type of pain typically worsens with fatigue or overwork and improves with rest.

Why Dang Gui Di Huang Yin Helps

Dang Gui Di Huang Yin targets the root cause by deeply replenishing Kidney Yin and Essence through Shu Di Huang and Shan Zhu Yu. Du Zhong directly strengthens the lower back and is one of the most important herbs in TCM for lumbar health. Niu Xi guides the formula's action downward to the lower body and itself strengthens the sinews and bones. Dang Gui supplements Blood and promotes circulation, helping nourishment reach the affected area. Together, these herbs restore the Kidney's capacity to support the lumbar region from the inside out.

Also commonly used for

Knee Pain

Weak, sore knees due to Kidney and Liver insufficiency

Osteoporosis

Bone weakness from Kidney Essence deficiency

Amenorrhea

Absent or scanty menstruation from Blood and Essence deficiency

Constipation

Yin-deficiency type constipation with dry stools

Menopausal Symptoms

Menopausal symptoms related to Kidney Yin and Essence decline

Eye Fatigue

Chronic tiredness from depleted Kidney Essence

What This Formula Does

Every TCM formula has a specific set of actions — here's what Dang Gui Di Huang Yin does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Dang Gui Di Huang Yin is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Dang Gui Di Huang Yin performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Dang Gui Di Huang Yin works at the root level.

This formula addresses a core pattern of Kidney Essence deficiency leading to malnourishment of the lower back and knees. In TCM, the Kidneys are said to "govern the bones" and store Essence, which is the fundamental substance supporting skeletal integrity, marrow production, and the strength of the lower body. The Liver, closely related to the Kidneys through the concept that "Liver and Kidney share a common source," governs the sinews (tendons, ligaments, and connective tissue). When Kidney Essence becomes depleted, whether through aging, chronic illness, overwork, or constitutional weakness, the bones and sinews of the lumbar region and knees lose their nourishing supply.

The lower back is often called the "mansion of the Kidneys" (腰为肾之府) in classical texts. When Kidney Yin and Essence are insufficient, the lumbar spine and knee joints become poorly nourished, resulting in a dull, persistent aching pain that worsens with fatigue and improves with rest. Because Essence depletion often affects both Yin and Yang aspects of the Kidneys, patients may also experience general weakness of the legs, difficulty standing for long periods, and a sense of heaviness or limpness in the lower limbs. The formula addresses this by simultaneously replenishing Kidney Yin and Essence as its primary strategy, while also gently warming Kidney Yang to ensure the bones and sinews receive both nourishment and functional support.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly sweet with sour and slightly bitter notes. Sweet to nourish and tonify Essence and Blood, sour to astringently retain Kidney Essence, and mildly bitter to direct action downward.

Channels Entered

Ingredients

7 herbs

The herbs that make up Dang Gui Di Huang Yin, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
Kings — Main ingredient driving the formula
Shu Di Huang

Shu Di Huang

Prepared Rehmannia root

Dosage 9 - 15g
Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Dang Gui Di Huang Yin

The primary herb of the formula, Shu Di Huang strongly nourishes Kidney Yin and replenishes Essence and marrow. As the heaviest-dosed ingredient, it addresses the root deficiency of Kidney Yin that underlies the condition.
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 9g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Dang Gui Di Huang Yin

Nourishes and invigorates Blood, and alleviates pain. It works alongside Shu Di Huang to replenish Blood and Essence, and its moving quality helps prevent stagnation from the rich tonifying herbs.
Deputies — Assists and enhances the King
Shan Zhu Yu

Shan Zhu Yu

Asiatic cornelian cherry fruit

Dosage 3g
Temperature Slightly Warm
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys

Role in Dang Gui Di Huang Yin

Nourishes and astringes the Liver and Kidney, helping to secure Essence and prevent its leakage. Its sour and warm nature complements the King herbs by stabilizing the Kidney's storing function.
Shan Yao

Shan Yao

Chinese yam

Dosage 6g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys

Role in Dang Gui Di Huang Yin

Tonifies the Spleen and Kidney simultaneously, supporting postnatal Essence production. By strengthening the Spleen (the source of acquired Essence), it ensures the body can continually replenish what the Kidney stores.
Assistant — Supports or moderates other herbs
Du Zhong

Du Zhong

Eucommia bark

Dosage 6g
Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Dang Gui Di Huang Yin

Tonifies the Liver and Kidney and strengthens sinews and bones. Its warm nature gently supports Kidney Yang, working alongside the Yin-nourishing herbs to address both aspects of Kidney deficiency and directly targeting lower back and knee weakness.
Envoys — Directs the formula to its target
Niu Xi

Niu Xi

Achyranthes root

Dosage 4.5g
Temperature Neutral
Taste Bitter (苦 kǔ), Sour (酸 suān), Sweet (甘 gān)
Organ Affinity Liver, Kidneys

Role in Dang Gui Di Huang Yin

Tonifies the Liver and Kidney, strengthens the sinews and bones, and importantly directs the formula's action downward to the lower back and knees where the symptoms manifest.
Gan Cao

Gan Cao

Licorice root

Dosage 2.4g
Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach

Role in Dang Gui Di Huang Yin

Harmonizes all the herbs in the formula and mildly tonifies Spleen Qi to support the digestive system's absorption of the rich tonifying ingredients.

Why This Combination Works

How the herbs in Dang Gui Di Huang Yin complement each other

Overall strategy

This formula addresses Kidney Essence deficiency causing the lower back and knees to lose nourishment. The strategy is primarily to enrich Kidney Yin and supplement Blood, while gently supporting Kidney Yang, so that the sinews, bones, and lumbar region are restored.

King herbs

Shu Di Huang (prepared Rehmannia) is the chief ingredient at the highest dose, powerfully nourishing Kidney Yin and replenishing Essence and marrow. Dang Gui (Angelica) serves as co-King by supplementing and invigorating Blood, ensuring that nourishment reaches the sinews and lower back. Together they form the core Yin-Blood nourishing axis of the formula.

Deputy herbs

Shan Zhu Yu (Cornus fruit) astringes and stabilizes Kidney Essence while nourishing the Liver, preventing the Essence built up by the King herbs from dispersing. Shan Yao (Chinese yam) tonifies both Spleen and Kidney, reinforcing the postnatal source of Essence so that Kidney reserves can be continually replenished.

Assistant herbs

Du Zhong (Eucommia bark) acts as a reinforcing assistant, directly strengthening the sinews and bones and mildly warming Kidney Yang. This is important because the formula is predominantly Yin-nourishing, and Du Zhong ensures that Yang is also gently supported. As Zhang Jiebin's formula rationale states, the overall approach is primarily to nourish Yin while also supplementing Kidney Yang, so that the lower back and knees naturally regain their strength.

Envoy herbs

Niu Xi (Achyranthes) tonifies the Liver and Kidney, strengthens the lower body, and critically guides the formula's therapeutic action downward to the lumbar region and knees. Zhi Gan Cao (honey-prepared licorice) harmonizes all the ingredients and supports the Spleen to aid absorption of the heavy tonifying substances.

Notable synergies

The Shu Di Huang and Shan Zhu Yu pairing creates a build-and-hold dynamic: one deeply replenishes Essence while the other prevents its leakage. Dang Gui paired with Niu Xi combines Blood nourishment with downward-directing action, ensuring that the therapeutic benefit reaches the lower back and legs. Du Zhong and Niu Xi together form a classic lower-body strengthening pair, directly targeting weak sinews and bones in the lumbar region.

How to Prepare

Traditional preparation instructions for Dang Gui Di Huang Yin

Use approximately 400 ml (two zhōng) of water. Bring to a boil and simmer until reduced to roughly 320 ml (about 80% of the original volume). Strain and drink warm on an empty stomach. Take once daily.

Common Modifications

How practitioners adapt Dang Gui Di Huang Yin for specific situations

Added
Lai Fu Zi

3 - 6g, to warm and restore Kidney Yang

Rou Gui

3g, to warm the Ming Men fire and assist Yang

When Kidney Yang is significantly depleted alongside Yin deficiency, adding warming herbs like Fu Zi and Rou Gui follows Zhang Jiebin's principle of supporting the fire of the Ming Men to balance the formula's predominantly Yin-nourishing action.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Dang Gui Di Huang Yin should not be used or requires extra caution

Avoid

Lower back pain due to Damp-Heat accumulation or acute inflammation, where the rich, tonifying nature of this formula could trap pathogenic factors and worsen the condition.

Caution

Lower back pain caused by Blood stasis with no underlying deficiency. This formula is primarily supplementing and does not strongly move Blood or dispel stasis.

Caution

Spleen deficiency with poor digestion, loose stools, or abdominal bloating. The heavy, cloying nature of Shu Di Huang and other enriching herbs may further burden the Spleen. Consider adding Spleen-strengthening herbs or using a different approach.

Caution

Excess-type conditions or robust constitutions with no signs of Kidney deficiency. Tonifying formulas should not be used when there is no deficiency to tonify.

Avoid

Acute external pathogen invasion (colds, flu). Tonifying formulas can trap exterior pathogens, potentially worsening the illness.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. Niu Xi (Achyranthes root) has Blood-moving and downward-directing properties that may stimulate uterine activity and is traditionally listed among herbs that should be avoided or used very cautiously in pregnancy. While the other herbs in the formula are generally considered safe, the inclusion of Niu Xi means this formula should only be used during pregnancy under the direct supervision of an experienced practitioner, and ideally with Niu Xi removed or substituted. Du Zhong, by contrast, is traditionally considered beneficial for pregnancy (it stabilizes the fetus), but this does not offset the concern with Niu Xi.

Breastfeeding

Generally considered compatible with breastfeeding. The herbs in this formula are primarily nourishing and tonifying, and none are known to produce toxic or harmful metabolites that would pose a significant risk through breast milk. Shu Di Huang (prepared Rehmannia) is rich and cloying, which could potentially cause mild digestive discomfort in the nursing mother, but this is unlikely to affect the infant. Niu Xi has mild Blood-moving properties, but at the doses used in this formula, this is not a significant concern during the postpartum breastfeeding period. Nevertheless, use under practitioner guidance is always recommended.

Children

This formula is designed for adults with Kidney Essence deficiency, a pattern that typically manifests with aging or chronic depletion rather than in childhood. Pediatric use is uncommon and generally not indicated. In rare cases where a child presents with constitutional Kidney deficiency (e.g., delayed bone development, weak lower back), the formula may be considered at significantly reduced doses (typically one-third to one-half the adult dose, adjusted by age and body weight) under close practitioner supervision. The cloying nature of Shu Di Huang should be watched carefully, as children's digestive systems are more sensitive.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Dang Gui Di Huang Yin

Gan Cao (Glycyrrhiza/Licorice): The honey-processed licorice in this formula may interact with several pharmaceutical drug classes. Glycyrrhizin in licorice can cause potassium loss and sodium retention, potentially interacting with antihypertensive medications (reducing their efficacy), diuretics (compounding potassium depletion), cardiac glycosides such as digoxin (hypokalemia increases digoxin toxicity), and corticosteroids (additive mineralocorticoid effects). The dose of Gan Cao in this formula is relatively small (2.4g), which reduces but does not eliminate these concerns.

Dang Gui (Angelica sinensis): Contains coumarins that may mildly potentiate the effects of anticoagulant and antiplatelet medications (warfarin, aspirin, clopidogrel), potentially increasing bleeding risk. Patients on blood-thinning medications should be monitored.

Niu Xi (Achyranthes): Has mild Blood-activating properties that could theoretically add to anticoagulant effects when combined with blood-thinning drugs.

Du Zhong (Eucommia bark): Has demonstrated mild antihypertensive effects in pharmacological studies. Patients taking blood pressure medications should monitor for additive hypotensive effects.

Usage Guidance

Practical advice for getting the most out of Dang Gui Di Huang Yin

Best time to take

On an empty stomach, as specified in the original text (空腹服). Typically taken in the morning before breakfast, or divided into two doses taken before meals.

Typical duration

Typically prescribed for 2-4 weeks as an initial course, then reassessed. As a tonifying formula for chronic Kidney deficiency, it may be taken intermittently over several months.

Dietary advice

While taking this formula, favor warm, easily digestible foods that support the Kidneys and Spleen, such as black beans, walnuts, black sesame seeds, bone broth, lamb, and warm congee. Avoid cold and raw foods (salads, iced drinks, raw sushi) which can impair Spleen function and hinder the absorption of this rich, nourishing formula. Limit greasy, heavy, and overly sweet foods, as they may compound the cloying nature of Shu Di Huang and cause digestive stagnation. Avoid excessive caffeine and alcohol, which can deplete Kidney Essence. The classical instruction is to take this formula on an empty stomach (空腹服) for optimal absorption.

Dang Gui Di Huang Yin originates from Jǐng Yuè Quán Shū (《景岳全书》, Complete Works of Zhang Jingyue), Volume 51, by Zhang Jiebin Míng dynasty, ~1624 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Dang Gui Di Huang Yin and its clinical use

Source text from the Jing Yue Quan Shu (《景岳全书》卷五十一):

The original formula annotation states:

「本方主治肾精不足,腰府失养所致的腰膝疼痛等症。方中熟地滋肾阴,益精髓,山茱萸酸温滋肾益肝,并为主药;山药滋肾健脾,杜仲补肾阳、强筋骨,当归补血活血止痛,均为辅药;牛膝补肝肾而强筋骨,引药下行,甘草调和诸药,并为使药。全方以滋阴为主,兼补肾阳,则腰膝自强。」

Translation: This formula primarily treats insufficiency of Kidney Essence, where the lumbar region loses nourishment, resulting in pain of the lower back and knees. In the formula, Shu Di Huang (prepared Rehmannia) nourishes Kidney Yin and enriches the Essence and marrow. Shan Zhu Yu (Cornus fruit), sour and warm, nourishes the Kidneys and benefits the Liver; together these serve as the principal herbs. Shan Yao (Chinese yam) nourishes the Kidneys and strengthens the Spleen; Du Zhong (Eucommia bark) tonifies Kidney Yang and strengthens the sinews and bones; Dang Gui (Angelica root) nourishes and activates Blood and relieves pain; all serve as assisting herbs. Niu Xi (Achyranthes root) tonifies the Liver and Kidneys while strengthening the sinews and bones, and guides the formula's action downward. Gan Cao (Licorice) harmonizes all the herbs, serving as the envoy. The whole formula primarily nourishes Yin while also supplementing Kidney Yang, so that the lower back and knees naturally regain their strength.

Historical Context

How Dang Gui Di Huang Yin evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Dang Gui Di Huang Yin originates from the Jing Yue Quan Shu (《景岳全书》, "Complete Works of Jing Yue"), Volume 51, composed by the renowned Ming Dynasty physician Zhang Jiebin (张介宾, courtesy name Jingyue 景岳, 1563–1640). Zhang Jiebin was the leading figure of the Warm Supplementation school (温补学派) and is considered one of the most influential physicians in Chinese medical history. He championed the idea that true Yin and true Yang are both commonly insufficient, countering the prevailing emphasis on clearing Heat and purging that had followed the teachings of Zhu Danxi.

This formula exemplifies Zhang Jiebin's characteristic approach of building therapeutic strategies around the Kidney as the root of life. He was famous for creating numerous new formulas derived from modifications of Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill), including the celebrated Zuo Gui Wan, You Gui Wan, and the various "Yin" and "Yang" decoction series (煎). Dang Gui Di Huang Yin reflects his principle of using a small number of precisely chosen herbs with focused therapeutic intent. His Jing Yue Quan Shu, completed toward the end of his life and published posthumously around 1640, contains 186 new formulas, averaging only about six herbs per formula, a deliberate philosophy of therapeutic precision.