Herb Whole plant / Aerial parts (全草 quán cǎo)

Jiao Gu Lan

Gynostemma · 绞股蓝

Gynostemma pentaphyllum (Thunb.) Makino · Herba Gynostemmatis Pentaphylli

Also known as: Qi Ye Dan (七叶胆), Southern Ginseng

Images shown are for educational purposes only

Often called "southern ginseng" because it shares key active compounds with Ginseng, Gynostemma is a gentle tonic herb that supports the body's Qi without being overly warming. It is widely consumed as a health tea in southern China and is valued for its ability to help manage cholesterol and blood lipid levels, support healthy blood sugar, reduce fatigue, and promote a calm state of mind.

TCM Properties

Temperature

Cool

Taste

Bitter (苦 kǔ), Sweet (甘 gān)

Channels entered

Lungs, Spleen, Kidneys

Parts used

Whole plant / Aerial parts (全草 quán cǎo)

Available in our store
View in Store
From $23.00

Educational content Consult qualified TCM practitioners for diagnosis and treatment

What This Herb Does

Every herb has a specific set of actions — here's what Jiao Gu Lan does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Jiao Gu Lan is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Jiao Gu Lan performs to restore balance in the body:

How these actions work

'Tonifies Qi and strengthens the Spleen' means this herb replenishes the Spleen's functional capacity, making it useful for fatigue, poor appetite, and general weakness. Despite being a cool-natured herb, its sweet flavour allows it to gently nourish the Spleen Qi without the drying or warming effects of herbs like Ginseng. This quality makes it suitable for people who need Qi support but tend to run warm or have signs of Heat.

'Resolves Phlegm and stops coughing' refers to the herb's ability to clear accumulated Phlegm from the Lungs and calm a cough, particularly when Phlegm arises from Spleen weakness failing to properly transform fluids. It is used for chronic bronchitis with productive cough.

'Clears Heat and resolves toxins' reflects its cool nature, which can address low-grade inflammatory conditions, sore throat, and viral infections. This action is supported by its bitter taste, which has a descending, draining quality that helps clear pathogenic Heat from the body.

'Reduces turbidity and lowers lipids' is a modern clinical action describing the herb's well-known ability to help regulate blood lipid levels. In TCM terms, elevated blood lipids are understood as Phlegm-Dampness turbidity accumulating in the vessels, and this herb's Spleen-strengthening and Phlegm-resolving actions address the root cause.

'Calms the spirit' means it has a mild sedating, anxiety-reducing effect. It is used for restlessness, insomnia, and stress-related tension. Classical sources describe it as having the ability to 'nourish the Heart and calm the spirit' (养心安神).

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Jiao Gu Lan is used to help correct these specific patterns.

Why Jiao Gu Lan addresses this pattern

When the Spleen Qi is deficient, the body's ability to transform food into usable nourishment declines, leading to fatigue, loose stools, and poor appetite. Jiǎo Gǔ Lán's sweet flavour enters the Spleen channel and directly tonifies Spleen Qi. Unlike warming Qi tonics such as Ginseng, its cool nature makes it particularly suitable when Spleen Qi Deficiency is accompanied by mild Heat signs such as a dry mouth or slight irritability, allowing it to replenish Qi without generating unwanted warmth.

A practitioner would look for one or more of these signs

Eye Fatigue

Persistent tiredness and lack of stamina

Poor Appetite

Reduced desire to eat

Loose Stools

Soft or unformed stools due to weak digestion

Abdominal Pain

Fullness and distension after eating

Commonly Used For

These are conditions where Jiao Gu Lan is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

TCM Interpretation

In TCM, high blood lipids are not viewed as an isolated biochemical finding but as a manifestation of Phlegm-Dampness turbidity (痰浊) accumulating in the blood vessels. The root cause typically traces back to the Spleen's impaired ability to properly transform and transport fluids and nutrients. When the Spleen is weak, unprocessed 'turbid' substances build up rather than being cleanly metabolized. Over time, this turbidity settles in the vessels and contributes to what Western medicine calls atherosclerosis. Contributing factors often include diet, emotional stress damaging the Liver and Spleen, and constitutional Kidney weakness in older patients.

Why Jiao Gu Lan Helps

Jiǎo Gǔ Lán addresses hyperlipidaemia through its combined ability to strengthen Spleen Qi and directly resolve Phlegm turbidity. Its sweet flavour tonifies the Spleen to restore proper fluid metabolism at the root level, while its bitter, cool nature actively drains and clears the accumulated turbidity from the vessels. Modern pharmacological research has confirmed that gypenosides can lower total cholesterol, LDL cholesterol, and triglycerides. The herb's gentle, non-warming nature makes it safe for long-term use as a daily tea, which is how it is most commonly consumed for this condition in clinical practice.

Also commonly used for

Hypertension

Mild blood pressure support

Chronic Hepatitis

Hepatoprotective effects, used in viral hepatitis

Chronic Gastritis

Chronic stomach inflammation

Eye Fatigue

General debility and low stamina

Insomnia

Difficulty sleeping related to stress or restlessness

Peptic Ulcer

Gastric and duodenal ulcers

Leukopenia

Low white blood cell counts, especially after chemotherapy or radiation

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Cool

Taste

Bitter (苦 kǔ), Sweet (甘 gān)

Channels Entered

Lungs Spleen Kidneys

Parts Used

Whole plant / Aerial parts (全草 quán cǎo)

Dosage & Preparation

These are general dosage guidelines for Jiao Gu Lan — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

15-30g (decoction); 3-6g (powder)

Maximum dosage

Up to 30g per day in decoction. For powdered form, up to 6g per day. When used as tea for daily health maintenance, 3-5g per brewing is standard.

Dosage notes

For daily health maintenance as tea: 3-5g brewed with boiling water, can be re-infused multiple times. For lowering blood lipids, blood pressure, or blood sugar: use the bitter varieties at the higher end of the dosage range (15-30g in decoction or up to 6g as powder). For tonifying Qi and strengthening the body: use the sweet (甘味) five-leaf or seven-leaf varieties, which have higher saponin content. It is advisable to start with a small dose (3g as tea) and gradually increase to assess tolerance, as the cold nature can cause digestive upset in sensitive individuals. Do not discard the first infusion when making tea, as this contains the highest concentration of active gypenosides.

Preparation

No special decoction handling required. Jiao Gu Lan is simply decocted normally or, more commonly, brewed directly as a tea with boiling water (80°C or above is needed to dissolve the saponins effectively). When making tea, do not rinse away the first infusion, as it contains the highest concentration of beneficial gypenosides.

Common Herb Pairs

These ingredients are traditionally combined with Jiao Gu Lan for enhanced therapeutic effect

Huang Qi
Huang Qi Huáng Qí 15g : Jiǎo Gǔ Lán 15g (1:1)

Jiǎo Gǔ Lán and Huáng Qí together powerfully tonify Qi, but their different thermal natures create balance. Huáng Qí is warm and strongly lifts Yang Qi, while Jiǎo Gǔ Lán is cool and clears Heat. Combined, they produce robust Qi tonification without generating excess Heat, making the pair well-suited for patients who need Qi support but cannot tolerate purely warming herbs.

When to use: Fatigue and debility with mild Heat signs such as dry mouth, slight irritability, or warm palms, where straight Huáng Qí alone might be too warming.

Shan Zha
Shan Zha Jiǎo Gǔ Lán 15g : Shān Zhā 15g (1:1)

Jiǎo Gǔ Lán resolves Phlegm turbidity and strengthens the Spleen, while Shān Zhā (hawthorn) invigorates Blood, dissolves food stagnation, and directly reduces lipid accumulation. Together they address both the Phlegm and Blood Stasis components of hyperlipidaemia and cardiovascular risk.

When to use: High blood lipids, early-stage atherosclerosis, or a feeling of chest stuffiness with a greasy tongue coating, especially when accompanied by food stagnation or digestive sluggishness.

Dan Shen
Dan Shen Dān Shēn 15g : Jiǎo Gǔ Lán 15g (1:1)

Dān Shēn invigorates Blood and dispels Blood Stasis, while Jiǎo Gǔ Lán tonifies Qi and resolves Phlegm turbidity. Their combination tackles both Phlegm obstruction and Blood Stasis in the vessels, the two main pathological products driving cardiovascular disease in TCM. Additionally, both herbs have calming effects on the spirit.

When to use: Cardiovascular conditions with signs of both Phlegm turbidity (elevated lipids, chest oppression) and Blood Stasis (stabbing chest pain, dark or purple tongue), such as in coronary heart disease.

Jue Ming Zi
Jue Ming Zi Jiǎo Gǔ Lán 10g : Jué Míng Zǐ 10g (1:1)

Jué Míng Zǐ (Cassia seed) clears Liver Heat, brightens the eyes, and moistens the intestines, while Jiǎo Gǔ Lán clears Heat, tonifies Qi, and lowers lipid turbidity. Together they address Liver Heat with Phlegm-Dampness, a common presentation in hypertension with elevated cholesterol.

When to use: Hypertension with headache, red eyes, constipation, and elevated blood lipids. This is a popular daily tea combination in China for metabolic syndrome.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Ren Shen
Jiao Gu Lan vs Ren Shen

Both tonify Qi and are used for fatigue and debility, and they even share some identical saponin compounds (ginsenosides/gypenosides). However, Rén Shēn is warm, strongly tonifies the primal Qi, and rescues collapse, while Jiǎo Gǔ Lán is cool, milder in its Qi-tonifying strength, and simultaneously clears Heat and resolves Phlegm. Choose Rén Shēn for severe Qi collapse or Yang Deficiency with cold signs. Choose Jiǎo Gǔ Lán for chronic, mild Qi Deficiency with Heat signs, or when long-term gentle supplementation is needed, such as for metabolic support.

Ci Wu Jia
Jiao Gu Lan vs Ci Wu Jia

Both are adaptogenic Qi tonics used to increase stamina, enhance immunity, and resist fatigue. Cì Wǔ Jiā (Siberian ginseng) is warm and acrid, better suited for cold-type deficiency with wind-damp pain. Jiǎo Gǔ Lán is cool and bitter, better for patients with Heat signs, elevated lipids, or Phlegm-Dampness. Both are classified under Qi-tonifying herbs in modern Materia Medica textbooks.

Hong Jing Tian
Jiao Gu Lan vs Hong Jing Tian

Both tonify Qi, invigorate Blood, and are used for fatigue and cardiovascular support. Hóng Jǐng Tiān (Rhodiola) is more warming and has a stronger Blood-invigorating action, making it better for altitude sickness and cases with prominent Blood Stasis. Jiǎo Gǔ Lán is cool, focuses more on clearing Phlegm turbidity and lowering lipids, and is better for patients with Heat signs or metabolic syndrome.

Common Substitutes & Adulterants

Related species and common adulterations to be aware of when sourcing Jiao Gu Lan

Gynostemma longipes is a closely related species sometimes used as a substitute for G. pentaphyllum in some Asian countries, particularly for similar traditional indications such as diabetes and hypertension. However, its phytochemical profile differs. Other Gynostemma species (there are about 13 worldwide, 11 found in China) may be sold interchangeably, but saponin content varies greatly between species and even between varieties of G. pentaphyllum (three-leaf, five-leaf, seven-leaf, and nine-leaf forms all have different profiles). Five-leaf creeper (Parthenocissus quinquefolia, known as wu ye di jin in Chinese) can be confused with Jiao Gu Lan visually due to similar leaf form, but it is an entirely different plant family (Vitaceae) with no medicinal overlap. Counterfeit "Pingli Jiao Gu Lan" is a known market problem, where material from other regions is fraudulently labeled as originating from the premium Pingli County source.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Jiao Gu Lan

Non-toxic

Jiao Gu Lan is classified as non-toxic. In animal studies, oral administration of the water extract at 10,000 mg/kg in mice produced no deaths within 72 hours. Rats fed 8 g/kg daily for one month showed no abnormalities in general condition, weight gain, food intake, blood tests, urine tests, or tissue pathology. The oral LD50 of the crude extract in rats exceeds 10 g/kg, indicating a very wide safety margin. Some individuals may experience mild gastrointestinal side effects such as nausea, bloating, or loose stools, particularly those with cold-type constitutions. These effects are related to its cold nature rather than toxicity and resolve upon discontinuation.

Contraindications

Situations where Jiao Gu Lan should not be used or requires extra caution

Caution

Spleen and Stomach cold deficiency (脾胃虚寒) with loose stools or diarrhea. Jiao Gu Lan is cold in nature and can worsen symptoms of cold in the digestive system, including nausea, vomiting, bloating, and diarrhea.

Caution

Pregnancy. Insufficient safety data exists for use during pregnancy. Some sources advise pregnant women or those planning to become pregnant to avoid Jiao Gu Lan.

Caution

Concurrent use with anticoagulant or antiplatelet medications. Jiao Gu Lan may have blood-activating properties that could enhance anticoagulant effects and increase bleeding risk.

Caution

Patients with known hypotension or already on antihypertensive medication should use with caution, as Jiao Gu Lan has blood-pressure-lowering effects that could cause excessive hypotension.

Caution

Patients on hypoglycemic medications should use with caution, as Jiao Gu Lan may lower blood sugar and potentiate hypoglycemic effects.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Insufficient safety data is available for use during pregnancy. Some Chinese sources explicitly advise that pregnant women or those planning to become pregnant should avoid Jiao Gu Lan. Its cold nature could theoretically be unfavorable for fetal development in constitutionally cold individuals. Until more definitive safety data becomes available, it is best avoided during pregnancy as a precautionary measure.

Breastfeeding

No specific safety data is available regarding the transfer of Jiao Gu Lan constituents into breast milk. Given the lack of evidence, caution is advised. Nursing mothers should consult a qualified practitioner before use. The herb's cold nature may theoretically affect the infant's digestion if significant amounts pass into breast milk.

Children

There is limited formal pediatric dosage data. One reference from the Immunological Chinese Medicine literature notes that long-term oral administration of gypenoside total saponins to physically weak children may improve constitution and reduce recurrent respiratory infections. Dosage should be reduced proportionally based on age and body weight (typically one-third to one-half of the adult dose for older children). The bitter taste may make acceptance difficult for young children. It is generally not recommended for infants or toddlers. Consult a qualified practitioner for pediatric use.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Jiao Gu Lan

Anticoagulant/antiplatelet drugs (e.g. warfarin, aspirin, clopidogrel): Jiao Gu Lan may have mild blood-activating effects. Concurrent use could theoretically increase bleeding risk. Monitor closely if co-administered.

Antihypertensive medications: Jiao Gu Lan has documented blood-pressure-lowering effects. Combined use with antihypertensives may lead to excessive hypotension. Blood pressure monitoring is advised.

Hypoglycemic agents (e.g. metformin, insulin): Studies show Jiao Gu Lan can lower blood glucose and improve insulin sensitivity. Concurrent use may potentiate hypoglycemic effects, requiring closer blood sugar monitoring and possible dose adjustment of medications.

Lipid-lowering drugs (e.g. statins): Jiao Gu Lan has demonstrated lipid-lowering activity in clinical trials. Additive effects are possible when combined with pharmaceutical lipid-lowering agents. Liver function should be monitored.

Immunosuppressants: Jiao Gu Lan has immune-modulating properties and may interfere with immunosuppressive therapy. Caution is warranted in organ transplant recipients or patients on immunosuppressant medications.

Dietary Advice

Foods and dietary considerations when taking Jiao Gu Lan

Avoid cold, raw, and icy foods when using Jiao Gu Lan therapeutically, as these compound its already cold nature and may worsen digestive discomfort. People with cold-type constitutions can pair it with warming ingredients such as ginger, red dates, or brown sugar to offset the cold property. When using Jiao Gu Lan for metabolic benefits (lipid or sugar lowering), a balanced diet low in greasy, fatty foods and refined sugars will complement its therapeutic effects.

Botanical Description

Physical characteristics and morphology of the Jiao Gu Lan source plant

Gynostemma pentaphyllum (Thunb.) Makino is a herbaceous climbing vine in the Cucurbitaceae (gourd/cucumber) family. The stems are slender and branching, with longitudinal ridges and grooves, and the plant attaches itself to supports using tendrils. The leaves are arranged alternately in a bird's-foot (pedate) pattern, typically composed of 5 to 7 serrated leaflets (sometimes 3 or 9). The central leaflet is 3 to 12 cm long and 1.5 to 4 cm wide, with side leaflets being smaller. Both leaf surfaces are deep green above and pale green beneath, with short stiff hairs or nearly hairless.

The plant is dioecious (separate male and female plants). Male flowers grow in slender, multi-branched panicles with thread-like flower stalks. The tiny flowers are greenish-yellow with five-pointed petals. The fruit is a fleshy, spherical berry about 5 to 6 mm in diameter that turns black when ripe, is smooth and hairless, and contains two pendulous, heart-shaped seeds about 4 mm across with a bumpy surface. Flowering occurs from March to November, with fruiting from April to December.

Jiao Gu Lan grows naturally in shaded, moist environments at elevations of 300 to 3,200 meters, commonly found in mountain valley forests, sparse woodlands, thickets, and roadside grass. It prefers warm, humid conditions with partial shade and rich, well-drained soil with a pH of 6.0 to 7.5. The plant is widely distributed across southern China, India, Nepal, Bangladesh, Myanmar, Vietnam, Malaysia, Indonesia, Korea, and Japan.

Sourcing & Harvesting

Where Jiao Gu Lan is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Summer and autumn (3 to 4 harvests per year). Tender shoots and leaves for tea are best picked in early morning before 9am during the peak growing season (May to July). The whole herb (aerial parts) is harvested when stems reach 2 to 3 meters. Underground rhizomes are harvested in autumn of the third year.

Primary growing regions

The premier production region (道地药材) for Jiao Gu Lan is Pingli County (平利县) in Ankang, Shaanxi Province, which has been officially designated as the "Origin of Chinese Jiao Gu Lan" and holds the only National Geographic Indication Protected Product status for this herb. Pingli County has 7 of the world's 13 known Gynostemma species/strains, and its product has the highest documented saponin content (up to 15.28%). Other important production areas include Hubei Province (especially Shennongjia), Guangxi Province (Jinxiu), Hunan, Guizhou, Yunnan, Fujian, Zhejiang (Hangzhou's West Lake hills), Anhui, Jiangxi, and Guangdong. The Qinling-Daba mountain region in southern Shaanxi is considered the global center of highest-quality Jiao Gu Lan, sometimes called the world's "Jiao Gu" (绞谷). Outside China, it grows wild in India, Nepal, Bangladesh, Myanmar, Vietnam, Malaysia, Indonesia, Korea, and Japan.

Quality indicators

Good quality Jiao Gu Lan herb should have intact, green-colored leaves and stems without excessive yellowing or browning. When brewed as tea, high-quality material produces a clear, bright emerald-green liquor. The aroma should be a distinctive fresh, slightly herbal fragrance. The taste is initially mildly bitter (more so in seven-leaf varieties) with a characteristic sweet aftertaste (回甘). Five-leaf and seven-leaf varieties with higher saponin content are preferred for medicinal purposes. When the tea is first brewed, numerous fine bubbles should rise to the surface, which indicates rich saponin content. Pingli County origin is considered the gold standard, with the highest verified saponin levels. Avoid material that smells musty, appears dark or degraded, or lacks the characteristic sweet aftertaste.

Classical Texts

Key passages from the classical Chinese medical texts that describe Jiao Gu Lan and its therapeutic uses

Jiu Huang Ben Cao (救荒本草, Materia Medica for Famine Relief)

Author: Zhu Su (朱橚), published 1406 CE

This is the earliest known written record of Jiao Gu Lan. It was described not as a medicinal herb but as a wild plant that could be eaten during famine to stave off hunger. The entry included a sketch of the plant and described its appearance and habitat. Jiao Gu Lan was listed among wild edible plants that people could forage for survival during food shortages.

Ben Cao Gang Mu (本草纲目, Comperta of Materia Medica)

Author: Li Shizhen (李时珍), published 1578 CE

Li Shizhen included Jiao Gu Lan in his comprehensive pharmacopoeia, identifying it for medicinal use. This represented the earliest major pharmacological recognition of the plant beyond its role as a famine food.

Note: Jiao Gu Lan is not a herb with extensive classical medical literature compared to herbs found in the Shen Nong Ben Cao Jing or Shang Han Lun. Its major medical recognition came primarily in the modern era (post-1970s), when Japanese and Chinese researchers identified its rich saponin content.

Historical Context

The history and evolution of Jiao Gu Lan's use in Chinese medicine over the centuries

Jiao Gu Lan has a fascinating history that sets it apart from most Chinese herbs. Unlike the majority of TCM herbs that were documented in ancient pharmacopoeias for their medicinal properties, Jiao Gu Lan first appeared in the Jiu Huang Ben Cao (Materia Medica for Famine Relief, 1406 CE) by Zhu Su, the fifth son of Emperor Zhu Yuanzhang (founder of the Ming Dynasty). This book catalogued 414 wild plants that could be eaten during famine, and Jiao Gu Lan was included purely as a survival food, not a medicine. Li Shizhen later referenced it in the Ben Cao Gang Mu (1578 CE), giving it some pharmacological recognition.

The herb remained relatively obscure for centuries until the 1970s and 1980s, when Japanese researchers (notably Professor Tsunematsu Takemoto of Tokushima Bunri University) discovered that Jiao Gu Lan contains dammarane-type saponins (called gypenosides) that are structurally identical to ginsenosides found in Panax ginseng. Of the approximately 130+ saponins identified in Jiao Gu Lan, 84 share the same core structure as ginseng saponins, and its total saponin content is roughly three times that of ginseng. This discovery earned it the nickname "Southern Ginseng" (南方人参). In 1986, the Chinese State Science and Technology Commission placed Jiao Gu Lan first on its "Spark Plan" list of important herbs for development, and in 2002 the Ministry of Health added it to the official list of approved health products.

The name "绞股蓝" literally means "twisting blue vine," referring to the plant's climbing, twining growth habit and the blue-green color of its foliage. Folk names include "Immortality Herb" (不老长寿药草), "Gospel Grass" (福音草), and "Seven-Leaf Gallbladder" (七叶胆, referencing its bitter taste and common seven-leaflet form). In the Japanese Ryukyu Islands (Okinawa), communities with notably high longevity rates traditionally consumed Jiao Gu Lan tea daily, which contributed to its modern reputation as a longevity tonic.

Modern Research

3 published studies investigating the pharmacological effects or clinical outcomes of Jiao Gu Lan

1

Systematic Review and Meta-analysis of RCTs: Gynostemma pentaphyllum for Dyslipidemia (2022)

Dai N, Zhao FF, Fang M, Pu FL, Kong LY, Liu JP. Frontiers in Pharmacology, 2022, 13:917521.

This systematic review included 22 randomized controlled trials with 2,407 participants to evaluate the lipid-lowering effects of Jiao Gu Lan. The analysis found that Jiao Gu Lan used alone or as an add-on therapy showed comparable lipid-lowering effects to n-3 fatty acids and red yeast rice for normalizing serum lipids, supporting its traditional use for cardiovascular health.

DOI
2

Double-blind RCT: Gynostemma pentaphyllum Extract for Anxiety Reduction in Chronically Stressed Adults (2019)

Choi EK, Won YH, Kim SY, Noh SO, Park SH, Jung SJ, Lee CK, Hwang BY, Lee MK, Ha KC, Baek HI, Kim HM, Ko MH, Chae SW. Phytomedicine, 2019, 52:198-205.

A double-blind, placebo-controlled trial with 72 healthy adults under chronic psychological stress. Participants received either 200 mg of G. pentaphyllum ethanol extract twice daily or placebo. The extract group showed significant reductions in anxiety as measured by the State-Trait Anxiety Inventory, supporting its traditional calming and spirit-settling properties.

PubMed
3

Double-blind RCT: Gynostemma pentaphyllum Extract (ActivAMP) on Body Composition in Overweight Adults (2022)

Rao A, Clayton P, Briskey D. Journal of Human Nutrition and Dietetics, 2022, 35:583-589.

A 16-week double-blind, randomized, placebo-controlled trial in overweight men and women found that supplementation with G. pentaphyllum extract significantly reduced body weight and fat mass compared to placebo. The treatment group also showed reductions in plasma triglycerides, ALT, and TNF-alpha, suggesting anti-inflammatory and metabolic benefits. The proposed mechanism involves activation of AMP-activated protein kinase (AMPK).

DOI

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.