Zi Dang Gao

Lithospermum and Angelica Paste · 紫当膏

A simple, time-tested external ointment made from lithospermum root (Zi Cao) and Chinese angelica root (Dang Gui) in sesame oil and beeswax. It helps heal minor burns, cuts, insect bites, eczema, and other skin conditions by clearing inflammation, improving local blood flow, and promoting new skin growth. This is a gentle, natural preparation suitable for all ages, including infants.

Origin Wai Ke Zheng Zong (外科正宗, Orthodox Manual of External Diseases) by Chen Shigong (陈实功) — Míng dynasty, 1617 CE
Composition 4 herbs
Zi Cao
King
Zi Cao
Dang Gui
Deputy
Dang Gui
Ma You
Assistant
Ma You
Feng La
Envoy
Feng La
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zi Dang Gao is designed to correct these specific patterns.

Why Zi Dang Gao addresses this pattern

Toxic Heat affecting the skin manifests as red, swollen, hot, and painful lesions, often with pus formation, ulceration, or blistering. This formula directly targets this pattern through the cold, toxin-resolving action of Zi Cao, which clears Heat from the Blood level and detoxifies the affected area. Dang Gui supports recovery by invigorating Blood to reduce swelling and promote tissue regeneration. The sesame oil base moistens damaged skin while extracting and delivering the active medicinal compounds. This makes the ointment especially well suited for burns, infected wounds, abscesses, and inflamed skin conditions where Heat and toxins are the primary pathogenic factors.

A practitioner would look for one or more of these signs

Skin Burns

First and second degree burns with redness, blistering, and pain

Eczema

Red, hot, inflamed skin lesions with itching

Ulcer

Non-healing ulcerated sores with local heat and possible discharge

Wounds

Cuts, abrasions, and traumatic wounds slow to heal

Keratitis

Inflamed, irritated skin with redness and discomfort

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Zi Dang Gao when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Toxic-Heat Blood Stasis

TCM Interpretation

In TCM, eczema is understood as a condition where Wind, Dampness, and Heat accumulate in the skin. In the acute or subacute stage, Heat and toxins are the dominant factors, producing red, hot, itchy, and sometimes weeping skin lesions. Over time, Blood stasis and Blood deficiency may develop, leading to dry, thickened, darkened skin that is slow to heal. The skin is nourished by Blood, so when Blood flow is impaired or Blood Heat is present, the skin loses its healthy texture and becomes vulnerable to recurring flare-ups.

Why Zi Dang Gao Helps

Zi Dang Gao addresses eczema from two complementary angles. Zi Cao clears the Heat and toxins that drive the inflammatory, itchy redness of eczema, while its shikonin content provides antibacterial and anti-inflammatory effects. Dang Gui nourishes and invigorates Blood, moistening the dry and damaged skin from within the ointment base. The sesame oil further softens and protects the skin barrier, which is critical in eczema management. This formula is most appropriate for subacute or chronic dry eczema rather than weeping or heavily exudative lesions, where additional Dampness-draining herbs may be needed.

Also commonly used for

Psoriasis

Mild to moderate psoriasis with dryness and scaling

Ulcer

Chronic ulcers, pressure sores, leg ulcers

Wounds

Cuts, abrasions, surgical wounds

Chilblains

Cold-induced skin damage

Acne

Inflammatory acne with redness and swelling

Sunburn

UV-induced skin inflammation

Insect Bites

Mosquito and insect bites with itching and swelling

Chapped Skin

Cracked, fissured skin on hands and feet

What This Formula Does

Every TCM formula has a specific set of actions — here's what Zi Dang Gao does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Zi Dang Gao is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Zi Dang Gao performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Zi Dang Gao works at the root level.

This formula addresses skin conditions where Heat-Toxin (热毒) has lodged in the Blood level, damaging the skin and underlying tissues. In TCM theory, when pathogenic Heat enters the Blood, it can "scorch" the skin from within, causing redness, swelling, burning pain, and tissue breakdown. This Heat can arise from external injury (burns, scalds, abrasions), from accumulated internal Heat pushing outward, or from toxic factors penetrating through the skin surface.

When Heat-Toxin damages the Blood level locally, two problems develop simultaneously: the Heat itself causes inflammation, redness, and pain, while the resulting Blood stasis and fluid damage impair the skin's ability to repair and regenerate. The tissue dries out, fails to produce healthy new flesh (granulation), and becomes vulnerable to infection. This is why simply clearing Heat is not enough. The damaged area also needs nourishment, moistening, and restored Blood flow to heal properly.

Zi Dang Gao addresses both sides of this problem. The cooling, toxin-resolving action targets the root cause (Heat-Toxin in the Blood), while the Blood-nourishing and skin-moistening action restores the conditions needed for tissue regeneration. Applied externally, the ointment delivers these actions directly to the affected site, working at the local Blood and skin level rather than through systemic circulation.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Cool

Taste Profile

Predominantly sweet and slightly bitter, with an oily, bland base. The sweet quality moistens and nourishes damaged tissue, while the bitter aspect clears Heat-Toxin from the skin.

Target Organs

Ingredients

4 herbs

The herbs that make up Zi Dang Gao, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Zi Cao

Zi Cao

Gromwell root

Dosage 3 - 9g
Temperature Cold
Taste Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Heart, Liver

Role in Zi Dang Gao

Clears Heat, cools the Blood, resolves toxicity, and promotes tissue regeneration. As the primary medicinal herb, it directly addresses toxic Heat in the skin, reduces inflammation, and encourages new skin growth.
Deputy — Assists and enhances the King
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 9 - 15g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Zi Dang Gao

Nourishes and invigorates Blood, moistens the skin, reduces swelling and pain, and promotes the growth of new tissue (granulation). Complements Zi Cao by improving local blood circulation to support wound healing.
Assistant — Supports or moderates other herbs
Ma You

Ma You

Sesame oil

Dosage 120 - 500mL
Temperature Cool
Taste Sweet (甘 gān)
Organ Affinity Large Intestine
Preparation Used as the base oil for extraction by slow-cooking the herbs until exhausted

Role in Zi Dang Gao

Serves as the extraction medium for the fat-soluble active compounds of Zi Cao and Dang Gui. Moistens and nourishes the skin, neutralizes mild toxins, and provides a protective layer over wounds.
Envoy — Directs the formula to its target
Feng La

Feng La

Beeswax

Dosage 15 - 45g
Temperature Slightly Warm
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Spleen, Stomach, Large Intestine
Preparation Melted into the strained medicated oil while still warm

Role in Zi Dang Gao

Acts as the solidifying agent (excipient) that transforms the medicated oil into a semi-solid ointment. Also contributes mild detoxifying, pain-relieving, and tissue-regenerating properties, and helps seal the wound to promote healing.

Why This Combination Works

How the herbs in Zi Dang Gao complement each other

Overall strategy

This ointment addresses skin conditions caused by toxic Heat and Blood stasis by combining Heat-clearing, Blood-nourishing, and tissue-regenerating actions in an externally applied paste. The formula works by resolving the Heat and toxins that damage the skin while simultaneously promoting healthy blood flow and new tissue growth to restore the skin's integrity.

King herbs

Zi Cao (Lithospermum root) is the King herb. It is cold in nature and enters the Blood level, where it clears Heat, cools the Blood, and resolves toxicity. In external application, its active compound shikonin provides antibacterial, anti-inflammatory, and wound-healing effects, directly targeting the root cause of hot, inflamed, or infected skin lesions.

Deputy herbs

Dang Gui (Chinese Angelica root) serves as the Deputy. While Zi Cao clears the pathogenic Heat, Dang Gui nourishes and invigorates Blood in the affected area. Improved local blood circulation brings nourishment to damaged tissues, reduces swelling and pain, and promotes the formation of new granulation tissue. Together, Zi Cao and Dang Gui create a synergy that clears the old (Heat, toxins, dead tissue) and generates the new (fresh tissue, healthy skin).

Assistant herbs

Ma You (sesame oil) is the assistant, functioning both as the pharmaceutical vehicle that extracts the fat-soluble medicinal compounds from Zi Cao and Dang Gui, and as a therapeutic ingredient in its own right. It moistens and nourishes dry, cracked, or damaged skin, provides a protective lipid barrier, and has mild toxin-neutralizing properties.

Envoy herbs

Feng La (beeswax) serves as the Envoy. It solidifies the formula into a usable ointment form, ensures the medicated oil adheres to the wound surface, and contributes its own mild pain-relieving and tissue-regenerating actions. By creating a semi-occlusive barrier, it helps maintain a moist wound environment conducive to healing.

Notable synergies

The pairing of Zi Cao and Dang Gui is the heart of this formula. Zi Cao's cold, toxin-resolving nature and Dang Gui's warm, Blood-moving nature complement each other precisely: one clears the pathogen while the other supports recovery. Research has confirmed that the combination of lithospermum root and angelica root in oil extraction produces a synergistic enhancement of anti-inflammatory, analgesic, and wound-healing effects beyond what either herb achieves alone.

How to Prepare

Traditional preparation instructions for Zi Dang Gao

Slice or break the Dang Gui (Chinese Angelica root) and Zi Cao (Lithospermum root) into small pieces. Place the herbs into sesame oil (Ma You) and soak for 1 to 3 days. Then heat the oil with the herbs over a gentle flame, cooking slowly until the herbs are dried out and the oil has turned a deep purplish-red colour. Strain out all herb residue through fine cloth, retaining the clear medicated oil.

Reheat the strained medicated oil, then add the beeswax (Huang La / Feng La) and stir continuously until the wax is completely dissolved and well incorporated. Pour the mixture into clean ceramic or glass containers. Allow to cool completely and solidify at room temperature into a semi-solid ointment. Store sealed in a cool, dark place.

For external use only: apply an appropriate amount directly to the affected skin area, or spread onto gauze and apply as a dressing. Change the dressing once or twice daily.

Common Modifications

How practitioners adapt Zi Dang Gao for specific situations

Added
Huang Lian

9g, clears Heat and dries Dampness

Huang Qin

9g, clears Heat and dries Dampness

Huang Qi

9g, clears Heat and dries Dampness

Da Huang

9g, clears Heat and resolves toxicity

Adding the 'three yellows' (San Huang) plus Da Huang strengthens the Heat-clearing and Dampness-drying capacity for conditions with more discharge, pus, or weeping. This creates the well-known 'Zi Huang Gao' (紫黄膏) variant.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Zi Dang Gao should not be used or requires extra caution

Avoid

Open, deep wounds with heavy bleeding. This ointment is intended for superficial skin conditions and should not be applied to deep, actively hemorrhaging wounds that require surgical intervention.

Avoid

Known allergy to sesame oil (Ma You) or beeswax (Feng La/Huang La). Although all ingredients are natural and generally safe, individuals with confirmed sesame allergy should avoid use.

Caution

Weeping, heavily exudative skin lesions with copious discharge. The oily ointment base can trap moisture and may worsen conditions where dampness is the predominant pathogenic factor. Such cases may require formulas with stronger Heat-clearing and Dampness-drying properties.

Caution

Cold-type skin conditions without signs of Heat. Since both Zi Cao and the overall formula are cool in nature, they are not suited for pale, cold, non-inflamed lesions caused by Yang deficiency or Blood stasis from Cold.

Avoid

Large-area third-degree burns or severe skin infections. These require professional medical intervention; the ointment is appropriate only for minor first- and second-degree burns and mild infections.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Generally considered safe for external use during pregnancy. All ingredients (Zi Cao, Dang Gui, sesame oil, beeswax) are applied topically, and systemic absorption is minimal. However, while Dang Gui taken orally can stimulate uterine activity, its presence in this external ointment at low concentrations poses negligible risk. Pregnant women should avoid applying the ointment over large body surface areas or on broken skin near the abdomen. As a precaution, consult a qualified practitioner before use during pregnancy.

Breastfeeding

Considered safe for use during breastfeeding. This is an external ointment applied to the skin, and the ingredients have minimal systemic absorption. All components (Zi Cao, Dang Gui, sesame oil, beeswax) are natural substances with long histories of safe topical use. Avoid applying the ointment directly on or near the nipple area if breastfeeding, as the infant could ingest the ointment. If treating cracked nipples, thoroughly clean the area before nursing.

Children

This external ointment is widely considered safe for infants and children. In East Asian clinical practice, it is commonly used for diaper rash, insect bites, minor burns, and childhood eczema. Since all ingredients are food-grade natural substances (Zi Cao, Dang Gui, sesame oil, beeswax), even accidental small ingestion is not considered dangerous. For infants, apply a thin layer to the affected area. Avoid application near the eyes, mouth, or nostrils. For children with very sensitive skin, test on a small patch first. No specific dosage adjustment is needed as this is a topical preparation, but use sparingly on very young infants (under 3 months) and consult a practitioner if the condition does not improve within a few days.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Zi Dang Gao

As an external topical ointment with minimal systemic absorption, Zi Dang Gao has very limited potential for drug interactions. However, a few considerations apply:

  • Topical corticosteroids or immunosuppressant creams: Avoid applying simultaneously to the same area. The oily ointment base may alter absorption of other topical medications. Stagger application times if both are needed.
  • Topical antibiotics: Research suggests Shiunko itself has antibacterial properties. While not directly contraindicated, the combination may be redundant or may alter the intended drug concentration at the skin surface.
  • Anticoagulant medications (warfarin, heparin): While systemic absorption is minimal, Dang Gui and Zi Cao both have Blood-activating properties. On extensively broken or ulcerated skin with large surface area exposure, there is a theoretical (though unlikely) concern of enhanced anticoagulant effect.

Usage Guidance

Practical advice for getting the most out of Zi Dang Gao

Best time to take

Apply in the evening after cleansing the skin (ideally after bathing), and again in the morning if needed. For wound care, apply every 8-12 hours, covering with clean gauze.

Typical duration

Apply 1-3 times daily until the skin condition resolves, typically 3-14 days for minor burns, insect bites, and acute lesions. Chronic conditions like eczema or psoriasis may require 2-4 weeks of consistent use, reassessed by a practitioner.

Dietary advice

While taking this external ointment, avoid sour and fishy foods (classical dietary prohibition for external wound medications). Spicy, greasy, and heavily stimulating foods should also be minimized, as they can generate internal Heat that aggravates the skin condition being treated. Favor bland, cooling foods such as green vegetables, mung beans, and fresh fruits to support the formula's Heat-clearing action from within.

Zi Dang Gao originates from Wai Ke Zheng Zong (外科正宗, Orthodox Manual of External Diseases) by Chen Shigong (陈实功) Míng dynasty, 1617 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Zi Dang Gao and its clinical use

From the Wai Ke Zheng Zong (《外科正宗》, Orthodox Manual of External Medicine) by Chen Shigong:

On the original "Run Ji Gao" (Flesh-Moistening Ointment) preparation: "麻油四两,当归五钱,紫草一钱同熬,药枯滤清,将油再熬,加黄蜡五钱化尽倾入碗内,顿冷。"

Translation: "Sesame oil four liang, Dang Gui five qian, Zi Cao one qian, decoct together. When the herbs are exhausted, strain and clarify. Reheat the oil, add beeswax five qian until fully dissolved, pour into a bowl, and allow to cool."

The Wai Ke Zheng Zong further praised this category of external preparations as: "乃外科收敛药中之神药" ("Truly a divine medicine among external astringent remedies").

Historical Context

How Zi Dang Gao evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Zi Dang Gao traces its origins to the Ming Dynasty physician Chen Shigong (陈实功), whose landmark text Wai Ke Zheng Zong (《外科正宗》, 1617 CE) included the formula under the name "Run Ji Gao" (润肌膏, Flesh-Moistening Ointment). A related but more complex formula in the same text, "Sheng Ji Yu Hong Gao" (生肌玉红膏), also used Zi Cao and Dang Gui alongside additional herbs. The simpler Run Ji Gao focused purely on the Zi Cao and Dang Gui combination extracted in sesame oil with beeswax as the base.

The formula later traveled to Japan, where during the Edo period (early 19th century), the renowned surgeon Hanaoka Seishu (华冈青洲) refined the preparation method, adding lard to improve consistency, and renamed it "Shiunko" (紫云膏, Purple Cloud Ointment). He recorded this in his work Shunrinken Ko-ho Benran (《春林轩膏方便览》). The formula became one of the most widely used topical Kampo medicines in Japan and remains an over-the-counter product there today. An even earlier precursor, the "Shen Xiao Dang Gui Gao" (神效当归膏), appeared in the Song Dynasty's He Ji Ju Fang (《和剂局方》) using only Dang Gui, sesame oil, and beeswax, without Zi Cao.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Zi Dang Gao

1

Shiunko promotes epithelization of wounded skin (Animal study, 2004)

Huang KF, Hsu YC, Lin CN, Tzeng JI, Chen YW, Wang JJ. American Journal of Chinese Medicine. 2004; 32(3): 389-396.

This animal study tested Shiunko on experimental wounds in rats, comparing it against povidone-iodine and saline treatments. The Shiunko-treated group showed significantly lower wound infection rates (0% vs 40% in the saline group after Pseudomonas inoculation) and higher rates of complete skin regrowth (epithelization) on both sterile and contaminated wounds. The researchers concluded that Shiunko both prevents infection and actively promotes new skin formation, while povidone-iodine disinfected but did not promote healing.

2

Shiunko and acetylshikonin promote reepithelialization, angiogenesis, and granulation tissue formation in wounded skin (Animal study, 2008)

Huang KF, Hsu YC, Lin CN, Tzeng JI, Chen YW, Wang JJ. American Journal of Chinese Medicine. 2008.

Building on the 2004 study, this research compared Shiunko and its active component acetylshikonin against gentamicin and silver sulfadiazine ointments on rat wounds. Shiunko-treated wounds showed significantly higher rates of new skin growth, new blood vessel formation, and granulation tissue development than conventional disinfectant ointments, on both sterile and infected wounds. The formula outperformed standard wound care agents for tissue regeneration.

PubMed
3

Efficacy of Shiunko for the treatment of atopic dermatitis (Clinical pilot study, 1999)

Sakaguchi M, Inoue S, Kamimura H. Acta Dermatologica (Kyoto). 1999.

This small clinical study applied Shiunko, white petrolatum, and salt water to the skin of atopic dermatitis patients. Shiunko showed clinical effectiveness in 57% of patients (4 of 7), compared to 0% for petrolatum and 14% for salt water. Bacterial counts (primarily Staphylococcus aureus) were also reduced in the Shiunko group, suggesting the ointment has antibacterial properties relevant to eczema management.

PubMed
4

Phase II Controlled Trial of Shiunko Ointment for Cutaneous Leishmaniasis (RCT, 2016)

Na-Bangchang K, et al. Evidence-Based Complementary and Alternative Medicine. 2016; Article ID 8025012.

This randomized, placebo-controlled trial tested Shiunko ointment in 40 Ethiopian patients with cutaneous leishmaniasis. While cure rates were comparable between groups, Shiunko showed a marked 69% reduction in lesion size compared to 22% for placebo at week 16, with a significantly faster rate of lesion shrinkage during treatment. The ointment was well-tolerated with a high safety profile, and showed particular benefit for wound closure in patients with ulcerated lesions.

PubMed
5

Potential Efficacy of Shiunko for Anti-EGFR Monoclonal Antibody-Induced Skin Fissure (Case series, 2024)

National Cancer Center Hospital East. Published 2024.

This case series from the National Cancer Center Hospital East in Japan reported on the use of Shiunko ointment for skin fissures caused by anti-EGFR cancer drugs (panitumumab or cetuximab). The ointment was applied twice daily to grade 2 skin fissures in colorectal cancer patients. The study represented the first report on Shiunko's potential for managing this specific chemotherapy side effect, leveraging the wound-healing properties of its shikonin derivatives.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.