Formula

You Gui Wan

Right-Return Pill | 右归丸

Also known as:

Restore the Right Pill , Restore the Right Kidney Pill

Properties

Yang-tonifying formulas · Warm

Key Ingredients

Zhi Fu Zi, Rou Gui, Lu Jiao Jiao (鹿角胶)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical warming and tonifying formula designed to restore Kidney Yang, the body's foundational warmth and vitality. It is commonly used for people experiencing deep fatigue, persistent cold sensations, lower back weakness, reduced sexual function, or frequent urination due to depletion of the Kidney's warming capacity. The formula combines Yang-warming herbs with nourishing substances to rebuild vitality from within, following the principle that Yang is best restored by providing it with a nourishing Yin foundation.

Formula Category

Main Actions

  • Tonifies Kidney Yang
  • Benefits Essence and Fills the Marrow
  • Warms the Ming Men Fire
  • Nourishes Blood
  • Strengthens the Sinews and Bones

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. You Gui Wan is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why You Gui Wan addresses this pattern

Kidney Yang deficiency is the primary pattern this formula targets. When the Kidney's Yang and Ming Men (Gate of Vitality) Fire decline, the body loses its foundational source of warmth and vitality. This manifests as pervasive cold, fatigue, weakened lower back and knees, and reproductive dysfunction. You Gui Wan directly restores Kidney Yang through Fu Zi, Rou Gui, and Lu Jiao Jiao while simultaneously replenishing the Yin and Essence substrate (via Shu Di Huang, Shan Zhu Yu, Gou Qi Zi) so that Yang has a material foundation to anchor to. The formula's 'pure tonifying without draining' design makes it particularly suited for advanced or chronic Kidney Yang depletion where aggressive draining would further weaken the patient.

A practitioner would look for one or more of these signs

Eye Fatigue

Deep, chronic fatigue with physical exhaustion

Cold Extremities

Cold hands and feet, aversion to cold

Lower Back Pain

Weakness and soreness of the lower back and knees

Erectile Dysfunction

Impotence or reduced sexual function

Frequent Urination

Clear, frequent urination, especially at night

Loose Stools

Loose stools or chronic diarrhea from Spleen-Kidney Yang failure

Infertility

Male or female infertility due to Yang depletion

How It Addresses the Root Cause

You Gui Wan addresses Kidney Yang Deficiency with decline of Ming Men (life gate) fire. In TCM, the Kidneys are the root of all Yin and Yang in the body. The Ming Men fire, housed within the Kidneys, is the pilot light of the entire system. It warms the body, drives reproduction and growth, supports digestion by warming the Spleen, and underpins the body's ability to transform fluids and maintain vitality.

When this fundamental fire weakens, whether through aging, prolonged illness, constitutional weakness, or excessive strain, the body gradually loses its warmth and drive. Cold signs predominate: the person feels chilled (especially in the low back and knees), energy drops, sexual function declines, the stools become loose as the Spleen loses its warming support ("fire failing to generate earth"), and urination becomes frequent and clear. The tongue turns pale with white coating, and the pulse sinks and slows. Essence and marrow become depleted alongside the Yang, leading to weak bones and a deep sense of exhaustion.

Critically, because Yin and Yang are interdependent, the Essence (a Yin substance) that houses and anchors Yang also becomes insufficient. Simply blasting in hot herbs would be like lighting a fire with no fuel. The pathomechanism therefore involves both the decline of Yang fire and the depletion of the Yin-Essence substrate that Yang depends on. The formula must warm the fire while also replenishing its fuel, which is why Zhang Jing-Yue insisted on "seeking Yang within Yin."

Formula Properties

Temperature

Warm

Taste Profile

Predominantly sweet and warm, with secondary pungent notes from Cinnamon and Aconite. The sweetness tonifies and nourishes Essence, while the pungency disperses and warms Yang.

Target Organs
Kidneys Liver Spleen
Channels Entered
Kidney Liver Spleen Du Mai (督脉) Governing Vessel

Formula Origin

Jǐng Yuè Quán Shū (《景岳全书》, Collected Treatises of Jǐng Yuè) by Zhāng Jǐng Yuè, Volume 51, New Formulas of Eight Formations - Tonifying Formation

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in You Gui Wan

Detailed information about each herb in You Gui Wan and their roles

Kings
Deputies
Assistants
Zhi Fu Zi
Zhi Fu Zi

Prepared Aconite Root

Dosage: 6 - 18g

Temperature Hot
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Kidneys, Spleen
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in You Gui Wan

Powerfully warms Kidney Yang, revives depleted Yang Qi, and expels internal cold. As the most intensely warming herb in the formula, it directly addresses the core pathomechanism of Ming Men Fire decline.

Rou Gui
Rou Gui

Cinnamon bark

Dosage: 6 - 12g

Temperature Hot
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Liver, Spleen, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in You Gui Wan

Warms and fortifies Kidney Yang, reinforces the Ming Men Fire, and guides floating Yang back to its source. Works synergistically with Fu Zi to restore the foundational warmth of the Kidneys.

Lu
Lu Jiao Jiao (鹿角胶)

Dosage: 9 - 12g

Role in You Gui Wan

A potent blood-and-flesh substance (血肉有情之品) that warms Kidney Yang while also replenishing Essence (Jing) and tonifying the marrow. Bridges the gap between warming Yang and nourishing the material foundation of the Kidneys.

Shu Di Huang
Shu Di Huang

Prepared Rehmannia root

Dosage: 24 - 30g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in You Gui Wan

The heaviest-dosed herb in the formula, it deeply nourishes Kidney Yin, fills Essence, and enriches the Blood. Provides the Yin material foundation from which Yang can be regenerated, embodying the 'seeking Yang within Yin' principle.

Shan Zhu Yu
Shan Zhu Yu

Cornelian Cherry Fruit

Dosage: 9 - 12g

Temperature Slightly Warm
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in You Gui Wan

Tonifies the Liver and Kidneys, astringes Essence to prevent leakage, and secures sweating. Helps retain the body's vital substances that tend to escape when Kidney Yang is deficient.

Shan Yao
Shan Yao

Chinese yam

Dosage: 12g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in You Gui Wan

Tonifies the Spleen and Kidneys simultaneously, supporting both digestion and Essence storage. Particularly important when Kidney Yang decline has weakened the Spleen's digestive function (Fire failing to generate Earth).

Gou Qi Zi
Gou Qi Zi

Chinese Wolfberry Fruit

Dosage: 9 - 12g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Lungs
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in You Gui Wan

Nourishes Liver and Kidney Yin, enriches the Blood, and benefits Essence. Complements Shu Di Huang in building the Yin substrate needed for Yang restoration.

Tu Si Zi
Tu Si Zi

Chinese Dodder Seed

Dosage: 9 - 12g

Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Spleen
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in You Gui Wan

Tonifies both Kidney Yang and Yin, secures Essence, and controls urination. Its balanced tonifying action strengthens the Kidney from both the Yang and Yin sides, and helps consolidate the leaking of seminal fluids and urine.

Du Zhong
Du Zhong

Eucommia bark

Dosage: 9 - 12g

Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in You Gui Wan

Strengthens the Liver and Kidneys, fortifies sinews and bones, and specifically addresses lower back and knee weakness. Also calms the fetus, making it relevant when Kidney Yang deficiency underlies threatened miscarriage.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 9g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in You Gui Wan

Tonifies and invigorates the Blood, working alongside Lu Jiao Jiao to nourish Essence and Blood. Ensures adequate Blood circulation to support the warming and tonifying actions of the formula.

Modern Research (2 studies)

  • Biomechanical Analysis of Ovariectomized Osteoporosis Rats with Kidney Deficiency (Preclinical study, 2022)
  • Mechanism of Treatment of Kidney Deficiency and Osteoporosis is Similar by Traditional Chinese Medicine (Review, 2016)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

30 minutes before meals, with warm water or lightly salted warm water, morning and evening. The original text specifies taking before meals (食前) with boiling water or dilute salt water.

Typical Duration

Often taken for 4-8 weeks as a course of treatment, then reassessed. As a chronic tonifying formula, some patients may take it for several months with periodic breaks, under practitioner guidance.

Dietary Advice

Avoid cold and raw foods (salads, iced drinks, raw fruit, sushi) while taking this formula, as they counteract the warming action and burden the Spleen. Greasy, heavy, and overly rich foods should also be limited, since the formula already contains cloying herbs like Shu Di Huang and Lu Jiao Jiao that are hard to digest. Favor warm, cooked, easily digestible meals: congee, soups, stews, and lightly spiced foods. Warming ingredients like ginger, lamb, walnuts, leeks, and cinnamon complement the formula's action. Alcohol should be avoided, particularly with the presence of Fu Zi (Aconite). Avoid eating turnip (Lai Fu Zi / radish) in excess, as it traditionally counteracts tonifying herbs.

Special Populations

Pregnancy

Contraindicated in pregnancy. The formula contains Zhi Fu Zi (prepared Aconite), which is classified as a pregnancy-prohibited substance in TCM. Aconite contains aconitine alkaloids that can stimulate uterine contractions and carry inherent toxicity risks even in processed form. Rou Gui (Cinnamon bark) is also traditionally cautioned during pregnancy due to its strongly warming, Blood-moving properties. Lu Jiao Jiao (Deer antler glue) has hormone-like effects. While the formula is sometimes used in TCM fertility treatment for Yang-deficient infertility, it should be discontinued once pregnancy is confirmed, and any such use must be under close professional supervision.

Breastfeeding

Use with caution during breastfeeding. While You Gui Wan does not contain strongly toxic or purgative herbs that pose a major transfer risk through breast milk, it does contain Zhi Fu Zi (prepared Aconite), which contains trace aconitine alkaloids that may theoretically pass into breast milk. Rou Gui (Cinnamon bark) is generally considered compatible with breastfeeding in moderate doses. The Yin-nourishing herbs (Shu Di Huang, Gou Qi Zi, Dang Gui) may actually support milk production in Yang-deficient mothers with insufficient lactation. However, given the presence of Fu Zi, any use during breastfeeding should only occur under the guidance of a qualified practitioner who can monitor both mother and infant.

Pediatric Use

You Gui Wan is not a typical pediatric formula, as Kidney Yang Deficiency severe enough to require this level of warming supplementation is uncommon in children. The original text notes that for honey pill form, children under 7 should use half the adult dose. In modern prepared pill form (9g honey pills), practitioners typically reduce to one-quarter to one-half the adult dose depending on age and body weight. Fu Zi (Aconite) demands special caution in children due to narrower safety margins for aconitine. Any pediatric use should be short-term, closely monitored by a qualified practitioner, and only when there are clear signs of Kidney Yang Deficiency (such as delayed development, cold limbs, enuresis, or failure to thrive with Yang-deficient signs).

Drug Interactions

Cardiac glycosides (e.g. digoxin): Zhi Fu Zi (Aconite) contains aconitine alkaloids that affect cardiac rhythm. Concurrent use with cardiac glycosides may increase the risk of arrhythmias. This combination should be avoided or used only under strict medical supervision with cardiac monitoring.

Antihypertensive medications: Rou Gui (Cinnamon bark) and Fu Zi may cause blood pressure fluctuations through their warming, vasodilating, and sympathetic-stimulating properties. Patients on antihypertensives should have their blood pressure monitored more frequently.

Anticoagulant and antiplatelet drugs (e.g. warfarin, aspirin): Dang Gui (Angelica sinensis) has documented blood-activating effects and contains coumarins that may potentiate the effects of anticoagulant medications, increasing bleeding risk.

Hypoglycemic drugs: Rou Gui has been shown in some research to affect insulin sensitivity. Diabetic patients on glucose-lowering medications should monitor blood sugar levels closely when taking this formula.

Hormone replacement therapy or hormonal medications: You Gui Wan has been shown to modulate the hypothalamic-pituitary-gonadal axis and affect sex hormone levels. Concurrent use with exogenous hormones may produce unpredictable additive effects.

Contraindications

Avoid

Yin Deficiency with Heat signs (tidal fever, night sweats, hot palms and soles, red tongue with little coating). This warming formula will further damage Yin and inflame Deficiency Fire.

Avoid

Kidney Deficiency complicated by Dampness or turbidity. This formula is purely tonifying without any draining or drying component, so it will trap and worsen Dampness.

Avoid

Damp-Heat patterns (bitter taste, yellow greasy tongue coating, dark scanty urine). The warming and enriching herbs will aggravate both Heat and Dampness.

Avoid

Active external pathogen invasion (cold, flu, fever). Tonifying formulas can trap the pathogen inside the body and should be stopped during acute infections.

Caution

Spleen and Stomach weakness with poor digestion. The heavy, cloying nature of Shu Di Huang, Lu Jiao Jiao, and Dang Gui may overwhelm weak digestion. Modify the formula or address Spleen Qi first.

Caution

Hypertension. The warming herbs Fu Zi and Rou Gui may cause blood pressure fluctuations. Use only under close practitioner supervision.

Caution

Loose stools or diarrhea. The original text notes that Dang Gui should be omitted if stools are loose (便溏勿用). Dose adjustments are needed.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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