Formula

Yi Gan Tang

抑肝汤

Also known as:

Yi Gan San (抑肝散, Liver-Suppressing Powder)

Properties

Internal Wind-extinguishing formulas · Slightly Cool

Key Ingredients

Gou Teng

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula originally developed for children that calms the Liver, eases irritability and tension, and supports the Spleen. It is widely used today for nervousness, sleep difficulties, agitation, and emotional instability in people of all ages, and has received significant research attention in Japan for managing behavioral symptoms in elderly patients with cognitive decline.

Formula Category

Main Actions

  • Calms the Liver and Extinguishes Wind
  • Clears Liver Heat
  • Strengthens the Spleen
  • Nourishes Blood and Softens the Liver
  • Relaxes Spasms and Relieves Urgency

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Yi Gan Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Yi Gan Tang addresses this pattern

When Liver Blood is insufficient, it fails to anchor Liver Yang and nourish the sinews, allowing internal Wind to stir. This produces spasms, tremors, twitching, teeth grinding, restless sleep, and emotional agitation. Yi Gan San addresses this directly: Gou Teng calms the Wind and clears the Heat that accompanies it, while Dang Gui and Chuan Xiong replenish and move Liver Blood to address the root deficiency. Chai Hu ensures Liver Qi flows smoothly so it does not generate further Heat. The overall effect is to calm Wind at the branch level while nourishing the Blood foundation that prevents its recurrence.

A practitioner would look for one or more of these signs

Twitching

Involuntary twitching of muscles, eyelids, or limbs

Teeth Grinding

Teeth grinding or jaw clenching, especially during sleep

Seizures

Convulsions or spasms, particularly in children

Irritability

Easily angered, nervous temperament

Insomnia

Restless sleep, difficulty settling

Tremors

Trembling of hands or limbs

How It Addresses the Root Cause

Yi Gan Tang addresses a pattern where the Liver loses its ability to spread Qi smoothly, generating internal Wind and deficiency Heat that disturb both the nervous system and the digestive system. In TCM, the Liver is responsible for the free flow of Qi and for storing Blood. When Liver Blood becomes insufficient, it can no longer anchor and nourish the Liver's Yang aspect. The resulting "deficiency Heat" (虚热) is not a raging fire but a relative excess of Yang caused by the weakened Yin and Blood failing to keep it in check. This unstable Liver generates internal Wind, which manifests as tremors, spasms, convulsions, teeth grinding, eye twitching, and general nervous agitation.

The Liver in its agitated state also attacks the Spleen ("Wood overacting on Earth"), disrupting digestion and causing nausea, phlegm production, abdominal bloating, and poor appetite. Meanwhile, the rising Liver Wind and Heat disturb the Heart and Spirit, leading to irritability, restless sleep, night crying in children, anxiety, and fright. This creates a self-reinforcing cycle: poor digestion weakens Blood production, which further starves the Liver, which generates more Wind and Heat. The formula intervenes at every point in this cycle, calming the Liver, extinguishing Wind, nourishing Blood, and strengthening the Spleen simultaneously.

Formula Properties

Temperature

Slightly Cool

Taste Profile

Predominantly bitter and sweet with mild acrid notes. The bitter and acrid qualities (from Chai Hu, Chuan Xiong, and Gou Teng) disperse, move Qi, and clear Heat, while the sweet quality (from Bai Zhu, Fu Ling, Gan Cao, and Dang Gui) tonifies the Spleen and nourishes Blood.

Target Organs
Liver Spleen Heart
Channels Entered
Liver Spleen Pericardium Gallbladder

Formula Origin

Bǎo Yīng Cuō Yào (保婴撮要, Gathered Essentials for Protecting Infants) by Xuē Kǎi (薛铠) and Xuē Jǐ (薛己)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Yi Gan Tang

Detailed information about each herb in Yi Gan Tang and their roles

Gou Teng
Gou Teng

Gambir vine stems and hooks

Dosage: 6 - 12g

Temperature Cool
Taste Sweet (甘 gān)
Organ Affinity Liver, Pericardium
Parts Used Stem (茎 jīng)
Role in Yi Gan Tang

Clears Liver Heat, calms Liver Wind, and stops spasms and convulsions. As the principal herb, it directly addresses the core pathomechanism of Liver Wind stirring internally due to Liver deficiency-Heat, providing the formula's primary sedative and antispasmodic action.

Chai Hu
Chai Hu

Bupleurum root

Dosage: 3 - 6g

Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs
Parts Used Root (根 gēn)
Role in Yi Gan Tang

Courses the Liver and resolves constraint, allowing Liver Qi to flow freely. It complements Gou Teng by addressing the Qi stagnation dimension of Liver dysfunction while also providing a mild Heat-clearing action through its ascending and dispersing nature.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 6 - 9g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Yi Gan Tang

Nourishes and harmonizes the Blood to soften and emolliate the Liver. When Liver Qi is excessive, Liver Blood becomes depleted. Dang Gui replenishes this deficiency, addressing the root cause that allows Wind to stir.

Chuan Xiong
Chuan Xiong

Sichuan lovage rhizome

Dosage: 3 - 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium
Parts Used Rhizome (根茎 gēn jīng)
Role in Yi Gan Tang

Moves Blood and activates Qi within the Blood level. It assists Dang Gui in nourishing and regulating Liver Blood, while its upward-moving and dispersing nature helps relieve headache and dizziness associated with Liver Wind.

Bai Zhu
Bai Zhu

White Atractylodes rhizome

Dosage: 6 - 9g

Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Yi Gan Tang

Strengthens the Spleen and dries Dampness, protecting the Spleen from being overwhelmed by the overactive Liver (Wood overacting on Earth). This prevents digestive symptoms such as vomiting, bloating, and poor appetite.

Fu Ling
Fu Ling

Poria

Dosage: 6 - 9g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Yi Gan Tang

Fortifies the Spleen, leaches Dampness, and calms the spirit. Working alongside Bai Zhu to protect the Spleen, Fu Ling also contributes a gentle spirit-quieting effect that supports the formula's overall calming action.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Yi Gan Tang

Harmonizes all herbs in the formula, supplements the Spleen, and relaxes tension and spasms. Its sweet flavour moderates the Liver and assists Gou Teng in relieving convulsions and muscular twitching.

Modern Research (4 studies)

  • Systematic review and meta-analysis of RCTs: Yokukansan for behavioral and psychological symptoms of dementia (2013)
  • Updated meta-analysis of RCTs: Yokukansan for BPSD (2016)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

After meals, two to three times daily. The classical text specifies post-meal administration (饭后服). Taking it after food reduces potential digestive sensitivity from Chai Hu and protects the Spleen.

Typical Duration

Acute conditions (childhood convulsions, acute agitation): 3-7 days. Chronic neurological or psychiatric conditions (BPSD, anxiety, insomnia): 4-12 weeks with regular reassessment.

Dietary Advice

Avoid excessively spicy, greasy, and fried foods, which generate Heat and aggravate Liver Fire. Alcohol should be strictly avoided as it produces Damp-Heat and further agitates the Liver. Caffeine and other stimulants may counteract the formula's calming properties and should be minimized. Favor foods that nourish Blood and calm the Liver: leafy green vegetables, celery, chrysanthemum tea, goji berries, and small amounts of dark-colored fruits. Easily digestible grains like rice and millet support the Spleen-strengthening aspect of the formula. Regular, unhurried meals at consistent times help stabilize Liver Qi and support digestive recovery.

Special Populations

Pregnancy

Use with caution during pregnancy and only under professional guidance. Chuan Xiong (Ligusticum chuanxiong) is a Blood-moving herb with mild uterine-stimulating properties, and Chai Hu (Bupleurum) can raise and mobilize Qi. Together these create a mild but real concern for uterine stimulation, particularly in the first trimester or in pregnancies with a history of threatened miscarriage. The formula is not absolutely contraindicated but should be prescribed at reduced dosages with careful monitoring by a qualified practitioner.

Breastfeeding

Generally considered compatible with breastfeeding when used at standard dosages. The classical instructions for this formula actually specify "子母同服" (mother and child take it together), reflecting its original use in breastfeeding pairs where the mother's condition was understood to affect the infant. Gan Cao (Licorice) in the formula may affect electrolyte balance if used at high doses over prolonged periods. Any new gastrointestinal changes or unusual fussiness in the nursing infant should prompt discontinuation and reassessment.

Pediatric Use

Yi Gan Tang was originally designed as a pediatric formula and remains one of the most commonly used formulas for children in both Chinese and Japanese herbal medicine. In Japan (as Yokukansan, TJ-54), it is officially approved for childhood night crying and childhood nervousness. Dosage should be adjusted according to the child's age and weight. A common guideline is roughly one-third of the adult dose for children under 5, and one-half for children aged 5-10. The classical text specifies that for nursing infants, the mother should also take the formula (子母同服), as the herbs pass through breastmilk and the mother's emotional state directly affects the child. Gou Teng (Uncaria) should be added late in the decoction (final 10-15 minutes) to preserve its active alkaloids. The formula's gentle nature makes it appropriate even for very young children when prescribed by a qualified practitioner.

Drug Interactions

Gan Cao (Licorice root) in this formula contains glycyrrhizin, which can cause pseudoaldosteronism (sodium retention, potassium loss, elevated blood pressure) with prolonged use. It may interact with:

  • Antihypertensives: Licorice can counteract blood pressure-lowering effects.
  • Diuretics (especially thiazides and loop diuretics): Increased risk of hypokalemia when combined with Licorice.
  • Digoxin and cardiac glycosides: Licorice-induced hypokalemia may increase the toxicity of these drugs.
  • Corticosteroids: Licorice potentiates the effect of corticosteroids by inhibiting their metabolism, potentially increasing side effects.

Gou Teng (Uncaria hook) contains alkaloids with serotonin receptor activity (5-HT1A partial agonism, 5-HT2A antagonism). Caution is warranted when combining with:

  • SSRIs, SNRIs, and other serotonergic medications: Theoretical risk of additive serotonergic effects, though clinical reports of serotonin syndrome with Yokukansan are not established.
  • Sedatives, benzodiazepines, and sleep medications: Additive sedative effects are possible given the formula's calming properties.

Chuan Xiong (Ligusticum) has mild antiplatelet activity. Caution with anticoagulants (warfarin) and antiplatelet drugs (aspirin, clopidogrel), though the dose in this formula is small.

Contraindications

Caution

Spleen and Stomach deficiency Cold with diarrhea and no signs of Liver excess or Wind. The formula's cool, dispersing herbs (Chai Hu, Gou Teng) may further weaken a purely Cold-deficient digestion.

Caution

Excess Liver Fire or hyperactive Liver Yang with strong constitutional excess and no Blood or Spleen deficiency. This formula is designed for a deficiency-based pattern (Liver deficiency Heat) and may be insufficient for robust excess presentations, which require stronger Heat-clearing or Yang-subduing formulas.

Caution

Yin deficiency with vigorous Fire signs (night sweats, severe malar flush, a deep red tongue with no coat). The formula does not strongly nourish Yin, and Chai Hu can further injure Yin in such cases.

Caution

Pregnancy without practitioner supervision. Chuan Xiong (Ligusticum) is an activating Blood-moving herb, and Chai Hu can raise and move Qi. Neither is absolutely contraindicated in pregnancy, but both warrant caution.

Cautions & Warnings

is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Liu Wei Di Huang Wan.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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