Formula

Qi Ju Di Huang Wan

Lycium, Chrys & Rehmannia Formula | 杞菊地黄丸

Also known as:

Lycium Fruit Chrysanthemum and Rehmannia Pill , Rehmannia Six Combination with Lycii berries and Chrysanthemum , Rehmannia Six Combination with Goji berries and Chrysanthemum

Properties

Yin-tonifying formulas · Slightly Cool

Key Ingredients

Shu Di Huang

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula that nourishes the Liver and Kidneys to support eye health and clear vision. It is used for blurred vision, dry eyes, sensitivity to light, excessive tearing in wind, dizziness, and ringing in the ears caused by Liver and Kidney Yin deficiency. Built on the famous Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill) with the addition of goji berry and chrysanthemum flower for their vision-supporting properties.

Formula Category

Main Actions

  • Nourishes Liver and Kidney Yin
  • Brightens the Eyes
  • Clears Liver Heat
  • Tonifies Kidney Essence
  • Calms the Liver and Subdues Yang

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qi Ju Di Huang Wan is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Qi Ju Di Huang Wan addresses this pattern

This is the primary pattern for which Qi Ju Di Huang Wan was designed. When Kidney Yin is depleted, it fails to nourish the Liver (its 'child' organ in five-element theory). Since the Liver 'opens to the eyes' and Liver Blood and Yin are essential for visual clarity, this combined deficiency manifests prominently in the eyes: blurred vision, dry eyes, light sensitivity, and tearing in wind. The formula directly replenishes Kidney Yin with Shu Di Huang and Shan Zhu Yu, nourishes the Liver with Gou Qi Zi, and clears heat from the eyes with Ju Hua and Mu Dan Pi. The balanced 'three tonifying, three draining' architecture ensures replenishment without creating stagnation.

A practitioner would look for one or more of these signs

Blurry Vision

Gradual onset, worsening with fatigue or eye strain

Dry Eyes

Chronic dryness, gritty sensation

Photophobia

Sensitivity to light, difficulty in bright environments

Excessive Sweating

Tearing when exposed to wind (迎风流泪)

Dizziness

Chronic, mild dizziness or lightheadedness

Tinnitus

Ringing in the ears, often low-pitched

Lower Back Pain

Soreness and weakness in the lower back and knees

How It Addresses the Root Cause

The core problem this formula addresses is a depletion of Yin in both the Liver and the Kidneys, with symptoms that particularly affect the eyes and head. In TCM, the Kidneys store Essence and are the root of Yin for the entire body. The Liver stores Blood and governs the free flow of Qi. These two organs share a close relationship: in Five Phase theory, the Kidneys (Water) nourish the Liver (Wood), and Kidney Essence and Liver Blood are mutually generating. When Kidney Yin becomes depleted, it can no longer nourish the Liver, leading to a dual deficiency of Liver and Kidney Yin.

Because the Liver "opens to the eyes" (肝开窍于目), the eyes depend on adequate Liver Blood and Yin for moisture, nourishment, and clear vision. When Liver Yin is insufficient, the eyes become dry, sensitive to light, and vision grows blurry. Furthermore, when Yin is weak, it fails to anchor Yang, allowing Liver Yang to rise unchecked. This rising Yang produces dizziness, headache, and tinnitus. In some cases, mild deficiency Heat also develops, as Yin can no longer keep the body's warming functions in check.

The formula addresses this entire cascade: it replenishes Kidney Yin at the root, nourishes the Liver to restore moisture and Blood supply to the eyes, gently clears any rising Heat or Yang, and stabilizes the relationship between the two organs so that the eyes and head are properly nourished again.

Formula Properties

Temperature

Slightly Cool

Taste Profile

Predominantly sweet and slightly sour, with subtle bitter notes. Sweet to tonify and nourish, sour to astringe Essence, and mildly bitter to clear Heat from the Liver.

Target Organs
Liver Kidneys Spleen
Channels Entered
Liver Kidney Spleen

Formula Origin

Yi Ji Bao Jian (医级宝鉴) by Dong Xiyuan (董西园)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Qi Ju Di Huang Wan

Detailed information about each herb in Qi Ju Di Huang Wan and their roles

Kings
Deputies
Assistants
Shu Di Huang
Shu Di Huang

Prepared Rehmannia root

Dosage: 24g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Qi Ju Di Huang Wan

Strongly nourishes Kidney Yin, replenishes Essence (Jing), and tonifies the Blood. As the heaviest herb by dosage in the formula, it anchors the entire prescription by addressing the root cause: Kidney Yin deficiency. By filling the Kidney Essence, it provides the foundation for nourishing the Liver and eyes.

Gou Qi Zi
Gou Qi Zi

Goji berry

Dosage: 9 - 15g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Lungs
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Qi Ju Di Huang Wan

Nourishes and tonifies both the Liver and Kidneys, benefits the Essence, and brightens the eyes. It reinforces the King herb's Yin-nourishing action while adding a specific affinity for the Liver and eyes, making it one of the two key additions that distinguish this formula from Liu Wei Di Huang Wan.

Shan Zhu Yu
Shan Zhu Yu

Asiatic cornelian cherry fruit

Dosage: 12g

Temperature Slightly Warm
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Qi Ju Di Huang Wan

Nourishes the Liver and Kidneys and restrains the leakage of Essence. Its astringent nature helps prevent Kidney Essence from draining away, enabling the tonic effect of Shu Di Huang to accumulate. It also supports the Liver, complementing Gou Qi Zi.

Shan Yao
Shan Yao

Chinese yam

Dosage: 12g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in Qi Ju Di Huang Wan

Tonifies the Spleen and consolidates the Kidneys. The Spleen is the source of postnatal Essence, so strengthening it ensures a steady supply of nourishment to replenish Kidney Yin. It stabilizes the Essence and supports digestion so the rich tonic herbs are properly absorbed.

Ju Hua
Ju Hua

Chrysanthemum flower

Dosage: 9 - 10g

Temperature Slightly Cool
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Liver
Parts Used Flower (花 huā)
Role in Qi Ju Di Huang Wan

Clears the Liver, calms Liver Yang, disperses wind-heat, and brightens the eyes. It is the second key addition distinguishing this formula. While the other herbs nourish from below (tonifying Yin), Ju Hua works from above, gently clearing heat and excess from the head and eyes. Its cool, light nature balances the rich, heavy tonic herbs.

Ze Xie
Ze Xie

Water plantain rhizome

Dosage: 9g

Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Qi Ju Di Huang Wan

Drains Kidney turbidity and leaches dampness. It prevents the rich, cloying nature of Shu Di Huang from causing stagnation in the Kidneys, which could generate more deficiency heat. Paired with Shu Di Huang, it ensures that tonification does not lead to congestion.

Mu Dan Pi
Mu Dan Pi

Tree peony root bark

Dosage: 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Qi Ju Di Huang Wan

Clears deficiency heat from the Liver and cools the Blood. It moderates the warming, astringent nature of Shan Zhu Yu, preventing that herb from generating excess heat. It also directly addresses any Liver fire that may be contributing to eye symptoms.

Fu Ling
Fu Ling

Poria

Dosage: 9g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Qi Ju Di Huang Wan

Strengthens the Spleen and drains dampness. It supports Shan Yao in fortifying the Spleen while preventing fluid accumulation from the heavy tonic herbs. Together with Ze Xie and Mu Dan Pi, it forms the 'three draining' component that keeps the formula balanced and prevents stagnation.

Modern Research (3 studies)

  • Systematic Review: Chinese Herbal Medicine Qi Ju Di Huang Wan for Essential Hypertension (2013)
  • RCT: Clinical Evaluation of Chi-Ju-Di-Huang-Wan for Dry Eye (2005)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Twice daily, ideally 30-60 minutes after meals to reduce any digestive heaviness from the rich, Yin-nourishing herbs. Some classical sources recommend taking it in the evening, as Yin-nourishing formulas align with the body's natural evening Yin cycle.

Typical Duration

Often taken for 4-8 weeks as an initial course, then reassessed. As a gentle tonic formula, it may be used long-term (months) for chronic Yin deficiency conditions under practitioner guidance. If symptoms do not improve after 4 weeks, seek professional evaluation.

Dietary Advice

Avoid foods that are hard to digest, greasy, or overly rich, as these can impair absorption and worsen the formula's tendency toward cloying dampness. Cold and raw foods (ice cream, cold salads, raw fish) should be minimized, as they can weaken the Spleen's digestive function and counteract the formula's nourishing effects. Spicy, hot foods (chili peppers, strong alcohol, deep-fried foods) should also be limited, as they generate Heat and can aggravate the underlying Yin deficiency. Foods that support the formula's action include dark leafy greens, goji berries, black sesame seeds, walnuts, mulberries, chrysanthemum tea, and dark-colored fruits like blueberries and blackberries. These foods nourish Liver Blood and Kidney Essence. Adequate hydration is important for supporting Yin.

Modern Usage

Qi Ju Di Huang Wan nourishes the Kidneys and Liver. It is used for Liver and Kidney Yin Deficiency with symptoms such as dizziness, tinnitus, sensitivity to light, tearing in the wind, and blurred vision.

Special Populations

Pregnancy

Generally considered safe in standard doses, but should only be used during pregnancy under professional guidance. The formula contains no strongly moving, Blood-breaking, or uterine-stimulating herbs. However, the cloying nature of Shu Di Huang (prepared Rehmannia) may aggravate nausea or digestive sluggishness common in pregnancy. Mu Dan Pi (tree peony bark) has mild Blood-cooling and Blood-moving properties, which warrants caution in pregnancy, though at the dosages used in this formula the risk is low. Official Chinese OTC labeling states that pregnant women should use this product under physician guidance.

Breastfeeding

Generally considered compatible with breastfeeding at standard doses, but official labeling recommends use under physician guidance for nursing mothers. The formula's ingredients are gentle, nourishing herbs with a long history of safe use. No specific concerns about transfer of harmful substances through breast milk have been documented. The rich, Yin-nourishing quality of the formula may even theoretically support postpartum recovery. However, the cloying nature of Shu Di Huang could potentially reduce appetite or cause digestive discomfort in sensitive individuals, which might indirectly affect milk production if nutrition intake is impaired.

Pediatric Use

This formula was originally derived from Liu Wei Di Huang Wan, which was itself created by the Song Dynasty pediatrician Qian Yi specifically for children. Qi Ju Di Huang Wan can be used in children, but official labeling states that children should take it under physician guidance and adult supervision. Dosage should be reduced according to the child's age and body weight: roughly one-quarter to one-third of the adult dose for children aged 3-6, and one-half for children aged 7-14. The honey pill form may need to be broken into smaller pieces for younger children. The formula is not typically used in infants or very young children (under age 3) without specific professional recommendation. Young patients presenting with eye strain from excessive screen use may benefit from this formula if a Yin deficiency pattern is confirmed.

Drug Interactions

Official Chinese pharmacopeia labeling states that drug interactions for Qi Ju Di Huang Wan are "not yet clearly established" (尚不明确). However, based on the pharmacological properties of its individual herbs, the following theoretical interactions merit awareness:

  • Antihypertensive medications: The formula has demonstrated blood-pressure-lowering effects in clinical studies. When combined with antihypertensive drugs (ACE inhibitors, calcium channel blockers, beta-blockers), an additive hypotensive effect is possible. Blood pressure should be monitored if used concurrently.
  • Hypoglycemic agents: Several ingredients (particularly Shan Yao and Gou Qi Zi) may have mild blood-sugar-lowering effects. Diabetic patients on insulin or oral hypoglycemics should monitor blood glucose levels.
  • Anticoagulant and antiplatelet drugs: Mu Dan Pi (tree peony bark) has mild Blood-activating properties. While the effect at standard formula doses is minor, caution is advisable when combined with warfarin, heparin, or antiplatelet agents.
  • Diuretics: Ze Xie and Fu Ling both promote urination. Concurrent use with pharmaceutical diuretics could theoretically enhance fluid loss.

Patients taking any prescription medications should consult their healthcare provider before adding this formula.

Contraindications

Caution

Spleen and Stomach Yang deficiency with loose stools or diarrhea. The formula's rich, Yin-nourishing herbs (especially Shu Di Huang) are cloying and can further impair an already weak digestive system.

Avoid

Active exterior pattern (common cold, flu, fever). Tonifying and enriching herbs can trap the pathogen inside the body and worsen or prolong the illness. The formula should be suspended until the exterior condition resolves.

Avoid

Kidney Yang deficiency presenting with cold limbs, pallor, profuse clear urination, and cold low back. This formula is designed for Yin deficiency patterns and would further deplete Yang if used inappropriately.

Caution

Dampness or Phlegm accumulation with heavy limbs, a greasy tongue coat, and poor appetite. The rich, moistening nature of Shu Di Huang may worsen Dampness.

Avoid

Known allergy or hypersensitivity to any ingredient in the formula.

Caution

Patients with severe chronic conditions (hypertension, heart disease, liver disease, diabetes, kidney disease) should only use this formula under professional medical supervision.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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