Formula

Long Dan Xie Gan Tang

Gentiana Cleansing Decoction | 龙胆泻肝汤

Also known as:

Gentiana formula , Gentian Decoction to Drain the Liver , Gentiana Combination

Properties

Heat-clearing formulas · Cold

Key Ingredients

Long Dan Cao

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula*

Traditional Chinese Medicine background and properties

Formula Description*

A powerful cooling formula used to address conditions caused by excess heat and dampness in the Liver and Gallbladder systems. It is commonly used for red, painful eyes, headaches, ear problems, irritability, urinary difficulties, and skin conditions like shingles, particularly when accompanied by a bitter taste in the mouth, dark urine, and a feeling of heat or inflammation along the sides of the body or in the genital area.

Formula Category*

Main Actions*

  • Drains excess Fire from the Liver and Gallbladder
  • Clears Damp-Heat from the Lower Burner
  • Clears Heat from the Liver channel
  • Promotes Urination and Drains Dampness
  • Nourishes Blood and Yin to prevent damage from bitter cold

TCM Patterns*

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Long Dan Xie Gan Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Long Dan Xie Gan Tang addresses this pattern

When Liver Fire blazes intensely, it flares upward along the Liver and Gallbladder channels to the head, causing headaches, red painful eyes, ringing in the ears or sudden deafness, a bitter taste in the mouth, and irritability. The Liver channel connects to the top of the head and links to the eyes, so upflaring fire produces symptoms concentrated in these areas. Long Dan Xie Gan Tang directly quenches this fire with its powerful team of bitter, cold herbs. Long Dan Cao, Huang Qin, and Zhi Zi form the core fire-draining unit, while Chai Hu channels their action precisely into the Liver and Gallbladder meridians. Sheng Di Huang and Dang Gui prevent the fire from further consuming Blood and Yin, which the Liver needs to function properly.

A practitioner would look for one or more of these signs

Headaches

Severe, throbbing, often at the vertex or temples

Red Eyes

Red, painful, swollen eyes

Tinnitus

Sudden onset, often loud and high-pitched

Bitter Taste In The Mouth

Persistent bitter taste in the mouth

Irritability

Easy anger, restlessness, agitation

Rib-Side Pain

Distending pain along the sides of the torso

Insomnia

Difficulty sleeping due to restless agitation

Constipation

Dry stools from Heat consuming fluids

How It Addresses the Root Cause*

This formula addresses two related manifestations of the same underlying problem: excess Heat and Damp-Heat accumulating in the Liver and Gallbladder systems.

The Liver channel runs a long path through the body. It encircles the genital region, spreads through the ribcage, connects to the eyes, and reaches the crown of the head. The Gallbladder channel winds around the ears and along the sides of the head. When intense Fire builds up in these two organ systems, it flares upward along these channel pathways, producing symptoms in the head and face: headache at the top of the head, red and painful eyes, ringing in the ears or sudden hearing loss, ear swelling, a bitter taste in the mouth, and pain along the ribs. The tongue turns red with a yellow coating, and the pulse feels tight and forceful.

When the problem involves not just Fire but also Dampness combining with Heat, the pathology tends to pour downward, because Dampness is heavy and turbid by nature. Since the Liver channel passes directly through the genital area, Damp-Heat accumulating there produces swelling, itching, foul-smelling discharge, excessive sweating of the groin, painful or turbid urination, and in women, thick yellow vaginal discharge with odor. The tongue coating becomes greasy and yellow, reflecting the Damp-Heat component. In both scenarios, the root problem is excess: the Liver and Gallbladder are overwhelmed by pathogenic Fire or Damp-Heat that must be drained and expelled, while the body's Yin and Blood must be protected from being scorched by the very herbs used to clear the excess.

Formula Properties*

Temperature

Cold

Taste Profile

Predominantly bitter and cold with mild sweet and bland undertones. The bitter taste drains Fire and dries Dampness, while the bland quality promotes urination to resolve Damp-Heat. Sweet notes from Gan Cao and Dang Gui soften the harshness and protect the Stomach.

Target Organs
Liver Gallbladder Urinary Bladder Small Intestine
Channels Entered
Liver Gallbladder Bladder Small Intestine San Jiao

Formula Origin

Yi Fang Ji Jie (医方集解, Medical Formulas Collected and Analyzed) by Wang Ang

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Supplier Information

Treasure of the East

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Ingredients in Long Dan Xie Gan Tang

Detailed information about each herb in Long Dan Xie Gan Tang and their roles

Kings
Deputies
Assistants
Envoys
Long Dan Cao
Long Dan Cao

Chinese gentian root

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder
Parts Used Root (根 gēn)
Role in Long Dan Xie Gan Tang

The chief herb of the formula and its namesake. Extremely bitter and cold, it both drains intense fire from the Liver and Gallbladder and clears Damp-Heat from the lower body. It is uniquely effective at fulfilling both therapeutic aims of the formula simultaneously.

Huang Qin
Huang Qin

Baical skullcap root

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Parts Used Root (根 gēn)
Role in Long Dan Xie Gan Tang

Bitter and cold, it reinforces the King herb's ability to drain fire and dry Dampness. It also clears Heat from the Lungs and upper body, broadening the formula's fire-draining scope.

Zhi Zi
Zhi Zi

Gardenia fruit

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Long Dan Xie Gan Tang

Bitter and cold, it clears Heat and drains fire from all three Burners. Working alongside Huang Qin, it strengthens the King herb's fire-draining action and also helps conduct Heat downward and outward through the urine.

Ze Xie
Ze Xie

Water plantain rhizome

Dosage: 9 - 12g

Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Long Dan Xie Gan Tang

Promotes urination to drain Damp-Heat downward and out through the Bladder. It provides a physical exit route for the pathogenic dampness and heat that the formula is clearing.

Mu Tong
Mu Tong

Akebia stem

Dosage: 3 - 6g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Small Intestine, Urinary Bladder
Parts Used Stem (茎 jīng)
Role in Long Dan Xie Gan Tang

Clears Heat from the Heart and promotes urination, guiding Damp-Heat out through the Small Intestine and Bladder. Works together with Ze Xie and Che Qian Zi to create a strong dampness-draining team.

Che Qian Zi
Che Qian Zi

Plantain Seed

Dosage: 6 - 9g

Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Lungs, Small Intestine
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Long Dan Xie Gan Tang

Promotes urination and clears Heat, reinforcing the downward drainage of Damp-Heat through the urinary tract. Also clears the eyes, which supports the formula's use for eye redness.

Shu Di Huang
Shu Di Huang

Prepared Rehmannia root

Dosage: 9 - 12g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Long Dan Xie Gan Tang

Sweet, bitter, and cold, it nourishes Yin and cools the Blood. This is a critical restraining assistant: it prevents the many bitter, drying herbs in the formula from damaging the body's Yin fluids and Blood, which the Liver heat has already begun to consume.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 3 - 6g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Long Dan Xie Gan Tang

Nourishes and invigorates the Blood without causing stagnation. Because the Liver stores the Blood, and both the pathogenic heat and the formula's cold, drying herbs can injure Liver Blood, Dang Gui protects the Liver's vital substance while the formula purges the excess.

Chai Hu
Chai Hu

Bupleurum root

Dosage: 3 - 6g

Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs
Parts Used Root (根 gēn)
Role in Long Dan Xie Gan Tang

Serves a dual envoy function: it channels and directs the other herbs into the Liver and Gallbladder meridians, and it gently spreads and regulates Liver Qi. This subtle ascending and dispersing quality prevents the formula's heavy, descending, cold herbs from overly suppressing the Liver's natural function of ensuring the smooth flow of Qi.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Long Dan Xie Gan Tang

Harmonizes the actions of all the other herbs, protects the Stomach from the formula's strongly bitter and cold nature, and moderates the harsh tastes. Used in its raw form to retain a mild Heat-clearing action.

Modern Research (3 studies)

  • Systematic Review and Meta-Analysis: Longdanxiegan Decoction for Hypertension (2018)
  • Systematic Review and Meta-Analysis: Long Dan Xie Gan Tang for Insomnia (2020)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

On an empty stomach (30 minutes before meals), following the classical instruction. Traditionally taken warm, once or twice daily. The classical text specifies following the dose with a light meal to protect the Stomach.

Typical Duration

Short-term use only: typically 3 to 7 days for acute presentations, reassessed by a practitioner. Should not be taken continuously beyond 2 weeks.

Dietary Advice

While taking this formula, avoid foods that generate Heat and Dampness: - Avoid alcohol, which generates Damp-Heat in the Liver (this was the original trigger in Li Dongyuan's case history). - Avoid greasy, deep-fried, and rich fatty foods that produce Dampness and Heat. - Avoid spicy and pungent foods (chili peppers, garlic, raw onions, lamb) that can intensify Liver Fire. - Reduce sugar and heavily sweetened foods, which contribute to Dampness. Foods that are helpful include: - Light, cooling vegetables such as celery, cucumber, mung bean sprouts, and bitter melon. - Mung bean soup and chrysanthemum tea, which gently clear Heat. - Adequate water intake to support the formula's diuretic drainage action. The classical instruction from the Lan Shi Mi Cang specifies taking the formula on an empty stomach, then following it with a light, nourishing meal (美膳压之) to protect the Stomach from the formula's bitter cold nature.

Modern Usage*

WHAT IS LONG DAN XIE GAN TANG?
Long Dan Xie Gan Tang, also known as Gentiana Cleansing Decoction, is a Traditional Chinese Medicine (TCM) formula developed by the medical scholar Ye Tianshi during the Qing Dynasty (1644-1911). This herbal remedy is designed to clear Heat and address conditions related to inflammation.

WHAT ARE THE BENEFITS OF LONG DAN XIE GAN TANG?
Long Dan Xie Gan Tang is commonly used in TCM to expel Heat from the Liver and Gallbladder meridians, alleviate symptoms of Damp-Heat, and soothe internal Wind. It may be helpful for conditions such as acute cystitis, urethritis, herpes zoster, and hypertension. Additionally, it can alleviate symptoms like tinnitus, migraines, and red, sore eyes.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Special Populations

Pregnancy

Use with caution during pregnancy. Several herbs in this formula raise specific concerns: - Mu Tong (Akebia stem) promotes strong downward drainage through the urinary tract and has traditionally been flagged as potentially harmful during pregnancy. - Ze Xie (Alisma) and Che Qian Zi (Plantago seed) are strongly diuretic and can deplete fluids. - The overall formula is intensely bitter and cold, which can injure Spleen Qi and potentially disturb fetal stability, as pregnancy relies on adequate Qi and Blood support. - Long Dan Cao (Gentiana) is extremely bitter and cold, and excessive cold in the lower abdomen is generally considered unfavorable during pregnancy. This formula should generally be avoided during pregnancy unless a qualified practitioner determines it is absolutely necessary for a severe acute condition and the benefits clearly outweigh the risks.

Breastfeeding

Caution is advised during breastfeeding. Specific considerations include: - The formula is strongly bitter and cold. Bitter cold properties can theoretically transfer through breast milk and may cause digestive upset (loose stools, poor feeding) in the nursing infant. - Long Dan Cao (Gentiana) is intensely bitter, and this taste may affect the palatability of breast milk. - Mu Tong and Ze Xie are strongly draining and diuretic, which could potentially reduce milk supply by depleting fluids. - Gan Cao (Licorice) may have mild hormonal effects. If a breastfeeding mother has a genuine Liver-Gallbladder Damp-Heat pattern requiring treatment, a practitioner should use the minimum effective dose for the shortest possible duration, monitor the infant for any digestive changes, and ensure the mother maintains adequate fluid intake.

Pediatric Use

Long Dan Xie Gan Tang can be used in children but requires careful consideration: - Children's bodies are described in TCM as having immature Spleen and Stomach function. This strongly bitter and cold formula can easily damage their digestive systems, so doses must be significantly reduced. - General guideline: children under 6 years should receive roughly one-quarter to one-third of the adult dose; children 6 to 12 may take one-third to one-half. Exact dosing should be determined by a qualified practitioner based on the child's age, weight, and constitution. - Duration should be strictly limited, typically only a few days for acute presentations. - The formula has historical use in pediatric acute conditions. The Lan Shi Mi Cang version was sometimes referenced for childhood Liver Heat patterns. However, a practitioner should confirm a genuine excess Heat pattern, as children also commonly present with deficiency patterns that mimic excess. - Mu Tong substitution is especially important in pediatric use due to developing kidneys.

Cautions & Warnings

Although Long Dan Xie Gan Tang is typically safe for most individuals, it may cause side effects in some cases. Pregnant, nursing, or postpartum women, as well as individuals with liver disease, should avoid or use Long Dan Xie Gan Tang with caution and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment.