Formula

Lian Po Yin

連朴飲

Also known as:

Wang Shi Lian Po Yin (王氏連朴飲) , Wang's Coptis and Magnolia Bark Drink

Key Ingredients

Huang Lian, Hou Po

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula for treating acute digestive upsets caused by a combination of Dampness and Heat lodging in the Stomach and intestines. It addresses simultaneous vomiting and diarrhea, a feeling of fullness and stuffiness in the chest and upper abdomen, irritability, and dark scanty urine, particularly during hot and humid seasons.

Formula Category

Main Actions

  • Clears Heat and Drains Dampness
  • Regulates Qi and Harmonizes the Middle Burner
  • Dries Dampness
  • Stops Vomiting
  • Eliminates Focal Distention and Fullness

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Lian Po Yin is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Lian Po Yin addresses this pattern

This is the primary pattern addressed by Lian Po Yin. When Dampness and Heat become equally entangled in the Spleen and Stomach, the normal ascending and descending functions of these organs are completely disrupted. The Stomach can no longer send food downward (causing vomiting), and the Spleen can no longer raise clear substances upward (causing diarrhea). The combination of Dampness blocking Qi flow and Heat generating irritability produces the characteristic mix of digestive turmoil with restlessness and a stifling sensation in the chest.

Huang Lian directly clears Heat and dries Dampness, while Hou Po moves stagnant Qi and transforms Dampness. Zhi Zi and Dan Dou Chi vent the depressed Heat causing irritability. Shi Chang Pu and Ban Xia further resolve Dampness and restore the Stomach's descending function. Lu Gen clears residual Heat and protects fluids. Together these herbs clear the Damp-Heat obstruction and re-establish normal Spleen and Stomach function.

A practitioner would look for one or more of these signs

Epigastric Fullness And Pain Relieved By Vomiting

Sudden, forceful vomiting

Diarrhea

Simultaneous vomiting and diarrhea

Epigastric Coldness

Chest and epigastric stuffiness and fullness

Irritability

Restlessness and irritability with Heat

Oliguria

Dark, scanty urine

Thirst

Thirst with desire to drink

How It Addresses the Root Cause

Lian Po Yin addresses a condition in which Dampness and Heat become entangled in the Middle Burner (the Spleen and Stomach system), most often triggered by exposure to warm, humid environmental conditions combined with dietary irregularities during the summer and autumn months. This is the classic setting for what the tradition calls "Hot Cholera" (热霍乱).

When Damp-Heat accumulates in the digestive system, it disrupts the normal ascending and descending functions of the Spleen and Stomach. The Stomach, whose natural movement is downward, fails to send food contents downward, leading to vomiting, nausea, and a sensation of fullness in the upper abdomen. The Spleen, whose role is to lift the clear nutrients upward, instead lets the "turbid" substances sink uncontrolled, producing diarrhea. In TCM terms, the clear and turbid fluids become mixed (清浊相干). The Heat component produces irritability, thirst, scanty dark urine, and a yellow tongue coating, while the Dampness component creates the characteristic greasy tongue coating, feelings of heaviness, and the sensation of oppression in the chest and epigastrium.

Because Dampness is heavy and sticky while Heat is active and agitating, the two pathogenic factors aggravate each other and create a self-reinforcing cycle. Simply clearing Heat alone would leave Dampness behind, and simply drying Dampness without clearing Heat would trap Heat further. The formula therefore must simultaneously address both components, which is precisely the therapeutic strategy Lian Po Yin was designed to accomplish.

Formula Properties

Temperature

Cool

Taste Profile

Predominantly bitter and acrid (pungent), with sweet undertones from Lu Gen. The bitter flavor clears Heat and dries Dampness, while the acrid flavor moves Qi and disperses stagnation.

Target Organs
Spleen Stomach Large Intestine
Channels Entered
Spleen Stomach Large Intestine

Formula Origin

Huo Luan Lun (霍乱论, Discussion of Sudden Turmoil Disorders) by Wang Shi Xiong (Wang Meng Ying)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Lian Po Yin

Detailed information about each herb in Lian Po Yin and their roles

Kings
Deputies
Assistants
Huang Lian
Huang Lian

Coptis rhizome

Dosage: 3g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen
Parts Used Rhizome (根茎 gēn jīng)
Role in Lian Po Yin

Clears Heat and dries Dampness in the Middle Burner. Its bitter, cold nature directly targets the core pathogenic factors of Damp-Heat blocking the Stomach and intestines.

Hou Po
Hou Po

Magnolia bark

Dosage: 6g

Temperature Warm
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs, Large Intestine
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Lian Po Yin

Promotes the movement of Qi and transforms Dampness, relieves the distention and fullness in the chest and epigastrium. Its bitter, warm, aromatic nature powerfully resolves Dampness that has accumulated in the Middle Burner.

Zhi Zi
Zhi Zi

Gardenia fruit

Dosage: 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Lian Po Yin

Clears depressed Heat from the chest and epigastrium, resolves irritability and restlessness. Paired with Dan Dou Chi, it forms the classical Zhi Zi Chi Tang combination to vent pent-up Heat from the upper body.

Dan Dou Chi
Dan Dou Chi

Fermented soybean

Dosage: 9g

Temperature Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Stomach
Parts Used Processed / Derived product (加工品 jiā gōng pǐn)
Role in Lian Po Yin

Clears and vents depressed Heat from the chest and epigastrium, dispels restlessness and a stifling sensation. Works synergistically with Zhi Zi to relieve irritability caused by Heat stagnating in the upper body.

Shi Chang Pu
Shi Chang Pu

Acorus rhizome

Dosage: 3g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Aromatic (芳香 fāng xiāng)
Organ Affinity Heart, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Lian Po Yin

Aromatically transforms Dampness and revives the Spleen. Its aromatic, penetrating nature helps break through the turbid Dampness obstructing the Middle Burner, supporting the King herbs in resolving the Damp-Heat stagnation.

Ban Xia
Ban Xia

Pinellia tuber

Dosage: 3g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Lian Po Yin

Dries Dampness and directs rebellious Stomach Qi downward to stop vomiting. Harmonizes the Stomach and works alongside the King herbs to restore the normal descending function of the Stomach.

Lu Gen
Lu Gen

Reed rhizome

Dosage: 60g

Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Lian Po Yin

Clears Heat, generates fluids, harmonizes the Stomach, and stops vomiting. Used in a notably large dose to counterbalance the drying nature of the other herbs, protecting body fluids that are easily damaged by both the disease and the drying medicinals.

Modern Research (2 studies)

  • Network meta-analysis: Comparative efficacy of 9 TCM formulas combined with standard quadruple therapy for H. pylori-associated gastritis (Systematic Review, 2022)
  • Jiawei Lianpu Yin inhibits H. pylori colonization and alleviates gastric mucosal inflammation: Integrated transcriptomics, network pharmacology, and experimental validation (Preclinical, 2025)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Warm, between meals (30-60 minutes before or after eating). In acute cases with active vomiting, take in small, frequent sips rather than a full dose at once.

Typical Duration

Acute use: 3-7 days. This is primarily an acute-phase formula. Reassess if symptoms do not improve within 3 days.

Dietary Advice

While taking Lian Po Yin, avoid greasy, fried, and heavy foods that generate Dampness and Heat. Cold and raw foods (including ice cream, raw salads, and chilled drinks) should also be avoided, as they impair the Spleen's already-compromised digestive function. Alcohol and spicy-hot foods will aggravate the Heat component of the pattern. Favor bland, easily digestible foods such as rice congee (porridge), cooked vegetables, and light broth. Small, frequent meals are preferable to large ones. Adequate hydration is important given the vomiting and diarrhea this formula treats, but fluids should be warm or at room temperature, taken in small sips.

Special Populations

Pregnancy

Use with caution during pregnancy. Ban Xia (Pinellia, even in its prepared form Zhi Ban Xia) is traditionally classified as a pregnancy-caution herb due to its potential to stimulate uterine activity and its inherent toxicity when raw. Zhi Zi (Gardenia) is cold-natured and may be too harsh for the digestive system during pregnancy. The overall cold and drying nature of this formula makes it generally unsuitable for pregnant women, who tend toward Blood and Yin deficiency. Should only be used under close practitioner supervision when genuinely indicated, and ideally for the shortest possible duration.

Breastfeeding

Use with caution during breastfeeding. Huang Lian (Coptis) contains berberine, which is known to transfer into breast milk. Berberine may cause gastrointestinal discomfort in nursing infants and has been historically associated with concerns about neonatal jaundice (it may displace bilirubin from albumin binding sites). Ban Xia, even in prepared form, carries mild toxicity concerns. The formula's strongly bitter and cold properties may also reduce appetite and potentially affect milk production in the mother. Use only when clearly indicated by a Damp-Heat pattern, at the lowest effective dose, and for the shortest duration necessary.

Pediatric Use

Lian Po Yin can be used in children for acute Damp-Heat gastrointestinal conditions, but with significant dosage reduction. General pediatric dosing guidelines suggest approximately one-third of the adult dose for children aged 3-6, and one-half for children aged 7-14, though exact amounts should be determined by a qualified practitioner based on the child's age, weight, and constitution. Huang Lian (Coptis) is very bitter and cold, and children's digestive systems are considered more delicate in TCM, so the duration should be kept short to avoid damaging the Spleen. The large dose of Lu Gen (Reed Rhizome) in the original formula may need proportional adjustment. Not recommended for infants under 1 year of age. For very young children (1-3 years), only use under close practitioner supervision.

Drug Interactions

Huang Lian (Coptis / Berberine-containing herb): Berberine, the primary alkaloid in Huang Lian, has documented interactions with several drug classes. It may enhance the hypoglycemic effects of diabetes medications (metformin, sulfonylureas, insulin), requiring blood glucose monitoring. Berberine inhibits CYP3A4 and CYP2D6 enzymes and can increase serum levels of drugs metabolized by these pathways, including cyclosporine, certain statins (simvastatin, atorvastatin), and some anticoagulants. Berberine also has mild blood pressure-lowering effects and may potentiate antihypertensive medications.

Ban Xia (Pinellia): Traditional incompatibilities (十八反) list Ban Xia as antagonistic to Wu Tou (Aconitum), though this is a concern within herbal prescribing rather than pharmaceutical drug interaction. No major pharmaceutical drug interactions are well-documented for prepared Pinellia specifically.

General consideration: The formula's effect on gastrointestinal motility and stomach acidity may alter the absorption of concurrently taken oral medications. Patients taking narrow therapeutic index drugs should take them at least 1-2 hours apart from this formula.

Contraindications

Avoid

Cold-Damp patterns (寒湿): This formula is designed exclusively for Damp-Heat conditions. Using it for vomiting and diarrhea caused by Cold-Dampness (characterized by a pale tongue with white coating, cold limbs, and preference for warmth) would worsen the condition, as the formula's cold and bitter herbs would further injure Spleen Yang.

Avoid

Spleen and Stomach Yang deficiency: Patients with chronic weak digestion, poor appetite due to Spleen Yang deficiency (pale tongue, weak pulse, cold limbs) should not use this formula. Huang Lian and Zhi Zi are cold-natured herbs that would further damage the already depleted Yang Qi of the digestive system.

Caution

Yin deficiency with internal Heat: Where vomiting or epigastric discomfort arises from depleted Yin fluids rather than excess Damp-Heat, this formula's drying herbs (Hou Po, Ban Xia) would further consume Yin and aggravate the condition.

Caution

Prolonged use beyond the acute phase: This formula is designed for acute Damp-Heat conditions. Extended use of its bitter, cold, and drying herbs can injure the Spleen and Stomach Qi and deplete fluids. It should be discontinued or modified once the acute symptoms resolve.

Cautions & Warnings

Lian Po Yin is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Lian Po Yin.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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