Formula

Ge Xia Zhu Yu Tang

Dang Gui & Corydalis Combination | 膈下逐瘀汤

Also known as:

Drive Out Stagnation Below the Diaphragm Decoction , Drive Out Stasis Below the Diaphragm Decoction

Key Ingredients

Tao Ren, Hong Hua

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula for fixed abdominal pain, masses, or bloating caused by blood stasis and Qi stagnation below the diaphragm. It works by vigorously moving stagnant blood while also promoting the smooth flow of Qi in the abdomen and flanks, and is commonly used for conditions such as liver enlargement, uterine fibroids, endometriosis, and chronic pelvic pain.

Formula Category

Main Actions

  • Invigorates Blood and Dispels Stasis
  • Moves Qi and Alleviates Pain
  • Disperses Accumulations and Dissipates Nodules
  • Soothes the Liver and Regulates Qi

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ge Xia Zhu Yu Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Ge Xia Zhu Yu Tang addresses this pattern

This formula was specifically designed for blood stasis lodged below the diaphragm. When blood stasis accumulates in the abdominal region, it can form palpable masses, cause fixed stabbing pain, and create a sensation of heaviness or dragging in the abdomen when lying down. The formula's large contingent of blood-moving herbs (Tao Ren, Hong Hua, Wu Ling Zhi, Chi Shao, Mu Dan Pi, Chuan Xiong, Dang Gui) directly breaks up stagnant blood and restores normal circulation, while Dang Gui simultaneously nourishes new blood to replace what has been dispersed.

A practitioner would look for one or more of these signs

Abdominal Masses

Palpable masses or lumps in the abdomen, flanks, or below the ribs

Stabbing Fixed Pain

Fixed, stabbing pain in the abdomen that does not move

Abdominal Distention

Sensation of abdominal heaviness or dragging, worse when lying down

Dark Complexion

Dark or purplish complexion

Pale Tongue

Dark purple tongue with stasis spots

Choppy Pulse

Choppy or wiry-choppy pulse

How It Addresses the Root Cause

This formula addresses a pattern where Blood stasis has become lodged in the area below the diaphragm, which in TCM encompasses the upper abdomen, the region around the Liver and Spleen organs, and the hypochondria (the area under the ribs on both sides). In TCM theory, the Liver is responsible for ensuring the smooth flow of Qi throughout the body, and when the Liver's Qi-moving function stagnates, Blood circulation in this region slows and eventually congeals. Over time, this stagnant Blood solidifies into fixed, palpable masses.

The disease logic unfolds in stages: emotional frustration, chronic illness, or physical trauma causes Liver Qi to stagnate. Since "Qi is the commander of Blood" (气为血之帅), when Qi stops flowing freely, Blood follows suit and becomes stuck. The resulting Blood stasis in the sub-diaphragmatic region manifests as fixed, stabbing pain that does not shift location, palpable masses in the abdomen or under the ribs, and a sensation of heaviness or dragging when lying down. Because the Liver and its paired organ the Gallbladder govern the flanks, pain often radiates to the hypochondriac region. The tongue typically shows a dark or purplish color with possible stasis spots, and the pulse is choppy or wiry, all hallmarks of combined Qi stagnation and Blood stasis.

Wang Qingren's insight was that many stubborn abdominal conditions previously attributed to other causes were in fact rooted in Blood stasis. He emphasized that "where there are formed masses, there must be tangible Blood" (结块者,必有形之血), and that the only effective approach was to directly dispel the stasis while simultaneously moving Qi to prevent it from re-forming. The formula therefore works by powerfully invigorating Blood to break up the stasis, while strongly regulating Liver Qi to address the root cause of stagnation, restoring normal circulation to the sub-diaphragmatic region.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly acrid and bitter with a sweet undertone. The acrid flavor moves Qi and Blood, the bitter flavor directs downward and disperses stasis, while the sweet taste of Gan Cao harmonizes and moderates.

Target Organs
Liver Spleen Stomach
Channels Entered
Liver Spleen Stomach

Formula Origin

Yi Lin Gai Cuo (医林改错, Correcting the Errors in the Forest of Medicine) by Wang Qing-Ren

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Ge Xia Zhu Yu Tang

Detailed information about each herb in Ge Xia Zhu Yu Tang and their roles

Kings
Deputies
Assistants
Envoys
Tao Ren
Tao Ren

Peach kernel

Dosage: 9g

Temperature Neutral
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Large Intestine
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Ge Xia Zhu Yu Tang

Breaks blood stasis and dispels congealed masses below the diaphragm. As the primary stasis-breaking herb used at a high dose, it directly addresses the core pathology of blood stasis accumulation.

Hong Hua
Hong Hua

Safflower flower

Dosage: 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver
Parts Used Flower (花 huā)
Role in Ge Xia Zhu Yu Tang

Invigorates blood circulation and dispels stasis, working together with Tao Ren as the core blood-moving pair to dissolve masses and relieve pain.

Wu Ling Zhi
Wu Ling Zhi

Flying squirrel feces

Dosage: 6g

Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Liver, Spleen
Parts Used Animal — secretion (动物分泌物 dòng wù fēn mì wù)
Role in Ge Xia Zhu Yu Tang

Disperses congealed blood and stops pain, reinforcing the King herbs in their stasis-breaking action. Particularly effective for fixed, stabbing abdominal pain due to blood stasis.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 9g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Ge Xia Zhu Yu Tang

Nourishes and invigorates blood simultaneously. It supports the stasis-dispelling action while preventing the aggressive blood-moving herbs from depleting healthy blood, ensuring that the formula dispels stasis without damaging the body's resources.

Chuan Xiong
Chuan Xiong

Sichuan lovage rhizome

Dosage: 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium
Parts Used Rhizome (根茎 gēn jīng)
Role in Ge Xia Zhu Yu Tang

Moves both blood and Qi, bridging the formula's two strategies. Known as the 'Qi herb within the blood', it enhances the power of all the blood-moving ingredients while also helping the Qi-regulating herbs work more effectively.

Chi Shao
Chi Shao

Red peony root

Dosage: 6g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver
Parts Used Root (根 gēn)
Role in Ge Xia Zhu Yu Tang

Cools the blood and disperses stasis, complementing the warming Qi-moving herbs and helping to clear any heat that may have developed from prolonged blood stasis.

Mu Dan Pi
Mu Dan Pi

Tree peony root bark

Dosage: 6g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Ge Xia Zhu Yu Tang

Clears heat from the blood and activates blood circulation. Works alongside Chi Shao to cool and move stagnant blood, addressing any heat generated by chronic stasis.

Xiang Fu
Xiang Fu

Nutgrass Galingale Rhizome

Dosage: 4.5g

Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)
Parts Used Rhizome (根茎 gēn jīng)
Role in Ge Xia Zhu Yu Tang

Spreads Liver Qi and relieves constraint. As the chief Qi-regulating herb in this formula, it addresses the underlying Liver Qi stagnation that contributes to blood stasis below the diaphragm.

Wu Yao
Wu Yao

Lindera root

Dosage: 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Kidneys, Urinary Bladder
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Ge Xia Zhu Yu Tang

Warms and moves Qi, disperses cold, and stops pain. Particularly effective for distending pain in the lower abdomen and flanks, it complements Xiang Fu in regulating Qi flow.

Yan Hu Suo
Yan Hu Suo

Corydalis rhizome

Dosage: 3g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Spleen
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Ge Xia Zhu Yu Tang

One of the strongest pain-relieving herbs in the Chinese materia medica, it moves both blood and Qi to stop pain. It is the formula's key analgesic ingredient.

Zhi Ke
Zhi Ke

Bitter orange fruit

Dosage: 4.5g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Sour (酸 suān)
Organ Affinity Spleen, Stomach, Large Intestine, Lungs
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Ge Xia Zhu Yu Tang

Regulates Qi and reduces distention, helping to relieve the sense of fullness and bloating in the epigastrium and abdomen that accompanies Qi stagnation.

Gan Cao
Gan Cao

Licorice root

Dosage: 9g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Ge Xia Zhu Yu Tang

Harmonizes all other herbs in the formula. Used at a relatively high dose here to moderate the strong dispersing action of the blood-moving herbs, and to assist in relieving pain through its antispasmodic properties.

Modern Research (3 studies)

  • Gexia-Zhuyu Tang prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cell proliferation (Animal study, 2012)
  • Pharmacodynamic evaluation of Gexia Zhuyu Decoction in the treatment of NAFLD and the molecular mechanism underlying the TRPM4 pathway regulation (Animal study, 2021)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

30 minutes to 1 hour after meals, twice daily (morning and evening). Taking it after meals reduces potential gastrointestinal irritation from the Blood-moving herbs.

Typical Duration

Typically prescribed for 2-8 weeks depending on condition severity, then reassessed. For acute pain with stasis, shorter courses of 1-2 weeks may suffice. For chronic masses or liver conditions, longer courses of 1-3 months with periodic reassessment are common.

Dietary Advice

Avoid cold, raw, and frozen foods and beverages, as these can constrict blood vessels and counteract the formula's Blood-moving action. Reduce greasy, fatty, and fried foods, which can generate Dampness and impede Qi flow in the Liver and Spleen. Avoid excessive alcohol, which produces Damp-Heat and can worsen Liver stagnation. Favor lightly cooked, warm foods that support smooth Qi circulation, such as leafy greens, small amounts of vinegar-dressed dishes, and foods with gentle Blood-moving properties like hawthorn, turmeric, and dark leafy vegetables. Avoid overeating, as an overly full Stomach burdens the sub-diaphragmatic region where this formula is directed.

Modern Usage

Ge Xia Zhu Yu Tang is known for its functions of invigorating Blood, dispelling Blood stasis, breaking up masses, and dissipating nodules. It is primarily used to treat conditions characterized by the accumulation of lumps or masses in the abdomen, with fixed pain that does not move, a sensation of heaviness in the abdomen when lying down, and chronic diarrhea caused by Blood stasis. Symptoms may include the formation of abdominal masses with fixed pain, abdominal heaviness when lying down, and persistent diarrhea.

Clinically, this formula is often used to treat conditions such as chronic active hepatitis, porphyria, diabetes, ectopic pregnancy, and infertility, especially when these conditions are associated with Blood stasis and Qi stagnation.

Special Populations

Pregnancy

Contraindicated in pregnancy. This formula contains several herbs with strong Blood-moving and stasis-breaking actions that pose serious risks during pregnancy. Tao Ren (Peach Kernel) and Hong Hua (Safflower) are well-known for their ability to stimulate uterine contractions and promote menstrual flow, making them potentially abortifacient. Dan Pi (Moutan Bark) cools and moves Blood and is also classified as cautioned or contraindicated in pregnancy. Wu Ling Zhi (Trogopterus Dung) has strong Blood-dispersing action. The combined effect of these herbs creates a formula with significant potential to cause uterine bleeding, threatened miscarriage, or premature labor. This formula should not be used at any stage of pregnancy.

Breastfeeding

Use with caution during breastfeeding. While there are no classical prohibitions specifically regarding lactation, several herbs in this formula have potent Blood-moving properties (Tao Ren, Hong Hua, Wu Ling Zhi, Dan Pi) whose active compounds may transfer into breast milk in small amounts. The potential effects on a nursing infant are not well studied. Yan Hu Suo (Corydalis) contains alkaloids (including tetrahydropalmatine) with analgesic and sedative properties that could theoretically affect an infant through breast milk. If the formula is clinically necessary for the mother, a qualified practitioner should weigh the benefits against potential risks and monitor both mother and infant. It may be advisable to use reduced dosages and to time feedings to minimize infant exposure.

Pediatric Use

Wang Qingren himself noted that Ge Xia Zhu Yu Tang could be used for childhood abdominal masses (小儿痞块), making it one of the few Blood-moving formulas with a classical pediatric indication. However, in children, dosages must be significantly reduced according to age and body weight, typically to one-third to one-half of the adult dose for school-age children, and further reduced for younger children. The formula's strong Blood-moving nature means it should only be used in pediatric cases where clear signs of Blood stasis and abdominal masses are present, and only under the supervision of an experienced practitioner. Duration of use in children should be shorter and closely monitored. This formula is not suitable for infants or toddlers.

Drug Interactions

Anticoagulant and antiplatelet medications: Multiple herbs in this formula (Tao Ren, Hong Hua, Dan Pi, Chi Shao, Dang Gui, Chuan Xiong, Wu Ling Zhi) have demonstrated antiplatelet aggregation and blood-activating effects. Combined use with warfarin, heparin, aspirin, clopidogrel, or direct oral anticoagulants (DOACs) may increase bleeding risk. INR and bleeding time should be monitored if concurrent use is unavoidable.

Gan Cao (Licorice) interactions: Gan Cao (甘草) in this formula contains glycyrrhizin, which can cause pseudoaldosteronism with prolonged use. It may interact with antihypertensive medications (by promoting sodium retention and potassium loss), corticosteroids (potentiating hypokalemic effects), digoxin and cardiac glycosides (hypokalemia increases toxicity risk), and diuretics (compounding electrolyte imbalances).

Yan Hu Suo (Corydalis) interactions: Contains tetrahydropalmatine and other alkaloids with analgesic and mild sedative properties. It may potentiate the effects of CNS depressants, sedatives, or opioid analgesics, and may interact with dopaminergic medications.

Hepatically metabolized drugs: Given the formula's strong action on liver circulation and its use in liver conditions, it may theoretically alter hepatic drug metabolism. Patients taking medications with narrow therapeutic windows that are liver-metabolized should use caution.

Contraindications

Avoid

Pregnancy. This formula contains multiple strong Blood-moving herbs (Tao Ren, Hong Hua, Dan Pi, Wu Ling Zhi) that can stimulate uterine contractions and risk miscarriage.

Avoid

Active hemorrhage or bleeding disorders. The formula's powerful Blood-moving action can worsen active bleeding from any cause, including heavy menstrual bleeding not caused by Blood stasis.

Caution

Blood deficiency without stasis. In patients who are primarily Blood-deficient (pale complexion, dizziness, thin pulse) without clear signs of Blood stasis, this formula's strong dispersing action can further deplete Blood.

Caution

Patients on anticoagulant or antiplatelet therapy. The Blood-invigorating herbs may potentiate the effects of blood-thinning medications and increase bleeding risk.

Caution

Qi deficiency-predominant patterns. In significantly Qi-deficient patients, the moving and dispersing nature of this formula may further exhaust the body's Qi. If used, tonifying herbs such as Huang Qi should be added.

Caution

Pre-surgical and post-surgical patients. Should be discontinued at least 1-2 weeks before scheduled surgery due to its Blood-moving properties, and not resumed until adequate post-surgical healing.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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