Formula

Xue Fu Zhu Yu Tang

Persica & Carthamus Combination | 血府逐瘀汤

Also known as:

Drive Out Stasis from the Mansion of Blood Decoction , Blood Mansion Eliminating Stasis Decoction , Persica & Carthamus Formula

Key Ingredients

Tao Ren, Hong Hua

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula designed to improve blood circulation in the chest, relieve pain, and ease emotional tension. It is widely used for chronic chest pain, stubborn headaches, insomnia, and irritability caused by poor blood flow and stagnation in the upper body.

Formula Category

Main Actions

  • Invigorates Blood and dispels stasis
  • Moves Qi and alleviates pain
  • Opens the chest and disperses stagnation
  • Soothes the Liver and resolves constraint
  • Guides Blood downward

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xue Fu Zhu Yu Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Xue Fu Zhu Yu Tang addresses this pattern

This is the primary pattern the formula was designed to treat, what Wang Qing-Ren called 'Blood stasis in the blood mansion of the chest' (胸中血府血瘀). The chest is where Qi gathers and Blood collects, and it is also a region traversed by the Liver channel. When Blood becomes stagnant in this area, it blocks Qi circulation, prevents clear Yang from rising, and over time generates Heat. The formula's King herbs (Tao Ren and Hong Hua) directly break up stasis, the Deputy herbs (Chi Shao, Chuan Xiong, Niu Xi) reinforce Blood movement and draw stasis downward, the Qi-regulating assistants (Chai Hu, Jie Geng, Zhi Ke) open chest Qi stagnation so Blood can flow, and the Blood-nourishing assistants (Dang Gui, Sheng Di Huang) ensure healthy Blood is replenished as stasis is cleared.

A practitioner would look for one or more of these signs

Chest Pain

Fixed, stabbing pain in the chest that persists over time

Headaches

Chronic headache with fixed location, needle-like quality

Insomnia

Difficulty sleeping, restless sleep with many dreams

Palpitations

Heart palpitations or a sensation of the heart racing

Hiccups

Persistent hiccups that do not respond to usual treatments

Irritability

Sudden irritability and emotional agitation

Afternoon Fever

Low-grade fever that worsens in the evening (tidal fever)

How It Addresses the Root Cause

The core disease mechanism addressed by Xue Fu Zhu Yu Tang is Blood stasis obstructing the chest (胸中血瘀证), with concurrent Qi stagnation. In TCM, the chest is described as the 'meeting place of Qi' and the 'gathering place of Blood,' and it is the territory through which the Liver channel traverses. When Blood becomes stagnant in this region, several interconnected problems develop.

First, stagnant Blood physically obstructs the flow of Qi, creating a vicious cycle: stagnant Blood impedes Qi movement, and stagnant Qi in turn makes the Blood even more sluggish. This obstruction of both Qi and Blood in the chest produces the hallmark symptom of fixed, stabbing chest pain. The blocked Qi cannot rise properly to the head, causing chronic headache with a piercing, fixed quality. When chest stasis affects the Stomach, the Stomach's normal downward movement reverses, producing persistent hiccups, dry retching, or choking when drinking water.

Second, when Blood stasis lingers, it generates Heat over time (瘀久化热). This internal Heat causes restlessness, a sensation of internal burning ('lantern disease'), and a characteristic pattern of tidal fever that worsens in the evening. When this stasis-generated Heat disturbs the Heart and its housing of the Spirit (心神), it leads to palpitations, insomnia, and vivid dreams. Meanwhile, prolonged stagnation constrains the Liver's ability to maintain the smooth flow of emotions, causing irritability and mood changes. The visible signs of Blood stasis, such as dark lips, darkened complexion around the eyes, a dark-purple tongue with possible stasis spots, and a choppy or wiry-tight pulse, all confirm that Blood is not circulating freely.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly pungent and bitter with a sweet undertone. The pungent quality moves Qi and Blood, the bitter quality directs downward and clears stasis-Heat, and the sweet quality harmonizes and nourishes to prevent damage from the moving herbs.

Target Organs
Heart Liver Lungs
Channels Entered
Heart Liver Lung

Formula Origin

Yi Lin Gai Cuo (《医林改错》, Corrections of Errors in Medical Works) by Wang Qing-Ren (王清任)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Xue Fu Zhu Yu Tang

Detailed information about each herb in Xue Fu Zhu Yu Tang and their roles

Kings
Deputies
Assistants
Envoys
Tao Ren
Tao Ren

Peach kernels

Dosage: 12g

Temperature Neutral
Taste Bitter, Sweet
Organ Affinity Heart, Large Intestine, Liver
Parts Used Dried ripe seed
Role in Xue Fu Zhu Yu Tang

Breaks up Blood stasis, disperses accumulations in the chest, and moistens dryness. Has the highest dosage in the formula, underscoring its role as the primary Blood-moving agent targeting the blood mansion (chest).

Hong Hua
Hong Hua

Safflowers

Dosage: 9g

Temperature Warm
Taste Pungent
Organ Affinity Heart, Liver
Parts Used Dried flower
Role in Xue Fu Zhu Yu Tang

Invigorates Blood circulation and dispels stasis with a faster and more vigorous action. Together with Tao Ren, forms the core stasis-breaking pair that directly addresses the primary pathology of Blood stagnation.

Chi Shao
Chi Shao

Red peony roots

Dosage: 6g

Temperature Cool
Taste Bitter
Organ Affinity Liver
Parts Used Dried root
Role in Xue Fu Zhu Yu Tang

Reinforces the King herbs in moving Blood and dispelling stasis while also cooling the Blood. Helps clear the Heat that develops from prolonged Blood stagnation.

Chuan Xiong
Chuan Xiong

Szechuan lovage roots

Dosage: 5g

Temperature Warm
Taste Pungent
Organ Affinity Gallbladder, Liver, Pericardium
Parts Used Dried rhizome
Role in Xue Fu Zhu Yu Tang

A key Blood-moving herb that also circulates Qi within the Blood. Its ascending and dispersing nature directs its action to the upper body and head, helping address headache from Blood stasis.

Niu Xi
Niu Xi

Achyranthes roots

Dosage: 9g

Temperature Neutral
Taste Bitter, Sour
Organ Affinity Kidneys, Liver
Parts Used Dried root
Role in Xue Fu Zhu Yu Tang

Invigorates Blood and unblocks the vessels. Its uniquely descending nature draws stagnant Blood downward and out of the chest, preventing Blood from pooling in the upper body. Balances the ascending actions of Jie Geng and Chai Hu.

Dang Gui
Dang Gui

Dong quai

Dosage: 9g

Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Liver, Spleen
Parts Used Dried root
Role in Xue Fu Zhu Yu Tang

Nourishes Blood while also gently moving it, helping to generate new Blood to replace what stasis has damaged. Prevents the strong Blood-breaking herbs from depleting the body's Blood supply.

Shu Di huang
Shu Di huang

Prepared rehmannia

Dosage: 9g

Temperature Warm
Taste Sweet
Organ Affinity Kidneys, Liver
Parts Used Prepared dried root tuber
Role in Xue Fu Zhu Yu Tang

Cools the Blood and clears Heat generated by prolonged stagnation. Also nourishes Yin and Blood, working alongside Dang Gui to ensure that vigorous stasis-dispelling does not injure the body's vital fluids.

Jie Geng
Jie Geng

Platycodon roots

Dosage: 5g

Temperature Neutral
Taste Bitter, Pungent
Organ Affinity Lungs
Parts Used Dried root
Role in Xue Fu Zhu Yu Tang

Opens and lifts the Lung Qi, directing the formula's actions upward into the chest (the 'blood mansion'). Paired with Zhi Ke, creates an ascending-descending dynamic that opens chest Qi stagnation. Also serves a guiding (Envoy) function by carrying the other herbs upward to the target area.

Zhi Ke
Zhi Ke

Bitter oranges

Dosage: 6g

Temperature Warm
Taste Bitter, Pungent, Sour
Organ Affinity Spleen, Stomach
Parts Used Dried ripe fruit
Role in Xue Fu Zhu Yu Tang

Regulates Qi and widens the chest. Its descending, dispersing action paired with the ascending Jie Geng creates a one-up-one-down Qi dynamic that breaks open Qi stagnation in the chest, allowing Blood to flow freely.

Chai Hu
Chai Hu

Bupleurum roots

Dosage: 3g

Temperature Cool
Taste Bitter
Organ Affinity Gallbladder, Liver
Parts Used Dried root and rhizome
Role in Xue Fu Zhu Yu Tang

Soothes and spreads the Liver Qi, relieves constraint, and lifts the clear Yang. Because the chest is the domain of the Liver channel, freeing Liver Qi is essential for resolving chest Blood stasis. Together with Zhi Ke and Jie Geng, comprehensively regulates Qi flow so that Qi movement can drive Blood circulation.

Gan Cao
Gan Cao

Liquorice

Dosage: 3g

Temperature Neutral
Taste Sweet
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Dried root and rhizome
Role in Xue Fu Zhu Yu Tang

Harmonizes all the herbs in the formula, moderating their actions and protecting the Stomach from potential irritation by the Blood-moving herbs.

Modern Research (4 studies)

  • Systematic Review and Meta-Analysis: Efficacy and Safety of Xue-Fu-Zhu-Yu Decoction for Coronary Heart Disease (2021)
  • Systematic Review and Meta-Analysis: Effectiveness and Safety of Xuefu Zhuyu Tang for Post-Stroke Depression (2020)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Take warm, twice daily (morning and evening), ideally 30-60 minutes after meals. The original text from Wang Qingren specifies that the decoction should be taken warm, never cold, as Blood stasis worsens with cold.

Typical Duration

Typically prescribed for 2-4 weeks initially, then reassessed. Acute conditions (e.g. post-traumatic chest pain) may respond in 3-7 days. Chronic conditions (e.g. long-standing headache, coronary heart disease) may require 4-8 weeks or longer with periodic reassessment.

Dietary Advice

Avoid cold and raw foods, iced drinks, and frozen desserts while taking this formula. Cold congeals Blood and can counteract the formula's Blood-moving action. Wang Qingren's original instructions emphasize that the decoction should be taken warm, never cold. Avoid greasy, heavy, and deep-fried foods that create Dampness and Phlegm, which can further obstruct Qi and Blood circulation. Foods that gently support blood circulation are beneficial: small amounts of vinegar, turmeric, hawthorn berries (shan zha), dark leafy greens, and moderate red wine are traditionally considered compatible. Avoid excessive alcohol consumption, which can generate Heat and interfere with the formula's balanced cooling and moving actions. Avoid overeating, as a full Stomach impedes Qi flow in the chest.

Modern Usage

Xue Fu Zhu Yu Tang is frequently utilized in Fertility Cycle Therapy during the menstrual period (days 1 to 5). This recommendation is based on guidelines from TCM Gynecological Technology and Chinese Herbal Formula sources.

Special Populations

Pregnancy

Contraindicated. This formula contains several strongly Blood-moving herbs that pose significant risks during pregnancy. Tao Ren (Peach Kernel) and Hong Hua (Safflower) are the chief herbs and are both classically categorized as contraindicated in pregnancy due to their ability to break up Blood stasis and potentially stimulate uterine contractions. Niu Xi (Achyranthes Root) is specifically noted for its downward-directing and Blood-moving actions, and is traditionally listed among herbs that can induce miscarriage. Chuan Xiong and Chi Shao also contribute significant Blood-moving effects. The cumulative action of these ingredients makes this formula unsafe for use at any stage of pregnancy. If a pregnant patient presents with Blood stasis symptoms, a qualified practitioner must select alternative approaches with much milder Blood-regulating herbs and careful monitoring.

Breastfeeding

Use with caution during breastfeeding. While the formula does not contain known lactation-suppressing or clearly toxic herbs, several of its Blood-moving ingredients (Tao Ren, Hong Hua, Chuan Xiong) have bioactive compounds that may transfer into breast milk. The clinical significance of this transfer is not well established. Gan Cao (Licorice) is present in this formula and can affect hormonal balance, though it is used in a small dose here. If Blood stasis symptoms are present in a breastfeeding mother, a practitioner should use the lowest effective dose, monitor the infant for any unusual signs (digestive upset, unusual sleepiness), and consider shortening the treatment course. Avoid concurrent use with medications that affect bleeding or clotting.

Pediatric Use

This formula is not commonly used in pediatric practice and requires careful consideration before use in children. Wang Qingren's original text does mention that the formula can address night crying in infants (小儿夜啼), suggesting he used it in pediatric cases, but this was in the specific context of Blood stasis patterns. If used in children, dosage should be significantly reduced based on age and body weight: roughly 1/4 to 1/3 of the adult dose for children aged 6-12, and even less for younger children. The strong Blood-moving herbs (Tao Ren, Hong Hua) may need to have their proportions reduced relative to other ingredients. This formula should not be used in children without confirmed Blood stasis signs (fixed pain, dark tongue, visible vascular markings). Pediatric use should be supervised by an experienced practitioner and limited to the shortest effective course.

Drug Interactions

Anticoagulant and antiplatelet medications (warfarin, heparin, aspirin, clopidogrel, rivaroxaban, apixaban): This is the most clinically significant interaction. Multiple herbs in this formula have demonstrated anticoagulant and antiplatelet effects. Tao Ren (Peach Kernel) has been shown in animal studies to have antithrombotic and anticoagulant properties. Hong Hua (Safflower) contains hydroxysafflor yellow A, which inhibits platelet aggregation. Chuan Xiong has antiplatelet and vasodilatory effects. Dang Gui (Angelica) contains ferulic acid and coumarin-like compounds that may enhance anticoagulant effects. Combined use may significantly increase bleeding risk and requires close monitoring of INR and other coagulation parameters.

Antihypertensive medications: The formula's vasodilatory effects (through Chuan Xiong, Chi Shao, and other Blood-moving herbs) may have additive effects with antihypertensive drugs, potentially causing excessive blood pressure lowering. Blood pressure should be monitored if used concurrently.

Gan Cao (Licorice) related interactions: Although present in a small dose (3g), Gan Cao contains glycyrrhizin which may interact with corticosteroids (potentiating effects), digoxin (via hypokalemia risk with prolonged use), diuretics (additive potassium loss), and antihypertensives (fluid retention may counteract blood pressure lowering).

Contraindications

Avoid

Pregnancy: This formula contains multiple herbs that strongly move Blood (Tao Ren, Hong Hua, Chuan Xiong, Niu Xi, Chi Shao), which may stimulate uterine contractions or cause bleeding. Niu Xi in particular is classically listed as contraindicated in pregnancy.

Avoid

Active hemorrhage or bleeding disorders: The formula's strong Blood-moving action could worsen any active bleeding, including heavy menstrual bleeding, gastrointestinal bleeding, or hemorrhagic stroke.

Caution

Patients on anticoagulant or antiplatelet therapy (warfarin, heparin, aspirin, clopidogrel): Multiple herbs in this formula have demonstrated antiplatelet and anticoagulant effects in pharmacological studies, posing a risk of additive bleeding. Close medical supervision is essential if combined use is unavoidable.

Caution

Patients with Qi deficiency or general debility who lack a clear Blood stasis pattern. The formula is predominantly dispersing and moving in nature, and can further deplete someone already weak.

Caution

Patients with Yin deficiency or Blood deficiency without concurrent Blood stasis. Although the formula contains Dang Gui and Sheng Di Huang to protect the Blood, its primary action is dispersing, which may consume Yin and Blood if stasis is not the main issue.

Caution

Planned surgery within 1-2 weeks: Due to the formula's anticoagulant and antiplatelet properties, it should be discontinued before elective surgical procedures to reduce bleeding risk.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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