Formula

Dang Gui Si Ni Tang

Dang Gui Four Decoction | 当归四逆汤

Also known as:

Dong Quai Frigid Extremities formula , Dong Quai Decoction for Frigid Extremities , Angelica Four Rebellious Decoction , Tangkuei Decoction for Frigid Extremities

Properties

Interior-warming formulas · Warm

Key Ingredients

Dang Gui, Gui Zhi

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula*

Traditional Chinese Medicine background and properties

Formula Description*

A classical warming formula used to improve circulation to the hands and feet and relieve cold-related pain. It works by nourishing the Blood and warming the channels when poor Blood supply and Cold cause the extremities to feel icy, numb, or painful. Commonly used for conditions such as Raynaud's disease, chilblains, menstrual cramps, and joint pain that worsen in cold weather.

Formula Category*

Main Actions*

  • Warms the Channels and Disperses Cold
  • Nourishes Blood and Unblocks the Vessels
  • Promotes blood circulation through the meridians
  • Dispels Cold and Alleviates Pain

TCM Patterns*

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Dang Gui Si Ni Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Dang Gui Si Ni Tang addresses this pattern

This is the primary pattern treated by Dang Gui Si Ni Tang. When the Blood is deficient, it cannot adequately fill and warm the vessels. If Cold then invades the channels (from external exposure or internal weakness), it congeals the already insufficient Blood, further blocking circulation. The result is that warming Qi cannot reach the extremities, producing cold hands and feet, and the Blood vessels become so poorly filled that the pulse grows thin and nearly imperceptible. Dang Gui and Bai Shao directly address the Blood deficiency by nourishing and replenishing Blood. Gui Zhi and Xi Xin target the Cold stagnation by warming the channels and dispersing the pathogenic Cold. Tong Cao opens the vessels to facilitate flow, while Da Zao and Zhi Gan Cao support the Spleen to ensure ongoing Blood production. The formula resolves both root (Blood deficiency) and branch (Cold stagnation) simultaneously.

A practitioner would look for one or more of these signs

Cold Extremities

Cold hands and feet, typically from the fingers/toes up to the wrists/ankles, not extending past elbows/knees

Faint Pulse

Pulse thin (细) and nearly imperceptible (欲绝)

Dull Pale Complexion

Pallid face reflecting Blood deficiency

Pale Tongue

Pale tongue body with thin white coating

Lumbar Pain

Pain in the lower back, hips, legs, feet, or shoulders worsened by cold

Thirst

Absence of thirst, indicating no internal Heat

How It Addresses the Root Cause*

The pattern this formula addresses arises from a combination of two factors: a person who is constitutionally Blood-deficient, and the invasion of Cold into the channels and meridians. In TCM, Blood is responsible for warming, moistening, and nourishing the tissues. When Blood is insufficient, the vessels become underfilled, and the body's warming capacity is weakened. If Cold then lodges in the channels (the pathways through which Qi and Blood circulate), it causes the blood to congeal and stagnate. The result is a kind of traffic jam: Qi and Blood cannot flow outward to reach the hands and feet, so they become icy cold.

A critical distinction is that in this pattern, the Cold is in the channels, not in the organs. The body's core Yang (its deep warming fire) is not collapsed. This is why the coldness is relatively mild, only reaching from the fingers to the wrists and from the toes to the ankles, unlike the severe, life-threatening coldness past the elbows and knees seen when core Yang fails. The pulse is thin (reflecting Blood deficiency) and nearly imperceptible (reflecting poor flow), but it is not faint or hollow as it would be in true Yang collapse. This fundamental difference in disease location explains why the treatment uses Blood-nourishing and channel-warming herbs rather than the drastic Yang-rescuing approach of Si Ni Tang.

Because the Liver stores Blood and governs the sinews, and the Jue Yin (Liver) channel circulates to the extremities, this condition is discussed in the Jue Yin disease chapter of the Shang Han Lun. When Liver Blood is insufficient and the Jue Yin channel is invaded by Cold, pain in the limbs, lower back, and legs may accompany the cold extremities. In women, the same mechanism of Blood deficiency with Cold stagnation can affect the uterus, producing painful periods and menstrual irregularity.

Formula Properties*

Temperature

Warm

Taste Profile

Predominantly sweet and acrid (pungent). The sweet taste from Dang Gui, Bai Shao, Da Zao, and Gan Cao nourishes Blood and supports the middle; the acrid taste from Gui Zhi, Xi Xin, and Dang Gui disperses Cold and promotes circulation through the channels.

Target Organs
Liver Heart Spleen
Channels Entered
Liver Heart Spleen

Formula Origin

Shāng Hán Lùn (傷寒論, Treatise on Cold Damage) by Zhāng Zhòngjǐng

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Supplier Information

Treasure of the East

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Ingredients in Dang Gui Si Ni Tang

Detailed information about each herb in Dang Gui Si Ni Tang and their roles

Kings
Deputies
Assistants
Envoys
Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 9 - 12g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Dang Gui Si Ni Tang

Nourishes and invigorates Blood, addresses the underlying Blood deficiency that is the root of this pattern. As a sweet, warm herb entering the Liver channel, it both replenishes depleted Blood and gently moves stagnation in the vessels.

Gui Zhi
Gui Zhi

Cinnamon twig

Dosage: 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder
Parts Used Twig (枝 zhī)
Role in Dang Gui Si Ni Tang

Warms the channels and disperses Cold, promoting the smooth flow of Blood through the vessels. Its acrid, warm nature opens the meridians and restores circulation to the cold extremities.

Bai Shao
Bai Shao

White peony root

Dosage: 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Dang Gui Si Ni Tang

Nourishes Blood and harmonizes the nutritive Qi (Ying Qi). Assists Dang Gui in replenishing Blood to fill the vessels, and paired with Gui Zhi harmonizes the protective and nutritive layers of the body.

Xi Xin
Xi Xin

Wild Ginger

Dosage: 3g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Lungs, Kidneys
Parts Used Root (根 gēn)
Role in Dang Gui Si Ni Tang

Disperses Cold from both the exterior and interior, penetrating deeply through the channels. Assists Gui Zhi in warming the meridians and driving out Cold that is congealing the Blood.

Tong Cao
Tong Cao

Rice paper pith

Dosage: 6g

Temperature Slightly Cool
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Lungs, Stomach
Parts Used Stem (茎 jīng)
Role in Dang Gui Si Ni Tang

Opens and unblocks the channels and vessels to facilitate the smooth flow of Blood and Qi. Its light, ascending nature helps the warming herbs reach throughout the meridian network. Note: the original Shang Han Lun used Mu Tong (木通); modern practice often substitutes Tong Cao due to safety concerns.

Da Zao
Da Zao

Jujube fruit

Dosage: 8 - 25g (or 8 - 25 pieces)

Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Dang Gui Si Ni Tang

Tonifies Spleen Qi and nourishes Blood, supporting the body's ability to generate new Blood. Used in large quantity (doubled from the parent Gui Zhi Tang formula) to both strengthen the Blood-nourishing effect of Dang Gui and Bai Shao, and to moderate the drying, acrid nature of Gui Zhi and Xi Xin so they do not injure Yin and Blood.

Gan Cao
Gan Cao

Licorice root

Dosage: 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Dang Gui Si Ni Tang

Tonifies Spleen Qi to support Blood production, and harmonizes all the herbs in the formula. Its sweet, warm nature assists the warming herbs in their action while tempering any harshness.

Modern Research (4 studies)

  • Systematic review and meta-analysis: Modified Danggui Sini Decoction as adjuvant therapy for angina pectoris in coronary heart disease (2024)
  • Systematic review and meta-analysis: Jueyin disease theory in the treatment of gangrene with TCM formulations (2025)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Warm, 30 minutes before meals, divided into 2-3 doses per day. The classical method specifies taking it warm (温服) three times daily.

Typical Duration

Acute conditions (e.g. frostbite, acute cold-limb episodes): 3-7 days. Chronic conditions (e.g. Raynaud's, chronic cold extremities, dysmenorrhea): 2-4 weeks per course, reassessed by a practitioner before continuing.

Dietary Advice

Avoid cold and raw foods, iced drinks, and cold-natured foods (such as raw salads, watermelon, pear, crab, and bitter melon) while taking this formula, as these can aggravate Cold stagnation in the channels and counteract the warming effects. Favor warm, cooked, and easily digestible foods. Beneficial additions include ginger tea, lamb or chicken broth, cinnamon, red dates, and warming spices. These support the formula's strategy of warming the channels and nourishing Blood. Avoid excessively greasy or heavy foods that may impair Spleen function and obstruct the generation of new Blood. Moderate consumption of rice wine (or a small amount of warm wine) is traditionally considered compatible, as it helps promote blood circulation.

Modern Usage*

Dang Gui Si Ni Tang can also be used to treat dysmenorrhea or chilblains caused by Blood Deficiency and Cold coagulation in women. Additionally, it is effective for treating cold hernia in the Liver Channel, which can cause symptoms such as cold pain in the lower abdomen with testicular retraction. It can also be for Dysmenorrhea, Urticaria, Lumbar disc herniation, Migraine and Raynaud's disease.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Special Populations

Pregnancy

Use with caution during pregnancy. Gui Zhi (Cinnamon Twig) promotes Blood circulation and Xi Xin (Asarum) has a strongly dispersing nature, both of which theoretically could stimulate uterine activity. Dang Gui (Angelica sinensis) also moves Blood and is traditionally used with care in pregnancy, particularly in the early stages. Tong Cao/Mu Tong has mild diuretic properties that require monitoring. While the formula is not categorically contraindicated (it does not contain strong abortifacients like Fu Zi or Da Huang), it should only be used during pregnancy under direct supervision of a qualified practitioner, and only when the Blood deficiency with Cold pattern is clearly confirmed and the clinical benefit outweighs potential risk.

Breastfeeding

Generally considered compatible with breastfeeding when used at standard therapeutic doses for short durations under professional guidance. Xi Xin (Asarum) is a potent herb used in small doses in this formula (typically 3g), and its volatile aromatic compounds could theoretically pass into breast milk and affect the nursing infant. Gui Zhi (Cinnamon Twig) and Dang Gui (Angelica) are mild herbs commonly used in postpartum recovery formulas in TCM tradition and are not considered problematic. However, there is no modern pharmacokinetic data on breast milk transfer for these herbs specifically. If the mother notes any unusual fussiness, loose stools, or feeding changes in the infant, the formula should be discontinued and a practitioner consulted.

Pediatric Use

Dang Gui Si Ni Tang can be used in children, particularly for chilblains (frostbite) or cold-type limb pain, but dosages must be significantly reduced according to the child's age and body weight. A common approach is to use one-third to one-half of the adult dose for children aged 6-12, and one-quarter for children under 6. Xi Xin (Asarum) requires particular caution in pediatric use due to its potency; the standard adult dose of 3g should be reduced proportionally. The formula is generally not recommended for infants under 1 year of age without specific guidance from a pediatric TCM specialist. As always with children, the prescription should be reassessed frequently and discontinued once symptoms resolve.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with Empty Heat due to Yin Deficiency should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.