Hua Rui Shi San

Ophicalcite Powder · 花蕊石散

Also known as: Hua Rui Shi Dan (花蕊石丹)

A powerful emergency formula used to stop severe bleeding caused by internal Blood stasis. It works by dissolving clotted, congealed Blood so that the body's vessels can heal and close. Originally designed for life-threatening situations such as massive hemorrhage from organ damage, postpartum blood loss with retained clots, and traumatic wounds, it combines two calcined minerals that warm and transform stasis. Because of its intensity, it is always followed by a restorative formula to rebuild the body's strength.

Origin Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方, Imperial Grace Formulary of the Tai Ping Era) — Sòng dynasty, first published ~1078-1151 CE
Composition 2 herbs
Hu
King
Hua Rui Shi (花蕊石, Ophicalcitum)
Liu Huang
Deputy
Liu Huang
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Hua Rui Shi San is designed to correct these specific patterns.

Why Hua Rui Shi San addresses this pattern

Hua Rui Shi San directly addresses Blood stasis by using the unique stasis-transforming power of calcined Ophicalcite. In this formula, Hua Rui Shi dissolves congealed Blood (making it turn into a yellowish fluid), while Liu Huang provides the Yang-warming force needed to drive stasis out when it has congealed due to Cold or Yang deficiency. The formula is particularly suited for acute, severe Blood stasis manifesting as hemorrhage, where the stasis itself is the cause of ongoing bleeding. This paradox, where stasis causes bleeding, is a key TCM insight: when old Blood blocks the vessels, fresh Blood cannot follow its proper course and spills out. By dissolving the obstruction, the formula restores normal Blood flow and stops the hemorrhage.

A practitioner would look for one or more of these signs

Hemoptysis

Coughing up large volumes of blood, especially from damaged internal organs

Hematemesis

Vomiting blood in large quantities, blood dark or clotted

Bleeding

Postpartum hemorrhage with retained lochia or clots

Bruising

Dark purple bruising with sharp pain from trauma, indicating internal Blood stasis

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Hua Rui Shi San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Blood Stasis Yang Deficiency with Cold-Damp

TCM Interpretation

In TCM, postpartum hemorrhage is often understood as a condition where 'old Blood' (lochia, clots, retained tissue) obstructs the uterine vessels, preventing them from closing properly. This creates a paradox: the stasis blocks normal healing, and fresh Blood continues to leak out around the obstruction. The underlying mechanism frequently involves Yang deficiency. Childbirth depletes the mother's Qi and Yang, and without adequate warmth, Blood congeals rather than flowing smoothly out of the uterus. This stagnant 'dead Blood' can also cause blood syncope (血晕), where the woman loses consciousness, and can prevent the placenta from descending.

Why Hua Rui Shi San Helps

Hua Rui Shi San is specifically designed for this scenario. Hua Rui Shi dissolves the congealed stasis blocking the uterus, transforming it into a thin fluid the body can expel. Liu Huang provides intense Yang warmth to counteract the Cold congealing that caused the stasis. Together, they clear the obstruction so that retained tissue (lochia, placenta) can descend and the uterine vessels can properly contract. Classical sources describe cases where a woman after delivery had retained placenta with blood distension and loss of consciousness, and a single dose of this formula caused her to regain consciousness as the stasis transformed and the placenta was expelled. The formula should be followed by Du Shen Tang (solo Ginseng decoction) to replenish the Qi depleted by both the hemorrhage and the powerful stasis-transforming action.

Also commonly used for

Hematemesis

Vomiting blood due to internal organ damage with Blood stasis

Retained Placenta

Failure to deliver the placenta after childbirth, with Blood stasis blocking its descent

Stillbirth Complications

Dead fetus retained in the uterus due to Blood stasis and Cold congealing

Nosebleeds

Severe epistaxis from Blood stasis with Cold

What This Formula Does

Every TCM formula has a specific set of actions — here's what Hua Rui Shi San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Hua Rui Shi San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Hua Rui Shi San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Hua Rui Shi San works at the root level.

Hua Rui Shi San addresses bleeding that arises from Blood stasis obstructing the normal pathways of Blood circulation. In TCM theory, when Blood becomes stagnant, it can block the vessels and force fresh Blood to overflow out of its proper channels. The result is dramatic hemorrhage — coughing or vomiting large quantities of blood — yet the root problem is not simply that Blood is escaping, but that old stagnant Blood is blocking the way and preventing normal circulation.

This type of bleeding is particularly associated with consumptive disorders (lao sun, 劳损) and traumatic injuries, where damage to the organs or tissues causes Blood to congeal internally. In the context of the Shi Yao Shen Shu, the formula specifically targets the severe hemorrhage of lung consumption (fei lao, 肺痨), where repeated coughing injures the Lung's delicate vessels and stagnant Blood accumulates in the chest. The body cannot reabsorb this old Blood on its own, so new Blood continues to spill out. Cold may also contribute: when Yang is insufficient, it cannot properly move Blood, allowing it to congeal further.

The formula works by powerfully transforming the stagnant Blood — classical sources say it "turns blood into water" (化血为水) — thereby clearing the obstruction so that new Blood can flow in its proper pathways. Once stasis is dissolved, the bleeding stops naturally. However, because this is a forceful intervention that expends the body's resources, it must be followed by strong tonification (classically with Du Shen Tang) to replenish what was lost.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Warm

Taste Profile

Predominantly sour and astringent with a warm, pungent undercurrent — sour to astringe and stop bleeding, astringent to gather scattered Blood, with warmth from Sulfur (in the Ju Fang version) to dispel Cold stasis.

Channels Entered

Ingredients

2 herbs

The herbs that make up Hua Rui Shi San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
King — Main ingredient driving the formula
Hu

Hua Rui Shi (花蕊石, Ophicalcitum)

Dosage 500g (in the original combined preparation with Liu Huang)
Preparation Coarsely ground, then calcined together with Liu Huang in a sealed clay vessel overnight

Role in Hua Rui Shi San

The principal herb of the formula. Hua Rui Shi (Ophicalcite) has an astringent and sour nature that specializes in transforming Blood stasis and stopping bleeding. It can cause stagnant Blood to dissolve into a yellowish fluid that the body reabsorbs or expels, achieving hemostasis without trapping old Blood inside. It enters the Liver channel, which governs Blood storage.
Deputy — Assists and enhances the King
Liu Huang

Liu Huang

Sulfur

Dosage 120g (in the original combined preparation with Hua Rui Shi)
Temperature Warm
Taste Pungent
Organ Affinity Spleen, Kidneys, Large Intestine, Pericardium
Preparation Use bright, clear, high-quality sulfur. Coarsely ground and mixed evenly with Hua Rui Shi before calcination

Role in Hua Rui Shi San

Liu Huang is hot and acrid, entering the Kidney and Ming Men (Life Gate). It strongly warms the lower Jiao and reinforces Yang fire, helping to drive out Yin-Cold pathogenic forces that contribute to Blood congealing and stasis. When calcined together with Hua Rui Shi, the two minerals fuse, and the warming action of Liu Huang activates the stasis-transforming power of Hua Rui Shi. The combination creates a synergy that neither ingredient achieves alone.

Why This Combination Works

How the herbs in Hua Rui Shi San complement each other

Overall strategy

Hua Rui Shi San addresses hemorrhage caused by Blood stasis by simultaneously dissolving old congealed Blood and warming the body's Yang to restore the motive force that keeps Blood flowing in its proper channels. The strategy is to stop bleeding not through simple astringency, but by removing the underlying stasis that drives Blood out of the vessels.

King herb

Hua Rui Shi (Ophicalcite) is the King. Its sour and astringent nature enters the Liver channel, which governs Blood storage. Its unique ability is to 'transform Blood into water' (化血为水), meaning it dissolves static, congealed Blood into a thin yellowish fluid that can be reabsorbed or expelled. Unlike most Blood-moving herbs that risk further depleting Qi, Hua Rui Shi achieves stasis transformation through mineral astringency, making it simultaneously hemostatic and stasis-resolving.

Deputy herb

Liu Huang (Sulfur) is the Deputy. It is extremely hot and acrid, entering the Kidney and Ming Men. Its role is to provide the Yang warmth that powers Blood transformation. When Blood has congealed due to Cold or Yang deficiency, warmth is needed to 'melt' the stasis. The calcination process fuses the two minerals together, so that the warming fire of Liu Huang continuously drives Hua Rui Shi's stasis-dissolving action. Liu Huang also supplements the lower Jiao's fire, counteracting the Yin-Cold environment that allowed stasis to form in the first place.

Notable synergies

The calcination of the two minerals together is critical. The overnight firing at high heat creates a compound substance that is more than the sum of its parts. The delivery vehicle Tong Bian (boy's urine) has a salty and cold nature that descends downward, which serves two purposes: it directs the formula's action downward and inward to where the stagnant Blood resides, and it tempers the harsh, intensely hot nature of the two calcined minerals, preventing them from injuring the body's Yin fluids. The addition of wine (for men) or vinegar (for women) further customizes the formula by guiding it through the appropriate Blood channels.

How to Prepare

Traditional preparation instructions for Hua Rui Shi San

Combine coarsely ground Hua Rui Shi and Liu Huang, mixing them evenly. Line the inside of a clay (earthenware) jar with a paste of paper fiber and glue-thickened clay, large enough to hold the drug mixture. Once the clay lining has dried, place the mixed herbs inside. Seal the mouth of the jar tightly with clay and place in a drying oven until heated through.

Set the sealed jar on a platform of four bricks. Surround and cover it completely with charcoal (traditionally one 'cheng', approximately 15 kg). Starting around the si-wu period (9 AM to 1 PM), light the fire from the bottom and let the flame gradually rise to the top. If any charcoal falls away, replace it. Let the fire burn continuously through the night until all the charcoal is consumed and the fire dies out naturally. Wait another full night for the jar to cool completely before opening.

Remove the calcined product, grind it to a very fine powder, and sieve it through silk gauze. Store in a porcelain container with a tight lid.

Internal use: Take 3g (moderate cases) to 9g (severe cases) per dose, mixed into warmed Tong Bian (fresh boy's urine). For men, add an equal portion of rice wine to the Tong Bian. For women, add an equal portion of rice vinegar instead. Take after meals.

External use: Apply the fine powder directly onto the wound site for traumatic bleeding.

Important note: After the stagnant Blood has transformed and the acute bleeding has stopped, the patient should be followed up promptly with a strong Qi-supplementing formula such as Du Shen Tang (Ginseng Decoction) to replenish the Qi that was inevitably consumed during the hemorrhage.

Common Modifications

How practitioners adapt Hua Rui Shi San for specific situations

Added
Ren Shen

30g, decocted separately as Du Shen Tang (Solo Ginseng Decoction) and administered immediately after the formula takes effect

In blood syncope, the Qi has collapsed along with the Blood. After Hua Rui Shi San dissolves the stasis and revives consciousness, a large dose of Ren Shen must be given urgently to rescue the depleted Qi and prevent further collapse.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Hua Rui Shi San should not be used or requires extra caution

Avoid

Bleeding due to Blood Heat with no Blood stasis. The classical text Ben Cao Jing Shu specifically warns against using this formula when bleeding is caused by Fire flaring upward forcing Blood to overflow, rather than by internal injury with congealed Blood causing chest and diaphragm pain.

Avoid

Absence of Blood stasis. The Ben Cao Jing Shu states: 'When there is no stagnant Blood retained internally, do not take internally.' This formula is designed specifically for bleeding accompanied by stasis, and is inappropriate for deficiency-type bleeding without stasis.

Caution

Prolonged or excessive use. The Ben Cao Qiu Zhen warns that Hua Rui Shi is a forceful (劫) medicinal, and overuse can damage Yin and Blood. After bleeding stops, the patient should be supported with tonifying formulas such as Du Shen Tang (Unaccompanied Ginseng Decoction).

Caution

Yin deficiency with vigorous Fire. Sulfur (Liu Huang) in the Ju Fang version is strongly warming and toxic with prolonged use; patients with Yin deficiency and internal Heat should avoid this formula.

Avoid

Pregnancy. The formula is traditionally used to expel dead fetus and retained placenta, indicating its powerful Blood-moving properties, which pose a risk of inducing miscarriage.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated in pregnancy. Hua Rui Shi is traditionally indicated for expelling dead fetus and retained placenta, which demonstrates its powerful ability to move and break Blood stasis in the uterus. The Ben Cao Gang Mu explicitly states it can 'expel a dead fetus and release the placenta' (下死胎,落胞衣). In the Ju Fang version, Sulfur (Liu Huang) is also categorized as prohibited during pregnancy. These properties make the formula dangerous for pregnant women, as it may stimulate uterine contractions and cause miscarriage.

Breastfeeding

Use with caution during breastfeeding. Hua Rui Shi is a mineral substance (calcium/magnesium carbonate) and its components could potentially pass into breast milk. The Ju Fang version contains Sulfur (Liu Huang), which is classified as toxic and should not be used during lactation. Even the Shi Yao Shen Shu version, which uses Hua Rui Shi alone, is a powerful stasis-breaking agent that can deplete Yin and Blood, which may reduce breast milk production. If absolutely necessary for postpartum hemorrhage with stasis, use should be brief and under close practitioner supervision, with immediate transition to tonifying formulas afterward.

Children

Not generally appropriate for pediatric use. Hua Rui Shi San is a powerful emergency formula for severe hemorrhage with Blood stasis, a presentation uncommon in children. The classical dosage instructions and administration method (mixed with children's urine, wine, or vinegar) are designed for adults. The Ben Cao Qiu Zhen warns that Hua Rui Shi is a forceful (劫) medicinal that can damage Yin and Blood with overuse, making it especially unsuitable for children whose Yin and Blood are still developing. If a pediatric case of traumatic bleeding requires topical application of the powder, only minimal amounts should be used under strict practitioner supervision.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Hua Rui Shi San

Anticoagulant and antiplatelet medications: Hua Rui Shi San is a hemostatic formula designed to stop bleeding and transform Blood stasis. Its use alongside anticoagulants (warfarin, heparin) or antiplatelet drugs (aspirin, clopidogrel) could create unpredictable effects — potentially opposing the anticoagulant action or, paradoxically, increasing bleeding risk due to its stasis-breaking properties. Concurrent use should be avoided.

Sulfur toxicity (Ju Fang version): The version containing Liu Huang (Sulfur) should not be combined with Mang Xiao (Mirabilite/Glauber's salt), as this is a classical incompatibility (相反). Sulfur can also interact with medications metabolized through hepatic pathways, and prolonged internal use carries risk of cumulative toxicity.

Iron supplements and calcium-based medications: As a mineral-based formula rich in calcium carbonate, Hua Rui Shi may interfere with the absorption of tetracycline antibiotics, fluoroquinolones, iron supplements, and thyroid medications if taken simultaneously. A two-hour separation between doses is advisable.

Usage Guidance

Practical advice for getting the most out of Hua Rui Shi San

Best time to take

After meals (食后服下), as specified in the classical instructions. For acute hemorrhage, take immediately regardless of timing.

Typical duration

Acute/emergency use only: typically a single dose or 1–3 doses to stop active hemorrhage, followed immediately by tonifying formulas.

Dietary advice

During and after use, avoid cold and raw foods, as these may promote Blood congelation and counteract the formula's warming, stasis-transforming action. Avoid spicy, greasy, or heavily fried foods that could irritate the vessels and promote further bleeding. The classical instructions note that after the formula stops the bleeding, the patient should be supported with tonifying preparations (such as Du Shen Tang), suggesting a bland, easily digestible, nourishing diet with foods that support Blood production: well-cooked soups, congee, red dates, and dark leafy greens. Alcohol should be limited or avoided unless specifically prescribed as part of the formula's preparation method.

Hua Rui Shi San originates from Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方, Imperial Grace Formulary of the Tai Ping Era) Sòng dynasty, first published ~1078-1151 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Hua Rui Shi San and its clinical use

Shi Yao Shen Shu (十药神书) — Ge Kejiu:
「治五脏崩损,涌喷血成升斗:花蕊石火煅存性,研为末,用童便一盅,炖温,调末三钱,甚者五钱,食后服下。男子用酒一半,女人用醋一半,与童便和药服,使瘀血化为黄水,后以独参汤补之。」
Translation: "Treats collapse-damage of the five Zang organs with surging blood amounting to sheng or dou [large volumes]: Calcine Hua Rui Shi, retaining its properties, and grind to a powder. Use one cup of children's urine, warm it, and mix in three qian of the powder (five qian in severe cases), taken after meals. For men, mix with half wine; for women, mix with half vinegar, combined with children's urine to take the medicine. This causes stagnant blood to transform into yellow water. Afterwards, supplement with Du Shen Tang [Unaccompanied Ginseng Decoction]."

Ben Cao Gang Mu (本草纲目) — Li Shizhen:
「花蕊石,其功专于止血,能使血化为水,酸以收之也。而又能下死胎,落胞衣,去恶血。」
Translation: "Hua Rui Shi's action focuses on stopping bleeding; it can cause blood to transform into water, and its sour nature gathers and restrains. It can also expel a dead fetus, release the placenta, and eliminate malign blood."

Cheng Fang Bian Du (成方便读):
「花蕊石散为破血之峻剂,功专化血为水。花蕊石化其既瘀之血;硫黄补下焦之火,以祛阴邪,童便有降下之功,且以制二石之悍性耳。」
Translation: "Hua Rui Shi San is a forceful formula for breaking Blood, specializing in transforming blood into water. Hua Rui Shi transforms already-stagnant blood; Sulfur supplements the Fire of the Lower Burner to dispel Yin pathogenic factors; children's urine has a downward-directing action and also tempers the harsh nature of the two minerals."

Xue Zheng Lun (血证论):
「此药独得一气之偏,神于化血。他药行血,皆能伤气,此独能使血自化,而气不伤,真去瘀妙品。」
Translation: "This medicine uniquely obtains a special quality of Qi, miraculous in transforming blood. Other medicines that move blood all injure Qi, but this alone can cause blood to transform by itself without damaging Qi — a truly marvelous substance for removing stasis."

Historical Context

How Hua Rui Shi San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Hua Rui Shi San exists in two historically distinct versions. The earlier version appears in the Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), the Song dynasty government formulary first compiled around 1078–1085 CE. This version combines Hua Rui Shi (Ophicalcite, one liang) with Liu Huang (Sulfur, four liang), calcined together in a sealed clay pot, and is used both externally for traumatic wounds and internally (mixed with children's urine or wine) for internal bleeding and obstetric emergencies including postpartum hemorrhage, retained placenta, and fetal death.

The more celebrated version comes from the Shi Yao Shen Shu (十药神书, "Divine Book of Ten Remedies"), written by the Yuan dynasty physician Ge Kejiu (葛可久, given name Ge Qiansun 葛乾孙, c. 1305–1353). Ge Kejiu was from Changzhou (now Suzhou, Jiangsu), came from a medical family, and was renowned for treating consumptive bleeding disorders. His version uses Hua Rui Shi alone (calcined and ground), taken with warm children's urine after meals. In the Shi Yao Shen Shu, it is listed as the second formula (乙字, "yi" character) and is specifically designed for catastrophic hemoptysis in lung consumption (肺痨, pulmonary tuberculosis), where patients might cough up blood "by the sheng or dou" (measuring cups). The Shi Yao Shen Shu is considered China's earliest surviving monograph on pulmonary tuberculosis. The Qing dynasty master Ye Tianshi (叶天士) was noted for his skilled application of Ge Kejiu's ten formulas in clinical practice.

The formula also has an alias Hua Rui Shi Dan (花蕊石丹) recorded in the Jiu Shang Mi Zhi (救伤秘旨). Various later texts expanded on the formula by combining Hua Rui Shi with other trauma and Blood-moving herbs for surgical and bone-injury applications.