Dang Gui San

Dang Gui Powder · 当归散

Also known as: An Tai Wan (安胎丸, Fetus-Calming Pill), Wu Wei An Tai Wan (五味安胎丸, Five-Ingredient Fetus-Calming Pill), Shao Yao Tang (芍药汤, Peony Decoction)

A traditional Chinese herbal formula from the Jin Gui Yao Lue (Essential Prescriptions of the Golden Cabinet), used during pregnancy to nourish blood, clear heat, and prevent miscarriage. It is commonly taken to support a healthy pregnancy, especially for women with a history of miscarriage or symptoms of vaginal bleeding and abdominal pain.

Origin Jin Gui Yao Lue (金匮要略) by Zhang Zhong Jing — Eastern Han dynasty, ~200 CE
Composition 5 herbs
Dang Gui
King
Dang Gui
Huang Qin
Deputy
Huang Qin
Bai Shao
Assistant
Bai Shao
Chuan Xiong
Assistant
Chuan Xiong
Bai Zhu
Envoy
Bai Zhu
Explore composition

Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Dang Gui San is designed to correct these specific patterns.

Why Dang Gui San addresses this pattern

Dang Gui San directly supplements Blood with Dang Gui and Bai Shao, the core Blood-tonifying pair. This addresses the root cause of fetal malnourishment and instability. Blood Deficiency often leads to Empty Heat, which Huang Qin clears, while Bai Zhu supports the Spleen to generate new Blood.

A practitioner would look for one or more of these signs

Pale Complexion

Pale or sallow complexion from Blood Deficiency

Vaginal Bleeding

Light vaginal bleeding during pregnancy

Lower Abdominal Pain

Dull, persistent lower abdominal pain

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Dang Gui San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

TCM Interpretation

In recurrent miscarriage, TCM often identifies a pattern of Blood Deficiency with underlying Heat. The mother's constitution may be weak, unable to supply enough Blood to sustain the embryo. Heat, whether from constitutional Yin deficiency or from Damp-Heat, further destabilizes the pregnancy. The Spleen, which generates Blood, may also be deficient, leading to a cycle of insufficient nourishment and fetal rejection.

Why Dang Gui San Helps

Dang Gui San directly replenishes Blood with Dang Gui and Bai Shao, ensuring the fetus receives adequate nourishment. Huang Qin clears the Heat that agitates the fetus, while Bai Zhu strengthens the Spleen to produce more Blood and prevent Dampness. The inclusion of Chuan Xiong moves Blood gently, ensuring that the tonifying herbs do not cause stagnation. This comprehensive approach stabilizes the pregnancy and reduces the likelihood of another loss.

Also commonly used for

Vaginal Bleeding

Stops uterine bleeding during pregnancy by cooling Blood and nourishing Yin

Irregular Menstruation

Regulates the cycle when Blood Deficiency with Heat leads to early or heavy periods

What This Formula Does

Every TCM formula has a specific set of actions — here's what Dang Gui San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Dang Gui San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Dang Gui San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Dang Gui San works at the root level.

During pregnancy, the mother's Blood nourishes the growing fetus. If the mother has underlying Blood Deficiency, the fetus loses its source of nourishment. This deficiency can generate Empty Heat, or pre-existing Damp-Heat may further disturb the Uterus. The combination of Blood Deficiency and Heat destabilizes the fetus, leading to restless fetus, abdominal pain, and vaginal bleeding. The Spleen, which produces Blood, may also be weakened, contributing to Dampness accumulation. This formula addresses the root (Blood Deficiency) and the branch (Heat and Dampness) to stabilize the pregnancy.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Cool

Taste Profile

Bitter and sweet with a hint of acrid; bitter to clear heat, sweet to tonify blood and spleen, acrid to move blood.

Channels Entered

Liver Spleen Ren Mai (任脉) Conception Vessel Chong Mai (冲脉) Penetrating Vessel

Ingredients

5 herbs

The herbs that make up Dang Gui San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
Envoy — Directs the formula to its target
King — Main ingredient driving the formula
Dang Gui

Dang Gui

Chinese Angelica root

Dosage 6 - 12g
Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen

Role in Dang Gui San

Nourishes Blood, regulates menstruation, and calms the fetus. The chief herb addressing Blood Deficiency.
Deputy — Assists and enhances the King
Huang Qin

Huang Qin

Baical skullcap root

Dosage 6 - 9g
Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach

Role in Dang Gui San

Clears Heat and dries Dampness, especially to calm the fetus by clearing Damp-Heat that disturbs the Uterus.
Assistants — Supports or moderates other herbs
Bai Shao

Bai Shao

White peony root

Dosage 6 - 12g
Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen

Role in Dang Gui San

Nourishes Blood, astringes Yin, and softens the Liver to alleviate abdominal pain and support the King herb.
Chuan Xiong

Chuan Xiong

Sichuan lovage rhizome

Dosage 3 - 9g
Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium

Role in Dang Gui San

Invigorates Blood and promotes Qi circulation, preventing the cloying nature of Blood-tonifying herbs and relieving pain.
Envoy — Directs the formula to its target
Bai Zhu

Bai Zhu

White Atractylodes rhizome

Dosage 6 - 12g
Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach

Role in Dang Gui San

Strengthens the Spleen and resolves Dampness, supporting the source of Blood production and directing the formula to the middle burner.

Why This Combination Works

How the herbs in Dang Gui San complement each other

Overall strategy

Dang Gui San is designed for pregnancy complicated by Blood Deficiency with Heat. It nourishes Blood to secure the fetus, clears Heat to remove the disturbance, and strengthens the Spleen to support Blood production, thereby preventing miscarriage.

King herbs

Dang Gui is the King herb. It is the primary Blood tonic in gynecology, entering the Liver, Heart, and Spleen channels. It directly supplements the Blood, ensuring the fetus is adequately nourished and the Uterus is stable.

Deputy herbs

Huang Qin is the Deputy. Its bitter, cold nature clears Heat and dries Dampness from the Uterus and the fetus. By removing the pathogenic Heat that agitates the fetus, it directly calms the pregnancy.

Assistant herbs

Bai Shao assists the King by nourishing Blood and astringing Yin. It also softens the Liver to relieve abdominal pain, a common symptom in threatened miscarriage. Chuan Xiong is a Blood-invigorating assistant that moves Qi and Blood. It prevents the cloying stagnation that can result from heavy Blood tonics and alleviates pain by promoting circulation.

Envoy herbs

Bai Zhu serves as the Envoy. It strengthens the Spleen to generate Blood and resolve Dampness, supporting the source of Blood production. It also guides the formula's action to the middle burner, harmonizing the entire composition.

Notable synergies

The pairing of Dang Gui and Bai Shao is a classic Blood-nourishing duo that also regulates menstruation and relieves pain. Huang Qin and Bai Zhu form a well-known pregnancy-safe pair that clears Heat and strengthens the Spleen, directly addressing two key factors in fetal instability.

How to Prepare

Traditional preparation instructions for Dang Gui San

Grind the five ingredients into a fine powder. Take 1.5 g of the powder per dose with warm wine, twice a day. In modern practice, it is also commonly prepared as a decoction with the above dosages, simmered in water for 20-30 minutes, and taken in two divided doses daily.

Common Modifications

How practitioners adapt Dang Gui San for specific situations

Added
E Jiao

9g, to nourish Blood and stop bleeding

Ai Ye

6g, to warm the Uterus and stop bleeding

E Jiao and Ai Ye are a classic pair for stabilizing the fetus and stopping bleeding. They enhance the formula's hemostatic effect without disrupting the Blood-nourishing and Heat-clearing actions.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Dang Gui San should not be used or requires extra caution

Avoid

Not for use during the first trimester of pregnancy due to potential uterine stimulation from Dang Gui (Angelica sinensis) and possible risk of fetal malformation.

Avoid

Not for use in threatened miscarriage with active bleeding, as the formula contains blood-moving herbs.

Caution

Not suitable for pregnant women with cold patterns or absence of heat signs; only indicated when blood deficiency with heat is present.

Caution

Caution in patients with diarrhea due to spleen deficiency and cold, as Dang Gui is moistening and Huang Qin is cold.

Caution

Not for patients with exterior syndromes (e.g., acute cold or flu) as the tonifying nature may trap pathogens.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Dāng Guī Sǎn is contraindicated for routine use during pregnancy, especially in the first trimester. It contains Dāng Guī (Angelica sinensis), a blood-moving herb that may stimulate uterine activity. Observational studies suggest an association between Dāng Guī consumption in early pregnancy and increased rates of certain congenital malformations. Commercial Dāng Guī products may also contain heavy metals. The formula should only be used under strict supervision of a qualified TCM practitioner for specific patterns (blood deficiency with heat) in the second or third trimester, and only when potential benefits clearly outweigh risks and herb quality is verified.

Breastfeeding

No specific data on breast milk transfer exists for the herbs in this formula. However, Dāng Guī Sǎn is classically indicated for postpartum conditions, suggesting traditional acceptance during breastfeeding. Given the lack of modern safety evidence, caution is advised. Consult a TCM practitioner before use while nursing.

Children

Not commonly used in children. If employed for pediatric blood deficiency with heat, dosage must be adjusted based on weight under professional guidance.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Dang Gui San

No well-documented drug interactions exist. Dāng Guī may have mild anticoagulant effects, so caution is advised if combined with anticoagulant or antiplatelet medications. Huáng Qín (Scutellaria baicalensis) may influence cytochrome P450 enzymes in vitro, but clinical significance is unknown. Always consult a healthcare provider before concurrent use with prescription medications.

Usage Guidance

Practical advice for getting the most out of Dang Gui San

Best time to take

Take twice daily, traditionally with a small amount of rice wine or warm water. Best taken after meals to minimize potential stomach irritation.

Typical duration

As directed by a TCM practitioner. For pregnancy stabilization, it may be taken for weeks or months during the second and third trimesters under close supervision. For non-pregnancy conditions such as irregular menstruation, duration varies with response.

Dietary advice

Avoid cold, raw foods and dairy products that may generate dampness and impair spleen function. Minimize greasy, spicy, or heating foods that could exacerbate heat patterns. Favor warm, easily digestible foods to support the spleen's role in producing blood.

Dang Gui San originates from Jin Gui Yao Lue (金匮要略) by Zhang Zhong Jing Eastern Han dynasty, ~200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Dang Gui San and its clinical use

Source text from Jīn Guì Yào Lüè (金匮要略), Chapter on Pregnancy Diseases:

妇人妊娠,宜服当归散方。当归、黄芩、芍药、川芎各一斤,白术半斤。右五味,杵为散。酒饮服方寸匕,日再服。妊娠常服即易产,胎无苦疾,产后百病悉主之。

Translation: A pregnant woman should take Dāng Guī Sǎn. Dāng Guī, Huáng Qín, Sháo Yào, Chuān Xiōng, one jīn of each; Bái Zhú, half a jīn. Grind the five ingredients into a powder. Take one fāng cùn bǐ with wine, twice daily. If taken regularly during pregnancy, it facilitates easy labor, the fetus suffers no distress, and it governs all postpartum diseases.


From Jīn Guì Yào Lüè Xīn Diǎn (金匮要略心典) by Yóu Zàijīng:

妊娠之后,最虑湿热伤动胎气,故于芎、归、芍药养血之中,用白术除湿,黄芩除热。丹溪称黄芩、白术为安胎之圣药。夫芩、术非能安胎者,去其湿热而胎自安耳。

Translation: After conception, the greatest concern is damp-heat damaging the fetal Qì. Therefore, among Chuān Xiōng, Dāng Guī, and Sháo Yào which nourish blood, Bái Zhú eliminates dampness and Huáng Qín clears heat. [Zhū] Dān Xī called Huáng Qín and Bái Zhú the sacred herbs for calming the fetus. In truth, Qín and Zhú do not calm the fetus directly; by eliminating damp-heat, the fetus settles naturally.

Historical Context

How Dang Gui San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Dāng Guī Sǎn is one of the signature pregnancy formulas from Zhāng Zhòngjǐng's Jīn Guì Yào Lüè (Eastern Han dynasty, ~200 CE). It embodies the ancient principle of preventing habitual miscarriage by simultaneously nourishing blood, clearing heat, and drying dampness. Zhū Dān Xī (Yuán dynasty) later praised Huáng Qín and Bái Zhú as the "sacred herbs for calming the fetus," a reputation they owe to this formula. Over centuries, the powder was modified into pill form, known as Ān Tāi Wán (安胎丸) or Wǔ Wèi Ān Tāi Wán (五味安胎丸), and was adopted across numerous medical traditions. Interestingly, Zhāng Zhòngjǐng originally recommended it as a routine pregnancy supplement, a view that modern safety research has challenged, reflecting the evolving understanding of risk in different historical contexts.