Formula

Zhi Bo Di Huang Wan

Anemarrhen Rehmannia Eight Formula | 知柏地黄丸

Also known as:

Zhi Bai Di Huang Wan , Anemarrhena Phellodendron and Rehmannia Pill , Eight Flavor Tea , Zhi Bai Di Huang Tang

Properties

Yin-tonifying formulas · Cool

Key Ingredients

Shu Di Huang

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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$39.00 ($0.39/g)
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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula that nourishes the body's cooling Yin fluids while clearing excess internal heat. It is commonly used for symptoms such as hot flashes, night sweats, tinnitus, sore throat, dry mouth, and low back aching that arise when the Kidneys become depleted and the body overheats from within. It builds on the famous Liu Wei Di Huang Wan (Six Ingredient Rehmannia Pill) with two additional cooling herbs.

Formula Category

Main Actions

  • Nourishes Yin
  • Clears Deficiency Heat
  • Nourishes Kidney Yin
  • Supplements the Liver and Kidneys
  • Drains Ministerial Fire

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhi Bai Di Huang Wan is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Zhi Bai Di Huang Wan addresses this pattern

When the Kidneys' Yin (the body's deep cooling and moistening reserve) becomes depleted, it can no longer anchor and control Yang. The result is deficiency fire that flares upward and outward, producing heat signs that are worse in the afternoon and at night. This formula directly rebuilds Kidney Yin through Shu Di Huang, Shan Zhu Yu, and Shan Yao while the Zhi Mu/Huang Bai pair actively clears the resulting deficiency fire. The draining herbs (Ze Xie, Mu Dan Pi, Fu Ling) prevent fluid stagnation and clear secondary Heat from the Liver and Blood. This simultaneous nourishing-and-clearing approach addresses both the root (Yin depletion) and the branch (fire flaring) of the pattern.

A practitioner would look for one or more of these signs

Night Sweats

Sweating during sleep that stops upon waking, a hallmark of Yin deficiency allowing fluids to leak

Tidal Fever

Low-grade afternoon or evening fever, often described as 'steaming bone' sensation

Hot Palms And Soles

Five-centre heat: warmth radiating from palms, soles, and chest

Tinnitus

Ringing in the ears from insufficient Kidney Yin failing to nourish the ears

Nocturnal Emissions With Dreams

Deficiency fire disturbing the Essence, causing involuntary seminal loss

Dry Mouth

Dryness of mouth and throat from depleted fluids

Lower Back Pain

Weak, aching lower back and knees from Kidney deficiency

Scanty And Dark Urine

Small volume of concentrated dark urine reflecting depleted Yin and internal Heat

How It Addresses the Root Cause

This formula addresses a condition in which the Kidneys' Yin (the body's deep reserves of cooling, moistening, and nourishing substance) has become depleted. When Kidney Yin is insufficient, it can no longer keep the body's internal warmth in check. This warmth, known as "ministerial Fire" (Xiang Huo), is normally a healthy and essential warming force stored in the Kidneys. But without enough Yin to anchor and contain it, this Fire escapes upward and outward, producing what TCM calls "deficiency Heat" or "empty Fire."

The clinical result is a distinctive pattern of dryness and heat that is worse at night (when Yin should dominate). The person experiences tidal fevers (waves of heat, often in the afternoon or evening), night sweats (the escaped Fire forces fluids outward during sleep), a dry mouth and throat, ringing in the ears, aching lower back and knees (the Kidneys govern the lumbar region and bones), and dark scanty urine. If the escaped Fire disturbs the storage function of the Kidneys, seminal emission or excessive dreams may occur. Because the Liver and Kidneys share the same Yin root, Liver Yin also becomes insufficient, contributing to dizziness, blurred vision, and irritability.

The formula works by simultaneously replenishing the depleted Yin "water" at its source (the Kidneys) and directly clearing the pathological deficiency Fire that has arisen from that depletion. By restoring the Yin-Yang balance in the lower body, the ministerial Fire is re-anchored and the Heat symptoms resolve.

Formula Properties

Temperature

Cool

Taste Profile

Predominantly bitter and sweet with a sour undertone. The bitter quality (from Zhi Mu and Huang Bai) clears Heat and drains Fire, the sweet quality (from Shu Di Huang, Shan Yao, and Fu Ling) nourishes Yin and tonifies, and the sour note (from Shan Zhu Yu) astringes essence and prevents leakage.

Target Organs
Kidneys Liver
Channels Entered
Kidney Liver Bladder

Formula Origin

Yī Fāng Kǎo (医方考, Investigations of Medical Formulas) by Wú Kūn (吴昆), 1584 CE

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Zhi Bo Di Huang Wan

Detailed information about each herb in Zhi Bo Di Huang Wan and their roles

Kings
Deputies
Assistants
Envoys
Shu Di Huang
Shu Di Huang

Prepared Rehmannia root

Dosage: 24g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Zhi Bo Di Huang Wan

Strongly enriches Kidney Yin and nourishes the Essence and Blood. As the largest dose ingredient, it addresses the root deficiency of Kidney Yin that underlies the entire pattern.

Zhi Mu
Zhi Mu

Anemarrhena rhizome

Dosage: 6g

Temperature Cold
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Lungs, Stomach, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in Zhi Bo Di Huang Wan

Clears deficiency Heat and nourishes Yin. Its bitter and cold nature directly drains the flaring ministerial fire (xiang huo) while moistening dryness, reinforcing the formula's ability to address both the root Yin deficiency and the branch of excess Heat.

Huang Bo
Huang Bo

Phellodendron bark

Dosage: 6g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Kidneys, Urinary Bladder
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Zhi Bo Di Huang Wan

Drains ministerial fire and clears Damp-Heat from the Lower Burner. It strengthens and stabilizes Yin (jian yin), preventing further leakage of Yin fluids through its astringent cooling action, and works in tandem with Zhi Mu to powerfully clear deficiency fire.

Shan Zhu Yu
Shan Zhu Yu

Cornelian Cherry Fruit

Dosage: 12g

Temperature Slightly Warm
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Zhi Bo Di Huang Wan

Nourishes the Liver and Kidneys, astringes Essence and prevents leakage. Supports the King herb Shu Di Huang in replenishing Yin while helping to secure Essence that may be depleted through nocturnal emissions or excessive sweating.

Shan Yao
Shan Yao

Chinese yam

Dosage: 12g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in Zhi Bo Di Huang Wan

Tonifies the Spleen and Kidneys, stabilizing Essence and consolidating Qi. Ensures that the Spleen can support the generation and distribution of nourishing fluids, complementing the Kidney-focused tonification.

Mu Dan Pi
Mu Dan Pi

Tree peony root bark

Dosage: 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Zhi Bo Di Huang Wan

Clears Heat from the Liver and Blood, cools deficiency Heat. Drains Liver fire that often accompanies Kidney Yin deficiency, preventing the upward flaring of Heat that causes flushing, headache, and irritability.

Fu Ling
Fu Ling

Poria

Dosage: 9g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Zhi Bo Di Huang Wan

Promotes water metabolism and strengthens the Spleen. Leaches out Dampness that could otherwise obstruct the nourishing herbs, and supports the Spleen's role in transforming and transporting the rich Yin-tonifying herbs in this formula.

Ze Xie
Ze Xie

Water plantain rhizome

Dosage: 9g

Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Zhi Bo Di Huang Wan

Drains turbid Dampness downward and clears Kidney fire through urination. Prevents the heavy, cloying Yin-tonifying herbs from producing stagnation, and directs the formula's action downward to the Kidneys and Lower Burner.

Modern Research (4 studies)

  • Proteomic study on Zhibai Dihuang Granule treating Yin-deficiency-heat syndrome via immune regulation (Animal study, 2018)
  • Nephroprotective effects of Zhibai Dihuang Wan against aristolochic acid toxicity (Preclinical, 2020)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

On an empty stomach or 30 minutes before meals, with warm water or lightly salted warm water (to guide the herbs downward to the Kidneys).

Typical Duration

Often taken for 2 to 4 weeks as a course, then reassessed. Not recommended for prolonged unsupervised use due to the bitter-cold nature of Zhi Mu and Huang Bai, which may weaken the Spleen over time.

Dietary Advice

Avoid spicy, fried, and greasy foods while taking this formula, as they generate internal Heat and counteract the formula's cooling, Yin-nourishing effect. Also avoid alcohol and strong coffee, which are warming and Yin-depleting. Difficult-to-digest foods (heavy meats, sticky glutinous rice) should be limited, as the formula contains rich, cloying herbs that can burden the Spleen. Favor moistening, Yin-nourishing foods such as pear, lily bulb (bai he), black sesame, walnuts, silver ear fungus (yin er), honey, duck, and tofu. Mildly cooling soups and congees are ideal. Stay well hydrated with room-temperature or warm water.

Special Populations

Pregnancy

Use with caution during pregnancy (classified as 孕妇慎用 in Chinese pharmacopoeia). Huang Bai (Phellodendron bark) is bitter and cold, and its cooling, downward-draining nature could theoretically affect the uterine environment. Zhi Mu is also significantly cold. While the formula does not contain strongly abortifacient herbs, the overall cold nature of the prescription raises concern for the fetus. Pregnant women should only take this formula under direct guidance from a qualified practitioner who has confirmed the pattern and weighed the risks.

Breastfeeding

No specific contraindication for breastfeeding has been established, but caution is advised. The bitter-cold herbs Zhi Mu and Huang Bai could theoretically affect breast milk composition and quality, and their cold nature may be transmitted to the infant, potentially causing loose stools or reduced appetite in a nursing baby. Official Chinese pharmaceutical guidelines state that breastfeeding women should use this formula under physician guidance. If breastfeeding, monitor the infant for any digestive changes and consult a practitioner before use.

Pediatric Use

Zhi Bo Di Huang Wan can be used in children but should only be administered under the guidance of a qualified practitioner. Official Chinese pharmaceutical labeling states that pediatric use requires physician supervision and adult monitoring. Dosage must be significantly reduced based on the child's age and weight, typically to one-third to one-half of the adult dose for children over 6 years of age. The formula's cold nature makes it unsuitable for extended use in children, whose digestive systems are considered more delicate in TCM. Interestingly, the formula has been used clinically in China for conditions such as childhood mouth sores and female precocious puberty (in combination with other treatments), but only under specialist care.

Drug Interactions

Diuretics and antihypertensives: Ze Xie (Alisma) and Fu Ling (Poria) in this formula have mild diuretic effects. When combined with pharmaceutical diuretics or blood-pressure-lowering drugs, there is a theoretical risk of excessive fluid loss or enhanced hypotensive effects. Blood pressure and electrolytes should be monitored.

Diabetes medications (hypoglycemic agents): Zhi Mu (Anemarrhena) has demonstrated blood-sugar-lowering properties in pharmacological studies. Concurrent use with insulin or oral hypoglycemic drugs (such as metformin or sulfonylureas) may increase the risk of hypoglycemia. Blood glucose should be monitored closely if used together.

Aminoglycoside antibiotics (e.g. gentamicin): While research suggests the formula may be protective against aminoglycoside nephrotoxicity, the interaction has not been fully characterized in humans. Use alongside these antibiotics should be supervised by a physician.

Immunosuppressants: Given the formula's demonstrated effects on complement and immune regulation pathways, concurrent use with immunosuppressive drugs (e.g. corticosteroids, cyclosporine) should be approached with caution and physician oversight.

Contraindications

Avoid

Cold-type or Yang-deficient constitutions: people who feel cold easily, have cold hands and feet, prefer warm drinks, or have loose stools. This formula is cooling and Yin-nourishing, and will further suppress already-weak Yang.

Avoid

Active exterior conditions (common cold or flu with fever and chills). The rich, cloying Yin-tonifying herbs can trap pathogenic factors in the body and worsen the illness.

Caution

Spleen deficiency with loose stools or poor appetite. The cold and cloying nature of the formula (especially Shu Di Huang, Zhi Mu, and Huang Bai) can impair an already-weak Spleen, worsening digestion and causing diarrhea.

Caution

Qi deficiency as the primary pattern. If the patient's main problem is fatigue, shortness of breath, and weak constitution rather than Yin-deficiency Heat signs, this formula is not appropriate.

Caution

Should not be taken concurrently with cold/flu medications. The opposing therapeutic strategies may cause adverse effects.

Caution

Not for prolonged, unsupervised use. The bitter-cold herbs (Zhi Mu, Huang Bai) can damage the Spleen and Stomach over time. Reassess after symptoms improve.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Treasure of the East

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