Formula

Zhen Xin An Shen Tang

Zizyphus & Polygonum Stem Combination | 镇心安神汤

Also known as:

Anchors the Heart and Calm the Mind Decoction , Sedate the Heart and Calm the Spirit Decoction

Properties

Heavy sedating and spirit-calming formulas · Slightly Cool

Key Ingredients

Long Gu, Mu Li Ke

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A modern formula designed for stubborn insomnia and sleep disturbances. It uses heavy mineral substances to settle an agitated mind while nourishing Heart Blood and calming emotional tension. Particularly suited for people who have difficulty falling asleep, wake frequently, or experience restless sleep due to emotional stress, anxiety, or underlying deficiency of Qi and Blood.

Formula Category

Main Actions

  • Anchors and Calms the Spirit
  • Subdues Yang and settles anxiety
  • Nourishes Heart Blood
  • Calms the Liver
  • Dispels Stasis to Promote Healing
  • Promotes Quality Sleep

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhen Xin An Shen Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Zhen Xin An Shen Tang addresses this pattern

When Heart Blood is insufficient, the spirit (Shen) loses its residence and becomes restless, leading to insomnia, palpitations, and anxiety. Zhen Xin An Shen Tang addresses this through Suan Zao Ren and Ye Jiao Teng, which directly nourish Heart Blood, while Dan Shen ensures the Blood circulates properly to the Heart. Fu Shen supports Spleen function to sustain Blood production. The heavy minerals Long Gu and Mu Li anchor the spirit that has become unmoored due to insufficient Blood, providing symptomatic relief while the nourishing herbs rebuild the foundation.

A practitioner would look for one or more of these signs

Insomnia

Difficulty falling asleep or staying asleep

Palpitations

Heart palpitations, especially at night

Anxiety

Anxiety and restlessness

Excessive Sweating

Vivid or excessive dreaming

Poor Memory

Poor memory and forgetfulness

How It Addresses the Root Cause

This formula addresses insomnia that arises from a combination of Heart Blood insufficiency and unanchored Yang. In TCM theory, the Heart houses the Shen (the mind or spirit), and the Shen can only rest peacefully at night when it is properly nourished by Blood and anchored within the Heart. When Heart Blood becomes deficient — through prolonged worry, overwork, chronic illness, or aging — the Shen loses its material foundation and becomes restless, like a boat without a mooring. This leads to difficulty falling asleep, light or easily disrupted sleep, excessive dreaming, and anxiety.

At the same time, when Yin and Blood are insufficient, Yang is no longer properly counterbalanced. The Liver, which stores Blood and anchors the Ethereal Soul (Hun), can develop Yang rising when its Blood is depleted. This ascending, unanchored Yang further agitates the Shen above, creating a vicious cycle: the more restless the spirit, the more the Yang floats upward, and the worse the sleep becomes. The overall picture is one of Yin-Yang disharmony — Yang stays active when it should be quiet, and Yin cannot draw it back down into rest. Clinically, this manifests as trouble falling asleep, waking easily or too early, being unable to return to sleep, or in severe cases, complete sleeplessness through the night.

Zhen Xin An Shen Tang works by addressing both sides of this mechanism: it weighs down and anchors the floating Yang with heavy mineral substances, while simultaneously nourishing Heart Blood and calming the spirit through plant-based sedating herbs. By restoring the proper relationship between Yin and Yang, the Shen can settle back into the Heart and sleep is restored.

Formula Properties

Temperature

Slightly Cool

Taste Profile

Predominantly astringent, salty, and sweet — astringent and salty to anchor and settle the spirit, sweet to gently nourish Heart Blood.

Target Organs
Heart Liver
Channels Entered
Heart Liver Kidney

Formula Origin

Modern clinical formula (contemporary TCM hospital practice, c. 1985)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Zhen Xin An Shen Tang

Detailed information about each herb in Zhen Xin An Shen Tang and their roles

Kings
Deputies
Assistants
Long Gu
Long Gu

Dragon Bone (fossilised mammal bone)

Dosage: 30g

Temperature Neutral
Taste Sweet (甘 gān), Astringent (涩 sè)
Organ Affinity Heart, Liver, Kidneys
Parts Used Mineral (矿物 kuàng wù)
Role in Zhen Xin An Shen Tang

Heavy mineral substance that settles the Heart, calms the spirit, and anchors floating Yang. Used raw (Sheng) for its spirit-calming and Liver-pacifying effects. Its heavy, descending nature directly addresses the restless, unanchored spirit that characterizes severe insomnia.

Mu Li Ke
Mu Li Ke

Oyster shell

Dosage: 30g

Temperature Slightly Cool
Taste Salty (咸 xián), Astringent (涩 sè)
Organ Affinity Liver, Gallbladder, Kidneys
Parts Used Shell (壳 ké / 甲 jiǎ)
Role in Zhen Xin An Shen Tang

Works alongside Long Gu to heavily sedate and anchor the spirit. Nourishes Yin and subdues rising Yang, calms the Liver, and resolves restlessness. Together with Long Gu, the pair forms the core anchoring strategy of the formula.

Dan Shen
Dan Shen

Red sage root

Dosage: 30g

Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Pericardium
Parts Used Root (根 gēn)
Role in Zhen Xin An Shen Tang

Invigorates Blood and clears Heat from the Heart. Addresses blood stasis that may underlie chronic insomnia. Also soothes irritability and restlessness. Its blood-moving action ensures that Heart Blood circulates properly so the spirit has a stable residence.

Suan Zao Ren
Suan Zao Ren

Sour jujube seed

Dosage: 30g

Temperature Neutral
Taste Sweet (甘 gān), Sour (酸 suān)
Organ Affinity Heart, Liver, Gallbladder
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Zhen Xin An Shen Tang

Nourishes Heart Blood and Liver Yin while calming the spirit. The core nourishing component that addresses the underlying Blood deficiency. Dry-fried (Chao) to enhance its spirit-calming properties. Works from the nourishing side to complement the heavy anchoring of Long Gu and Mu Li.

Ye Jiao Teng
Ye Jiao Teng

Fleece-flower stem

Dosage: 30g

Temperature Neutral
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Heart, Liver
Parts Used Stem (茎 jīng)
Role in Zhen Xin An Shen Tang

Nourishes Heart Blood and calms the spirit. Its name literally means 'vine of night exchange,' reflecting its traditional use for promoting sleep. Also unblocks the channels, helping the formula's effects reach throughout the body.

He Huan Pi
He Huan Pi

Silktree Albizia Bark

Dosage: 15g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Liver, Lungs
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Zhen Xin An Shen Tang

Calms the spirit and relieves emotional constraint. Specifically addresses insomnia arising from emotional disturbance, depression, or unresolved feelings. Harmonizes the Liver and resolves Qi stagnation that may be disturbing sleep.

Fu Shen
Fu Shen

Poria with Hostwood

Dosage: 15g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Spleen
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Zhen Xin An Shen Tang

Calms the Heart and settles the spirit while gently strengthening the Spleen. Fu Shen (Poria with hostwood) is specifically chosen over regular Fu Ling for its superior spirit-calming properties. Supports the middle burner to ensure adequate Qi and Blood production.

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

First decoction taken one hour before bedtime; second decoction taken after lunch the following day. Rest quietly for 1-2 hours after the evening dose.

Typical Duration

Typically taken for 2-4 weeks as an initial course, then reassessed by a practitioner based on sleep improvement.

Dietary Advice

Avoid stimulating foods and beverages while taking this formula, particularly coffee, strong tea, alcohol, and chocolate, as these can counteract its calming, spirit-settling effects. Spicy, greasy, and heavily fried foods should also be minimized, as they can generate internal Heat and Phlegm that disturb the Shen. Favor light, easily digestible meals in the evening — porridge, steamed vegetables, and calming foods such as lily bulb (bai he), lotus seed (lian zi), and longan fruit (long yan rou) are traditionally recommended to support sleep. Eating the final meal at least two to three hours before bedtime allows the Stomach to settle and supports the natural descent of Yang Qi into rest.

Special Populations

Pregnancy

Generally considered safe in pregnancy at standard doses, but should be used with practitioner supervision. Dan Shen (Salvia root) invigorates Blood and has mild blood-moving properties, which warrants caution in pregnancy, particularly during the first trimester or in patients with a history of miscarriage. The mineral substances Long Gu and Mu Li are considered safe. He Huan Pi and Shou Wu Teng (Ye Jiao Teng) have no specific pregnancy contraindications but lack extensive safety data in pregnant populations. A qualified practitioner should assess the individual case before prescribing.

Breastfeeding

No specific contraindications are established for breastfeeding. The herbs in this formula are generally mild and are not known to have toxic metabolites that transfer significantly into breast milk. Dan Shen (Salvia root) and the mineral substances Long Gu and Mu Li are not associated with adverse effects on lactation or nursing infants. However, formal safety studies in breastfeeding populations are lacking. As a precaution, practitioners typically use moderate doses and monitor both mother and infant for any changes. If the infant shows unusual drowsiness, irritability, or feeding changes, the formula should be discontinued and a practitioner consulted.

Pediatric Use

This formula is primarily designed for adult insomnia and is not commonly prescribed for young children. For adolescents (approximately 12 years and older) experiencing insomnia from emotional stress or anxiety, it may be considered at reduced doses (typically one-third to one-half of the adult dose), with practitioner guidance. The heavy mineral ingredients Long Gu and Mu Li should be used cautiously in children with weak digestion. For children under 12, other approaches to insomnia (such as Gan Mai Da Zao Tang for restlessness) are generally preferred. Any pediatric use should be supervised by a qualified practitioner.

Drug Interactions

Dan Shen (Salvia root) is the primary herb of pharmacological concern for drug interactions. Dan Shen contains tanshinones and salvianolic acids that inhibit platelet aggregation and may potentiate the effects of anticoagulant medications (warfarin, heparin) and antiplatelet drugs (aspirin, clopidogrel), increasing the risk of bleeding. Dan Shen has also been shown to affect cytochrome P450 enzymes (particularly CYP3A4), which could alter the metabolism of many pharmaceutical drugs. Patients taking warfarin should have their INR monitored closely if using this formula.

Long Gu and Mu Li (mineral/shell substances) are rich in calcium carbonate and may interfere with the absorption of certain antibiotics (tetracyclines, fluoroquinolones), thyroid medications (levothyroxine), and iron supplements if taken concurrently. A gap of at least two hours between taking this formula and these medications is advisable.

Suan Zao Ren (Ziziphus seed) has documented sedative and anxiolytic properties that may have additive effects with benzodiazepines, barbiturates, and other CNS depressants, potentially causing excessive drowsiness. Patients using prescription sleep aids or anti-anxiety medications should be monitored for over-sedation.

Contraindications

Avoid

Insomnia caused by Phlegm-Heat disturbing the Heart. The formula lacks herbs that clear Phlegm or drain Fire, making it unsuitable for excess-type patterns involving thick, greasy tongue coating, a feeling of chest oppression, nausea, or bitter taste from Phlegm-Fire.

Avoid

Insomnia caused by Stomach disharmony (food stagnation or rebellious Stomach Qi). Symptoms like fullness, bloating, acid reflux, or heavy meals disrupting sleep require a different treatment approach.

Avoid

Insomnia caused by excess Liver Fire or vigorous Heart Fire. While the formula can subdue mild Yang rising, pronounced Fire signs (severe irritability, red face, bitter taste, constipation, dark urine) require formulas that clear Fire more directly.

Caution

Patients with significant Spleen Qi deficiency or loose stools should use with caution. The heavy mineral substances (Long Gu, Mu Li) and the cool nature of Dan Shen may burden a weak digestive system if used long-term without modification.

Caution

Patients on anticoagulant or antiplatelet therapy should use with caution due to the blood-invigorating properties of Dan Shen (Salvia root), which may potentiate bleeding risk.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Treasure of the East

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