Formula

Wu Zhuyu Tang

吴茱萸湯

Also known as:

Evodia Formula , Goshuyu-to (Japanese Kampo name)

Properties

Interior-warming formulas · Hot

Key Ingredients

Wu Zhu Yu

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A warming classical formula used to relieve nausea, vomiting, and headaches caused by internal Cold in the digestive system. It gently warms the Stomach and Liver while calming the upward surging of Cold turbidity that can cause vertex headaches, acid reflux, and cold hands and feet.

Formula Category

Main Actions

  • Warms the Middle Burner and tonifies deficiency
  • Directs Rebellious Qi Downward and Stops Vomiting
  • Warms the Liver Channel and Dispels Cold
  • Warms the Interior and Dispels Cold

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Wu Zhuyu Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Wu Zhuyu Tang addresses this pattern

This is the primary pattern for Wu Zhu Yu Tang. When the Liver and Stomach both suffer from Cold due to underlying Yang deficiency, the normal downward movement of Stomach Qi is disrupted. Cold causes the turbid Yin (which should descend) to surge upward instead. Wu Zhu Yu directly warms the Liver and Stomach while descending this rebellious Qi. Sheng Jiang reinforces the Stomach-warming and vomiting-stopping actions. Ren Shen and Da Zao address the underlying deficiency that allowed Cold to accumulate. The entire formula is precisely targeted at this mechanism of Cold turbidity rising from a weakened middle burner.

A practitioner would look for one or more of these signs

Epigastric Fullness And Pain Relieved By Vomiting

Vomiting after eating, or vomiting sour/clear fluids

Acid Reflux

Acid regurgitation and gnawing hunger

Nausea

Nausea and sensation of fullness in the chest and epigastrium

Epigastric Pain Relieved With Pressure Or Eating

Stomach pain relieved by warmth

Cold Limbs

Cold hands and feet, aversion to cold

Pale Tongue

Pale tongue with white slippery coating

How It Addresses the Root Cause

The root problem this formula addresses is a combination of deficiency and Cold in the Liver and Stomach, with turbid Yin rising upward instead of staying in its proper place below. In a healthy person, the Stomach Qi descends (carrying food downward for digestion) and the Liver Qi flows smoothly. When Cold invades these organs or when they become deficient in warming Yang Qi, the normal downward movement of the Stomach is reversed, and cold, turbid fluids surge upward. This is why vomiting is the hallmark symptom across all three classical presentations.

The Jue Yin (Liver) channel runs from the lower body upward, passing alongside the Stomach and meeting the Du Mai (Governing Vessel) at the crown of the head. When Liver Cold drives turbid Yin upward along this pathway, it can reach the vertex, producing the characteristic top-of-the-head headache. Meanwhile, excessive cold fluids accumulate in the Stomach, producing copious watery saliva or foamy spit. In the Shao Yin presentation, the Cold is more severe and systemic: the body's Yang cannot reach the extremities (causing ice-cold hands and feet), the Spleen and Stomach both fail (causing simultaneous vomiting and diarrhea), and the patient feels desperate agitation as the remaining Yang struggles against overwhelming Yin Cold.

In each case, the core disease logic is the same: deficiency of warming Qi in the middle and lower body allows Cold to dominate, reversing the normal downward flow and sending turbid Yin surging upward.

Formula Properties

Temperature

Hot

Taste Profile

Predominantly acrid and bitter with a sweet undertone. The acrid-bitter combination from Wu Zhu Yu and Sheng Jiang drives the warming and descending actions, while the sweet notes of Ren Shen and Da Zao tonify the middle and moderate the formula's intensity.

Target Organs
Liver Stomach Spleen Kidneys
Channels Entered
Liver Stomach Spleen Kidney

Formula Origin

Shang Han Lun (傷寒論) by Zhang Zhongjing

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Wu Zhuyu Tang

Detailed information about each herb in Wu Zhuyu Tang and their roles

Kings
Deputies
Assistants
Envoys
Wu Zhu Yu
Wu Zhu Yu

Evodia fruit

Dosage: 3 - 9g

Temperature Hot
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Spleen, Stomach, Kidneys
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Wu Zhuyu Tang

The chief herb and namesake of the formula. Acrid, bitter, and hot in nature, it enters the Liver, Spleen, Stomach, and Kidney channels. It warms the Stomach to stop vomiting, warms the Liver to descend rebellious Qi, and warms the Kidney to stop diarrhea. A single herb that addresses all three classical presentations of this formula.

Sheng Jiang
Sheng Jiang

Fresh ginger rhizome

Dosage: 10 - 18g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Wu Zhuyu Tang

Used in a large dose (the heaviest herb by weight in the original formula), fresh ginger is the classical 'sage herb for vomiting.' It powerfully warms the Stomach, disperses Cold, descends rebellious Stomach Qi, and assists Wu Zhu Yu in stopping vomiting. Together they form a potent combination for dispelling Cold and calming the upward surging of turbid Qi.

Ren Shen
Ren Shen

Ginseng root

Dosage: 6 - 9g

Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys
Parts Used Root (根 gēn)
Role in Wu Zhuyu Tang

Sweet and warm, it tonifies the Qi of the middle burner and strengthens the Spleen and Stomach. This addresses the underlying deficiency that allows Cold to take hold. It also helps protect body fluids that have been damaged by persistent vomiting, and its calming effect on the spirit helps relieve the restlessness and agitation seen in severe cases.

Da Zao
Da Zao

Chinese date (Jujube fruit)

Dosage: 4 - 6 pieces

Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Wu Zhuyu Tang

Sweet and neutral, it assists Ren Shen in tonifying the Spleen and nourishing Qi. When paired with Sheng Jiang, it harmonizes the Spleen and Stomach and helps moderate the acrid, hot nature of Wu Zhu Yu and Sheng Jiang, preventing them from being excessively drying. It also harmonizes the actions of all herbs in the formula.

Modern Research (3 studies)

  • Effects of Wu-chu-yu-tang on drug-metabolizing enzymes in mice (Preclinical, 2002)
  • Rutaecarpine: A promising cardiovascular protective alkaloid from Evodia rutaecarpa (Review, 2019)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Warm, taken 30 minutes after meals to reduce gastrointestinal irritation. Divide the daily dose into 2-3 servings. Rest quietly for 30 minutes after taking.

Typical Duration

Acute use: 3-7 days for episodes of vomiting, headache, or diarrhea. Chronic conditions may require 1-4 weeks with regular reassessment.

Dietary Advice

Avoid cold, raw, and icy foods and beverages while taking this formula, as they directly oppose its warming function. Greasy, heavy, or hard-to-digest foods should also be limited, since the Stomach is already struggling with its digestive function. Sour foods may aggravate acid reflux in susceptible patients. Warm, easily digested foods such as congee (rice porridge), cooked vegetables, and warm soups are ideal. Coffee and strong tea should be avoided as they may increase gastric irritation and interact with the formula's pharmacological effects.

Special Populations

Pregnancy

Use with caution under professional supervision. Wu Zhu Yu (Evodia) is classified as acrid, bitter, and hot, and has been noted to potentially stimulate uterine contractions. However, it is worth noting that this formula has traditionally been used by experienced practitioners to treat pregnancy-related vomiting (morning sickness) of the cold-deficiency type, as documented in clinical case reports. In those cases it was applied only after careful pattern differentiation confirmed Liver-Stomach deficiency Cold. The formula should not be self-administered during pregnancy. Dosage reduction may be appropriate. Avoid entirely in pregnancy with any signs of Heat or threatened miscarriage.

Breastfeeding

No specific classical prohibitions exist for breastfeeding. The formula contains no known toxic herbs, and the ingredients (Evodia fruit, Ginseng, Fresh Ginger, Jujube Dates) are commonly used in food and medicine. However, the acrid and hot nature of Wu Zhu Yu may theoretically transfer through breast milk and could cause irritability or digestive upset in the nursing infant. Use only under practitioner guidance, at the lowest effective dose, and monitor the infant for any changes in feeding behavior, stool, or temperament.

Pediatric Use

Wu Zhu Yu Tang can be considered for children presenting with clear cold-deficiency vomiting patterns, but dosage must be significantly reduced according to age and body weight. A common guideline is to use one-third to one-half of the adult dose for children aged 6-12, and one-quarter for children under 6. The acrid-hot nature of Wu Zhu Yu may be poorly tolerated by young children, so the herb's dosage in particular should be conservative. Always administer under professional supervision. This formula is not suitable for infants without expert guidance.

Drug Interactions

CYP1A2 substrates: Preclinical research has demonstrated that Wu Zhu Yu Tang significantly induces the liver enzyme CYP1A2, primarily due to the alkaloid rutaecarpine in the Evodia fruit. Drugs metabolized by CYP1A2 (such as theophylline, caffeine, clozapine, olanzapine, and certain antidepressants like fluvoxamine) may be cleared more rapidly, potentially reducing their therapeutic effect. Concurrent use warrants monitoring.

Anticoagulants and antiplatelet agents: Rutaecarpine has demonstrated vasodilatory and anti-thrombotic effects in preclinical models. Caution is advised when combining this formula with blood-thinning medications such as warfarin, as there is a theoretical risk of altered drug metabolism or additive effects.

Antihypertensive medications: Wu Zhu Yu has complex cardiovascular effects (both vasodilatory and potentially blood-pressure-raising through its hot nature). Patients on blood pressure medications should be monitored for unexpected fluctuations.

Contraindications

Avoid

Yin deficiency with Heat signs (red tongue with little coating, night sweats, five-palm heat). Wu Zhu Yu is acrid, bitter, and hot in nature, making it entirely inappropriate for any pattern involving Yin deficiency Fire.

Avoid

Vomiting, headache, or abdominal pain caused by Heat or excess patterns (e.g. Stomach Fire, Liver Fire flaring). As one clinical source emphasizes, if there are ANY Heat signs present, adverse reactions after taking this formula will be pronounced.

Caution

Persons with a tendency toward hypertension or those with uncontrolled high blood pressure should use this formula with caution, as Wu Zhu Yu may cause blood pressure fluctuations.

Caution

Patients with significant fluid depletion or Yin-fluid damage from prolonged vomiting or diarrhea. While the formula contains Ren Shen and Da Zao to protect fluids, the acrid-hot nature of Wu Zhu Yu and Sheng Jiang may further consume Yin if the deficiency is severe.

Caution

After taking the decoction, some patients may experience temporary chest tightness, worsening headache, or dizziness. These reactions typically resolve within about 30 minutes. Patients should rest quietly after taking the formula.

Cautions & Warnings

Wu Zhu Yu Tang is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Wu Zhu Yu Tang.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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