Formula

Sheng Mai San

Ginseng & Schisandra Formula | 生脉散

Also known as:

Generate the Pulse Powder , Ginseng and Ophiopogon Powder , Ginseng and Dwarf lilyturf Powder , Generate the Pulse Drink , Ginseng Powder to Generate the Pulse

Properties

Qi-tonifying formulas · Slightly Warm

Key Ingredients

Ren Shen

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical three-herb formula used to restore vitality when both Qi and body fluids have been depleted. It addresses fatigue, shortness of breath, excessive sweating, dry throat, and weak pulse caused by heat exhaustion, chronic illness, or prolonged coughing that has weakened the Lungs. In modern practice, it is also widely used as supportive treatment for heart conditions including heart failure and irregular heartbeat.

Formula Category

Main Actions

  • Tonifies Qi
  • Generates Fluids
  • Nourishes Yin
  • Astringes to Stop Sweating
  • Astringes the Lungs and Stops Cough

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Sheng Mai San is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Sheng Mai San addresses this pattern

This is the primary pattern Sheng Mai San addresses. When both Qi and Yin (body fluids) are depleted simultaneously, the body loses its ability to maintain normal function and hydration. Ren Shen directly replenishes the Qi, Mai Men Dong restores Yin and fluids, and Wu Wei Zi prevents further loss through its astringent nature. The formula's three-pronged approach of tonifying, moistening, and containing precisely matches the pathomechanism where Qi is too weak to hold fluids in, fluids are too depleted to nourish the body, and both continue to leak out through sweating and shortness of breath.

A practitioner would look for one or more of these signs

Eye Fatigue

Exhaustion and physical weakness, especially after heat exposure or prolonged illness

Shortness Of Breath

Shortness of breath worsened by exertion, reluctance to speak

Excessive Sweating

Spontaneous sweating or profuse sweating

Dry Mouth

Dry throat and mouth with thirst

Palpitations

Palpitations with a weak, thready, or rapid pulse

Dry Cough

Dry cough with little or no phlegm in chronic cases

How It Addresses the Root Cause

Sheng Mai San addresses a pattern known as Qi and Yin dual deficiency (气阴两虚), which arises through two main pathways. In the first, exposure to summer-heat or a prolonged febrile (warm) illness damages both Qi and body fluids. Heat forces the pores open, causing profuse sweating; since Qi follows the fluids outward, heavy sweating leads to simultaneous loss of fluids and Qi. The body becomes fatigued, short of breath, and parched with thirst. If this process continues unchecked, the pulse weakens and may become thready or scattered, reflecting the body's inability to fill the blood vessels with sufficient Qi and fluid.

In the second pathway, chronic coughing or chronic illness gradually exhausts the Lung's Qi and Yin reserves. The Lung governs Qi and regulates the body's surface defenses, so when Lung Qi is depleted, the person becomes short of breath and sweats spontaneously. When Lung Yin is also depleted, the Lung loses its moistening function, producing a dry cough with little sputum and a dry throat. In both scenarios, the common thread is that Qi is too weak to contain the fluids, and the fluids are too depleted to nourish the tissues and anchor the Qi. The formula intervenes by simultaneously replenishing Qi, generating new fluids, and astringently preventing further leakage — thereby "generating the pulse" (生脉), restoring fullness and strength to a weakened circulation.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly sweet and sour — sweet from Ren Shen and Mai Men Dong to tonify Qi and nourish Yin, sour from Wu Wei Zi to astringe and prevent further loss of fluids.

Target Organs
Heart Lungs
Channels Entered
Lung Heart

Formula Origin

Yi Xue Qi Yuan (医学启源, Medical Enlightenment) by Zhang Yuansu (张元素)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Sheng Mai San

Detailed information about each herb in Sheng Mai San and their roles

Kings
Deputies
Assistants
Ren Shen
Ren Shen

Ginseng root

Dosage: 9 - 15g

Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys
Parts Used Root (根 gēn)
Role in Sheng Mai San

Powerfully tonifies the source Qi and Lung Qi, generates body fluids. As the King herb, it directly addresses the core problem of Qi depletion that underlies the weak pulse, fatigue, and shortness of breath.

Tian Men Dong
Tian Men Dong

Asparagus tuber

Dosage: 9 - 15g

Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Sheng Mai San

Nourishes Yin, moistens the Lungs, clears Heat, and directly generates body fluids. Complements Ren Shen by addressing the Yin and fluid depletion aspect of the pattern, while its cooling nature counterbalances any warmth from the King herb.

Wu Wei Zi
Wu Wei Zi

Schisandra berry

Dosage: 3 - 6g

Temperature Warm
Taste Sour (酸 suān), Sweet (甘 gān)
Organ Affinity Lungs, Heart, Kidneys
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Sheng Mai San

Astringes the Lungs, stops excessive sweating, generates fluids, and prevents further leakage of Qi and Yin. Its sour and astringent nature seals the Lung Qi that the other two herbs are working to replenish, ensuring that the tonified Qi and fluids are retained rather than lost.

Modern Research (4 studies)

  • Cochrane Systematic Review: Shengmai for Heart Failure (2014, updated from 2012)
  • Systematic Review and Meta-Analysis: Shengmai San for Anthracycline Cardiotoxicity (2022)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Between meals or on an empty stomach (traditionally described as before meals, 饭前空腹服用), two to three times daily. Can also be taken without regard to meal timing (不拘时服) as stated in classical sources.

Typical Duration

Acute use (summer-heat depletion, post-febrile recovery): 3-7 days. Chronic Qi-Yin deficiency patterns (chronic cough, heart conditions): 2-4 weeks or longer, reassessed by a practitioner.

Dietary Advice

Favor easily digestible, nourishing foods that support Qi and fluids: congee, soups, steamed vegetables, pears, lily bulb, and lightly prepared lean meats. Stay well hydrated with warm or room-temperature water. Avoid cold, raw, and icy foods and drinks, which can impair the Spleen's digestive function and hinder the formula's Qi-tonifying effects. Avoid greasy, heavy, or excessively spicy foods. Greasy foods generate Dampness and obstruct the formula's ability to nourish Yin, while excessive spice and heat can further damage fluids. Avoid excessive caffeine and alcohol, which can deplete Yin and counteract the formula's fluid-generating action. If taking this formula for summer-heat depletion, consuming mung bean soup or watermelon in moderation is acceptable, but avoid extremely cold preparations.

Modern Usage

Sheng Mai San is classified as a tonic and is known for its functions of replenishing Qi (vital energy), generating Body Fluids, astringing Yin (preserving vital essence), and stopping excessive sweating.
It is primarily used to treat syndromes characterized by the depletion of Qi and injury to Yin due to Evils such as Heat or Summer Heat. Symptoms include excessive sweating, mental fatigue, physical exhaustion, shortness of breath, reluctance to speak, dry throat, thirst, dry and red tongue with little coating, and a weak, rapid pulse. Clinically, it is often used to treat coughs caused by conditions such as tuberculosis, chronic bronchitis, and neurasthenia.

Special Populations

Pregnancy

Generally considered safe during pregnancy. None of the three ingredients (Ren Shen, Mai Men Dong, Wu Wei Zi) are classified as pregnancy-contraindicated in standard TCM pharmacopeias. Ren Shen (Ginseng) is widely used in pregnancy-safe formulas. However, as with any herbal formula during pregnancy, it should only be taken under the guidance of a qualified practitioner who can assess the individual situation. If high-dose Ginseng is used, monitoring for overstimulation is advisable.

Breastfeeding

No specific safety concerns have been documented for breastfeeding mothers taking Sheng Mai San. All three herbs (Ren Shen, Mai Men Dong, Wu Wei Zi) have long histories of use and are not known to produce harmful effects transmitted through breast milk. The formula's Qi-tonifying properties may theoretically support milk production in mothers who are fatigued and deficient. However, as with all herbal formulas during lactation, use should be guided by a qualified practitioner.

Pediatric Use

Sheng Mai San can be used in children with appropriate dose reductions. As a mild, three-herb tonifying formula with a good safety profile, it is generally suitable for pediatric use when indicated (Qi and Yin deficiency patterns). Typical pediatric dosage is roughly one-third to one-half of the adult dose for children aged 6-12, and one-quarter for children under 6, adjusted based on age, weight, and the practitioner's assessment. The modern oral liquid form (Sheng Mai Yin, 生脉饮) is convenient for children and may be given in proportionally reduced doses. As with adults, the formula should not be used in children with active infections or acute febrile illness where the pathogen has not been cleared.

Drug Interactions

Warfarin and anticoagulants: A published case report documented intracerebral hematoma in a patient taking warfarin concurrently with Sheng Mai Yin, suggesting a possible potentiation of anticoagulant effects. Ren Shen (Ginseng) has complex interactions with warfarin reported in the literature. Patients on anticoagulant therapy should use this formula only under close medical supervision with appropriate INR monitoring.

Nifedipine and calcium channel blockers: Animal studies have shown that Shengmai preparations may significantly increase systemic exposure to nifedipine (nearly two-fold) and decrease its clearance, though clinical relevance in humans has not been confirmed. Caution is warranted when combining this formula with calcium channel blockers, and blood pressure should be monitored.

Hypoglycemic agents: Ren Shen (Ginseng) may lower blood sugar levels. When combined with insulin or oral hypoglycemics, the risk of hypoglycemia may theoretically be increased. Blood glucose monitoring is advised.

Stimulants and caffeine: Ginseng's stimulatory properties may have additive effects with caffeine or stimulant medications, potentially causing nervousness or insomnia in sensitive individuals.

Contraindications

Avoid

External pathogenic factors still unresolved (外邪未解). If a person has an active cold, flu, or acute febrile illness where the pathogen has not been expelled, using this tonifying and astringent formula can trap the pathogen inside and worsen the condition.

Avoid

Summer-heat illness with strong fever and no signs of Qi or Yin depletion. When the heat pathogen is still vigorous and the body's fluids and Qi have not yet been significantly damaged, this formula is inappropriate because astringent herbs would retain the pathogenic Heat.

Avoid

Excess-type cough with copious phlegm. The astringent nature of Wu Wei Zi (Schisandra) can trap phlegm and obstruct its discharge, worsening the cough.

Avoid

Early-stage Warm Disease (温病初起) with high fever. The formula's tonifying and constraining properties can lock in Heat and prevent its release through the exterior.

Caution

Patients on warfarin or other anticoagulants should exercise caution, as a case report documented intracerebral hemorrhage possibly related to an interaction between Shengmai preparations and warfarin.

Caution

Patients with Yin deficiency accompanied by pronounced internal Heat or Fire. While this formula mildly nourishes Yin, its warm Ren Shen (Ginseng) component may aggravate Heat in such cases. Xi Yang Shen (American Ginseng) may be substituted.

Caution

Patients with significant Dampness or phlegm accumulation. The sweet tonifying nature of Ren Shen and the rich moistening quality of Mai Men Dong can worsen Dampness and phlegm.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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