Formula

Shen Tong Zhu Yu Tang

Cnidium & Notopterygium Combination | 身痛逐瘀汤

Also known as:

Drive Out Stasis from a Painful Body Decoction , Resolve Stasis formula

Properties

Hemostatic formulas · Slightly Warm

Key Ingredients

Tao Ren, Hong Hua

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula for chronic body pain that has not responded to other treatments. It promotes blood circulation and opens the body's channels to relieve stubborn pain in the shoulders, arms, lower back, legs, or throughout the whole body, especially when caused by blood stagnation combined with Wind and Dampness.

Formula Category

Main Actions

  • Invigorates Blood and Dispels Stasis
  • Unblocks the Channels and Alleviates Pain
  • Moves Qi and Alleviates Pain
  • Dispels Wind-Dampness
  • Unblocks the Channels and Collaterals

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shen Tong Zhu Yu Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Shen Tong Zhu Yu Tang addresses this pattern

This is the primary pattern the formula addresses. When Blood stasis lodges in the channels and collaterals, it blocks the normal flow of Qi and Blood, causing pain that is fixed in location, stabbing in quality, and chronic in duration. Wang Qing Ren observed that when conventional treatments for Wind-Cold-Dampness fail to resolve body pain, the underlying cause is often congealed Blood that has become trapped in the channels. The formula's core group of Blood-moving herbs (Tao Ren, Hong Hua, Chuan Xiong, Dang Gui, Mo Yao, Wu Ling Zhi) directly breaks up this stasis, while Di Long and Niu Xi open the channels to allow free circulation. Once Blood flows smoothly, pain resolves because the obstruction is removed.

A practitioner would look for one or more of these signs

Stabbing Fixed Pain

Pain in a fixed location that does not migrate, often stabbing or boring in quality

Moving Pain

Chronic joint or body pain that has not responded to conventional treatments

Shoulder Pain

Shoulder pain from Blood stasis blocking the channels

Lower Back Pain

Persistent lower back pain with a fixed, stabbing quality

Leg Pain

Pain in the legs or throughout the body that is worse at night

Dark Complexion

Dark or purplish tongue, possible static macules or ecchymoses

How It Addresses the Root Cause

In TCM, Bi syndrome (painful obstruction syndrome) is traditionally understood as arising from the invasion of Wind, Cold, and Dampness into the channels and joints. However, Wang Qingren identified a critical overlooked factor: Blood stasis (瘀血). His key insight was that in chronic, stubborn pain that does not respond to conventional treatments for Wind-Cold-Damp, the real culprit is congealed Blood obstructing the channels and collaterals.

Wang Qingren used a vivid analogy: when water encounters cold wind, it freezes into ice. Once the ice has formed, the wind and cold may have already passed, but the ice remains. Similarly, an initial invasion of pathogenic factors may cause Blood to congeal in the channels. Even after the original pathogen has been cleared or dissipated, the stagnant Blood persists, blocking the free flow of Qi and Blood through the affected meridians. Because "where there is no free flow, there is pain" (不通则痛), the obstruction causes fixed, stabbing pain that lingers for months or years. The tissues and joints lose their nourishment, leading to stiffness, muscle wasting, and further functional decline.

The pathomechanism therefore involves a vicious cycle: Qi stagnation and Blood stasis reinforce each other. Stagnant Blood blocks the channels, which impedes Qi flow. Impeded Qi flow in turn cannot push the Blood forward, making stasis worse. Wind-Dampness may also become trapped alongside the stasis, producing a complex, interwoven condition. The formula addresses this by simultaneously breaking up Blood stasis, moving Qi, opening the collaterals, and expelling residual Wind-Dampness, thereby restoring free circulation to the affected areas.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly acrid and bitter with underlying sweetness. Acrid to move Qi and Blood through the channels, bitter to dispel stasis and dry Dampness, sweet (from Gan Cao and Dang Gui) to moderate harshness and nourish Blood.

Target Organs
Liver Kidneys
Channels Entered
Liver Kidney Bladder Spleen

Formula Origin

Yi Lin Gai Cuo (医林改错, Corrections of Errors in Medical Works) by Wang Qing Ren

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Shen Tong Zhu Yu Tang

Detailed information about each herb in Shen Tong Zhu Yu Tang and their roles

Kings
Deputies
Assistants
Envoys
Tao Ren
Tao Ren

Peach kernel

Dosage: 9g

Temperature Neutral
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Large Intestine
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Shen Tong Zhu Yu Tang

Breaks up Blood stasis and invigorates Blood circulation throughout the body. As one of the primary Blood-moving herbs in the formula, it directly addresses the core pathomechanism of congealed Blood blocking the channels.

Hong Hua
Hong Hua

Safflower

Dosage: 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver
Parts Used Flower (花 huā)
Role in Shen Tong Zhu Yu Tang

Powerfully activates Blood and dispels stasis, working synergistically with Tao Ren to form the primary Blood-moving pair in the formula. Relieves pain caused by Blood stagnation.

Chuan Xiong
Chuan Xiong

Szechuan lovage rhizome

Dosage: 6g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium
Parts Used Rhizome (根茎 gēn jīng)
Role in Shen Tong Zhu Yu Tang

Invigorates Blood and promotes the movement of Qi, acting as a 'Qi herb within the Blood.' Its ability to move both Qi and Blood in the channels and collaterals makes it essential for treating pain throughout the body. Also expels Wind and alleviates pain.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 9g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Shen Tong Zhu Yu Tang

Nourishes and invigorates Blood simultaneously. This dual action ensures that the strongly Blood-moving herbs do not damage healthy Blood in the process of dispelling stasis. Supports the generation of new Blood after stasis is cleared.

Niu Xi
Niu Xi

Achyranthes root

Dosage: 9g

Temperature Neutral
Taste Bitter (苦 kǔ), Sour (酸 suān), Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Root (根 gēn)
Role in Shen Tong Zhu Yu Tang

Invigorates Blood and opens the channels, with a particular affinity for the lower body. Strengthens the sinews and bones and directs the formula's action downward to treat lower back and leg pain.

Qin Jiao
Qin Jiao

Large-leaf gentian root

Dosage: 3g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Stomach, Liver, Gallbladder
Parts Used Root (根 gēn)
Role in Shen Tong Zhu Yu Tang

Expels Wind-Dampness from the channels and relaxes the sinews. Unlike Qiang Huo, Qin Jiao can address both Cold and Heat types of painful obstruction, giving the formula broader applicability across Bi syndrome presentations.

Qiang Huo
Qiang Huo

Notopterygium root and rhizome

Dosage: 3g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Urinary Bladder, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in Shen Tong Zhu Yu Tang

Disperses Wind-Cold-Dampness and unblocks painful obstruction, particularly in the upper body and the Tai Yang channel. Pairs with Qin Jiao to address the external pathogenic factors (Wind-Dampness) that contribute to channel obstruction alongside the Blood stasis.

Mo Yao
Mo Yao

Myrrh

Dosage: 6g

Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Spleen
Parts Used Resin / Sap (树脂 shù zhī / 汁 zhī)
Role in Shen Tong Zhu Yu Tang

Activates Blood, disperses stasis, and alleviates pain. Works with Wu Ling Zhi to form a potent pain-relieving pair that targets stabbing, fixed pain from Blood stasis.

Wu Ling Zhi
Wu Ling Zhi

Flying squirrel feces

Dosage: 6g

Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Liver, Spleen
Parts Used Animal — secretion (动物分泌物 dòng wù fēn mì wù)
Role in Shen Tong Zhu Yu Tang

Invigorates Blood and resolves stasis, with strong analgesic action. Pairs with Mo Yao to enhance pain relief. Dry-frying moderates its strong properties and reduces any unpleasant taste.

Xiang Fu
Xiang Fu

Nutgrass rhizome

Dosage: 3g

Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Liver, Spleen, San Jiao (Triple Burner)
Parts Used Rhizome (根茎 gēn jīng)
Role in Shen Tong Zhu Yu Tang

Moves Qi and regulates its flow. Since Qi drives Blood ('when Qi moves, Blood moves'), Xiang Fu ensures the smooth circulation of Qi to support the Blood-moving action of the formula and relieve Qi stagnation that accompanies Blood stasis.

Di Long
Di Long

Earthworm

Dosage: 6g

Temperature Cold
Taste Salty (咸 xián)
Organ Affinity Liver, Spleen, Urinary Bladder, Lungs
Parts Used Animal — whole (全虫 quán chóng)
Role in Shen Tong Zhu Yu Tang

Opens the channels and collaterals and relieves joint stiffness. Its unique ability to unblock the network vessels (Luo Mai) makes it particularly effective for reaching deep into the channels where stasis has lodged.

Gan Cao
Gan Cao

Licorice root

Dosage: 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Shen Tong Zhu Yu Tang

Harmonizes and moderates all other herbs in the formula. Alleviates spasm and pain. Protects the Stomach from the potentially harsh Blood-moving and Wind-dispelling ingredients.

Modern Research (4 studies)

  • Systematic Review and Meta-analysis: Efficacy and Safety of Shentong Zhuyu Decoction for Lumbar Disc Herniation (2020)
  • In Vitro Study: Shentong Zhuyu Decoction Inhibits Inflammatory Response of Rheumatoid Arthritis Fibroblast-like Synoviocytes via MAPK p38/PPARγ/CTGF Pathway (2021)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

30 minutes after meals, twice daily (morning and evening), taken warm to promote circulation and reduce potential stomach irritation from the Blood-moving herbs.

Typical Duration

Typically prescribed for 2-4 weeks for acute flare-ups, or 4-8 weeks for chronic pain conditions, with reassessment by a practitioner. Wang Qingren's modifications suggest ongoing adjustment based on response.

Dietary Advice

Avoid cold and raw foods (ice water, raw salads, sashimi) as they can constrict the channels and worsen Blood stasis. Reduce intake of greasy, rich, or heavy foods that may generate Dampness and impede circulation. Avoid excessive alcohol, which can produce Damp-Heat and interfere with the formula's action. Favor warm, lightly cooked foods that support circulation, such as ginger tea, turmeric, small amounts of vinegar in cooking, dark leafy greens, and warming spices. Moderate intake of foods that gently support Blood flow, like black fungus (wood ear mushroom), hawthorn fruit, and small amounts of rice wine in cooking, may complement treatment.

Modern Usage

Shen Tong Zhu Yu Tang is a Traditional Chinese Medicine (TCM) formula classified under the "Promote Blood circulation" category of herbal remedies. This formula consists of 12 Chinese herbs known for their properties that enhance Blood circulation, promote Qi movement, alleviate pain, and disperse Blood Stasis.

Shen Tong Zhu Yu Tang is a Traditional Chinese Medicine (TCM) formula that invigorates the Blood, eliminates Stagnation, unblocks painful obstructions, and alleviates pain, particularly in conditions caused by Blood Stasis obstructing the channels and collaterals.

In modern practice, Shen Tong Zhu Yu Tang is often used to treat chronic pain, rheumatoid arthritis, and clot-related disorders. It is also considered beneficial for addressing circulatory issues, pain, and inflammation.

Special Populations

Pregnancy

Contraindicated during pregnancy. This formula contains several herbs with strong Blood-moving and stasis-breaking actions that pose a risk of stimulating uterine contractions and potentially causing miscarriage. The key herbs of concern include Tao Ren (Peach Kernel), Hong Hua (Safflower), Niu Xi (Achyranthes Root, which also directs Blood downward), Mo Yao (Myrrh), Wu Ling Zhi (Flying Squirrel Droppings), and Di Long (Earthworm). This formula should not be used at any stage of pregnancy.

Breastfeeding

Use with caution during breastfeeding. While there are no specific classical prohibitions for nursing mothers, the formula contains strong Blood-moving herbs (Tao Ren, Hong Hua, Mo Yao, Wu Ling Zhi) whose active compounds may transfer into breast milk. The potential effects on the infant are not well studied. If clinically necessary, it should be used under practitioner supervision at reduced dosages and for short durations. Monitor the infant for any signs of gastrointestinal upset or unusual fussiness.

Pediatric Use

This formula is not commonly prescribed for children in classical usage. Wang Qingren did not specifically indicate pediatric applications for Shen Tong Zhu Yu Tang. If considered for adolescents with chronic pain conditions showing clear signs of Blood stasis (fixed pain, dark tongue), dosages should be reduced to approximately one-third to one-half of adult doses depending on age and body weight. Generally not recommended for children under 12 without specialist guidance. The Blood-breaking herbs in this formula are relatively strong and may be excessive for the developing constitution of young children. A practitioner should carefully assess whether the pain pattern truly involves Blood stasis before considering this formula in pediatric cases.

Drug Interactions

Anticoagulant and antiplatelet medications: Multiple herbs in this formula (Tao Ren, Hong Hua, Dang Gui, Chuan Xiong, Mo Yao, Wu Ling Zhi, Niu Xi) have demonstrated anticoagulant or platelet-inhibiting effects. Concurrent use with warfarin, heparin, aspirin, clopidogrel, or other blood-thinning drugs may significantly increase bleeding risk. INR and coagulation parameters should be closely monitored if combined use is unavoidable.

NSAIDs (non-steroidal anti-inflammatory drugs): The formula has demonstrated anti-inflammatory and analgesic effects that may overlap with those of ibuprofen, diclofenac, and similar drugs. While not necessarily dangerous, combined use may increase gastrointestinal irritation, especially since Wu Ling Zhi and Mo Yao can be harsh on the stomach.

Gan Cao (Licorice root) interactions: Gan Cao contains glycyrrhizin, which may interact with corticosteroids (potentiating their effects), antihypertensive medications (counteracting their effect through sodium retention and potassium loss), digoxin (hypokalemia increasing toxicity risk), and diuretics (compounding potassium depletion).

Contraindications

Avoid

Pregnancy. The formula contains multiple potent Blood-moving herbs (Tao Ren, Hong Hua, Niu Xi, Mo Yao) that may stimulate uterine contractions and risk miscarriage.

Avoid

Active bleeding or hemorrhagic conditions. The strong Blood-invigorating action of this formula may worsen bleeding.

Caution

Patients on anticoagulant or antiplatelet therapy (e.g. warfarin, aspirin, clopidogrel). The Blood-moving herbs may potentiate anticoagulant effects and increase bleeding risk.

Caution

Significant Qi or Blood deficiency without modification. The formula's dispersing nature may further deplete the weak. Wang Qingren himself noted that for weak patients, Huang Qi (Astragalus) should be added in generous amounts (30-60g).

Caution

Pain due to acute external Wind-Cold-Damp invasion without underlying Blood stasis. This formula is designed for chronic, stubborn pain with stasis as the primary mechanism, not for acute Bi syndrome that responds to standard exterior-releasing treatment.

Caution

Patients with liver disease should use with caution, as the formula's Blood-moving action may place additional burden on compromised hepatic function.

Cautions & Warnings

Although Shen Tong Zhu Yu Tang is generally safe for most individuals, it can cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should either avoid or use Shen Tong Zhu Yu Tang with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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