Formula

Ma Zi Ren Wan

Apricot Kernel Formula | 麻子仁丸

Also known as:

Hemp Seed Pill , Cannabis Seed Pill , Ma Zi Ren Tang , Apricot Seed & Linum Formula

Properties

Purgative formulas · Slightly Cool

Key Ingredients

Huo Ma Ren

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula used to gently relieve constipation caused by dryness and heat in the intestines. It moistens the bowels, clears mild heat, and promotes the movement of Qi to restore regular bowel function. Particularly well suited for older adults, postpartum women, or anyone with dry, hard stools that are difficult to pass along with frequent urination.

Formula Category

Main Actions

  • Moistens the Intestines and Unblocks the Bowels
  • Drains Heat from the Stomach and Intestines
  • Descends Qi
  • Nourishes Yin and Moistens the Intestines

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ma Zi Ren Wan is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Ma Zi Ren Wan addresses this pattern

This is the primary pattern addressed by Ma Zi Ren Wan. When excess heat accumulates in the Stomach and intestines, it scorches the body's fluids. The Spleen, which normally distributes these fluids throughout the body, becomes 'constrained' (pi yue, 脾约) by the strong Stomach heat and can only send fluids downward to the Bladder rather than moistening the intestines. The result is frequent urination alongside dry, hard stools. Huo Ma Ren and Xing Ren directly moisten the parched intestines, Bai Shao replenishes the depleted fluids, and Da Huang with Zhi Shi and Hou Po clear the underlying heat and move the stagnation. The pill form with honey ensures a gradual, non-aggressive approach befitting a condition where fluids are already low.

A practitioner would look for one or more of these signs

Constipation

Dry, hard stools that are difficult to expel

Frequent Urination

Frequent urination, often with clear urine

Dry Mouth

Dry mouth and lips

Abdominal Distention

Mild abdominal bloating or fullness

Yellow Tongue Coating

Yellow, dry tongue coating

How It Addresses the Root Cause

Ma Zi Ren Wan addresses a pattern called Pi Yue (脾约, "Spleen Constraint"), first described in the Shang Han Lun. The core problem is a mismatch between the Stomach and the Spleen: the Stomach has excess Heat (described as "the Stomach being strong"), while the Spleen is weakened and unable to perform its normal job of distributing the body's fluids.

Normally, the Spleen takes the fluids produced by digestion and spreads them throughout the body, including to the intestines where they keep the stool moist. In this pattern, the Stomach's excess Heat essentially "constrains" the Spleen, preventing it from distributing fluids properly. Instead of spreading to all tissues, the fluids get funneled almost exclusively downward to the Bladder. The result is a characteristic pair of symptoms: frequent urination (because too much fluid goes to the Bladder) combined with dry, hard stools that are difficult to pass (because the intestines are deprived of moisture). The tongue tends to be red with little coating or dry coating, and the pulse is often thin and rapid, reflecting the dryness and mild Heat.

This is not a severe acute blockage like the patterns treated by the stronger Cheng Qi (Qi-Supporting) formulas. Rather, it is a chronic, moderate condition where dryness and mild Heat accumulate over time. The disease sits in the Yang Ming (Stomach and Large Intestine) system, but the root issue is the Spleen's failure to circulate fluids. It is commonly seen in elderly patients, those recovering from illness where fluids have been depleted, and in postpartum women.

Formula Properties

Temperature

Slightly Cool

Taste Profile

Predominantly bitter and sweet with oily richness. Bitter from Da Huang, Zhi Shi, and Hou Po to drain Heat and move Qi downward; sweet and oily from Huo Ma Ren, Xing Ren, and honey to moisten and lubricate the intestines; sour from Bai Shao to preserve Yin.

Target Organs
Spleen Stomach Large Intestine Lungs
Channels Entered
Spleen Stomach Large Intestine Lung

Formula Origin

Shang Han Lun (Discussion of Cold-Induced Disorders) by Zhang Zhongjing

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Ma Zi Ren Wan

Detailed information about each herb in Ma Zi Ren Wan and their roles

Kings
Deputies
Assistants
Huo Ma Ren
Huo Ma Ren

Hemp seed

Dosage: 15 - 20g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Large Intestine
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Ma Zi Ren Wan

The lead herb, rich in oils. It moistens the intestines and promotes bowel movement to directly address the core problem of dry stools from intestinal fluid depletion.

Xing Ren
Xing Ren

Bitter apricot kernel

Dosage: 9 - 10g

Temperature Slightly Warm
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Large Intestine
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Ma Zi Ren Wan

Descends Lung Qi and moistens the Large Intestine. Since the Lung and Large Intestine are paired organs, directing Qi downward from the Lung helps promote bowel movement from above while also adding lubrication.

Bai Shao
Bai Shao

White peony root

Dosage: 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Ma Zi Ren Wan

Nourishes Blood and preserves Yin fluids. It supports the Spleen and Liver to help restore the body's ability to generate and distribute fluids, addressing the underlying fluid deficiency that causes dry stools.

Da Huang
Da Huang

Rhubarb root and rhizome

Dosage: 9 - 12g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium
Parts Used Root (根 gēn)
Role in Ma Zi Ren Wan

Purges accumulated heat and unblocks the bowels. As part of the Xiao Cheng Qi Tang base within this formula, it provides direct purgative action, but the pill form and smaller effective dose ensure this action is gentle rather than harsh.

Zhi Shi
Zhi Shi

Immature bitter orange

Dosage: 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn), Sour (酸 suān)
Organ Affinity Spleen, Stomach, Large Intestine
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Ma Zi Ren Wan

Breaks up Qi stagnation and reduces distension. It works with Hou Po to move Qi downward through the digestive tract, helping push stagnant material along and relieve abdominal fullness.

Hou Po
Hou Po

Magnolia bark

Dosage: 9g

Temperature Warm
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs, Large Intestine
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Ma Zi Ren Wan

Promotes the movement of Qi and relieves abdominal distension and fullness. Together with Zhi Shi and Da Huang, it forms the Xiao Cheng Qi Tang component that gently clears heat and moves stagnation.

Modern Research (4 studies)

  • Efficacy of MaZiRenWan in Patients with Functional Constipation in a Randomized Controlled Trial (Three-arm RCT, 2019)
  • Efficacy of a Chinese Herbal Proprietary Medicine (Hemp Seed Pill) for Functional Constipation (Placebo-controlled RCT, 2011)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

On an empty stomach, 30 to 60 minutes before meals, with warm water. The classical instruction is to take pills three times daily, starting with a small dose and gradually increasing until effective.

Typical Duration

Typically used for 1 to 4 weeks for acute episodes of constipation, reassessed by a practitioner. May be taken intermittently for habitual constipation, but long-term continuous use is not recommended due to the Da Huang (Rhubarb) content.

Dietary Advice

Favor foods that moisten the intestines and promote smooth bowel movements: sesame seeds, walnuts, pine nuts, pears, figs, bananas, spinach, and other leafy greens. Drink adequate warm water throughout the day. Light, easily digestible foods like congee (rice porridge) with added oils or seeds support the formula's action. Avoid spicy, fried, and excessively dry or heating foods (chili peppers, deep-fried items, roasted nuts, lamb, strong alcohol) as these worsen intestinal Heat and dryness. Also limit astringent foods like unripe persimmons and strong tea, which can counteract the formula's moistening effect. Cold and raw foods in excess may impair Spleen function, so moderation is advisable even though this is not a warming formula.

Modern Usage

Ma Zi Ren Wan belongs to the category of purgative and moistening formulas and is used to lubricate the intestines, clear Heat, promote the movement of Qi, and relieve constipation. It is primarily used for constipation due to Dry-Heat in the Intestines and Stomach. Symptoms include dry, hard stools, frequent urination, a slightly yellow tongue coating, and scant tongue moisture.

Clinically, this formula is commonly used to treat constipation in individuals with Deficiency, the elderly, habitual constipation, postpartum constipation, and constipation after hemorrhoid surgery.

Special Populations

Pregnancy

Contraindicated during pregnancy. The formula contains Da Huang (Rhubarb), which is a recognized pregnancy-contraindicated herb due to its strong purgative and downward-draining action that may stimulate uterine contractions and risk miscarriage. Zhi Shi (Immature Bitter Orange) is also classified as a Qi-breaking herb that promotes strong downward movement and should be avoided during pregnancy. Even in pill form with a gentle dosing schedule, the combination of these herbs makes Ma Zi Ren Wan unsuitable for pregnant women. Pregnant women experiencing constipation should consult a qualified practitioner for safer alternatives.

Breastfeeding

Use with caution during breastfeeding. Da Huang (Rhubarb) contains anthraquinone compounds (such as emodin and rhein) that can pass into breast milk and may cause loose stools or diarrhea in the nursing infant. If the formula is clinically necessary, practitioners should use the lowest effective dose, monitor the infant for changes in stool patterns, and consider shorter treatment courses. The other herbs in the formula (Huo Ma Ren, Bai Shao, Xing Ren, Zhi Shi, Hou Po) are not specifically flagged for breastfeeding concerns at standard doses.

Pediatric Use

Ma Zi Ren Wan can be used in children, though with important adjustments. The formula has been included in pediatric clinical studies for constipation. Dosage must be significantly reduced according to the child's age and weight, typically to one-third to one-half of the adult dose for older children (over 6 years), and even less for younger children. The Da Huang (Rhubarb) content is the primary concern, as children are more sensitive to purgative herbs. Start at the lowest dose and increase gradually, following the classical principle of "increase until effective" (以知为度). Monitor carefully for loose stools, abdominal cramping, or diarrhea. Not generally recommended for infants or toddlers without direct practitioner supervision. For very young children with constipation, dietary adjustments and milder alternatives should be considered first.

Drug Interactions

Da Huang (Rhubarb) is the primary source of potential drug interactions in this formula:

  • Cardiac glycosides (e.g. digoxin): Da Huang's purgative action can cause potassium loss through diarrhea, potentially increasing the risk of digoxin toxicity. Electrolytes should be monitored if co-administered.
  • Anticoagulants and antiplatelet drugs (e.g. warfarin): Anthraquinone compounds in Da Huang may have additive effects on bleeding risk. Use with caution and monitor clotting parameters.
  • Oral medications with narrow therapeutic windows: The purgative action of the formula can accelerate intestinal transit, potentially reducing the absorption time and bioavailability of concurrently taken oral medications. It is advisable to separate dosing by at least 2 hours.
  • Diuretics and potassium-depleting drugs: The combined fluid-shifting effects of both the formula (which redirects fluid away from the intestines) and diuretics may compound electrolyte imbalances.

Bai Shao (White Peony Root) contains paeoniflorin, which has been shown in some pharmacological studies to affect hepatic drug-metabolizing enzymes. While clinical significance at standard formula doses is unclear, caution is warranted when co-administered with drugs metabolized through the liver.

Contraindications

Avoid

Pregnancy. The formula contains Da Huang (Rhubarb) and Zhi Shi (Immature Bitter Orange), both of which promote downward movement and purgation, posing a risk of stimulating uterine contractions or miscarriage.

Caution

Constipation due purely to Blood Deficiency without Heat. This formula addresses Intestinal Dryness from Heat, not Blood-deficient dryness. A Blood-nourishing formula like Run Chang Wan would be more appropriate.

Caution

Severely weak or debilitated patients. The Xiao Cheng Qi Tang component (Da Huang, Zhi Shi, Hou Po) can damage Qi in constitutionally weak individuals. Dosage must be reduced and the formula modified with tonifying herbs.

Avoid

Cold-type constipation (due to Yang Deficiency or interior Cold). This formula is cooling in nature and would worsen constipation caused by Cold congealing in the intestines.

Avoid

Loose stools or diarrhea. As a formula that promotes bowel movement and drains Heat, it should not be used when the stool is already loose or watery.

Avoid

Tree nut allergy. The formula contains Xing Ren (Apricot Kernel), which may trigger allergic reactions in sensitive individuals.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those Body Fluids and Blood Deficiency should use the formula with caution. It should not be used long term either.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Treasure of the East

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