Formula

Liu Wei Di Huang Wan

Six-Ingredient Pill with Rehmannia | 六味地黄丸

Also known as:

Rehmannia Six Combination , Longevity Blend , Rehmannia Six

Properties

Yin-tonifying formulas · Slightly Cool

Key Ingredients

Shu Di Huang

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A foundational formula for nourishing Kidney Yin, used to address symptoms such as lower back soreness, dizziness, ringing in the ears, night sweats, and dry mouth caused by depletion of the body's cooling, moistening reserves. Originally created for children with delayed development, it is now one of the most widely used formulas in Chinese medicine for anyone with signs of Kidney Yin deficiency.

Formula Category

Main Actions

  • Nourishes Kidney Yin
  • Supplements Liver and Spleen Yin
  • Benefits Essence and Fills the Marrow
  • Clears Deficiency Heat
  • Drains Dampness and Resolves Turbidity

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Liu Wei Di Huang Wan is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Liu Wei Di Huang Wan addresses this pattern

Kidney Yin deficiency is the primary pattern this formula was designed to treat. When the Kidney's Yin (its cooling, moistening, and nourishing capacity) becomes depleted, the body loses its ability to anchor Yang, leading to Empty Heat rising upward. Shu Di Huang directly replenishes Kidney Yin and fills the Essence, while Shan Zhu Yu prevents Essence from leaking and Shan Yao strengthens the Spleen's ability to generate new resources. Ze Xie drains turbid dampness from the Kidney, Mu Dan Pi clears the deficiency Heat that arises when Yin is insufficient, and Fu Ling assists the Spleen in transporting fluids properly. The net effect is a comprehensive restoration of Kidney Yin with simultaneous clearing of the secondary pathological products (dampness, deficiency Heat) that accumulate when Yin is weak.

A practitioner would look for one or more of these signs

Lower Back Pain

Soreness and weakness in the lower back and knees

Dizziness

Dizziness and blurred vision

Tinnitus

Ringing in the ears or reduced hearing

Night Sweats

Night sweats (stealing sweat)

Dry Mouth

Dry mouth and throat

Menopausal Hot Flashes

Heat in the palms, soles, and chest (five-centre heat)

Nocturnal Emission

Dream-disturbed emissions

How It Addresses the Root Cause

Liu Wei Di Huang Wan addresses the pattern of Kidney Yin deficiency, which in TCM represents a depletion of the body's fundamental cooling, moistening, and nourishing substance centered in the Kidneys. The Kidneys store Essence (Jing), which is the basis of growth, development, and reproduction, and Kidney Yin is the material foundation that keeps the body's warmth (Yang) in check.

When Kidney Yin becomes depleted, the body loses its capacity to cool and moisten itself. Without sufficient Yin to anchor and control Yang, deficiency Heat arises internally. This produces the characteristic signs: tidal fever and night sweats (Heat escaping when Yin is at its lowest during sleep), warm palms and soles, dry mouth and throat, dizziness and tinnitus (the ears and brain lack nourishment from Kidney Essence), and aching lower back and knees (the Kidneys govern the bones, and their weakness shows first in the lumbar region). Because the Kidneys, Liver, and Spleen share deep functional relationships in TCM, Kidney Yin deficiency commonly leads to Liver Yin insufficiency (causing dizziness and eye problems) and a failure to support the Spleen's digestive function.

The formula works by replenishing Kidney Yin and Essence at their source while simultaneously addressing the secondary consequences of this depletion. Its famous "three tonifying, three draining" structure ensures that nourishment is delivered without creating stagnation. The draining components prevent the rich, cloying tonics from generating Dampness or trapping residual Heat, allowing the body to rebuild its Yin reserves gradually and sustainably.

Formula Properties

Temperature

Slightly Cool

Taste Profile

Predominantly sweet and sour with mild bitterness and blandness. Sweet to nourish and tonify, sour to astringe and preserve Essence, bland to gently drain Dampness.

Target Organs
Kidneys Liver Spleen
Channels Entered
Kidney Liver Spleen

Formula Origin

Xiǎo Ér Yào Zhèng Zhí Jué (小儿药证直诀, Key to Therapeutics of Children's Diseases) by Qián Yǐ (钱乙)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Liu Wei Di Huang Wan

Detailed information about each herb in Liu Wei Di Huang Wan and their roles

Kings
Deputies
Assistants
Shu Di Huang
Shu Di Huang

Prepared Rehmannia root

Dosage: 24g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Liu Wei Di Huang Wan

Heavily nourishes Kidney Yin, fills the Essence, and enriches the marrow. As the primary herb in the formula with the heaviest dosage, it directly addresses the root cause of Kidney Yin deficiency.

Shan Zhu Yu
Shan Zhu Yu

Cornelian Cherry Fruit

Dosage: 12g

Temperature Slightly Warm
Taste Sour (酸 suān), Astringent (涩 sè)
Organ Affinity Liver, Kidneys
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Liu Wei Di Huang Wan

Nourishes the Liver and Kidney and restrains the leakage of Essence through its astringent quality. Based on the principle that Liver and Kidney share a common source, supporting Liver Yin reinforces Kidney Yin.

Shan Yao
Shan Yao

Chinese yam

Dosage: 12g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in Liu Wei Di Huang Wan

Tonifies the Spleen Yin and stabilizes the Kidney. By strengthening the Spleen (the postnatal root), it supports the body's ability to generate and replenish Essence, complementing Shu Di Huang's direct Kidney supplementation.

Ze Xie
Ze Xie

Water plantain rhizome

Dosage: 9g

Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Liu Wei Di Huang Wan

Drains dampness and clears turbidity from the Kidney, preventing the accumulation of pathological fluid. It also offsets the heavy, cloying nature of Shu Di Huang, ensuring the tonic herbs do not cause stagnation.

Mu Dan Pi
Mu Dan Pi

Tree peony root bark

Dosage: 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Liu Wei Di Huang Wan

Clears deficiency Heat and cools the Liver, addressing virtual fire that arises from Yin depletion. It also moderates the warm, astringent nature of Shan Zhu Yu, preventing it from trapping Heat.

Fu Ling
Fu Ling

Poria

Dosage: 9g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Liu Wei Di Huang Wan

Strengthens the Spleen by draining dampness through gentle leaching, supporting Shan Yao's Spleen-tonifying action. Together with Ze Xie, it helps drain pathological dampness so that true Yin can be restored to its proper place.

Modern Research (4 studies)

  • Systematic Review of LWDHW Combined with Antihypertensive Drugs for Essential Hypertension (2012)
  • Effect of LWDHW on CYP2C19, CYP2D6, and CYP3A4 Activities in Healthy Volunteers (Crossover Clinical Trial, 2012)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

On an empty stomach with warm water, traditionally in the morning and/or evening. The classical instruction is 'kong xin' (空心, on an empty stomach). If digestive discomfort occurs, it may be taken 30 minutes after meals instead.

Typical Duration

Typically taken for 4 to 8 weeks as a course of treatment, then reassessed by a practitioner. For chronic Kidney Yin deficiency, intermittent courses (such as one month on, one to two weeks off) are often recommended to prevent the formula's enriching nature from impeding digestion over time.

Dietary Advice

While taking this formula, favor foods that support Yin nourishment: black sesame, walnuts, goji berries, black beans, pork, duck, pears, lily bulb, and wood ear mushroom. Avoid excessively spicy, greasy, or fried foods, as these generate Heat and Dampness that counteract the formula's intent. Cold and raw foods should also be moderated, as they can further burden the Spleen, whose function may already be challenged by the cloying nature of this formula. Alcohol and strong coffee should be minimized, as they are drying and Heat-generating. During colds or acute digestive illness, suspend the formula and resume after recovery.

Modern Usage

Liu Wei Di Huang Wan is renowned for its gentle, tonifying properties. It is used for TCM patterns such as: General Yin Deficiency, Kidney Yin Deficiency (with Empty-Heat), Heart and Kidney Yin Deficiency, Liver and Kidney Yin Deficiency, Blood Deficiency and etc.

TCM practitioners commonly prescribe Liu Wei Di Huang Wan for conditions such as lower back and knee soreness, tinnitus, five-center heat, frequent urination, weak constitution and other symptoms related to above mentioned patterns.

Liu Wei Di Huang Wan was developed by the physician Qian Yi during the Song Dynasty (960–1279 AD). This herbal remedy has traditionally been used to balance Yin and Yang energies, addressing a variety of kidney and liver health issues.

Special Populations

Pregnancy

Generally considered relatively safe during pregnancy when used under professional guidance for a confirmed Kidney Yin deficiency pattern, as the formula contains no strongly moving, descending, or toxic herbs. However, Mu Dan Pi (Moutan bark) has mild Blood-moving properties and is traditionally listed among herbs requiring caution in pregnancy. Ze Xie (Alisma) is a diuretic that promotes fluid drainage. The enriching, cloying nature of Shu Di Huang may also aggravate nausea or digestive discomfort common in pregnancy. Pregnant individuals should not self-prescribe this formula and should consult a qualified practitioner who can assess whether it is appropriate for their specific condition.

Breastfeeding

No specific contraindications for breastfeeding have been established for Liu Wei Di Huang Wan. The formula contains no known toxic components likely to transfer into breast milk in harmful concentrations. However, the cloying, enriching nature of the formula can impair digestion and potentially reduce appetite, which could indirectly affect milk production in women with weak Spleen and Stomach function. Breastfeeding mothers with loose stools or poor appetite should use with caution. As with all herbal formulas during breastfeeding, professional guidance is recommended to confirm appropriate pattern differentiation.

Pediatric Use

Liu Wei Di Huang Wan was originally created specifically for pediatric use by the Song dynasty pediatric specialist Qian Yi. It is historically well-established as a children's formula and remains widely used in pediatric practice for conditions related to Kidney Essence insufficiency, including delayed development (late fontanelle closure, delayed walking, delayed teething, slow speech development), childhood night sweats, bedwetting, and recurrent febrile convulsions in constitutionally Yin-deficient children. Dosage must be adjusted by age. For concentrated pill forms: ages 1-2, approximately 3-4 pills per dose dissolved in warm water; ages 2-4, approximately 4-6 pills (may be chewed); over age 4, approximately 6-8 pills. Typically given once daily after the evening meal. Treatment should be discontinued if the child develops loose stools, loss of appetite, or shows no improvement after one week. Children who are overweight, have thick tongue coatings, or show signs of Dampness or Phlegm accumulation are generally not suitable candidates.

Drug Interactions

CYP enzyme modulation: Clinical studies in healthy volunteers have produced mixed findings. One study found that 14-day administration of LWDHW induced CYP1A2 activity and suppressed CYP2A6 and N-acetyltransferase 2 (NAT2). This could theoretically increase the clearance of CYP1A2 substrates (such as theophylline, clozapine, and certain antidepressants) and decrease the clearance of CYP2A6 substrates. A separate trial found no significant effect on CYP2C19, CYP2D6, or CYP3A4. Overall pharmacokinetic interaction risk appears modest, but caution is warranted with narrow-therapeutic-index drugs metabolized via CYP1A2.

Antiarrhythmic drugs: One traditional Chinese pharmaceutical reference cautions against concurrent use of Liu Wei Di Huang Wan with propafenone or quinidine, citing a theoretical risk of cardiac adverse effects. This interaction is not well-documented in peer-reviewed research but is noted in Chinese clinical pharmacy guidelines.

Hypoglycemic medications: Because LWDHW has demonstrated mild blood sugar-lowering effects in clinical studies, concurrent use with insulin or oral hypoglycemics (such as metformin or sulfonylureas) could theoretically enhance hypoglycemic effects. Blood glucose should be monitored more closely if combining these treatments.

General guidance: When combining Liu Wei Di Huang Wan with any pharmaceutical medication, it is advisable to separate administration by at least 30 minutes and to inform both the prescribing physician and pharmacist of concurrent use.

Contraindications

Avoid

Kidney Yang deficiency (signs: cold limbs, pale complexion, aversion to cold, cold lower back, copious clear urination, loose stools, pale tongue with white coating, deep slow pulse). This formula nourishes Yin and may further weaken Yang, worsening symptoms.

Avoid

Active external pathogen invasion (common cold, flu, fever). The rich, tonifying nature of this formula may trap the pathogen inside the body ('closing the door on the thief'), delaying recovery. Suspend use until the acute illness resolves.

Caution

Spleen deficiency with Dampness or Phlegm (signs: poor appetite, abdominal bloating, loose stools, heavy limbs, thick greasy tongue coating). The cloying, enriching herbs Shu Di Huang and Shan Zhu Yu can further impair digestion and generate more Dampness.

Caution

Damp-Heat patterns (signs: bitter taste, yellow greasy tongue coating, scanty dark urine, foul-smelling stools). The enriching Yin-nourishing herbs may feed the Dampness and worsen the condition.

Caution

Weak digestive function in the elderly or those with chronic gastrointestinal disorders. The formula's rich, sticky quality (particularly Shu Di Huang) can be difficult to digest, potentially causing nausea, bloating, or diarrhea. Consider combining with digestive-supporting herbs if use is necessary.

Cautions & Warnings

Liu Wei Di Huang Wan is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Liu Wei Di Huang Wan.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Treasure of the East

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