Formula

Ling Gui Zhu Gan Tang

苓桂术甘湯

Also known as:

Fu Ling Gui Zhi Bai Zhu Gan Cao Tang (茯苓桂枝白术甘草湯) , Ling Gui Shu Gan Tang

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical four-herb formula used to address dizziness, heart palpitations, chest fullness, and shortness of breath caused by a weak digestive system failing to properly process fluids. It gently warms the body and helps move excess fluid accumulation, particularly when someone feels heavy, waterlogged, or dizzy upon standing.

Formula Category

Main Actions

  • Warms Yang and Transforms Fluid Retention
  • Strengthens the Spleen and Resolves Dampness
  • Subdues Rushing Qi (Ben Tun)
  • Resolves Phlegm-Fluid Retention

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ling Gui Zhu Gan Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Ling Gui Zhu Gan Tang addresses this pattern

Phlegm-Fluid retention (痰饮) is the primary pattern this formula was designed for. When the Spleen's Yang is weak, it cannot properly transform and transport body fluids. These fluids collect and stagnate, forming what TCM calls "thin fluid" (饮) in the chest and upper abdomen. Fu Ling directly drains this accumulated fluid through urination, Gui Zhi warms Yang to transform it, and Bai Zhu strengthens the Spleen to prevent it from reforming. The formula embodies Zhang Zhongjing's guiding principle for phlegm-fluid disorders: use warm medicinals to gently resolve them.

A practitioner would look for one or more of these signs

Dizziness

Especially upon standing or changing position, caused by turbid fluid clouding the head

Palpitations

Heart palpitations from fluid disturbing the Heart

Exertional Dyspnea

Shortness of breath from fluid pressing on the Lungs

Chest Stiffness

Fullness and distension in the chest and hypochondrium

Hypochondrial Pain That Is Worse On Coughing And Breathing

Cough with thin, watery sputum

Nausea

Nausea or sensation of Qi rushing upward to the chest

How It Addresses the Root Cause

This formula addresses a condition where the body's middle region (the Spleen and Stomach system) has become too cold and weak to properly manage fluids. In TCM, the Spleen is the primary organ responsible for transforming and transporting water and dampness throughout the body. When Spleen Yang (the warming, activating aspect of the Spleen) becomes deficient, this transport function falters. Fluids that should be distributed and utilized instead collect and stagnate internally, forming what TCM calls "phlegm-fluid" (痰饮, tan yin), a thin, watery pathological accumulation distinct from normal body fluids.

This fluid stagnation creates a cascade of symptoms depending on where it pools. When it collects below the heart (the upper digestive region), it causes a sensation of fullness and stuffiness in the chest and flanks. Because the clear Yang Qi of the Spleen can no longer rise upward to nourish the head and sensory organs, dizziness and visual blurring result. When fluid surges upward to harass the Heart and Lungs, the person experiences palpitations, shortness of breath, and sometimes coughing. The classical texts describe this as "Qi surging upward into the chest" (气上冲胸). The tongue coating becomes white and slippery (a hallmark sign of internal cold fluid), and the pulse tends to be slippery or deep and tight, both indicating fluid accumulation driven by Yang deficiency.

Zhang Zhongjing's principle for treating this condition is captured in his famous teaching: "For diseases of phlegm-fluid retention, use warm medicinals to harmonize them." The logic is straightforward: since the fluid accumulation arises from cold and weakness, warming the center restores the Spleen's ability to transform and transport fluids, while simultaneously guiding excess water downward and out through urination. The formula does not forcefully drain, but gently warms and restores normal fluid metabolism from within.

Formula Properties

Temperature

Warm

Taste Profile

Predominantly sweet and bland with mild pungency. Sweet from Gan Cao and Fu Ling tonifies the Spleen; bland from Fu Ling drains dampness through urination; pungent from Gui Zhi warms Yang and promotes Qi movement.

Target Organs
Spleen Heart Lungs Urinary Bladder
Channels Entered
Spleen Heart Lung Bladder

Formula Origin

Jin Gui Yao Lue (金匮要略) by Zhang Zhongjing

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Ling Gui Zhu Gan Tang

Detailed information about each herb in Ling Gui Zhu Gan Tang and their roles

Kings
Deputies
Assistants
Envoys
Fu Ling
Fu Ling

Poria

Dosage: 12 - 20g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Ling Gui Zhu Gan Tang

Strengthens the Spleen and promotes urination to drain accumulated fluid from the middle burner. As the highest-dosed herb, it directly addresses the core problem of fluid retention by channeling excess water downward through the urinary tract while simultaneously supporting the Spleen's ability to process fluids.

Gui Zhi
Gui Zhi

Cinnamon twig

Dosage: 9 - 15g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder
Parts Used Twig (枝 zhī)
Role in Ling Gui Zhu Gan Tang

Warms the Yang and transforms Qi to resolve fluid retention. Its warm, acrid nature acts like sunlight evaporating stagnant water, helping the body's Yang Qi to reassert control over fluid metabolism. It also calms the upward surging of Qi (descends counterflow), directly relieving the sensation of Qi rushing up to the chest, dizziness, and palpitations.

Bai Zhu
Bai Zhu

White Atractylodes rhizome

Dosage: 6 - 10g

Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Ling Gui Zhu Gan Tang

Strengthens the Spleen and dries Dampness, addressing the root cause of fluid accumulation. By restoring the Spleen's transporting function, it prevents new fluid from pooling. Works synergistically with Fu Ling to bolster the Spleen and with Gui Zhi to warm and mobilize the middle burner.

Gan Cao
Gan Cao

Licorice root

Dosage: 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Ling Gui Zhu Gan Tang

Tonifies Spleen Qi and harmonizes the other herbs in the formula. Combined with Gui Zhi, it generates Yang through the classical 'acrid-sweet transforming into Yang' mechanism. It also moderates Fu Ling's draining action to prevent excessive fluid loss that might damage normal body fluids.

Modern Research (4 studies)

  • Systematic Review and Meta-Analysis: Linggui Zhugan Decoction for Premature Contraction in Coronary Heart Disease (2022)
  • Clinical Evidence and Potential Mechanisms for Management of Serum Lipids and Obesity: Systematic Review with Network Pharmacology (2022)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Divide into three doses taken warm throughout the day, ideally 30 minutes before meals or between meals on a relatively empty stomach. The classical instruction specifies "fen wen san fu" (分温三服), meaning to divide into three portions and take warm.

Typical Duration

Typically prescribed for 1 to 4 weeks for acute fluid retention episodes, then reassessed. Chronic conditions (recurrent dizziness, palpitations from phlegm-fluid) may require intermittent courses of 4 to 8 weeks with periodic reassessment.

Dietary Advice

Avoid cold, raw, and icy foods and beverages, as they further burden the Spleen Yang that this formula is working to restore. Reduce intake of greasy, oily, and heavy foods that promote dampness and phlegm. Minimize dairy products and excessively sweet foods, which can generate dampness. Favor warm, easily digestible foods such as congee (rice porridge), cooked grains, lightly steamed vegetables, ginger tea, and mild soups. Small, frequent meals are better than large heavy ones. The classical instruction after taking this formula notes that "urination should become free," so adequate (but not excessive) warm fluid intake supports the formula's action.

Special Populations

Pregnancy

Use with caution during pregnancy. Gui Zhi (Cinnamon Twig) is warming and promotes circulation, which is generally acceptable in moderate doses, but Gan Cao (Licorice, specifically glycyrrhizin) has been associated with potential corticosteroid-like and estrogenic effects. Research suggests high-dose or prolonged licorice intake during pregnancy may increase the risk of preterm delivery and may stimulate the fetal hypothalamic-pituitary-adrenal axis. While the dose of Zhi Gan Cao in this formula is relatively small (6g), pregnant women should consult a qualified practitioner before use. Not absolutely contraindicated, but caution is warranted.

Breastfeeding

Generally considered compatible with breastfeeding. The four herbs in this formula (Fu Ling, Gui Zhi, Bai Zhu, Zhi Gan Cao) are mild and commonly used in postpartum care. Fu Ling and Bai Zhu are frequently included in formulas to support Spleen function during lactation. Gan Cao (Licorice) at the low dose in this formula (6g) is unlikely to cause problems, though prolonged high-dose licorice use could theoretically affect electrolyte balance. No specific adverse effects on breast milk or nursing infants have been documented for this formula. As always, use under practitioner guidance.

Pediatric Use

This formula can be used in children with appropriate dosage reduction. As a general guideline: children aged 6-12 may receive approximately half the adult dose; children aged 2-6 may receive one-quarter to one-third the adult dose. Infants under 2 should only receive this formula under close practitioner supervision. The herbs in this formula are mild and well-tolerated. Gui Zhi (Cinnamon Twig) is warm but not harsh, and Fu Ling is gentle enough for pediatric use. For children who resist the taste, the decoction can be given in small, frequent sips. Monitor for any signs of excessive dryness or thirst, which would indicate the formula may be too warming.

Drug Interactions

Gan Cao (Licorice) interactions: The Zhi Gan Cao (honey-processed Licorice) in this formula contains glycyrrhizic acid, which has well-documented drug interactions:

  • Cardiac glycosides (digoxin): Licorice can promote potassium loss, increasing sensitivity to digoxin and raising the risk of digoxin toxicity and cardiac arrhythmias. Concurrent use should be avoided or closely monitored.
  • Potassium-depleting diuretics (furosemide, thiazides): Licorice's mineralocorticoid-like effects compound with these diuretics to increase the risk of hypokalemia. Electrolytes should be monitored if combined.
  • Antihypertensive drugs: Licorice can cause sodium and water retention, potentially reducing the effectiveness of blood pressure medications.
  • Hypoglycemic agents (insulin, metformin, sulfonylureas): Glycyrrhizic acid has glucocorticoid-like activity that can raise blood sugar, potentially counteracting diabetes medications.
  • Warfarin: Licorice may interact with warfarin metabolism, potentially altering its anticoagulant effect. Monitoring of INR is advised.
  • Corticosteroids: Licorice inhibits cortisol metabolism, potentially increasing steroid blood levels and side effects.

Gui Zhi (Cinnamon Twig): Contains cinnamaldehyde, which has mild blood-thinning properties. Theoretically, it may have an additive effect with anticoagulant or antiplatelet drugs, though clinical significance at standard formula doses is uncertain.

Contraindications

Avoid

Yin deficiency with Heat signs (dry mouth, red tongue with little coating, night sweats). This formula is warming and drying in nature and would further deplete Yin fluids.

Avoid

Phlegm-Heat or Damp-Heat patterns. The warm nature of Gui Zhi (Cinnamon Twig) and the drying quality of Bai Zhu (White Atractylodes) would worsen Heat conditions.

Caution

Severe Kidney Yang deficiency with flooding edema. This formula addresses mild to moderate fluid retention from Spleen Yang deficiency. Severe cases with Kidney Yang collapse require stronger formulas such as Zhen Wu Tang.

Caution

Patients with uncontrolled hypertension. Gan Cao (Licorice) can promote sodium and water retention, potentially raising blood pressure. Use with caution and monitor.

Caution

Patients with hypokalemia or those on potassium-depleting medications. Gan Cao (Licorice) can further lower potassium levels.

Cautions & Warnings

Ling Gui Zhu Gan Tang is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Ling Gui Zhu Gan Tang.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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