Formula

Liang Ge San

凉膈散

Properties

Heat-clearing formulas · Cold

Key Ingredients

Lian Qiao

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula that clears intense heat from the chest, diaphragm, and digestive tract. It is commonly used for conditions involving high fever, irritability, mouth sores, sore throat, constipation, and a red face or lips caused by excessive internal heat in the upper and middle body. The formula works by both clearing heat from above and moving it downward through the bowels.

Formula Category

Main Actions

  • Clears Heat and Drains Fire
  • Promotes Bowel Movement
  • Clears Upper Jiao Heat
  • Clears Heat and Drains Fire from the Middle Burner
  • Resolves Toxicity
  • Clears Heat from the Chest and Diaphragm

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Liang Ge San is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Liang Ge San addresses this pattern

This is the primary pattern Liang Ge San was designed to treat. When intense heat accumulates in the organs of the upper body (Heart, Lungs) and middle body (Stomach, Intestines), it creates a situation where formless, blazing fire burns upward while formed, dry heat clumps below. Lian Qiao, Huang Qin, Bo He, and Dan Zhu Ye clear the formless fire from above, while Da Huang and Mang Xiao purge the formed accumulation from below. Zhi Zi connects both levels by draining fire through the urine. The formula's strategy of 'purging to clear' is specifically designed for this dual-level heat pattern.

A practitioner would look for one or more of these signs

Breast Heat

Burning sensation in the chest and diaphragm area

Irritability

Restlessness and agitation from heat disturbing the Heart

Sore

Painful sores on the tongue, lips, or mouth lining

Red Face

Flushed red face, dry cracked lips

Thirst

Strong thirst with desire for cold drinks

Constipation

Dry, difficult bowel movements from heat drying the intestines

Dark Urine

Scanty, dark yellow, or burning urination

Sore Throat

Red, swollen, painful throat

Nosebleeds

Epistaxis from heat forcing blood upward

Insomnia

Inability to sleep peacefully due to internal heat

How It Addresses the Root Cause

Liang Ge San addresses a condition where intense Heat has accumulated in both the Upper and Middle Burners (the chest, diaphragm, and digestive tract). In TCM theory, the diaphragm area (膈, ge) is a pivotal junction between the upper body (Heart, Lungs) and the middle body (Stomach, intestines). When pathogenic Heat lodges here, it creates a two-level crisis that feeds on itself.

In the Upper Burner, formless (intangible) Fire blazes upward. Because Fire by nature rises, it scorches the sensory openings: the eyes become red, the lips crack and dry, the tongue and throat swell, and mouth sores erupt. When this Heat invades the Heart, it disturbs the spirit (shen), causing restlessness, inability to sleep, and in severe cases, delirious or manic speech. Nosebleeds and vomiting blood can occur as Heat forces Blood out of the vessels.

In the Middle Burner, Heat combines with dry Stomach and Intestinal contents to form tangible, solid obstruction. Fluids are scorched away, so stools become hard and dry, urine turns dark and scanty, and the person feels intensely thirsty. This internal blockage prevents the normal downward movement of Qi through the digestive tract, which paradoxically traps more Heat above, worsening the upper symptoms. The tongue is red with yellow coating and the pulse is slippery and rapid, both confirming intense interior Heat. Clearing only the upper Fire would leave the middle obstruction in place, and purging only the bowels would leave the upper Fire unresolved. Both levels must be addressed simultaneously.

Formula Properties

Temperature

Cold

Taste Profile

Predominantly bitter and salty-cold, with a sweet moderating note. The bitter flavour drains Heat and dries, the salty flavour softens hardness and purges downward, and the sweet flavour of Gan Cao and honey buffers the harsh purgative action.

Target Organs
Heart Stomach Large Intestine Lungs San Jiao (Triple Burner)
Channels Entered
Heart Stomach Large Intestine Lung San Jiao

Formula Origin

Tai Ping Hui Min He Ji Ju Fang (太平惠民和剂局方), Volume 6

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Liang Ge San

Detailed information about each herb in Liang Ge San and their roles

Kings
Deputies
Assistants
Envoys
Lian Qiao
Lian Qiao

Forsythia fruit

Dosage: 12 - 18g

Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Liang Ge San

Used at the highest dose to clear Heat and resolve toxicity. Its light, ascending nature allows it to disperse and vent accumulated heat from the Upper Burner and chest, addressing the core pathomechanism of blazing heat in the diaphragm region.

Da Huang
Da Huang

Rhubarb root and rhizome

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium
Parts Used Root (根 gēn)
Role in Liang Ge San

Purges heat downward by opening the bowels, clearing accumulated heat and dryness from the Middle Burner and intestines. Together with Mang Xiao, it borrows the Yang Ming (Stomach and Large Intestine) channel as an exit route for heat.

Mang Xiao
Mang Xiao

Mirabilite

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Stomach, Large Intestine
Parts Used Mineral (矿物 kuàng wù)
Role in Liang Ge San

Softens hardened stool and flushes accumulated heat and dryness from the intestines. Its salty, cold nature complements Da Huang to clear formed heat clumping in the Middle Burner.

Huang Qin
Huang Qin

Baical skullcap root

Dosage: 5 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Parts Used Root (根 gēn)
Role in Liang Ge San

Clears constrained heat from the chest, diaphragm, and Lungs. Focuses its clearing action on the Upper and Middle Burners, reinforcing the King herb's heat-clearing function from a different angle.

Zhi Zi
Zhi Zi

Gardenia fruit

Dosage: 5 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Liang Ge San

Clears heat from all three Burners and guides fire downward, draining heat through the urine. Connects the upper clearing action with the lower purging action, ensuring fire is conducted out from below.

Bo He
Bo He

Peppermint herb

Dosage: 3 - 6g

Temperature Cool
Taste Acrid / Pungent (辛 xīn), Aromatic (芳香 fāng xiāng)
Organ Affinity Lungs, Liver
Parts Used Whole plant / Aerial parts (全草 quán cǎo)
Role in Liang Ge San

Its light, cool, dispersing nature clears the head, benefits the eyes, and soothes the throat. Vents constrained heat from the Upper Burner outward, embodying the classical principle of 'venting depressed fire' (火郁发之).

Dan Zhu Ye
Dan Zhu Ye

Lophatherum herb

Dosage: 3 - 6g

Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Stomach, Small Intestine
Parts Used Whole plant / Aerial parts (全草 quán cǎo)
Role in Liang Ge San

Clears heat from the Heart and Upper Burner, promotes urination to guide heat downward and out. Assists Bo He in dispersing upper body heat and calming irritability.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Liang Ge San

Together with honey, moderates the harsh purging action of Da Huang and Mang Xiao so they clear heat without injuring the Stomach. Its sweet taste 'lingers at the diaphragm' level, protecting fluids and harmonizing all the other herbs.

Modern Research (3 studies)

  • LGS protects against LPS-induced inflammation through cholinergic anti-inflammatory pathway (Preclinical in vitro/in vivo study, 2016)
  • LGS attenuates LPS-induced acute lung injury through up-regulating miR-21 (Preclinical study, 2020)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

After meals (食后温服), taken warm, as specified in the original text. This helps buffer the strong purgative action on the Stomach.

Typical Duration

Acute use only: 1–3 days typically, stopped as soon as bowel movements normalize (得利下住服). Rarely exceeds 5–7 days.

Dietary Advice

While taking this formula, avoid greasy, fried, rich, and spicy foods, which generate further Heat and obstruct digestion. Alcohol should be strictly avoided as it adds Heat. Cold, raw foods and iced drinks should also be limited, as although the condition involves Heat, icy foods may impair the Stomach's digestive function during recovery. Light, easily digestible foods are preferred: plain congee (rice porridge), steamed vegetables, and clear soups. Fresh fruits like pears and watermelon, which are naturally cooling, may be taken in moderation. Once the bowels have moved and symptoms improve, gradually return to a normal diet and discontinue the formula promptly.

Special Populations

Pregnancy

Contraindicated. Da Huang (Rhubarb) and Mang Xiao (Mirabilite/Glauber's salt) are both classified as pregnancy-caution (慎用) or pregnancy-prohibited herbs in classical materia medica. Da Huang promotes intestinal peristalsis and Blood movement, which can stimulate uterine contractions and risk miscarriage. Mang Xiao has strong purgative action that may also endanger pregnancy. The original text of the Tai Ping Hui Min He Ji Ju Fang explicitly notes that pregnant women should avoid this formula (孕妇忌用或慎用本方). This formula should not be used during any trimester of pregnancy.

Breastfeeding

Use with significant caution. Da Huang (Rhubarb) contains anthraquinone compounds that are excreted in breast milk, which may cause diarrhea in nursing infants. Classical materia medica texts note that breastfeeding women should avoid Da Huang for this reason. Mang Xiao's strong purgative effects could also affect the nursing mother's fluid balance and milk production. If this formula is absolutely necessary for a breastfeeding mother, it should be used only briefly under professional supervision, and the infant should be monitored for loose stools or digestive upset.

Pediatric Use

Liang Ge San has historically been used in pediatrics, particularly for childhood febrile convulsions (小儿惊风) associated with intense Heat. The original Song Dynasty text explicitly includes pediatric dosing instructions: children may take half the adult dose (approximately 1.5g of the powdered formula for young children), adjusted further according to age. However, given the strong purgative action of Da Huang and Mang Xiao, pediatric use requires careful professional supervision. The formula should only be used in children with clear signs of Excess Heat (high fever, constipation, red tongue, yellow coating) and never for deficiency patterns. Once bowel movements normalize, the formula should be stopped immediately to prevent damage to the child's relatively delicate digestive system. Infants and very young children (under age 2) should generally not receive this formula.

Drug Interactions

Gan Cao (Licorice root) in this formula contains glycyrrhizin, which can cause potassium loss and sodium/water retention with prolonged use. This creates potential interactions with:

  • Cardiac glycosides (e.g. digoxin): Licorice-induced hypokalemia may increase toxicity and risk of arrhythmias.
  • Diuretics (especially thiazides and loop diuretics): Additive potassium depletion, increasing risk of dangerous hypokalemia.
  • Antihypertensive medications: Glycyrrhizin's mineralocorticoid effect (sodium retention, potassium loss) may counteract blood pressure lowering.
  • Corticosteroids: May potentiate both the therapeutic and adverse effects of corticosteroids through similar mineralocorticoid pathways.

Da Huang (Rhubarb) contains anthraquinone glycosides that powerfully stimulate bowel motility. Key interactions include:

  • Oral medications generally: The purgative action may reduce intestinal transit time and decrease absorption of concurrently administered oral drugs.
  • Anticoagulants (e.g. warfarin): Da Huang has mild Blood-moving properties; combined use may theoretically increase bleeding risk.
  • Cardiac glycosides (e.g. digoxin): Diarrhea-induced electrolyte loss (especially potassium) may enhance digoxin toxicity.

Mang Xiao (Mirabilite/sodium sulfate) is an osmotic laxative. The resulting fluid loss and electrolyte shifts can interact with diuretics, antihypertensives, and drugs sensitive to hydration status. Patients on lithium should be cautious, as sodium and fluid changes can alter lithium levels.

Contraindications

Avoid

Pregnancy. This formula contains Da Huang (Rhubarb) and Mang Xiao (Mirabilite), both of which stimulate intestinal motility and can promote uterine contractions. Classical sources explicitly list pregnancy as a contraindication.

Avoid

Patients with constitutional weakness, Qi deficiency, or Spleen-Stomach vacuity. The formula's strongly purgative and cold nature can readily injure Spleen and Stomach Qi, worsening deficiency conditions.

Avoid

Yin deficiency with internal Heat (without true Excess). This formula is designed exclusively for Excess Heat patterns. Using it in Yin-deficient Heat will further damage Yin fluids and deplete the body.

Caution

Elderly or frail patients. The harsh purgative action of Da Huang and Mang Xiao may cause excessive fluid loss, electrolyte imbalance, or collapse in patients with underlying weakness.

Caution

Patients with chronic diarrhea or loose stools. The purgative ingredients will worsen existing bowel looseness and further injure Spleen Qi.

Caution

Once the bowels have been cleared (得利下住服). The original text instructs to stop taking the formula as soon as bowel movements become smooth. Continued use after purgation is achieved risks unnecessary injury to the Stomach and Spleen.

Cautions & Warnings

Liang Ge San is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Liang Ge San.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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