Formula

Er Xian Tang

Two Immortals Decoction | 二仙汤

Also known as:

Circuligo and Epimedium Combination

Properties

Yin and Yang tonifying formulas · Slightly Warm

Key Ingredients

Xian Mao, Yin Yang Huo

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula*

Traditional Chinese Medicine background and properties

Formula Description*

A modern formula designed to address the hormonal and constitutional changes that occur around menopause, including hot flushes, mood changes, insomnia, fatigue, and cold limbs. It works by simultaneously warming and nourishing the Kidneys while clearing the excess heat that results from internal imbalance. Although originally developed for women, it is also used for men experiencing similar age-related changes.

Formula Category*

Main Actions*

  • Tonifies Kidney Yang
  • Tonifies Kidney Essence
  • Drains Ministerial Fire
  • Secures the Chong and Ren Vessels
  • Nourishes Blood

TCM Patterns*

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Er Xian Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Er Xian Tang addresses this pattern

When both Kidney Yin and Kidney Yang decline together, which commonly occurs during the transition around menopause or with ageing, the body loses its ability to maintain temperature regulation, hormonal balance, and reproductive function. Kidney Yang insufficiency causes cold limbs, fatigue, and weakness in the lower back and knees, while the simultaneous Yin deficiency allows deficiency Fire to flare upward, producing hot flushes, night sweats, and irritability. Er Xian Tang addresses this dual deficiency directly: Xian Mao, Yin Yang Huo, and Ba Ji Tian warm the Kidney Yang and replenish Essence, while Zhi Mu and Huang Bai nourish Yin and clear the deficiency Fire. Dang Gui nourishes Blood and regulates the Penetrating and Governing Vessels. The formula thus restores Kidney Yin-Yang balance from both sides simultaneously.

A practitioner would look for one or more of these signs

Menopausal Hot Flashes

Alternating with chills, worse at night

Night Sweats

From deficiency Fire flaring upward

Lower Back Pain

Soreness and weakness in lumbar area and knees

Dizziness

With tinnitus and a feeling of emptiness in the head

Insomnia

Difficulty sleeping with vivid dreams

Cold Limbs

Especially cold feet, alternating with episodes of flushing heat

Irritability

Emotional instability with anxiety and restlessness

Irregular Menstruation

Erratic cycle length and flow volume before cessation

How It Addresses the Root Cause*

Er Xian Tang addresses a complex condition rooted in the decline of Kidney Yin and Kidney Yang together, a situation most commonly seen during the menopausal transition but also encountered in aging men and in certain chronic illnesses. In TCM theory, the Kidneys store the body's foundational Essence and govern the balance between Yin (the cooling, nourishing, material aspect) and Yang (the warming, activating, functional aspect). As a person ages or as the Kidneys become depleted, both Yin and Yang can weaken simultaneously.

When Kidney Yang becomes insufficient, the body's warming function falters, leading to cold extremities, lower back weakness, fatigue, and a general sense of chilliness. At the same time, when Kidney Yin is also depleted, it can no longer anchor or restrain the body's residual Yang, which then "floats" upward as what is called "Deficiency Fire" or "Empty Heat." This produces symptoms like hot flushes, night sweats, irritability, insomnia, and a feeling of heat rushing to the head and face. The paradoxical picture of feeling cold below while experiencing waves of heat above is the hallmark of this pattern.

In women, the Kidneys also govern the Chong Mai (Penetrating Vessel) and Ren Mai (Conception Vessel), the two extraordinary channels most closely tied to reproductive and menstrual function. When both Kidney Yin and Yang decline, the Chong and Ren lose their regulation, resulting in menstrual irregularity, emotional volatility, and eventually cessation of menstruation. The formula works by simultaneously warming Kidney Yang (to restore the foundation below) and clearing Deficiency Fire (to pull the drifting Yang back down), while nourishing Blood to re-regulate the Chong and Ren vessels.

Formula Properties*

Temperature

Slightly Warm

Taste Profile

Predominantly acrid (pungent) and bitter with a sweet undertone. The acrid quality from the warming Yang tonics (Xian Mao, Yin Yang Huo, Ba Ji Tian) disperses and activates, while the bitter quality from Huang Bai and Zhi Mu clears Heat and preserves Yin. Dang Gui adds a sweet, moistening character.

Target Organs
Kidneys Liver Uterus
Channels Entered
Kidney Liver Chong Mai (冲脉) Penetrating Vessel Ren Mai (任脉) Conception Vessel

Formula Origin

Zhōng Yī Fāng Jì Lín Chuáng Shǒu Cè (《中医方剂临床手册》, Clinical Manual of TCM Formulas), Shanghai Shuguang Hospital

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Supplier Information

Treasure of the East

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Ingredients in Er Xian Tang

Detailed information about each herb in Er Xian Tang and their roles

Kings
Deputies
Assistants
Xian Mao
Xian Mao

Curculigo rhizome

Dosage: 9 - 15g

Temperature Hot
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Kidneys, Liver, Spleen
Parts Used Rhizome (根茎 gēn jīng)
Role in Er Xian Tang

Powerfully warms the Kidney Yang, tonifies Kidney Essence, and helps regulate the Penetrating and Governing Vessels. As the primary Yang-warming herb, it directly addresses the root Kidney Yang deficiency.

Yin Yang Huo
Yin Yang Huo

Epimedium leaf

Dosage: 9 - 15g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Whole plant / Aerial parts (全草 quán cǎo)
Role in Er Xian Tang

Works alongside Xian Mao to warm the Kidney Yang and tonify Kidney Essence. Also helps harness and settle ascending deficiency Fire from the Gate of Vitality, and unblocks the flow of Yang Qi.

Ba Ji Tian
Ba Ji Tian

Morinda root

Dosage: 9 - 12g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Kidneys, Liver
Parts Used Root (根 gēn)
Role in Er Xian Tang

Reinforces the King herbs in warming and tonifying Kidney Yang, strengthening sinews and bones. Its nature is gentle and moist rather than harsh and drying, which complements the stronger warming action of the two King herbs without creating excessive dryness.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 9g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Er Xian Tang

Nourishes and gently invigorates the Blood, moistens dryness, and regulates the Penetrating (Chong Mai) and Governing (Ren Mai) Vessels. By enriching Blood and nourishing the Liver, it supports the reproductive system and helps regulate the menstrual cycle.

Huang Qi
Huang Qi

Astragalus root

Dosage: 4.5 - 9g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs
Parts Used Root (根 gēn)
Role in Er Xian Tang

Clears deficiency Heat and drains Kidney Fire. Crucially, it tempers the hot, drying nature of the King herbs (Xian Mao and Yin Yang Huo), preventing them from generating excessive Heat. Also helps guide ministerial Fire back down to its lower source.

Zhi Mu
Zhi Mu

Anemarrhena rhizome

Dosage: 4.5 - 9g

Temperature Cold
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Lungs, Stomach, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in Er Xian Tang

Enriches Kidney Yin, clears Heat, moistens dryness, and generates fluids. Works together with Huang Bai to clear deficiency Fire and nourish Yin, counterbalancing the warming herbs in the formula to prevent overheating.

Modern Research (5 studies)

  • Randomized, Double-Blind, Controlled Trial of Er-Xian Decoction for Menopausal Symptoms in Perimenopausal Women (RCT, 2013)
  • Treatment of Menopausal Symptoms with Er-Xian Decoction: A Systematic Review (Systematic Review/Meta-analysis, 2008)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Twice daily, morning and evening, taken warm after meals to reduce potential gastrointestinal irritation from Xian Mao.

Typical Duration

Typically taken in courses of 20 days (one treatment cycle), often continued for 2-3 months with periodic reassessment by a practitioner. Long-term use beyond 3 months should include monitoring of liver and kidney function.

Dietary Advice

Avoid excessively cold, raw, and icy foods and beverages, as these can impair the formula's warming action on Kidney Yang. Also avoid heavily spicy, greasy, or deep-fried foods and alcohol, which generate Heat and may aggravate the Deficiency Fire component of the condition. Foods that gently support the Kidneys are beneficial: black sesame seeds, walnuts, goji berries (in moderation), black beans, and warm soups with lamb or bone broth. Moderate intake of soy products is acceptable but should not be excessive given the formula's phytoestrogenic properties. During the course of treatment, maintain emotional balance and avoid excessive stress. Smoking should be avoided. The original clinical guidelines specifically note: avoid tobacco, alcohol, and pungent/irritating foods during the treatment period.

Modern Usage*

Er Xian Tang is a relatively modern Chinese herbal formula. It was developed in the 1960s by physicians in Zhejiang Province, China, and consists of six herbs that work synergistically to balance and nourish Kidney energy. It is often used to alleviate menopausal symptoms such as hot flashes, mood swings, and fatigue.

TCM practitioners recommend Er Xian Tang for individuals with a thready, rapid pulse and symptoms of Kidney Yin Deficiency, which leads to Fire, or Kidney Yang Deficiency. These symptoms may include headaches, amenorrhea, sweating, irritability, insomnia, urinary tract infections, heart palpitations, and hot flashes.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Special Populations

Pregnancy

Contraindicated during pregnancy. Xian Mao (Curculigo rhizome) is classified as mildly toxic (有小毒) in the Chinese Pharmacopoeia and is traditionally prohibited for pregnant women. It contains saponins and alkaloids (including lycorine) that pose a risk of hepatic and reproductive toxicity. Yin Yang Huo (Epimedium) is a potent Kidney Yang tonic with hormonal modulating properties that make it inappropriate during pregnancy. Dang Gui (Chinese Angelica) promotes Blood circulation and can stimulate uterine activity. The overall warming and Blood-moving character of the formula creates unacceptable risk during pregnancy. Do not use.

Breastfeeding

Not recommended during breastfeeding without professional supervision. Xian Mao (Curculigo) is classified as mildly toxic and is specifically listed as contraindicated for breastfeeding women in Chinese pharmacological references due to concerns about transfer of its saponin and alkaloid compounds through breast milk. The formula's hormonal modulating effects (it contains phytoestrogenic compounds that act on estrogen receptors) also raise concerns about potential influence on lactation and infant hormonal exposure. If a breastfeeding woman has a clear indication for this formula, a qualified practitioner should weigh the benefits carefully and consider modifications or alternative formulas.

Pediatric Use

Er Xian Tang is not appropriate for children. The formula was specifically designed for conditions related to age-related decline of Kidney Yin and Yang, principally menopausal and andropausal syndromes. These pathologies do not occur in pediatric patients. Furthermore, Xian Mao (Curculigo) is mildly toxic, and both Xian Mao and Yin Yang Huo (Epimedium) have hormonal modulating properties (androgenic and estrogenic effects) that could interfere with normal childhood development and puberty. Chinese pharmacological references explicitly list children as a contraindicated population for Xian Mao. This formula should not be used in pediatric patients.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.