Formula

Chai Hu Jia Long Gu Mu Li Tang

Bupleurum plus Dragon Bone and Oyster Shell Decoction | 柴胡加龙骨牡蛎汤

Also known as:

Bupleurum and Dragon Bone Decoction

Properties

Spirit-calming formulas · Slightly Warm

Key Ingredients

Chai Hu

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula used to calm the mind, relieve anxiety, and settle restlessness. It addresses a pattern where emotional stress, chest tightness, irritability, disturbed sleep, and feelings of heaviness arise from internal disruption affecting the Liver, Gallbladder, and digestion. Originally created for complex cases involving both excess and deficiency, it combines herbs that regulate Qi flow with heavy mineral substances that anchor and stabilize the spirit.

Formula Category

Main Actions

  • Harmonizes the Shaoyang
  • Calms the Spirit and Settles Fright
  • Clears Heat and Drains Fire
  • Harmonizes the Three Yang Channels
  • Promotes Urination and Drains Dampness
  • Clears Interior Heat

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Chai Hu Jia Long Gu Mu Li Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Chai Hu Jia Long Gu Mu Li Tang addresses this pattern

This formula was specifically created for a Shaoyang pattern complicated by the consequences of improper purgative treatment. When the Shaoyang pivot becomes disrupted, the Gallbladder and Triple Burner lose their regulatory function. Chai Hu and Huang Qin directly harmonize the Shaoyang, releasing constraint and clearing Heat from the half-exterior, half-interior level. Gui Zhi assists by opening the exterior Yang pathways, while Da Huang drains accumulated Heat from the interior. The formula restores the Shaoyang pivot's role as mediator between exterior and interior, upper and lower, allowing Qi, fluids, and Heat to move properly again.

A practitioner would look for one or more of these signs

Chest Stiffness

Fullness and oppression in the chest and hypochondrium

Irritability

Restlessness, easily startled, emotional agitation

Insomnia

Difficulty sleeping, disturbed dreams

Bitter Taste In The Mouth

Bitter taste in the mouth, especially in the morning

Difficulty Urinating

Inhibited urination

Constipation

Dry stools or constipation from internal Heat

Generalized Body Heaviness

Heaviness of the whole body with difficulty turning over

How It Addresses the Root Cause

This formula addresses a complex, layered condition where disease has become trapped at multiple levels of the body simultaneously. The classical scenario describes a person who originally had an external illness (Cold Damage) that was treated incorrectly with strong purging. This erroneous treatment weakened the body's interior, allowing pathogenic Heat to plunge inward from the surface while the original condition remained unresolved. The result is a tangled state where the exterior, interior, upper, and lower parts of the body are all affected at once, with a mixture of excess and deficiency.

At the core of this pathomechanism is disruption of the Shao Yang (Lesser Yang) pivot, the body's mechanism for regulating communication between interior and exterior. When this pivot becomes stuck, the Gallbladder and Liver lose their ability to freely circulate Qi. Heat becomes trapped in the chest and diaphragm region, producing a sensation of oppressive fullness. This constrained Heat agitates the Heart and spirit, leading to restlessness, anxiety, fright, and even confused or delirious speech. The spirit (Shen), which normally rests peacefully in the Heart, becomes unsettled and "floats" upward because Heat disturbs its residence. Meanwhile, the weakened Spleen and the disrupted Triple Burner (San Jiao) lose their ability to properly manage water metabolism, causing urinary difficulty and a heavy, waterlogged sensation throughout the body. Stagnant Heat in the Stomach and intestines produces further agitation and delirium.

In modern clinical application, practitioners recognize this same fundamental pattern (constrained Liver-Gallbladder Heat agitating the Heart spirit, with disrupted fluid metabolism) in conditions such as anxiety, depression, insomnia, epilepsy, and various psychosomatic complaints. The key diagnostic indicators are chest oppression, emotional agitation or fright, disturbed sleep, and often difficulty urinating or a feeling of bodily heaviness.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly bitter and acrid with a salty undertone. Bitter to clear Heat and drain downward, acrid to disperse constraint and move Qi, salty from the heavy mineral substances to anchor and settle the spirit.

Target Organs
Heart Liver Gallbladder Stomach Spleen Brain
Channels Entered
Liver Gallbladder Heart Stomach Spleen Bladder

Formula Origin

Shāng Hán Lùn (傷寒論, Treatise on Cold Damage) by Zhāng Zhòngjǐng, Article 107

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Chai Hu Jia Long Gu Mu Li Tang

Detailed information about each herb in Chai Hu Jia Long Gu Mu Li Tang and their roles

Kings
Deputies
Assistants
Envoys
Chai Hu
Chai Hu

Bupleurum root

Dosage: 9 - 15g

Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs
Parts Used Root (根 gēn)
Role in Chai Hu Jia Long Gu Mu Li Tang

The chief herb of the formula, used at the highest dosage. Chai Hu resolves the Shaoyang (lesser Yang) level by spreading Liver Qi, releasing constraint, and lifting stagnation from the half-exterior, half-interior level. It addresses the core pathomechanism of Qi stagnation in the Shaoyang pivot causing chest fullness, irritability, and emotional disturbance.

Long Gu
Long Gu

Dragon bone (fossilized bone)

Dosage: 9 - 30g

Temperature Neutral
Taste Sweet (甘 gān), Astringent (涩 sè)
Organ Affinity Heart, Liver, Kidneys
Parts Used Mineral (矿物 kuàng wù)
Role in Chai Hu Jia Long Gu Mu Li Tang

A heavy mineral substance that anchors the spirit, calms the mind, and settles restlessness and fright. Long Gu directly addresses the key symptoms of anxiety, palpitations, insomnia, and emotional agitation by weighing down and stabilizing the unsettled spirit (Shen).

Mu Li
Mu Li

Oyster shell

Dosage: 9 - 30g

Temperature Slightly Cool
Taste Salty (咸 xián), Astringent (涩 sè)
Organ Affinity Liver, Gallbladder, Kidneys
Parts Used Shell (壳 ké / 甲 jiǎ)
Role in Chai Hu Jia Long Gu Mu Li Tang

Works synergistically with Long Gu to anchor the spirit and calm the mind. Mu Li additionally subdues rising Yang and softens hardness. Together with Long Gu, it provides the heavy, settling, mineral-based action that defines this formula's spirit-calming character.

Huang Qin
Huang Qin

Chinese skullcap root

Dosage: 4.5 - 10g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Parts Used Root (根 gēn)
Role in Chai Hu Jia Long Gu Mu Li Tang

Pairs with Chai Hu to harmonize the Shaoyang level. While Chai Hu disperses outward, Huang Qin clears Heat inward, particularly clearing Gallbladder Fire and upper Burner Heat that contribute to irritability, bitter taste, and mental restlessness.

Gui Zhi
Gui Zhi

Cinnamon twig

Dosage: 4.5 - 10g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder
Parts Used Twig (枝 zhī)
Role in Chai Hu Jia Long Gu Mu Li Tang

Warms and promotes the flow of Yang Qi, assisting the restoration of normal Qi circulation in the exterior (Tai Yang level). Working with Fu Ling, it promotes water metabolism to address urinary difficulty and body heaviness, and it helps unblock the Yang Qi that has become stagnant internally.

Fu Ling
Fu Ling

Poria

Dosage: 4.5 - 15g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Chai Hu Jia Long Gu Mu Li Tang

Calms the spirit and promotes urination. Fu Ling addresses two aspects of the pattern simultaneously: it drains Dampness through the urinary tract to relieve body heaviness and difficult urination, while also calming the Heart spirit to support the mineral substances in settling anxiety.

Da Huang
Da Huang

Rhubarb root and rhizome

Dosage: 3 - 6g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium
Parts Used Root (根 gēn)
Role in Chai Hu Jia Long Gu Mu Li Tang

Purges Heat from the Yang Ming (Stomach and Intestines), addressing the internal Heat that causes delirium and constipation. Its downward-draining action clears accumulated Heat and guides it out through the bowels. Added late in decoction to preserve its purgative strength.

Ban Xia
Ban Xia

Pinellia tuber

Dosage: 6 - 12g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Chai Hu Jia Long Gu Mu Li Tang

Harmonizes the Stomach and directs rebellious Qi downward to relieve nausea and chest fullness. Ban Xia also dries Dampness and transforms Phlegm, addressing any Phlegm accumulation that may be clouding the mind and contributing to mental confusion or disturbed speech.

Ren Shen
Ren Shen

Ginseng root

Dosage: 4.5 - 10g

Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys
Parts Used Root (根 gēn)
Role in Chai Hu Jia Long Gu Mu Li Tang

Tonifies the Qi of the Middle Burner and supports the body's righteous Qi (Zheng Qi), which has been damaged by the initial illness and mistreatment. Without Ren Shen's support, the formula's dispersing and draining herbs could further weaken the patient. Modern practice often substitutes Dang Shen (Codonopsis).

Sheng Jiang
Sheng Jiang

Fresh ginger rhizome

Dosage: 4.5 - 10g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Chai Hu Jia Long Gu Mu Li Tang

Harmonizes the Stomach and assists Ban Xia in descending rebellious Qi and alleviating nausea. Sheng Jiang also helps to moderate the cold nature of some of the other ingredients and harmonizes the overall formula.

Da Zao
Da Zao

Chinese date (Jujube fruit)

Dosage: 4 - 6 pieces

Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Chai Hu Jia Long Gu Mu Li Tang

Tonifies the Spleen and nourishes the Blood, working with Ren Shen to support the body's righteous Qi. Together with Sheng Jiang, Da Zao harmonizes the formula and helps regulate the relationship between the protective Qi (Wei Qi) and nutritive Qi (Ying Qi).

Modern Research (4 studies)

  • Meta-analysis and Network Pharmacology: Pharmacological Mechanism of CLM for Treating Depression (2023)
  • Systematic Review and Meta-Analysis: CLM for Poststroke Depression (2021)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Traditionally taken warm, twice daily (morning and evening), 30 minutes to 1 hour after meals to reduce potential digestive discomfort from Da Huang and mineral ingredients.

Typical Duration

Acute episodes: 1 to 2 weeks. Chronic conditions (anxiety, insomnia, depression): 4 to 8 weeks with regular reassessment and modification by a practitioner.

Dietary Advice

Avoid spicy, greasy, and heavily fried foods, which can generate more Heat and Phlegm and counteract the formula's clearing action. Alcohol should be strictly avoided as it generates Damp-Heat and further agitates the spirit. Caffeine and other stimulants should be minimized, as they may worsen the restlessness and insomnia the formula is designed to treat. Cold and raw foods in excess should also be limited to protect the Spleen and Stomach (the formula already has draining components like Da Huang that can tax digestion). Favor bland, easily digestible foods such as congee, lightly cooked vegetables, and mild soups. The classical Shang Han Lun dietary prohibition for Gui Zhi-containing formulas applies: avoid raw or cold foods and raw scallions.

Modern Usage

Clinically, it is primarily used to treat various diseases of the psychiatric, neurological, urinary, cardiovascular, and digestive systems, such as anxiety, depression, insomnia, epilepsy, palpitations, hypertension, cardiophobia, stomach diseases, and urethral syndrome.

Special Populations

Pregnancy

Contraindicated during pregnancy. Da Huang (Rhubarb) has a strong purgative action that drains downward and may stimulate uterine contractions. Ban Xia (Pinellia) is traditionally classified as contraindicated in pregnancy. The original formula also contains Qian Dan (lead oxide), which is toxic and teratogenic, though modern formulations substitute it with safer minerals. Gui Zhi (Cinnamon twig) is warming and blood-moving, which adds additional concern. This formula should not be used during pregnancy under any circumstances.

Breastfeeding

Use with caution during breastfeeding. Da Huang (Rhubarb) contains anthraquinone compounds that may transfer into breast milk and cause loose stools or colic in the nursing infant. If the original toxic ingredient Qian Dan (lead oxide) is used rather than a modern substitute, lead can accumulate in breast milk and is dangerous to infants. Even with modern mineral substitutes, this formula's overall draining and settling nature makes it less suitable during lactation without practitioner supervision. If clinically necessary, the lowest effective dose should be used for the shortest possible duration, and the infant should be monitored for digestive upset.

Pediatric Use

This formula can be used in children and adolescents, but requires significant dosage reduction and careful practitioner supervision. As a general guideline: children aged 6 to 12 may receive approximately one-third to one-half of the adult dose, while adolescents aged 12 and above may receive one-half to two-thirds. The original ingredient Qian Dan (lead oxide) must never be used in children due to extreme sensitivity to lead toxicity; only modern mineral substitutes (Ci Shi, Dai Zhe Shi) should be employed. Da Huang dosage should be especially conservative to avoid excessive purging, as children are more prone to fluid loss. This formula is generally not recommended for children under 6 years of age. Classical case literature does include use in adolescents (e.g. a 16-year-old patient treated for recurrent febrile episodes with good results), suggesting the formula is appropriate for older pediatric patients when the pattern clearly fits.

Drug Interactions

Da Huang (Rhubarb) contains anthraquinones with known laxative effects. It may reduce absorption of orally administered drugs by accelerating intestinal transit. Da Huang can also potentiate the effects of anticoagulants (e.g. warfarin) and antiplatelet agents due to its mild blood-moving properties, increasing bleeding risk.

Gui Zhi (Cinnamon twig) contains cinnamaldehyde, which may have mild antiplatelet activity. Combined with anticoagulants or antiplatelet drugs, there is a theoretical increased bleeding risk.

Ren Shen (Ginseng) may interact with warfarin (potentially reducing its efficacy), MAO inhibitors (risk of overstimulation), and hypoglycemic agents (ginseng may potentiate blood sugar lowering effects). It may also reduce the effectiveness of immunosuppressants.

Ban Xia (Pinellia) in processed form is generally safe, but caution is warranted with concurrent sedative medications (benzodiazepines, barbiturates, Z-drugs) as the formula's overall spirit-settling action may have additive sedative effects.

Mineral substances (Long Gu, Mu Li, and substitutes for Qian Dan) are calcium-rich and may reduce absorption of tetracycline antibiotics, fluoroquinolones, bisphosphonates, and thyroid hormones if taken simultaneously. A two-hour gap between this formula and such medications is advisable.

Contraindications

Avoid

Pregnancy: the formula contains Da Huang (Rhubarb), which has a strong downward-draining action that may stimulate uterine contractions, and Ban Xia (Pinellia), which is traditionally listed as contraindicated in pregnancy.

Avoid

Deficiency patterns without excess: this formula is designed for conditions with significant excess (Heat, Phlegm, constraint). Using it in pure deficiency states (Qi deficiency, Blood deficiency, or Yin deficiency without concurrent excess) can worsen anxiety, insomnia, and irritability.

Avoid

If the original formula containing Qian Dan (lead oxide/minium) is used, treatment must not exceed one week due to the risk of lead toxicity. Modern practice almost universally substitutes Qian Dan with Ci Shi (magnetite), Dai Zhe Shi (hematite), or Sheng Tie Luo (iron filings).

Caution

Patients with chronic diarrhea or loose stools due to Spleen Yang deficiency: the formula includes Da Huang (Rhubarb), which may aggravate loose stools and further deplete the Spleen. Dose reduction or removal of Da Huang may be appropriate.

Caution

Patients with Yin deficiency and significant fluid depletion: Chai Hu (Bupleurum) in larger doses may further exhaust Liver Yin. In Yin-deficient patients, the formula should be used cautiously with appropriate Yin-nourishing modifications (e.g. adding Bai Shao).

Caution

Patients with significant Blood deficiency presenting primarily as pallor, dizziness, and thin pulse without signs of Heat or constraint. The predominantly draining and settling nature of this formula is not suitable for pure Blood deficiency.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

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Manufacturing, supplier, and product specifications

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