Herb Whole plant / Aerial parts (全草 quán cǎo)

Long Kui

Black nightshade herb · 龙葵

Solanum nigrum L. · Herba Solani Nigri

Also known as: Long Kui Cao (龙葵草)

Images shown are for educational purposes only

Long Kui (black nightshade) is a cooling herb used in Chinese medicine primarily for hot, inflamed conditions like boils, abscesses, skin infections, and sore throat. It also helps with difficult urination and swelling, and is widely used in China as a supportive herb alongside conventional cancer treatments. Because it contains small amounts of potentially toxic alkaloids, it should only be used under professional guidance.

TCM Properties

Temperature

Cold

Taste

Bitter (苦 kǔ), Sweet (甘 gān)

Channels entered

Urinary Bladder

Parts used

Whole plant / Aerial parts (全草 quán cǎo)

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What This Herb Does

Every herb has a specific set of actions — here's what Long Kui does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Long Kui is primarily used to support these areas of health:

How these actions work

'Clears Heat and resolves toxins' is Long Kui's primary action. Being Cold in nature and Bitter in taste, it powerfully drains Heat and eliminates toxic accumulations from the body. In practice, this means it is used for hot, inflamed conditions like boils, abscesses, sore throat, and skin infections (erysipelas, eczema). The bitter taste drives downward and dries Dampness, while the Cold nature directly opposes pathogenic Heat. This action also underlies its modern clinical use as a supportive herb in cancer treatment, where the accumulation of Heat-toxins is understood as a key factor in tumour formation.

'Invigorates Blood and reduces swelling' means Long Kui can move stagnant Blood and disperse swelling in injured or inflamed tissues. This is why classical texts such as the Ben Cao Zheng Yi describe it as "an excellent herb for surgery to clear Heat and reduce swelling" and note its use for traumatic injuries with bruising and Blood stasis. It can be applied topically as a poultice for swollen, painful injuries or sores.

'Promotes urination and reduces edema' reflects Long Kui's ability to open the water pathways through the Bladder channel. When Heat or Dampness accumulates in the lower body causing painful, scanty, or burning urination and edema, Long Kui helps by clearing the Heat and facilitating the passage of urine. This action connects directly to its use in acute kidney inflammation with swelling and reduced urine output.

'Cools Blood and stops bleeding' indicates that when Heat enters the Blood level, causing it to move recklessly and producing symptoms like vomiting blood or heavy uterine bleeding, Long Kui's Cold nature can cool the Blood and help stop the bleeding.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony. Long Kui is used to help correct these specific patterns.

Why Long Kui addresses this pattern

Toxic Heat is a pattern where pathogenic Heat concentrates and produces visible inflammation, often manifesting as painful red swellings, abscesses, boils, or infected sores. Long Kui is Cold in nature and Bitter in taste, giving it a strong downward-draining and Heat-clearing action. It enters the Bladder channel, which governs the body's lower waterways, but its toxin-resolving action has broad reach across skin and soft tissues. The herb directly counteracts the intense Heat and toxic accumulation at the root of this pattern, while its Blood-invigorating property helps disperse the local swelling and stagnation that accompany purulent infections.

A practitioner would look for one or more of these signs

Boils

Red, hot, painful skin abscesses

Skin Infection

Infected sores or carbuncles with pus

Sore Throat

Swollen, painful throat from Heat-toxins

Erysipelas

Fiery red skin rash (erysipelas / 丹毒)

Commonly Used For

These are conditions where Long Kui is frequently used — but only when they arise from the specific patterns it addresses, not in all cases

Arises from: Toxic-Heat

TCM Interpretation

In TCM, eczema is most commonly understood as an accumulation of Dampness and Heat in the skin, often compounded by toxic factors. The skin becomes red, itchy, weeping, and inflamed because pathogenic Heat and Dampness are trapped in the surface layers of the body. When the condition is acute and intensely itchy with red lesions, the pattern leans toward Toxic Heat. Chronic cases may involve underlying Blood Deficiency or Wind, but the acute inflammatory presentation points to Heat and Dampness as the primary culprits.

Why Long Kui Helps

Long Kui is Cold and Bitter, which directly clears the Heat and drains the Dampness that drive eczema flare-ups. Clinical observations have documented its effectiveness as an anti-itch agent: its cooling and swelling-reducing properties help calm the inflamed skin, reduce redness, and relieve itching. It can be taken internally as a decoction and also applied externally as a wash for affected areas. Its diuretic action provides an additional pathway for expelling Dampness from the body.

Also commonly used for

Boils

Abscesses and carbuncles from Heat-toxins

Erysipelas

Red, spreading skin inflammation

Sore Throat

Swollen painful throat

Urinary Tract Infection

Painful or burning urination

Edema

Swelling with reduced urine

Chronic Bronchitis

Chronic cough with phlegm

Dysentery

Damp-Heat dysentery

Bruises

Traumatic injuries with swelling

Prostatitis

Prostate inflammation with Heat signs

Herb Properties

Every herb has an inherent temperature, taste, and affinity for specific channels — these properties determine how it interacts with the body

Temperature

Cold

Taste

Bitter (苦 kǔ), Sweet (甘 gān)

Channels Entered

Urinary Bladder

Parts Used

Whole plant / Aerial parts (全草 quán cǎo)

Dosage & Preparation

These are general dosage guidelines for Long Kui — always follow your practitioner's recommendation, as dosages vary based on the formula and your individual condition

Standard dosage

15-30g

Maximum dosage

Up to 30g (dried herb) or 60g (fresh herb) in decoction under practitioner supervision. Do not exceed without careful monitoring due to glycoalkaloid toxicity risk.

Dosage notes

The standard decoction dose is 15 to 30g of the dried herb, or double (30-60g) when using fresh material. For external use, an appropriate amount of fresh herb is pounded and applied as a poultice, or the decoction is used as a wash. For chronic bronchitis, clinical reports have used approximately 30g dried whole herb daily (as a prepared tablet formulation) in 10-day treatment courses with 5-7 day rest intervals between courses. For anti-cancer applications in Chinese clinical practice, Long Kui is typically used in larger doses (up to 60g of fresh herb) combined with other herbs such as Bai Hua She She Cao, She Mei, and Bai Ying, always under close practitioner supervision. Due to its slight toxicity, treatment courses should be kept as short as clinically necessary. The herb has a mild stimulant quality (the classical texts note it 'reduces drowsiness'), so it is best taken during daytime rather than evening.

Preparation

No special decoction handling is required. Long Kui is simply decocted normally with other herbs. Fresh herb may be used when available (at double the dried dosage). For external use, fresh herb is pounded into a paste and applied directly to the affected skin area, or the decoction liquid is used as a wash.

Common Herb Pairs

These ingredients are traditionally combined with Long Kui for enhanced therapeutic effect

Ban Zhi Lian
Ban Zhi Lian Long Kui 30g : Ban Zhi Lian 30-60g

Long Kui and Ban Zhi Lian (Scutellaria barbata) together powerfully clear Heat-toxins and dissipate nodules. Long Kui contributes its Blood-invigorating and diuretic actions, while Ban Zhi Lian adds strong Heat-clearing and Blood-moving properties. Together they produce a synergistic anti-tumour and toxin-resolving effect that exceeds either herb alone.

When to use: Used in cancer support formulas, particularly for digestive tract cancers, liver cancer, and gynaecological cancers. Also for severe Heat-toxin abscesses and masses.

Bai Hua She She Cao
Bai Hua She She Cao 1:1 to 1:2 (Long Kui 30g : Bai Hua She She Cao 30-60g)

Long Kui and Bai Hua She She Cao (Hedyotis / Oldenlandia) combine two of the strongest Heat-clearing and toxin-resolving herbs. Bai Hua She She Cao excels at clearing Heat and resolving toxins in the Stomach and intestines, while Long Kui adds its Bladder-channel diuretic action and Blood-invigorating effect. Together they provide broad-spectrum toxin clearance.

When to use: Used in formulas for cancer support, especially liver and digestive cancers, as well as for severe skin infections and inflammatory conditions.

Pu Gong Ying
Pu Gong Ying 1:1 (both 15-30g)

Long Kui and Pu Gong Ying (dandelion) together clear Heat-toxins from skin and soft tissues. Pu Gong Ying is particularly effective for breast abscesses and upper body sores, while Long Kui has a broader scope including lower body Damp-Heat. Together they address abscesses and boils throughout the body with complementary toxin-clearing actions.

When to use: Boils, abscesses, carbuncles, and other skin infections with Heat-toxin signs (redness, swelling, pain, pus).

Ba
Bai Ying 1:1 (both 15-30g)

Long Kui and Bai Ying (Solanum lyratum) are closely related botanically (both Solanum species) and share Heat-clearing, toxin-resolving, and anti-tumour properties. Bai Ying also clears Wind-Dampness and benefits the joints, while Long Kui is stronger at promoting urination and invigorating Blood. Together they reinforce each other's toxin-clearing and nodule-dissipating effects.

When to use: Cancer support formulas, especially when combined with other toxin-clearing herbs. Also for chronic inflammatory skin conditions with underlying Dampness.

Comparable Ingredients

These ingredients have overlapping uses — here's how to tell them apart

Bai Hua She She Cao
Long Kui vs Bai Hua She She Cao

Both clear Heat-toxins and are widely used in cancer support formulas. Bai Hua She She Cao (Hedyotis) is stronger at clearing Heat from the Stomach and Large Intestine channels and promoting urination, making it more suited to Damp-Heat conditions of the digestive tract. Long Kui is more effective at invigorating Blood and reducing swelling, and enters the Bladder channel specifically, making it better for urinary system Heat and traumatic injuries with Blood stasis.

Ban Zhi Lian
Long Kui vs Ban Zhi Lian

Both are Cold, Bitter herbs that clear Heat-toxins and are commonly used together for tumours. Ban Zhi Lian (Scutellaria barbata) has a stronger Blood-invigorating and stasis-dispelling action and is particularly noted for treating Blood stasis with masses. Long Kui has a more pronounced diuretic effect and is more commonly used for edema, urinary difficulty, and skin conditions like eczema.

Ba
Long Kui vs Bai Ying

Both are Solanum-family plants with overlapping Heat-clearing and anti-tumour actions. Bai Ying (Solanum lyratum) additionally dispels Wind-Dampness and is used for joint pain and Damp Bi syndrome, while Long Kui is stronger at promoting urination and cooling Blood to stop bleeding. Long Kui is used as the whole aerial plant, while Bai Ying uses the vine and stem.

Identity & Adulterants

Related species and common adulterations to be aware of when sourcing Long Kui

Long Kui (Solanum nigrum) can be confused with several related plants: 1. Shao Hua Long Kui (少花龙葵, Solanum nigrum var. pauciflorum): A variety found in southern Chinese provinces, sometimes used interchangeably as Long Kui in herbal medicine, though it is formally a different variety. 2. Long Zhu (龙珠): Classical texts distinguish Long Kui (berries ripen green to black) from Long Zhu (berries ripen green to red). They are treated as related but distinct, with Long Kui considered more effective. 3. Deadly nightshade (Atropa belladonna): A much more toxic plant in the same Solanaceae family. While they share common names in English ('nightshade'), they are in different genera and Atropa belladonna is far more dangerous. Confusion is more common in Western contexts. 4. Bai Ying (白英, Solanum lyratum): Another medicinal Solanum species sometimes used alongside Long Kui in anti-cancer formulas, but with different properties. The two should not be substituted for each other without proper identification.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herb.

Toxicity Classification

Classical Chinese pharmacopoeia toxicity rating for Long Kui

Slightly toxic

Long Kui contains glycoalkaloids, primarily solanine, solasonine, and solamargine. These compounds are most concentrated in the unripe green berries (up to 4.2% alkaloid content) and decrease as the plant matures. Solanine acts similarly to saponins and can lyse (destroy) red blood cells. Overdose symptoms include headache, abdominal pain, nausea, vomiting, diarrhea, dilated pupils, heart rate irregularities (initially fast then slow), confusion, and in severe cases coma. Fatalities have been reported in children who ate unripe fruit. The toxicity mechanism involves cholinesterase inhibition and cell membrane disruption. At standard medicinal dosages (15-30g of dried herb in decoction), the toxicity is mild and clinically manageable. Boiling in decoction partially destroys solanine (it is nearly insoluble in water). The herb should be used for limited courses and discontinued once the acute Heat-toxin condition resolves. In cases of suspected overdose, gastric lavage with strong tea water is a traditional first-aid measure, followed by symptomatic treatment similar to that for sprouted potato poisoning.

Contraindications

Situations where Long Kui should not be used or requires extra caution

Caution

Spleen and Stomach deficiency-cold (脾胃虚寒): Long Kui is bitter and cold in nature. People with cold-type digestive weakness, chronic loose stools, or poor appetite due to Spleen-Stomach Yang deficiency should avoid internal use, as it can further damage digestive function.

Avoid

Pregnancy: The glycoalkaloids in Long Kui (particularly solanine) have been shown in toxicological studies to affect embryonic development, with potential for miscarriage and birth defects. Avoid use during pregnancy.

Avoid

Consumption of unripe (green) fruit: The unripe green berries of Solanum nigrum contain the highest concentration of toxic glycoalkaloids. Ingesting unripe fruit can cause serious poisoning including vomiting, diarrhea, pupil dilation, confusion, and in severe cases coma or death (particularly dangerous in children). Never eat unripe Long Kui fruit.

Caution

Excessive or prolonged use: Due to its slight toxicity, Long Kui should not be taken at high doses or for extended periods without practitioner supervision. Overuse may lead to reduced white blood cell counts and elevated blood sugar. Discontinue once the Heat-toxin condition has resolved.

Caution

Diabetes or blood sugar concerns: Long Kui alkaloids (solanine, solasonine) have been shown to raise blood sugar levels in pharmacological studies. People with diabetes or impaired glucose tolerance should use with caution.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Contraindicated during pregnancy. Toxicological studies have confirmed that solanine and related glycoalkaloids in Long Kui can affect embryonic development, potentially causing miscarriage and birth defects. Solanine glycoalkaloids have been shown to disrupt cell membranes and inhibit cholinesterase, mechanisms that pose direct risk to fetal development. Pregnant individuals should strictly avoid this herb in any form.

Breastfeeding

Not recommended during breastfeeding. Long Kui contains glycoalkaloids (solanine, solasonine, solamargine) that have a relatively long clearance time in the body (over 24 hours, meaning they can accumulate). While there are no specific studies on transfer of these alkaloids through breast milk, the known toxicity profile and the sensitivity of infants to even low doses of glycoalkaloids make it prudent to avoid this herb while nursing.

Children

Use with great caution in children. Children are more susceptible to glycoalkaloid toxicity than adults, and there have been reports of fatalities in children who consumed unripe Long Kui berries. If prescribed for a child by a qualified practitioner (for example, for skin conditions as described in classical sources), the dosage should be significantly reduced from the adult range, typically one-third to one-half depending on age and body weight. External application (as a poultice of fresh herb) is generally safer for children than internal use. Never allow children to eat unripe green berries of this plant.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Long Kui

Hypoglycaemic agents: Long Kui alkaloids (solanine, solasonine) have been shown in pharmacological studies to raise blood sugar. This could potentially counteract the effects of insulin, metformin, sulfonylureas, or other glucose-lowering medications. Blood glucose should be monitored if Long Kui is used alongside diabetes medications.

Cholinesterase inhibitors: Solanine glycoalkaloids inhibit cholinesterase activity. Concurrent use with cholinesterase inhibitor drugs (such as donepezil, rivastigmine, or neostigmine, used for Alzheimer's disease or myasthenia gravis) could theoretically produce additive cholinergic effects or unpredictable interactions.

Anticoagulant or antiplatelet medications: Long Kui has traditional blood-activating (huo xue) properties. While the clinical significance is not well studied, caution is warranted when combining with warfarin, heparin, or antiplatelet drugs, as there may be an additive effect on bleeding risk.

Note: Formal drug interaction studies for Long Kui are extremely limited. The above interactions are inferred from the known pharmacological properties of its active constituents. Patients taking pharmaceutical medications should consult both their prescribing doctor and a qualified TCM practitioner before using this herb.

Dietary Advice

Foods and dietary considerations when taking Long Kui

As Long Kui is a cold-natured herb used to clear Heat and toxins, avoid excessively cold or raw foods during the treatment period to protect the Stomach and Spleen. Light, easily digestible meals are recommended. Classical sources note that Long Kui should not be eaten together with green onions (cong) and Chinese chives (xie). When used fresh as food (cooked young shoots), it should always be thoroughly boiled first, and the cooking water discarded, to reduce glycoalkaloid content.

Botanical Description

Physical characteristics and morphology of the Long Kui source plant

Solanum nigrum L. is an annual herbaceous plant in the Solanaceae (nightshade) family, typically growing 30 to 120 cm tall. The stems are erect, branching, and nearly hairless or finely downy, green to purplish in colour. Leaves are alternate, ovate to heart-shaped, 4 to 7.5 cm long and 2 to 5 cm wide, with wavy or coarsely toothed margins. The small, drooping flowers are borne in umbel-like clusters arising from the leaf axils, with white to pale purple bell-shaped corollas surrounding prominent bright yellow anthers. The fruit is a spherical berry, 6 to 8 mm in diameter, turning from green to glossy purple-black when ripe. Inside are numerous small, flattened, sesame-seed-shaped yellow seeds.

Long Kui is remarkably adaptable and grows in fields, roadsides, waste ground, streambanks, and at the edges of woodlands across temperate to tropical regions worldwide. It thrives in warm, moist conditions and is not particular about soil type, though it grows best in organically rich, well-drained loam. The flowering period runs from June to September, with fruits maturing from July to December.

Sourcing & Harvesting

Where Long Kui is sourced, when it's harvested or collected, and how to assess quality

Harvesting season

Summer and autumn (typically June to October), harvested as the whole above-ground plant, used fresh or dried.

Primary growing regions

Long Kui (Solanum nigrum) is widely distributed across temperate to tropical regions of Europe, Asia, and the Americas. In China, it grows in nearly every province, commonly found along roadsides, field edges, wastelands, streambanks, and at forest margins. Unlike many Chinese herbs, Long Kui does not have a strongly defined dao di (terroir) region, as it is an extremely common and adaptable weed. It is native to Southeast Asia and has naturalized worldwide. The herb is collected from wild populations rather than being cultivated as a specialty crop in any particular region.

Quality indicators

Good quality dried Long Kui should have abundant leaves that are green or brownish-green in colour, with tender young stems. The stems should be hollow and cylindrical with visible surface wrinkling. Any remaining berries should be spherical with wrinkled brownish-yellow to brownish-black skin. The herb should have no significant odour, and the berries should taste bitter with a slight sourness. Preferred specimens are those with more leaves and less woody stem material. Avoid specimens that are yellowed, excessively dried and crumbly, or show signs of mould.

Classical Texts

Key passages from the classical Chinese medical texts that describe Long Kui and its therapeutic uses

Tang Ben Cao (《唐本草》, Tang Dynasty Materia Medica)

Original: 食之解劳少睡,去虚热肿。

Translation: "Eating it relieves fatigue and reduces drowsiness, and removes deficiency Heat and swelling."

Ben Cao Zheng Yi (《本草正义》, Rectifying the Meaning of the Materia Medica)

Original: 龙葵,可服可敷,以清热通利为用,故并治跌仆血瘀,尤为外科退热消肿之良品也。

Translation: "Long Kui may be taken internally or applied externally. Its function is to clear Heat and promote the smooth flow [of fluids]. Therefore it also treats blood stasis from falls and injuries, and is especially an excellent remedy in surgery for reducing fever and dispersing swelling."

Shi Liao Ben Cao (《食疗本草》, Dietetic Materia Medica)

Original: 主丁肿,患火丹疮。和土杵,敷之。

Translation: "It mainly treats boils and swellings, as well as fire-elixir sores (erysipelas). Pound with earth and apply as a poultice."

Dian Nan Ben Cao (《滇南本草》, Materia Medica of Southern Yunnan)

Original: 治小儿风热,攻疮毒,洗疥瘫痒痛,祛皮肤风。

Translation: "Treats Wind-Heat in children, attacks sore-toxins, washes scabies and painful itching, and dispels Wind from the skin."

Ben Cao Gang Mu (《本草纲目》, Compendium of Materia Medica) by Li Shizhen

Original (on flavour and nature): 气味(苗、茎、叶、根)苦、微甘、滑、寒、无毒。

Translation: "Flavour and nature (of the shoots, stems, leaves, and roots): bitter, slightly sweet, smooth, cold, non-toxic."

Note: Li Shizhen classified Long Kui as non-toxic, while many other sources consider it slightly toxic (有小毒). Modern consensus aligns with the 'slightly toxic' classification due to its glycoalkaloid content.

Historical Context

The history and evolution of Long Kui's use in Chinese medicine over the centuries

Long Kui has a long history in Chinese medicine. The earliest known medicinal record appears in the Yao Xing Lun (《药性论》, Treatise on the Properties of Medicinals), a Tang Dynasty text. The Tang Ben Cao (also known as the Xin Xiu Ben Cao, 《新修本草》), China's first state-compiled pharmacopoeia from 659 CE, recorded it under the name 'Ku Cai' (苦菜, 'bitter vegetable') and noted it was found particularly in the Guan and He regions of northern China. The Tang sources already recognized that it should be cooked before eating and not consumed raw, showing early awareness of its mild toxicity.

Li Shizhen, in the Ming Dynasty Ben Cao Gang Mu (1578), distinguished two related plants: Long Kui (龙葵), whose berries ripen from green to black, and Long Zhu (龙珠), whose berries ripen red. He described Long Kui as growing everywhere from the fourth month, with edible young shoots. The name 'Long Kui' literally means 'dragon mallow', though its many folk names across China reflect its widespread presence: Lao Ya Yan Jing Cao ('old crow's eye grass'), Tian Qie Zi ('heaven eggplant'), Hei Gu Niang ('black maiden'), and Ye Pu Tao ('wild grape'), among dozens of regional nicknames.

In modern times, Long Kui has attracted significant research interest for its anti-tumor potential. Since the mid-20th century, Chinese clinicians have used it in combination with other Heat-clearing and toxin-resolving herbs (such as Bai Hua She She Cao and Bai Ying) as adjunctive treatment for various cancers. It is included in several patented Chinese medicine anti-cancer formulations.

Modern Research

5 published studies investigating the pharmacological effects or clinical outcomes of Long Kui

1

Comprehensive Review: Traditional Uses, Phytochemistry, and Pharmacology of Solanum nigrum (2022)

Wang H, et al. Frontiers in Pharmacology, 2022, Volume 13, Article 918071.

A comprehensive review covering botany, traditional uses, phytochemistry, pharmacology, and toxicity of S. nigrum. The review identified 188 chemical constituents, with steroidal saponins, alkaloids, phenols, and polysaccharides as major bioactive groups. Pharmacological activities documented include antitumor, anti-inflammatory, antioxidant, antibacterial, and neuroprotective effects in both laboratory and animal studies.

Link
2

Systematic Review: Anticancer Properties of Solamargine (2017)

Kalalinia F, Karimi-Sani I. Phytotherapy Research, 2017, 31(6): 858-870.

A systematic review of 33 articles (27 concerning anticancer effects) on solamargine, a key steroidal alkaloid glycoside from Solanum nigrum. The review found solamargine exhibits anticancer activity through multiple pathways including cell survival pathways, tumor suppressor activation, caspase-mediated apoptosis, mitochondrial pathways, and inhibition of drug resistance mechanisms. All evidence was preclinical (cell and animal studies).

Link
3

Narrative Review: Antitumor Studies of Solanine (2021)

Luo S, Tian GJ, Yu FX, Wen ZD. Translational Cancer Research, 2021, 10(3): 1578-1582.

A narrative review summarizing 20 years of research (2000-2020) on the antitumor effects of solanine, the primary alkaloid extract of S. nigrum. The review found solanine shows antitumor activity against multiple cancer types by targeting different protein pathways. While large-scale clinical trials are lacking, basic pharmacological and toxicological studies suggest solanine may be a candidate for cancer drug development or as an adjuvant agent.

Link
4

Literature Review: Active Components of Solanum nigrum and Antitumor Effects (2024)

Zhao ZD, Hu C, Li L, Zhang JQ, Zhang LC. Cancer Medicine, 2024, 13: e7314.

A review analyzing active constituents of S. nigrum and their anticancer mechanisms. The key antitumor monomers identified are solanine, solamargine, solasonine, and solasodine. These steroidal alkaloids showed robust antitumor properties alone or combined with other drugs, working through multiple mechanisms including apoptosis induction, cell cycle arrest, and metastasis inhibition.

Link
5

Case Report: Acute Interstitial Nephritis Induced by Solanum nigrum (2016)

Kim YJ, et al. Medicine, 2016, 95(49): e5583.

The first reported case of biopsy-confirmed acute interstitial nephritis (AIN) following prolonged ingestion of raw S. nigrum extract by a 72-year-old man who had been taking it twice daily for two months. The patient developed kidney failure with severe edema and elevated creatinine. He was successfully treated with corticosteroid therapy. This case highlights the potential renal toxicity of S. nigrum with chronic excessive use.

PubMed

Research on individual TCM herbs is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.