Formula

Run Chang Wan

润肠丸

Also known as:

Smooth Tea Pill (润肠丸)

Properties

Purgative formulas · Neutral

Key Ingredients

Huo Ma Ren

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula designed to relieve constipation caused by internal heat drying out the intestines, combined with sluggish blood flow. It moistens the bowels and gently promotes movement, making it particularly suited for dry, hard, difficult-to-pass stools accompanied by poor appetite. Unlike harsh laxatives, it addresses the underlying dryness and blood stagnation rather than simply forcing the bowels to move.

Formula Category

Main Actions

  • Moistens the Intestines and Unblocks the Bowels
  • Nourishes Blood
  • Nourishes Yin
  • Moves Qi

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Run Chang Wan is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Run Chang Wan addresses this pattern

When internal heat accumulates in the Stomach and intestines over time, it scorches and consumes the body's fluids. The Large Intestine, deprived of adequate moisture, can no longer lubricate stool for smooth passage. Run Chang Wan directly counters this by flooding the intestines with the oily richness of Huo Ma Ren and Tao Ren while Da Huang clears the underlying heat that caused the dryness in the first place. This two-pronged approach both treats the symptom (dry stool) and addresses the cause (accumulated heat).

A practitioner would look for one or more of these signs

Constipation

Dry, hard stools that are difficult to pass

Dry Mouth

Dry mouth with desire to drink

Dark Skin
Poor Appetite

Decreased desire to eat

Red Tongue

Red tongue with dry yellow coating

Abdominal Distention

Bloating and abdominal discomfort

How It Addresses the Root Cause

Run Chang Wan addresses constipation that arises from insufficient Blood and Yin fluids in the body, a pattern called "intestinal dryness from Blood deficiency" (血虚肠燥). In TCM thinking, the Large Intestine needs adequate moisture and lubrication to move stools smoothly downward. Blood and body fluids provide this essential moisture. When Blood becomes deficient, whether from chronic illness, aging, blood loss (such as after childbirth), or prolonged emotional stress consuming Yin, the intestines lose their lubrication and become dry.

Think of the intestines like a water slide: without enough water flowing through, nothing moves. The stools become dry and hard, difficult to pass, and bowel movements become infrequent. Because the underlying problem is a lack of nourishment rather than a blockage or excess, the patient often looks pale or has dry skin, dry nails, and may feel tired. The pulse tends to feel thin (细) and choppy (涩), reflecting Blood deficiency and poor fluid circulation. The tongue may appear pale with a dry coating.

This is fundamentally different from constipation caused by excess Heat (where the body is overheated and drying out fluids aggressively) or from Qi stagnation (where things are stuck due to stress or emotional tension). In this pattern, the body simply does not have enough moisture. Pushing with strong purgatives would only further deplete the patient. The correct approach is to replenish what is missing: nourish the Blood, enrich the Yin, moisten the intestines, and gently encourage the Qi to move downward so that bowel function can resume naturally.

Formula Properties

Temperature

Neutral

Taste Profile

Predominantly sweet and oily with mild bitter notes. The sweet, oily quality of Huo Ma Ren and Tao Ren provides lubrication, while the sweet-bitter character of Dang Gui and Sheng Di nourishes Blood and Yin, and the mild bitterness of Zhi Ke promotes Qi movement.

Target Organs
Large Intestine Liver Kidneys
Channels Entered
Large Intestine Liver Kidney

Formula Origin

Pi Wei Lun (脾胃論, Treatise on the Spleen and Stomach) by Li Dongyuan (Li Gao)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Run Chang Wan

Detailed information about each herb in Run Chang Wan and their roles

Kings
Deputies
Assistants
Envoys
Huo Ma Ren
Huo Ma Ren

Hemp seed

Dosage: 30 - 45g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Large Intestine
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Run Chang Wan

The chief moistening agent of the formula. Rich in oils, hemp seeds lubricate the intestines, soften dry stools, and promote gentle bowel movements. Used at the highest dose, it directly addresses the core problem of intestinal dryness.

Tao Ren
Tao Ren

Peach kernel

Dosage: 30 - 45g

Temperature Neutral
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Large Intestine
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Run Chang Wan

Peach kernels work alongside hemp seeds to moisten the intestines with their oily nature while also invigorating blood circulation. This addresses the blood stagnation component of the constipation, helping to break up 'blood binding' that contributes to blocked bowels.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 15g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Run Chang Wan

The tail portion of Angelica root is specifically chosen for its stronger blood-invigorating action (compared to the whole root or head). It nourishes blood to address the underlying blood dryness and activates blood flow to resolve stasis contributing to constipation.

Da Huang
Da Huang

Rhubarb root and rhizome

Dosage: 15g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Spleen, Stomach, Large Intestine, Liver, Pericardium
Parts Used Root (根 gēn)
Role in Run Chang Wan

Rhubarb root purges accumulated heat from the Stomach and intestines and promotes bowel movement. Wine-baking softens its harsh purgative force so that it drains heat without causing cramping or excessive fluid loss, working in concert with the moistening herbs rather than overpowering them.

Qiang Huo
Qiang Huo

Notopterygium root and rhizome

Dosage: 15g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Urinary Bladder, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in Run Chang Wan

An unusual inclusion in a constipation formula, Qiang Huo disperses wind and directs the formula's action. Li Dongyuan's original indication includes 'wind binding' constipation, where pathogenic wind lodged internally contributes to intestinal stagnation. Qiang Huo addresses this wind component and helps lift and regulate the flow of Qi, assisting the downward-moving herbs to restore proper intestinal transit.

Modern Research (2 studies)

  • Meta-analysis of Modified RunChang-Tang for Functional Constipation (2021)
  • Systematic Review of Chinese Herbal Medicine for Constipation: Zheng-based Associations (2016)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

On an empty stomach, typically 30 minutes before meals in the morning and evening, to maximize absorption and promote gentle downward movement through the digestive tract.

Typical Duration

Often taken for 1 to 4 weeks, then reassessed. As this formula addresses an underlying deficiency pattern, longer courses may be needed, but a practitioner should re-evaluate after the initial period.

Dietary Advice

Favor foods that moisten the intestines and nourish Blood and Yin: sesame seeds (especially black sesame), walnuts, pine nuts, honey, pears, figs, bananas, spinach, and sweet potato. Adequate water intake is essential to support the formula's moistening action. Avoid excessively spicy, dry, or fried foods, which further deplete body fluids and worsen intestinal dryness. Limit consumption of strong tea, coffee, and alcohol, as these have diuretic effects that can dry the intestines. Cold and raw foods should be eaten in moderation, as they may impair Spleen function and hinder fluid production. Traditional dietary wisdom recommends congee (rice porridge) made with black sesame or walnuts as an excellent companion food during treatment, as it is easy to digest and directly supports the moistening strategy of the formula.

Special Populations

Pregnancy

Contraindicated during pregnancy. Tao Ren (Peach Kernel) is a well-established Blood-activating herb classified as contraindicated in pregnancy because it can stimulate uterine contractions and increase the risk of miscarriage. Dang Gui (Chinese Angelica) also moves Blood and, in some classical texts, is cautioned during early pregnancy. While Sheng Di and Huo Ma Ren are individually considered safe, the overall Blood-moving nature of this formula makes it unsuitable for pregnant women. If a pregnant woman experiences constipation, safer alternatives such as increased dietary fiber or gentler formulas without Blood-moving herbs should be considered under practitioner guidance.

Breastfeeding

Use with caution during breastfeeding. While no specific toxicity data exist for this formula in breastfeeding mothers, Da Huang (Rhubarb) is not present in the Shen's version, reducing the primary concern found in related laxative formulas. However, Tao Ren (Peach Kernel) has mild Blood-activating properties, and its constituents (including amygdalin in trace amounts) could theoretically pass into breast milk. Dang Gui and Sheng Di are generally considered compatible with breastfeeding in moderate doses. If used, the infant should be monitored for any signs of loose stools or digestive upset. It is advisable to consult a qualified practitioner before use during lactation.

Pediatric Use

Run Chang Wan may be used in children with appropriate dose reduction, but constipation in children more commonly involves dietary issues, Spleen Qi deficiency, or food accumulation rather than the Blood deficiency pattern this formula targets. When genuinely indicated (such as in chronically ill children with Blood deficiency signs), dosages are typically reduced to one-third of the adult dose for children aged 6-12, and one-quarter for children aged 3-6. It is generally not recommended for children under 3 years old without specific practitioner guidance. Tao Ren should be used cautiously in very young children. For most pediatric constipation, dietary modification and Spleen-strengthening approaches are preferred as first-line treatment.

Drug Interactions

Anticoagulant and antiplatelet medications: Tao Ren (Peach Kernel) and Dang Gui (Chinese Angelica) both have Blood-activating properties. Tao Ren contains amygdalin and various fatty acids, while Dang Gui contains ligustilide and ferulic acid, both of which have demonstrated mild antiplatelet effects in pharmacological studies. Concurrent use with warfarin, heparin, aspirin, or clopidogrel may theoretically increase bleeding risk and should be monitored.

Iron supplements: Sheng Di Huang (raw Rehmannia) contains tannins that may bind with iron supplements and reduce their absorption. It is advisable to separate administration by at least two hours.

Antihypertensive medications: Dang Gui has mild vasodilatory properties. While clinically significant interactions are uncommon, patients on antihypertensive drugs should be monitored for any additive blood pressure lowering effects.

Note: The Shen's version of Run Chang Wan does not contain Da Huang (Rhubarb), so the significant drug interactions associated with anthraquinone-containing laxatives (such as electrolyte depletion potentiating digoxin toxicity, or interference with mineral absorption) do not apply to this version. However, some commercial products sold as "Run Chang Wan" may use different compositions that include Da Huang, so practitioners should verify the exact formulation being used.

Contraindications

Avoid

Pregnancy. The formula contains Tao Ren (Peach Kernel), which activates Blood and may stimulate uterine contractions, posing a risk of miscarriage.

Avoid

Diarrhea or loose stools from Spleen deficiency. This formula is designed for dry, difficult stools. Using it when the bowels are already loose will worsen the condition.

Avoid

Constipation due to Yang deficiency with internal Cold. This formula is moistening and slightly cool in nature and is not suited for patients whose constipation stems from insufficient warmth in the lower body. Signs would include cold limbs, preference for warmth, pale tongue with white coating.

Caution

Excess Heat constipation with high fever and strong pulse. This formula gently moistens rather than forcefully purges. Acute, severe constipation from intense internal Heat requires a stronger purgative approach.

Caution

Patients on anticoagulant therapy. Tao Ren (Peach Kernel) and Dang Gui both have Blood-moving properties that could theoretically increase bleeding risk.

Cautions & Warnings

Run Chang Wan is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Run Chang Wan.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Treasure of the East

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