Herb

Ku Shen

Sophora root | 苦参

Also known as:

Sophora Root

Parts Used

Root (根 gēn)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Select Product Type

Select Supplier

Select Size

Quantity

$22.00 ($0.22/g)
For shipments to: United States Change
Standard Shipping (3-5 business days): $4.99
Express Shipping (1-2 business days): $9.99
Free shipping on orders over $75

About This Herb

Traditional Chinese Medicine background and properties

Herb Description

Kǔ Shēn is a strongly bitter, cold herb used primarily for conditions involving Dampness and Heat, especially skin problems like eczema and itching, digestive complaints like dysentery, and urinary difficulties. It is one of the most important herbs for treating itchy skin conditions and is frequently used both as an internal remedy and as an external wash.

Herb Category

Main Actions

  • Clears Heat and dries Dampness
  • Kills Parasites and Stops Itching
  • Promotes Urination
  • Disperses Wind

How These Actions Work

'Clears Heat and dries Dampness' is the primary action of Kǔ Shēn. Its intensely bitter taste has a powerful drying effect on pathological Dampness, while its cold nature clears away Heat. Together, these properties make it especially effective for conditions where Dampness and Heat combine in the lower part of the body, such as foul-smelling diarrhea with blood or mucus (dysentery), vaginal discharge, jaundice with dark urine, and painful urination. It works in a similar way to Huáng Lián and Huáng Bǎi but is considered even more intensely bitter and drying.

'Kills parasites and stops itching' refers to Kǔ Shēn's well-known ability to treat skin conditions caused by Damp-Heat, including eczema, scabies, ringworm, and genital itching. In classical language, 'Heat generates Wind, and Dampness generates parasites,' so by clearing both Heat and Dampness, Kǔ Shēn addresses the root cause of itching and parasitic skin conditions. It is widely used both internally and as an external wash for these purposes.

'Promotes urination' means Kǔ Shēn helps drain Damp-Heat downward and out through the urinary system. This makes it useful for painful or difficult urination caused by Heat in the Bladder, and also supports its role in treating jaundice by helping the body eliminate excess Dampness. 'Dispels Wind' refers to its ability to address Wind-type skin conditions such as widespread itching and rashes, especially when combined with Dampness and Heat.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Ku Shen is traditionally associated with these specific patterns.

The following describes this herb's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Ku Shen addresses this pattern

Kǔ Shēn's bitter taste powerfully dries Dampness while its cold nature clears Heat, making it a direct match for the Damp-Heat accumulation that defines this pattern. Its affinity for the Large Intestine and Stomach channels means it targets the gastrointestinal tract specifically. When Damp-Heat lodges in the Large Intestine, it disrupts normal bowel function and can damage blood vessels, leading to dysentery with blood and mucus. Kǔ Shēn clears the Heat that drives the inflammation and dries the Dampness that creates stagnation, restoring normal intestinal function.

A practitioner would look for one or more of these signs

Diarrhea

Foul-smelling diarrhea with mucus or blood

Bleeding

Blood in stool from intestinal Heat

Abdominal Pain

Abdominal cramping with urgency and tenesmus

Jaundice

Jaundice with dark urine from Damp-Heat

TCM Properties

Temperature

Cold

Taste

Bitter (苦 kǔ)

Channels Entered
Heart Liver Stomach Large Intestine Urinary Bladder
Parts Used

Root (根 gēn)

This is partial information on the herb's TCM properties. More detailed information is available on the herb's dedicated page

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

Quantity Description

Loading quantity information...

Concentration Ratio

Loading concentration information...

Fabrication Method

Loading fabrication information...

Supplier Certifications

Loading certifications information...

Botanical & Sourcing

Quality Indicators

Good quality Ku Shen root is firm and hard, difficult to break by hand. The outer bark is greyish-brown to yellowish-brown with longitudinal wrinkles and transverse lenticel-like bumps. The thin outer bark often peels and curls back, revealing a smooth, bright yellow inner surface underneath. Cross-section slices should be 3 to 6 mm thick, showing a yellowish-white cut surface with clearly visible radial lines and sometimes concentric ring patterns (from anomalous vascular bundles). The herb should have a faint smell and an extremely bitter taste. Avoid pieces that are soft, dark, or lack the characteristic bitter taste, as this may indicate water damage or poor alkaloid content. Per the Chinese Pharmacopoeia, total matrine and oxymatrine content should be no less than 1.2% on a dry weight basis.

Primary Growing Regions

Ku Shen grows widely across nearly all provinces of China except Qinghai and Xinjiang, so it does not have a single famous 'terroir' (道地) region in the way some other herbs do. The earliest classical source for its production was 'Runan' (汝南, roughly modern southern Henan and northern Hubei). Major modern commercial production centres include Shanxi, Henan, Hebei, and Inner Mongolia provinces, with the northern and north-central plains regions generally producing good quality root. Wild Ku Shen grows on sunny hillsides, sandy grasslands, and along streams. It is also found in Russia, Korea, Japan, and India.

Harvesting Season

Spring and autumn (春、秋二季). The roots are dug up, the root crown and small branch roots are removed, and the root is washed and dried, or sliced fresh and then dried.

Supplier Information

Treasure of the East

Loading supplier information...

Loading supplier attributes...

Miscellaneous Info

No additional information available

Usage & Safety

How to use this herb and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This herb is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

Loading storage and consumption information...

Traditional Dosage Reference

Standard

4.5–9g

Maximum

Up to 15g in severe Damp-Heat conditions such as acute dysentery, under practitioner supervision. Larger doses increase the risk of gastrointestinal distress and should be short-term only.

Notes

The standard dose of 4.5 to 9g is used for internal decoction to clear Damp-Heat in conditions like dysentery, jaundice, vaginal discharge, or urinary difficulty. For external use (skin washes for eczema, scabies, itching, vaginal washes for trichomonal vaginitis), much larger quantities may be used in the decoction bath, as the herb is not being ingested. Due to its extremely bitter and unpleasant taste, Ku Shen is often prescribed in pill or powder form rather than as a decoction when taken internally. The Ben Cao Xin Bian advises using Ku Shen 'in small amounts as an assistant herb, not in large amounts as a chief herb' due to its harsh, draining nature.

Processing Methods

Processing method

Clean Kǔ Shēn slices are stir-fried over high heat until the surface is charred black and the interior is scorched yellow, then sprinkled with a small amount of water to extinguish sparks, removed, and dried.

How it changes properties

Charring significantly reduces Kǔ Shēn's intensely bitter and cold nature. The process adds an astringent quality, shifting the herb's primary action from clearing Damp-Heat and killing parasites to stopping bleeding. The cold, descending nature becomes much milder.

When to use this form

Use the charred form for bleeding conditions such as bloody dysentery, intestinal wind bleeding (rectal bleeding), and hemorrhoidal bleeding. It is often combined with other charred hemostatic herbs such as Dì Yú Tàn and Huái Huā Tàn.

Toxicity Classification

Non-toxic

Ku Shen is classified as non-toxic (无毒) in classical texts and the Chinese Pharmacopoeia. However, it contains bioactive quinolizidine alkaloids including matrine, oxymatrine, sophoridine, and sophocarpine, which have significant pharmacological effects and can cause toxicity at high doses or with concentrated extracts. Symptoms of alkaloid overdose include salivation, unsteady gait, rapid breathing, rapid pulse, and in severe cases, convulsions, seizures, respiratory depression, and respiratory failure. The LD50 of oxymatrine by intravenous injection in mice is approximately 150 mg/kg. At standard decoction doses (4.5 to 9g), the alkaloid exposure is far below toxic thresholds. The risk is mainly with concentrated injectable preparations (such as Compound Kushen Injection) or with deliberate overdose, not with standard oral decoction use.

Contraindications

Caution

Spleen and Stomach deficiency-cold patterns (脾胃虚寒). Ku Shen is extremely bitter and cold in nature. It can severely injure the Spleen and Stomach in people with underlying cold-deficiency, causing diarrhea, abdominal pain, and loss of appetite.

Caution

Kidney Yang deficiency or vital essence depletion (肾阳虚衰, 真元不足). Classical sources consistently warn against use when 'Fire is weak and essence is cold' (火衰精冷). The Ben Cao Gang Mu and Ben Cao Hui Yan both specifically caution against use in the elderly or those with depleted constitutional Yang.

Caution

Yin deficiency without Damp-Heat. Ku Shen's intensely drying nature (苦燥) can further damage Yin fluids. It should only be used where there is genuine Damp-Heat, not where dryness or Yin deficiency predominates.

Caution

Prolonged use at high doses. Classical texts warn that long-term use can cause heaviness of the lower back (腰重) due to its purely descending, draining nature, which can deplete Kidney Qi.

Avoid

Concurrent use with Li Lu (藜芦, Veratrum). Ku Shen is listed under the Eighteen Incompatibilities (十八反) as one of the herbs that is 'opposed to' (反) Li Lu. This is a classical absolute prohibition.

Classical Incompatibilities

Ku Shen is incompatible with Li Lu (藜芦, Veratrum root) according to the Eighteen Incompatibilities (十八反). The classical verse states: '诸参辛芍叛藜芦' (all the Shen-named herbs, Xi Xin, and Shao Yao are opposed to Li Lu). Ku Shen is one of the 'various Shen' herbs included in this prohibition. These two herbs should not be used together in the same formula.

Special Populations

Pregnancy

Ku Shen should be used with caution during pregnancy. Its intensely bitter and cold nature can injure the Spleen and Stomach, potentially affecting nutrient absorption. The alkaloid components (matrine, oxymatrine) have demonstrated significant biological activity including effects on cell proliferation in laboratory studies. While there is no specific classical prohibition on use in pregnancy, its strongly descending and draining properties make it unsuitable for routine use in pregnant women. Avoid unless specifically prescribed by an experienced practitioner for a clear Damp-Heat condition, and limit duration of use.

Breastfeeding

Caution advised. The alkaloid components of Ku Shen (matrine, oxymatrine) are small molecules that may transfer into breast milk. Additionally, the herb's intensely cold and bitter nature can potentially affect the nursing mother's Spleen and Stomach function, which may indirectly impact milk quality or quantity. There are no specific clinical studies on Ku Shen use during lactation. Avoid oral use during breastfeeding unless specifically indicated and supervised by an experienced practitioner. Topical use (external washes for skin conditions) is generally considered safer.

Pediatric Use

Ku Shen is not commonly used in paediatric internal formulas due to its extremely bitter taste and strongly cold, draining nature, which can easily injure a child's developing digestive system. When used for children, dosage should be significantly reduced (typically one-third to one-half of the adult dose, depending on age and weight). External use, such as Ku Shen decoction washes for childhood eczema or skin itching, is more common and generally well tolerated. Internal use should only be short-term and under close practitioner supervision.

Drug Interactions

CYP450 enzyme interactions: Preclinical research has shown that matrine and oxymatrine can significantly induce CYP2B enzyme activity in a dose-dependent manner, and matrine at higher doses mildly inhibits CYP3A activity. This means Ku Shen or its alkaloid extracts could potentially alter the metabolism of pharmaceutical drugs processed through these pathways. Patients taking medications metabolized by CYP2B6 or CYP3A4 should exercise caution.

Anticoagulants and antiplatelet agents: Some in vitro studies suggest Sophora flavescens alkaloids may have effects on platelet function. Concurrent use with warfarin or similar drugs should be monitored.

Immunosuppressants and anti-cancer drugs: Given the immunomodulatory and anti-proliferative effects demonstrated in laboratory studies, there is a theoretical risk of interaction with immunosuppressive therapy or chemotherapy. Compound Kushen Injection is sometimes used as adjunctive cancer treatment in China, but such combinations require oncologist oversight.

Antiarrhythmic drugs: Ku Shen alkaloids have demonstrated quinidine-like antiarrhythmic effects in laboratory and clinical settings. Concurrent use with pharmaceutical antiarrhythmics (e.g. amiodarone, quinidine) may have additive effects and should be supervised.

Dietary Advice

While taking Ku Shen internally, avoid cold and raw foods, iced drinks, and greasy or heavy foods, as these can further burden the Spleen and Stomach, which are already challenged by the herb's cold, bitter nature. Eating easily digestible, warm, cooked foods helps protect digestive function during treatment. Classical dietary incompatibilities are not specifically recorded for Ku Shen, but general principles for bitter-cold herbs apply.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.