Formula

Huang Qi Gui Zhi Wu Wu Tang

Astragalus and Cinnamon Twig Five-Substance Decoction | 黄芪桂枝五物汤

Also known as:

Huang Qi Wu Wu Tang (黄芪五物汤) , Gui Zhi Wu Wu Tang (桂枝五物汤) , Wu Wu Tang (五物汤) , Huang Qi Gui Zhi Wu Wu Wan (pill form)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula used to improve circulation and relieve numbness, tingling, or weakness in the limbs caused by Qi deficiency and sluggish blood flow. It is especially suited for people who are prone to sweating, tire easily, and experience worsening symptoms in cold or windy conditions. Modern practitioners commonly apply it for peripheral neuropathy, post-stroke numbness, and Raynaud's phenomenon.

Formula Category

Main Actions

  • Tonifies Qi and warms the channels
  • Harmonizes the Nutritive and Defensive Qi
  • Nourishes Blood and dispels obstruction (Bi)
  • Warms the Channels and Disperses Cold
  • Warms and Unblocks Yang

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Huang Qi Gui Zhi Wu Wu Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Huang Qi Gui Zhi Wu Wu Tang addresses this pattern

Blood Obstruction (Xue Bi, 血痹) is a specific pattern where Qi deficiency leads to sluggish Blood circulation, and mild Wind-Cold pathogenic factors lodge in the blood vessels of the skin and flesh, causing numbness and loss of sensation. Unlike painful obstruction (Feng Bi), Blood Obstruction primarily manifests as numbness rather than pain. Huang Qi Gui Zhi Wu Wu Tang addresses this by tonifying Qi with Huang Qi to restore the driving force behind Blood circulation, warming and opening the channels with Gui Zhi and Sheng Jiang to disperse the lodged Wind-Cold, and nourishing Blood with Shao Yao to restore proper nutrition to the skin and muscles. The formula simultaneously treats both root (Qi deficiency) and branch (Blood stagnation with mild Wind-Cold).

A practitioner would look for one or more of these signs

Skin Numbness

Numbness or loss of sensation in the limbs or skin, the hallmark symptom

Tingling

Tingling or 'pins and needles' sensation in the extremities

Eye Fatigue

General fatigue and weakness, worse with exertion

Excessive Sweating

Spontaneous sweating, especially on exertion

Cold Extremities

Cold hands and feet due to impaired Yang circulation

Aversion To Cold

Sensitivity to wind and cold drafts

How It Addresses the Root Cause

This formula addresses a condition the Jin Gui Yao Lue calls Blood Bi (血痹, "blood obstruction"). The underlying disease logic begins with a person who is constitutionally deficient in Qi and Blood. Because Qi is weak, the body's defensive layer (Wei Qi) is not vigorous enough to keep pathogenic influences out. At the same time, the nutritive aspect (Ying Qi) that nourishes the blood vessels is also insufficient, so blood circulation becomes sluggish.

In this vulnerable state, even mild wind exposure — especially after physical exertion or sweating — can slip past the weakened defenses and lodge in the blood vessels and muscle layers. This external wind, combined with the pre-existing poor blood flow, causes the blood to congeal and stagnate in the peripheral channels. The result is numbness, tingling, and loss of sensation in the skin and limbs, sometimes with dull pain in fixed locations. The person's Yang Qi cannot reach the extremities, so the limbs may feel cold and heavy. The characteristic pulse is faint at the superficial positions (reflecting Qi weakness) and slightly tight at the deep position (reflecting the congealed blood). Unlike true Wind Bi (which involves strong pain that migrates from joint to joint), Blood Bi presents mainly as sensory loss and numbness, because the core problem is not rampant wind but rather insufficient Qi failing to push blood through the vessels.

The formula corrects this by simultaneously boosting Qi to restore the body's motive force and gently warming the channels to disperse the stagnation. Once Qi is strong enough to drive blood circulation and the mild wind is expelled, sensation and nourishment return to the affected tissues.

Formula Properties

Temperature

Warm

Taste Profile

Predominantly sweet and pungent — sweet (Huang Qi, Da Zao, Bai Shao) to tonify Qi and nourish Blood, pungent (Gui Zhi, Sheng Jiang) to warm the channels and disperse stagnation.

Target Organs
Spleen Lungs Heart Liver
Channels Entered
Spleen Lung Heart Liver

Formula Origin

Jin Gui Yao Lue (金匮要略, Essential Prescriptions of the Golden Chamber) by Zhang Zhongjing

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Huang Qi Gui Zhi Wu Wu Tang

Detailed information about each herb in Huang Qi Gui Zhi Wu Wu Tang and their roles

Kings
Deputies
Assistants
Huang Qi
Huang Qi

Astragalus root

Dosage: 9 - 30g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Lungs
Parts Used Root (根 gēn)
Role in Huang Qi Gui Zhi Wu Wu Tang

The chief herb of the formula, Huang Qi is sweet and warm. It powerfully tonifies Qi, strengthens the body's defensive (Wei) Qi at the surface, and drives the movement of Qi and Blood through the channels. By bolstering Qi, it addresses the root deficiency that allows pathogenic Wind to lodge in the blood vessels and cause numbness.

Gui Zhi
Gui Zhi

Cinnamon twig

Dosage: 9 - 15g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder
Parts Used Twig (枝 zhī)
Role in Huang Qi Gui Zhi Wu Wu Tang

Gui Zhi is acrid and warm. It warms and opens the channels, disperses Wind-Cold, and promotes Yang Qi circulation through the limbs. When paired with Huang Qi, the two reinforce each other: Gui Zhi helps Huang Qi reach the surface and extremities, while Huang Qi ensures that Gui Zhi's dispersing action does not weaken the body's defenses.

Bai Shao
Bai Shao

White peony root

Dosage: 9 - 15g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Huang Qi Gui Zhi Wu Wu Tang

Shao Yao nourishes the Blood and harmonizes the nutritive (Ying) layer. Paired with Gui Zhi, it balances Yin and Yang and regulates the interplay between the body's nutritive and defensive systems. It also softens and relaxes the blood vessels, helping to relieve the stiffness and impaired sensation caused by Blood stagnation.

Sheng Jiang
Sheng Jiang

Fresh ginger rhizome

Dosage: 15 - 30g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Huang Qi Gui Zhi Wu Wu Tang

Used at double the dosage of the other main herbs in the original formula, Sheng Jiang is acrid and warm. It strongly disperses Wind-Cold from the surface and carries the power of Huang Qi and Gui Zhi outward to the skin and extremities. Its large dose is key to the formula's effectiveness: it propels the other herbs to the body surface where the obstruction resides.

Da Zao
Da Zao

Chinese date (Jujube fruit)

Dosage: 4 - 12 pieces

Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Huang Qi Gui Zhi Wu Wu Tang

Da Zao is sweet and warm. It nourishes the Blood and Qi, supports the Spleen and Stomach to strengthen the source of Qi and Blood production, and harmonizes all the other herbs. Paired with Sheng Jiang, it helps regulate the nutritive and defensive systems together.

Modern Research (4 studies)

  • Meta-analysis of 16 RCTs on HGWWD for Diabetic Peripheral Neuropathy (2016)
  • Meta-analysis of 32 RCTs on HGWD for Chemotherapy-Induced Peripheral Neuropathy (2024)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Warm, 30 minutes after meals, two to three times daily. Classical instructions specify taking approximately 200ml warm per dose, three times daily.

Typical Duration

Chronic conditions: typically 4-12 weeks, reassessed regularly by a practitioner. May be taken for longer periods with modifications for chronic neuropathy.

Dietary Advice

While taking this formula, favour warm, cooked, easily digestible foods that support Qi and Blood, such as congee, soups, warm grains, dates, and lightly cooked vegetables. Avoid cold and raw foods (salads, iced drinks, raw fish), greasy or heavy foods, and excessive dairy, as these can impair Spleen function and counteract the warming, Qi-tonifying action of the formula. The Jin Gui Yao Lue advises against cold exposure during treatment. Light physical activity is encouraged to promote Qi and blood circulation, but overexertion and heavy sweating should be avoided, as these deplete the Qi this formula is designed to restore.

Special Populations

Pregnancy

Generally considered safe for use during pregnancy, as none of the five herbs (Huang Qi, Gui Zhi, Bai Shao, Sheng Jiang, Da Zao) are classified as pregnancy-prohibited or pregnancy-cautious substances in standard TCM pharmacopoeias. Gui Zhi is warm and mildly activating but is used at moderate dosage in this formula and is well-balanced by Bai Shao. However, as with any herbal formula during pregnancy, use should be supervised by a qualified practitioner who can adjust the dosage appropriately. The heavy dose of Sheng Jiang (fresh ginger) in the original prescription may warrant reduction in pregnancy to avoid excessive dispersing action.

Breastfeeding

No specific concerns have been identified for breastfeeding. All five herbs in the formula (Huang Qi, Gui Zhi, Bai Shao, Sheng Jiang, Da Zao) are common food-grade or mild medicinal substances with a long history of safe use. Huang Qi is traditionally used postpartum to support Qi recovery. No adverse effects on lactation or infant health have been reported in the literature. Standard clinical precautions apply: use under practitioner guidance and monitor for any changes in the infant.

Pediatric Use

This formula can be used in children with appropriate dosage reduction based on age and weight. General guidelines: children under 5 years should receive approximately one-quarter to one-third of the adult dose; children ages 5-10 may receive one-third to one-half; adolescents may take two-thirds to the full adult dose. The formula's ingredients are all mild and food-grade in nature, making it relatively well-tolerated in pediatric populations. However, the large dose of Sheng Jiang (fresh ginger) in the classical prescription may be too pungent for very young children and should be reduced. As always, pediatric use should be supervised by a qualified practitioner.

Drug Interactions

Anticoagulants and antiplatelet agents (e.g. warfarin, heparin, aspirin, clopidogrel): Gui Zhi (cinnamon twig) and Bai Shao (white peony root) have mild blood-activating properties. Concurrent use may theoretically enhance anticoagulant effects, potentially increasing bleeding risk. Clinical monitoring of coagulation parameters is advisable.

Hypoglycemic medications (e.g. metformin, insulin): Huang Qi (astragalus) has documented hypoglycemic effects. When this formula is used for diabetic peripheral neuropathy alongside glucose-lowering drugs, blood sugar should be monitored more closely, as additive hypoglycemic effects are possible.

Immunosuppressants (e.g. cyclosporine, tacrolimus): Huang Qi has well-documented immunomodulatory properties and can stimulate immune function. This may theoretically counteract the effect of immunosuppressive drugs. Caution and clinical supervision are warranted in transplant patients or those on immunosuppressive therapy.

Contraindications

Caution

Yin deficiency with Heat signs (e.g. night sweats, hot flashes, red tongue with scanty coating). This warming, Yang-promoting formula can worsen Yin-deficient Heat.

Caution

Excess Heat or active inflammatory conditions with redness, swelling, and heat. The warm nature of Gui Zhi and Sheng Jiang can aggravate excess Heat patterns.

Caution

Wind-Cold-Damp Bi syndrome (true Wind Bi) with strong exterior pathogenic factors and no underlying Qi deficiency. Blood Bi (which this formula treats) and Wind Bi have different pathomechanisms and require different strategies.

Caution

Patients with significant bleeding disorders or those on high-dose anticoagulant therapy, as the formula promotes blood circulation. Use with caution and clinical monitoring.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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