Wu Ling San

Five-Ingredient Powder with Poria · 五苓散

Also known as: Five Ling Powder, Hoelen Five Herb Formula, Five-Ingredient Powder with Poria,

A classical formula used to help the body process and move fluids properly, relieving water retention, swelling, and difficulty urinating. It is especially helpful when someone feels thirsty but cannot quench the thirst, or when drinking water leads to vomiting. Often called "the foremost formula for regulating water metabolism" in Chinese medicine.

Origin Shāng Hán Lùn (Treatise on Cold Damage) by Zhāng Zhòngjǐng — Eastern Hàn dynasty, circa 200 CE
Composition 5 herbs
Ze Xie
King
Ze Xie
Fu Ling
Deputy
Fu Ling
Zhu Ling
Deputy
Zhu Ling
Bai Zhu
Assistant
Bai Zhu
Gui Zhi
Assistant
Gui Zhi
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Educational content Consult qualified TCM practitioners for diagnosis and treatment

Patterns Addressed

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Wu Ling San is designed to correct these specific patterns.

Why Wu Ling San addresses this pattern

Wu Ling San was originally designed in the Shang Han Lun for the "water accumulation pattern" (蓄水证, xù shuǐ zhèng) of the Greater Yang (Tai Yang) system. When an external pathogen enters the Bladder channel and disrupts the Bladder's Qi transformation, water accumulates in the lower body instead of being properly distributed. The body is paradoxically both waterlogged and thirsty, because although there is plenty of fluid, the impaired Qi transformation prevents it from reaching where it is needed. Ze Xie, Fu Ling, and Zhu Ling drain the accumulated water through urination, Bai Zhu strengthens the Spleen's fluid-processing ability, and Gui Zhi restores the Bladder's warming and transformative function while also releasing any remaining surface pathogen.

A practitioner would look for one or more of these signs

Difficult Urination

Scanty or inhibited urination, the hallmark symptom

Thirst

Intense thirst with desire to drink, yet drinking does not relieve it

Epigastric Fullness And Pain Relieved By Vomiting

Water reversal: vomiting immediately after drinking water

Headaches

Headache with mild fever from lingering exterior pathogen

Edema

Generalized swelling from water overflowing to the skin and muscles

Commonly Prescribed For

These conditions can arise from the patterns above. A practitioner would consider Wu Ling San when these conditions are specifically caused by those patterns — not for all cases of these conditions.

Arises from: Kidney Yang Deficiency with Water overflowing Dampness Accumulation

TCM Interpretation

In TCM, edema is understood as the failure of the body's fluid metabolism system. Three organ systems are primarily responsible for moving water through the body: the Lungs distribute fluids downward and outward, the Spleen transforms and transports fluids in the middle, and the Kidneys and Bladder govern water in the lower body through a process called "Qi transformation." When any of these systems fail, water accumulates in the wrong places, producing swelling. Wu Ling San addresses the common scenario where the Bladder's Qi transformation is impaired and the Spleen is weakened, causing water to pool rather than circulate. The resulting pattern features reduced urination, thirst that is not relieved by drinking, and puffiness or swelling.

Why Wu Ling San Helps

Wu Ling San addresses edema at multiple levels of fluid metabolism. Ze Xie, Fu Ling, and Zhu Ling form a powerful trio that promotes urination and creates a clear exit pathway for the excess fluid. Bai Zhu strengthens the Spleen so that it can properly separate clear fluids from turbid ones, preventing new dampness from forming. Gui Zhi provides the crucial warming action that restores the Bladder's Qi transformation, essentially re-igniting the engine that drives fluid processing. Modern research has confirmed that the formula regulates aquaporin water channel proteins in the kidneys, and clinical studies have shown significant increases in urinary output and reductions in body weight in patients with nephritic edema.

Also commonly used for

Difficult Urination

Urinary retention or oliguria from impaired fluid metabolism

Epigastric Fullness And Pain Relieved By Vomiting

Vomiting after drinking water (water reversal), morning sickness with fluid retention

Headaches

Headache associated with fluid retention or weather changes

Nausea

Including hangover-related nausea with thirst and reduced urination

Kidney Stones

Nephrolithiasis prevention, especially calcium oxalate stones

Ascites

Liver cirrhosis ascites when combined with appropriate modifications

What This Formula Does

Every TCM formula has a specific set of actions — here's what Wu Ling San does in the body, explained in both everyday and TCM terms

Therapeutic focus

In practical terms, Wu Ling San is primarily used to support these areas of health:

TCM Actions

In TCM terminology, these are the specific therapeutic actions that Wu Ling San performs to restore balance in the body:

How It Addresses the Root Cause

TCM doesn't just suppress symptoms — it aims to resolve the underlying imbalance. Here's how Wu Ling San works at the root level.

Wu Ling San addresses a core disruption in the body's water metabolism. In TCM, fluids are absorbed by the Stomach, transported upward by the Spleen, distributed by the Lungs, and ultimately filtered downward through the San Jiao (Triple Burner) to the Bladder, where the Bladder's Qi-transforming function (气化) decides what is excreted as urine and what is recycled. When this Qi-transformation fails, water accumulates internally rather than circulating properly. This is the central pathological mechanism: Qi fails to transform, so water stagnates.

The classical presentation occurs when an external pathogen (wind-cold) lodges in the Tai Yang system and penetrates inward to disrupt the Bladder's function. Yang Qi, weakened by the illness or by excessive sweating, can no longer "steam" fluids into useful distribution. Water pools in the lower body (causing difficult urination and lower abdominal fullness) while the upper body is paradoxically deprived of moisture (causing intense thirst). The person drinks eagerly, but since the transport mechanism is broken, the water just adds to the internal pooling. In severe cases, water that cannot go down is forced back upward — the patient vomits immediately after drinking. This dramatic presentation is what Zhang Zhongjing named "water reversal" (水逆, shui ni).

The same basic mechanism, Qi failing to move water, can also manifest as edema (water overflowing to the skin), watery diarrhea (water flooding the intestines), dizziness with spitting of thin saliva (water-fluid rising to the head), or palpitations below the navel (water churning in the lower abdomen). The key insight is that this is not a lack of water but a failure of water distribution: there is too much water in the wrong places and not enough where it is needed.

Formula Properties

Every formula has an inherent temperature, taste, and affinity for specific organs — these properties determine how it interacts with the body

Overall Temperature

Slightly Warm

Taste Profile

Predominantly bland and slightly sweet, with a hint of pungency from Gui Zhi — bland to seep and drain Dampness, sweet to support the Spleen, and pungent to warm Yang and promote Qi transformation.

Target Organs

Urinary Bladder Spleen Kidneys San Jiao (Triple Burner)

Channels Entered

Bladder Spleen Kidney San Jiao

Ingredients

5 herbs

The herbs that make up Wu Ling San, organized by their role in the prescription

King — Main ingredient driving the formula
Deputy — Assists and enhances the King
Assistant — Supports or moderates other herbs
King — Main ingredient driving the formula
Ze Xie

Ze Xie

Water plantain

Dosage 10 - 15g
Temperature Cold
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Wu Ling San

Used in the largest dose, Ze Xie is sweet and bland, entering the Kidney and Bladder channels. It directly reaches the lower Jiao to promote urination and drain accumulated water-dampness, addressing the core problem of impaired Bladder Qi transformation.
Deputies — Assists and enhances the King
Fu Ling

Fu Ling

Poria-cocos mushrooms

Dosage 9 - 15g
Temperature Neutral
Taste Sweet
Organ Affinity Heart, Kidneys, Lungs, Spleen

Role in Wu Ling San

Sweet and bland, Fu Ling strengthens the Spleen while promoting urination and draining dampness. It reinforces the King herb's water-draining action and simultaneously supports the Spleen's capacity to transform and transport fluids, preventing dampness from re-accumulating.
Zhu Ling

Zhu Ling

Polyporus

Dosage 9 - 15g
Temperature Neutral
Taste Sweet
Organ Affinity Urinary Bladder, Kidneys

Role in Wu Ling San

Sweet and bland, Zhu Ling is a powerful dampness-draining herb that works alongside Fu Ling to powerfully enhance the diuretic effect. Together with Fu Ling and Ze Xie, it forms a trio of bland, water-draining substances that form the formula's core strategy.
Assistants — Supports or moderates other herbs
Bai Zhu

Bai Zhu

Atractylodes rhizomes

Dosage 9 - 15g
Temperature Warm
Taste Bitter, Sweet
Organ Affinity Spleen, Stomach

Role in Wu Ling San

Sweet, bitter and warm, Bai Zhu strengthens the Spleen and dries dampness. According to five-phase theory, strengthening Earth (Spleen) helps control Water. By restoring Spleen function, it ensures that fluids are properly transformed and transported rather than pooling as pathological dampness.
Gui Zhi

Gui Zhi

Cinnamon twigs

Dosage 3 - 6g
Temperature Warm
Taste Pungent, Sweet
Organ Affinity Heart, Lungs, Spleen

Role in Wu Ling San

Acrid and warm, Gui Zhi serves a dual role: internally it warms Yang and promotes Qi transformation in the Bladder, providing the motive force that enables the water-draining herbs to work effectively; externally it releases any lingering surface pathogen. A small dose drives the entire formula's transformative action.

Why This Combination Works

How the herbs in Wu Ling San complement each other

Overall strategy

The core problem is that the Bladder has lost its ability to transform and distribute fluids properly, causing water to accumulate internally. The strategy is primarily to drain the accumulated water through bland, seeping herbs, while simultaneously warming Yang to restore the Qi transformation that prevents water from re-accumulating.

King herbs

Ze Xie (Alisma) is used at the highest dose in the formula. Its bland, slightly cold nature allows it to reach directly into the Kidney and Bladder to leach out retained water through urination. As the King herb, it targets the formula's central objective: removing the pathological fluid that has accumulated in the lower Jiao due to impaired Bladder Qi transformation.

Deputy herbs

Fu Ling (Poria) and Zhu Ling (Polyporus) both augment Ze Xie's water-draining power. Fu Ling has the additional benefit of strengthening the Spleen, supporting the middle Jiao's role in fluid metabolism. Zhu Ling is more single-minded in its diuretic action, making the pair complementary: one drains and tonifies, the other drains with greater force.

Assistant herbs

Bai Zhu (White Atractylodes) is a reinforcing assistant that strengthens the Spleen to transform and transport dampness. This addresses the root cause from the perspective of the Earth phase controlling Water. Gui Zhi (Cinnamon Twig) is both a reinforcing assistant and, according to some commentators, serves as an envoy. Its warm, acrid nature warms Yang and promotes Qi transformation in the Bladder. This is like adding fire beneath a pot of water: without heat, water cannot be steamed and distributed. Gui Zhi also retains the ability to release any lingering external pathogen at the body surface, making the formula effective for combined exterior-interior conditions.

Notable synergies

The pairing of Fu Ling and Bai Zhu together strengthens the Spleen to control water from the middle Jiao, while the trio of Ze Xie, Fu Ling, and Zhu Ling provides layered water-draining action through the lower Jiao. Gui Zhi's warming action activates the entire formula: without it, the bland draining herbs would lack the driving force of Qi transformation. The classical commentator Kē Qín noted that Gui Zhi enables the fluids to "spread in all four directions, moistening the Heart and Lungs above and reaching the skin below," making it the catalyst that turns simple drainage into true fluid redistribution.

How to Prepare

Traditional preparation instructions for Wu Ling San

Classical method (powder): Grind all five herbs into a fine powder. Take one square-inch spoonful (approximately 6 to 10g) mixed with plain rice water (白饮, bái yǐn), three times daily. After taking the powder, drink plenty of warm water to encourage a gentle sweat, which signals that the formula is working. Rest and recuperate as appropriate.

Modern decoction method: When prepared as a decoction, use proportional dosages (Ze Xie 15g, Fu Ling 9g, Zhu Ling 9g, Bai Zhu 9g, Gui Zhi 6g). Decoct in approximately 1100ml of water, bring to a boil, then simmer on low heat for 30 to 40 minutes. Strain and obtain approximately 300ml of liquid. Divide into 2 to 3 warm doses throughout the day. Drink additional warm water after each dose. Note: some classical commentators such as Xú Língtāi advise that the powder form may be more effective than the decoction for this formula.

Common Modifications

How practitioners adapt Wu Ling San for specific situations

Added
Ge Gen

15g, raises Spleen Yang and relieves diarrhea

Huo Xiang

10g, transforms dampness and stops vomiting

Ge Gen raises clear Yang Qi to counter diarrhea and generates fluids, while Huo Xiang aromatically transforms dampness and addresses nausea and vomiting. If fever is prominent, Gui Zhi may be reduced or removed.

Educational content — always consult a qualified healthcare provider or TCM practitioner before using any herbal formula.

Contraindications

Situations where Wu Ling San should not be used or requires extra caution

Avoid

Yin deficiency with depleted fluids (阴虚津亏). Signs include dry mouth and throat, hot palms and soles, night sweats, and a red tongue with little coating. Because this formula actively drains fluids and warms Yang, it can further deplete Yin and worsen dehydration in these patients.

Caution

Damp-Heat patterns (湿热证). When there are signs of Heat predominating, such as dark scanty urine, yellow greasy tongue coating, and a rapid pulse, the warming nature of Gui Zhi (Cinnamon Twig) in this formula may aggravate the Heat. If used at all, Gui Zhi should be removed and cooling herbs added.

Caution

Prolonged or excessive use. Because the formula is predominantly draining in nature, extended use may injure Qi and Yin. It is best suited for short-term use while the pattern of water retention is active, not as a long-term tonic.

Caution

Concurrent use with high-dose pharmaceutical diuretics (e.g. furosemide/Lasix) without medical supervision. The combined diuretic effect may lead to excessive fluid loss or electrolyte imbalance.

Caution

Kidney Yang deficiency without Dampness accumulation. In patients with pure Kidney Yang deficiency (e.g. cold limbs, clear copious urination, sore low back), this formula may worsen symptoms because its diuretic herbs can further deplete already weak Kidney function without addressing the root deficiency.

Special Populations

Important considerations for pregnancy, breastfeeding, and pediatric use

Pregnancy

Use with caution during pregnancy. None of the five herbs in Wu Ling San are classically listed as prohibited in pregnancy, and the formula does not contain strongly Blood-moving or downward-draining herbs. However, Ze Xie (Alisma) and the two Ling herbs (Poria and Polyporus) have significant diuretic action, which could theoretically affect fluid balance during pregnancy. Gui Zhi (Cinnamon Twig) is mildly warming and dispersing. Pregnant women should only take this formula under the guidance of a qualified practitioner, for a limited duration, and at appropriately reduced doses. Avoid in the first trimester unless clearly indicated.

Breastfeeding

Wu Ling San is generally considered compatible with breastfeeding when used for short durations at standard doses. The herbs in this formula (Poria, Polyporus, Alisma, Atractylodes, Cinnamon Twig) are mild and widely used in postpartum care in traditional practice. However, due to the diuretic nature of the formula, excessive or prolonged use could theoretically reduce fluid volume and potentially affect milk production. Nursing mothers should use the formula only as needed under practitioner guidance, maintain adequate fluid intake, and discontinue if milk supply decreases.

Children

Wu Ling San can be used in pediatric cases, particularly for acute watery diarrhea in infants and young children where the TCM pattern matches (water-grain not separating, with watery stools and reduced urination). However, children's immature digestive systems require careful consideration. Dosages should be reduced proportionally: roughly one-quarter to one-third of the adult dose for children under 5, and one-half for children aged 6-12. National Master physician Zhang Jingsheng has noted the formula's effectiveness for summer infant diarrhea and autumn diarrhea due to cold-dampness. The powder form (as originally prescribed) is often preferred for young children as it is gentler. Always use under practitioner supervision and for limited duration. Monitor closely for signs of excessive fluid loss.

Drug Interactions

If you are taking pharmaceutical medications, be aware of these potential interactions with Wu Ling San

Pharmaceutical diuretics (furosemide, hydrochlorothiazide, spironolactone): Wu Ling San has demonstrated diuretic activity in pharmacological studies. Concurrent use with loop or thiazide diuretics may potentiate fluid and electrolyte loss, potentially leading to dehydration, hypokalemia, or hyponatremia. If combined use is necessary, electrolytes and kidney function should be monitored.

Lithium: Because the formula promotes urination and can alter fluid balance, it may theoretically affect lithium clearance. Changes in sodium and water handling can cause lithium levels to fluctuate, risking either toxicity or reduced efficacy.

Antihypertensive medications: The diuretic and fluid-shifting effects of Wu Ling San could add to the blood-pressure-lowering effect of antihypertensive drugs, increasing risk of hypotension. Gui Zhi (Cinnamon Twig) also has mild vasodilatory properties.

Anticoagulants (warfarin): Gui Zhi has mild blood-moving properties. While the small dose in Wu Ling San is unlikely to cause significant interaction, patients on warfarin or other anticoagulants should be monitored.

Usage Guidance

Practical advice for getting the most out of Wu Ling San

Best time to take

30 minutes before meals, three times daily, followed by warm water as classically instructed (多饮暖水). For acute presentations, can be taken regardless of meal timing.

Typical duration

Acute conditions (edema flare, water retention, acute diarrhea): 3-7 days. Subacute use: up to 2-3 weeks with reassessment. Not intended for prolonged continuous use due to its draining nature.

Dietary advice

While taking Wu Ling San, avoid cold and raw foods (ice cream, cold drinks, raw salads, sashimi) as these impair the Spleen's ability to transform fluids and work against the formula's warming, fluid-moving action. Also avoid greasy, heavy, and overly rich foods that generate more Dampness. Reduce salt intake, as excess salt promotes water retention. Light, warm, and easily digestible foods are preferred: plain rice porridge, cooked vegetables, and mild soups. The original text instructs patients to drink warm water (暖水) after taking the formula to help the medicine work. Avoid alcohol, as it generates Dampness and Heat.

Wu Ling San originates from Shāng Hán Lùn (Treatise on Cold Damage) by Zhāng Zhòngjǐng Eastern Hàn dynasty, circa 200 CE

Classical Texts

Key passages from the classical Chinese medical texts that first described Wu Ling San and its clinical use

Shang Han Lun (《伤寒论》), Clause 71:
「太阳病,发汗后,大汗出,胃中干,烦躁不得眠,欲得饮水者,少少与饮之,令胃气和则愈。若脉浮,小便不利,微热消渴者,五苓散主之。」
"In Tai Yang disease, after sweating therapy with profuse sweating, if the stomach is dry and there is irritability and insomnia, and the person desires to drink water, give small sips to harmonize the Stomach Qi and recovery will follow. But if the pulse is floating, urination is difficult, there is mild fever and thirst that is not quenched by drinking, Wu Ling San governs."

Shang Han Lun (《伤寒论》), Clause 74:
「中风,发热六七日不解而烦,有表里证,渴欲饮水,水入则吐者,名曰水逆,五苓散主之。」
"In wind-strike with fever for six or seven days that does not resolve, with irritability, simultaneous exterior and interior signs, thirst with desire to drink, yet water is vomited immediately upon ingestion — this is called 'water reversal' (shui ni). Wu Ling San governs."

Jin Gui Yao Lue (《金匮要略》), Phlegm-Fluid chapter:
「假令瘦人脐下有悸,吐涎沫而癫眩,此水也,五苓散主之。」
"Suppose a thin person has palpitations below the navel, spits watery saliva, and has dizziness — this is water. Wu Ling San governs."

Shang Han Lun, Administration Instructions:
「上五味,捣为散,以白饮和服方寸匕,日三服,多饮暖水,汗出愈。」
"The above five ingredients are pounded into a powder and taken with plain rice water in a square-inch spoonful dose, three times daily. Drink plenty of warm water; recovery comes when sweating appears."

Historical Context

How Wu Ling San evolved over the centuries — its origins, lineage, and place in the broader tradition of Chinese medicine

Wu Ling San was created by Zhang Zhongjing (张仲景) during the late Eastern Han dynasty (around 200 CE) and appears in both the Shang Han Lun and the Jin Gui Yao Lue, with a total of 11 clauses referencing the formula. It has been called "the foremost formula for expelling water retention, both internal and external" (逐内外水饮之首剂) by Zhao Yuhuang in the Gu Jin Ming Yi Fang Lun (《古今名医方论》), and has historically been praised as the premier water-regulating prescription in the Chinese herbal tradition.

Scholarly research suggests the formula was originally called "Zhu Ling San" (猪苓散) or "Wu Wei Zhu Ling San" (五味猪苓散, "Five-Ingredient Poria-Polyporus Powder"), later shortened to Wu Ling San. The Song-Jin era commentator Cheng Wuji (成无己) proposed in the Shang Han Ming Li Lun that the name derives from Fu Ling (Poria) being the principal herb. Ming dynasty physician Xu Hong offered a different interpretation: that "ling" (苓) is a homophone of "ling" (令, "command"), suggesting the formula "commands" water to move. This poetic reading was echoed by Qing dynasty writer Chen Lingshi.

Through the centuries, later formularies modified Wu Ling San in notable ways. The Taiping Huimin Hejiju Fang (Song dynasty) substituted Chi Fu Ling (red Poria) and Rou Gui (Cinnamon Bark) for the original white Fu Ling and Gui Zhi. Si Ling San (四苓散), created by removing Gui Zhi, appeared in Zhu Danxi's Dan Xi Xin Fa for cases without exterior symptoms. The combination with Ping Wei San produced Wei Ling Tang (胃苓汤), used for Dampness obstructing the Spleen and Stomach. The Jin Gui Yao Lue itself includes Yin Chen Wu Ling San, adding Yin Chen Hao for jaundice with Dampness predominating over Heat.

Modern Research

4 published studies investigating the pharmacological effects or clinical outcomes of Wu Ling San

1

Prospective Randomized Controlled Trial: Wu-Ling-San for Prevention of Recurrent Calcium Oxalate Nephrolithiasis (2013)

Lin E, Ho L, Lin MS, Huang MH, Chen WC. African Journal of Traditional, Complementary and Alternative Medicines, 2013, 10(5): 199-209.

This was the first placebo-controlled RCT of Wu Ling San for kidney stone prevention. 39 patients with recurrent calcium oxalate stones were randomized to WLS (2g three times daily) or placebo for one month. The WLS group showed significantly increased urine output and decreased serum BUN compared to placebo, with no electrolyte imbalance or adverse effects observed.

PubMed
2

In Vitro Study: Wu-Ling-San Inhibits Calcium Oxalate Crystallization (2007)

Chen YC, Ho CY, Chen LD, Hsu SF, Chen WC. American Journal of Chinese Medicine, 2007, 35(3): 533-541.

This laboratory study demonstrated that Wu Ling San effectively inhibited the nucleation, crystallization, and aggregation of calcium oxalate crystals in vitro, suggesting a mechanism by which the formula may help prevent kidney stone formation beyond simple diuresis.

3

Retrospective Study: Wu-Ling-San for Acute Low-Tone Sensorineural Hearing Loss (2012)

Fuse T, Hayashi T, Oota N, Fukase S, Asano S, Aoyagi M. Auris Nasus Larynx, 2013, 40(1): 76-80.

A retrospective review at a Tokyo hospital examined treatments for acute low-tone hearing loss (ALHL). Among 130 definite cases, the combination of oral steroid plus Wu Ling San achieved 100% recovery, significantly outperforming diuretic alone (59%), Wu Ling San alone (62%), or steroid plus diuretic (60%). The results suggest Wu Ling San's fluid-regulating properties may benefit inner-ear fluid disorders.

PubMed
4

Network Pharmacology and In Vivo Study: Wuling San Against Hyperuricemia (2023)

Zhang L, et al. Drug Design, Development and Therapy, 2023, 17: 1-15.

Using network pharmacology analysis and a rat model of hyperuricemia, researchers identified 49 active compounds and 108 potential targets in Wu Ling San. In vivo experiments confirmed that the formula significantly reduced serum uric acid in rats by improving oxidative stress markers and inhibiting inflammatory pathways (NF-kappaB). Key active compounds identified included cerevisterol, luteolin, and beta-sitosterol.

Research on TCM formulas is growing but still limited by Western clinical trial standards. These studies provide emerging evidence and should be considered alongside practitioner expertise.