Formula

Zhu Ye Shi Gao Tang

竹叶石膏汤

Also known as:

Zhu Ye Tang (竹叶汤)

Properties

Heat-clearing formulas · Cool

Key Ingredients

Shi Gao, Dan Zhu Ye

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula for recovery after febrile illness, addressing lingering low-grade heat combined with exhaustion, thirst, and nausea. It gently clears residual heat while replenishing Qi and body fluids that were damaged by the illness, and calms the stomach to stop nausea.

Formula Category

Main Actions

  • Clears Heat from the Qi level
  • Generates Fluids
  • Tonifies Qi
  • Harmonizes the Stomach
  • Directs Rebellious Qi Downward and Stops Vomiting
  • Eliminates Irritability

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Zhu Ye Shi Gao Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Zhu Ye Shi Gao Tang addresses this pattern

This is the core pattern addressed by the formula. After a severe febrile illness, the body's Qi and Yin (fluids, moisture) have been consumed by the prolonged heat, while a residual ember of pathogenic heat remains unresolved. The Qi deficiency manifests as fatigue, shortness of breath, and emaciation; the Yin deficiency appears as thirst, dry mouth, red tongue with little coating, and rapid pulse; the lingering heat produces low-grade fever, sweating, irritability, and restlessness. The formula clears residual heat with Shi Gao and Zhu Ye while simultaneously rebuilding Qi with Ren Shen and restoring fluids with Mai Men Dong, addressing both the root deficiency and the lingering pathogen.

A practitioner would look for one or more of these signs

Low Grade Fever

Lingering low-grade fever that persists after a major illness

Eye Fatigue

Pronounced exhaustion and shortness of breath

Thirst

Persistent thirst with desire to drink

Nausea

Nausea or desire to vomit from Stomach Qi rebellion

Insomnia

Restless sleep or inability to sleep due to internal heat

Excessive Sweating

Sweating that worsens fluid depletion

How It Addresses the Root Cause

This formula addresses a very specific stage of illness: the aftermath of a febrile disease (whether from Cold Damage, Warm Disease, or Summer Heat) where the main battle is over but the body has not yet recovered. Two problems exist simultaneously, creating a delicate clinical situation.

The first problem is lingering residual Heat. Although the acute fever has largely subsided, pathogenic Heat has not been fully cleared from the Qi level (the body's deepest layer of functional activity outside the Blood). This leftover Heat continues to smolder like embers in spent ashes, as the Qing dynasty physician Ye Tianshi described: "the furnace smoke has ceased, but fire remains in the ashes" (炉烟虽息,灰中有火). This residual Heat causes low-grade fever, sweating, irritability, restlessness, and thirst.

The second problem is depletion of both Qi and body fluids (气津两伤). The prolonged febrile illness has consumed the body's Qi (leaving exhaustion, shortness of breath, and weakness) and burned through its Yin fluids (causing dry mouth, thirst, a red tongue with scanty coating, and a thin rapid pulse). The Stomach, which depends on adequate fluids to function and whose Qi naturally descends, has been doubly injured. Without sufficient fluids to moisten it and enough Qi to drive its downward movement, Stomach Qi rebels upward, producing nausea and the urge to vomit. The treatment challenge is that simply clearing the remaining Heat with cold herbs would further damage the already weakened Qi and fluids, while simply tonifying without addressing the residual Heat risks allowing the smoldering pathogen to flare up again. This formula solves the dilemma by clearing and supplementing simultaneously.

Formula Properties

Temperature

Cool

Taste Profile

Predominantly sweet and bland with an acrid undertone. The sweetness (from Ginseng, Licorice, Ophiopogon, and Rice) tonifies Qi and generates fluids, while the bland quality (from Bamboo Leaf and Rice) gently clears Heat and promotes fluid metabolism.

Target Organs
Lungs Stomach Heart
Channels Entered
Lung Stomach Heart

Formula Origin

Shāng Hán Lùn (傷寒論, Discussion of Cold Damage) by Zhāng Zhòngjǐng

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Zhu Ye Shi Gao Tang

Detailed information about each herb in Zhu Ye Shi Gao Tang and their roles

Kings
Deputies
Assistants
Envoys
Shi Gao
Shi Gao

Gypsum

Dosage: 30 - 50g

Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Parts Used Mineral (矿物 kuàng wù)
Role in Zhu Ye Shi Gao Tang

The primary heat-clearing herb. Its acrid, sweet, and very cold nature powerfully clears residual heat from the Qi level of the Lung and Stomach, generates fluids, and relieves thirst and irritability. Used at a heavy dosage to address lingering pathogenic heat.

Dan Zhu Ye
Dan Zhu Ye

Lophatherum herb

Dosage: 6 - 15g

Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Stomach, Small Intestine
Parts Used Whole plant / Aerial parts (全草 quán cǎo)
Role in Zhu Ye Shi Gao Tang

Sweet, bland, and cold, it clears heat from the Heart and Stomach, relieves irritability and restlessness, and guides heat downward and out through the urine. Works alongside Shi Gao to clear residual heat while being lighter and less harsh.

Ren Shen
Ren Shen

Ginseng root

Dosage: 6 - 9g

Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys
Parts Used Root (根 gēn)
Role in Zhu Ye Shi Gao Tang

Sweet and slightly warm, it powerfully tonifies the original Qi that was damaged during the febrile illness. When paired with Shi Gao, Ren Shen rapidly restores true Yin, and its tonifying action counterbalances the cold nature of the King herbs so that clearing heat does not further weaken the body.

Tian Men Dong
Tian Men Dong

Asparagus tuber

Dosage: 15 - 20g

Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Lungs, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Zhu Ye Shi Gao Tang

Sweet, slightly bitter, and cool, it nourishes Yin and generates fluids to replenish the body fluids damaged by prolonged heat. It moistens the Lung and Stomach, addressing dryness, thirst, and the red tongue with scanty coating.

Ban Xia
Ban Xia

Pinellia rhizome

Dosage: 6 - 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Zhu Ye Shi Gao Tang

Acrid and warm, it descends rebellious Stomach Qi to stop nausea and vomiting. Although warm and drying by nature, when combined with the cold, fluid-generating herbs in this formula, its drying properties are neutralized while its downward-directing action is preserved. It also helps transport fluids so that the tonifying herbs do not cause stagnation.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Zhu Ye Shi Gao Tang

Sweet and neutral, it tonifies the middle Qi, protects the Stomach from the cold properties of Shi Gao and Zhu Ye, and harmonizes all the herbs in the formula.

Feng Mi
Feng Mi

Honey

Dosage: 10 - 15g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Lungs, Spleen, Large Intestine
Parts Used Animal — secretion (动物分泌物 dòng wù fēn mì wù)
Role in Zhu Ye Shi Gao Tang

Sweet and neutral, it nourishes the Stomach, generates fluids, and buffers the cold nature of Shi Gao to protect the digestive system. Cooked into the decoction and then removed, it lends a gentle, protective quality to the formula.

Modern Research (1 study)

  • Effect of Modified Zhuye Shigao Decoction and its Components on Preventing Radiation Esophagitis of Rats (Preclinical Animal Study, 2014)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Warm, taken between meals (about 1 hour after eating), divided into 2-3 doses per day. The classical instruction is to take it warm (温服), three times daily.

Typical Duration

Acute use: 3-10 days for post-febrile recovery; may extend to 2-4 weeks for chronic Stomach Yin deficiency conditions, reassessed by a practitioner.

Dietary Advice

While taking this formula, favor light, easily digestible foods such as congee (rice porridge), clear soups, steamed vegetables, and mild fruits like pear and watermelon that support fluid recovery. Avoid greasy, fried, and heavily spiced foods that generate internal Heat and burden the already weakened Stomach. Cold and raw foods should be consumed in moderation to avoid further compromising digestive function. The classical text notes dietary prohibitions (食忌) of seaweed (海藻), lamb (羊肉), Chinese cabbage (菘菜), and maltose candy (饧). Alcohol and strong coffee should be avoided as they can aggravate Heat and further deplete Yin fluids.

Special Populations

Pregnancy

Generally considered safe in pregnancy when used appropriately under professional guidance. The formula contains no strongly abortifacient or uterine-stimulating herbs. However, Ban Xia (Pinellia) is traditionally listed among herbs to be used cautiously during pregnancy due to its acrid, drying nature, though it is used in small dosage here and its warming-drying properties are substantially moderated by the surrounding cool, moistening herbs. Shi Gao (Gypsum) is very cold and should be used with care in pregnant women with weak digestion. Consult a qualified practitioner before use during pregnancy.

Breastfeeding

No specific contraindications for breastfeeding have been documented for this formula. The herbs are generally mild and unlikely to transfer harmful substances through breast milk at standard therapeutic doses. Shi Gao (Gypsum) is a mineral that is poorly absorbed systemically, and the other herbs (Bamboo Leaf, Ophiopogon, Ginseng, Pinellia, Licorice, Rice) have long histories of safe traditional use. However, the formula's cooling nature may theoretically reduce milk supply in mothers with underlying Spleen-Stomach Cold, so it should be used with professional guidance. Gan Cao (Licorice) in prolonged or high-dose use can cause fluid retention, which nursing mothers should be aware of.

Pediatric Use

This formula has a well-documented history of pediatric use, particularly for childhood summer fevers (小儿夏季热), post-infectious recovery, and oral ulcers in children. Dosage should be reduced to approximately one-third to one-half of the adult dose for children aged 6-12, and one-quarter for children under 6, adjusted by body weight and constitution. Ren Shen (Ginseng) is often substituted with Tai Zi Shen (Pseudostellaria root) or Dang Shen (Codonopsis) in pediatric formulations to provide gentler tonification. The formula's combination of cooling and tonifying actions makes it well-suited for children recovering from febrile illness who show signs of lingering low fever, poor appetite, and thirst. Shi Gao dosage should be carefully adjusted downward for young children to avoid overcooling the Stomach.

Drug Interactions

Gan Cao (Licorice): Glycyrrhizin in Licorice can cause pseudoaldosteronism (sodium retention, potassium loss, and elevated blood pressure). This is clinically relevant for patients taking diuretics (especially potassium-wasting types like thiazides and loop diuretics), cardiac glycosides (digoxin, where hypokalemia increases toxicity risk), corticosteroids (additive mineralocorticoid effects), and antihypertensive medications (opposing effects). Licorice may also affect the metabolism of drugs processed by CYP3A4 enzymes.

Ren Shen (Ginseng): Ginseng may interact with anticoagulants and antiplatelet drugs (warfarin, aspirin) by affecting platelet aggregation. It may also interact with hypoglycemic agents (insulin, metformin) by independently lowering blood sugar, potentially causing hypoglycemia. Ginseng should be used cautiously alongside MAO inhibitors.

Shi Gao (Gypsum): As a calcium sulfate mineral, Shi Gao may reduce the absorption of tetracycline antibiotics, fluoroquinolones, and bisphosphonates through chelation if taken concurrently. Separate administration by at least 2 hours is advisable.

Ban Xia (Pinellia): Processed Pinellia is traditionally considered incompatible with Wu Tou (Aconite) preparations. No major documented pharmaceutical drug interactions, but its antiemetic action may theoretically mask nausea that serves as a warning sign for certain drug toxicities.

Contraindications

Caution

Active febrile illness with strong Heat and no Qi or Yin deficiency (full excess Heat patterns such as Bai Hu Tang presentations). This formula is designed for lingering residual Heat with simultaneous Qi and Yin depletion, not for acute high fever where the body's righteous Qi is still intact.

Avoid

Internal accumulation of Phlegm-Dampness. The formula's cool, moistening nature (from Shi Gao, Mai Men Dong, and Geng Mi) can worsen Dampness and Phlegm retention.

Avoid

Yang deficiency with fever (false Heat from true Cold). If fever arises from underlying Yang collapse rather than residual pathogenic Heat, the cold and Yin-nourishing nature of this formula will further damage Yang.

Avoid

Cold patterns of the Stomach and Spleen with vomiting (vomiting due to Cold, not Heat). Ban Xia in this formula addresses Heat-related nausea; if the root cause is Cold, the formula's overall cooling direction is inappropriate.

Caution

Patients with known sensitivity to gypsum (Shi Gao) or those on strict calcium-restricted diets should use this formula with caution, as Shi Gao (calcium sulfate) is a significant mineral component.

Cautions & Warnings

Zhu Ye Shi Gao Tang is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Zhu Ye Shi Gao Tang.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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