Formula

Xiao Chai Hu Tang

Minor Bupleurum Decoction | 小柴胡汤

Also known as:

Sho-saiko-to (小柴胡汤, Minor Bupleurum Decoction)

Properties

Harmonizing formulas · Slightly Cool

Key Ingredients

Chai Hu

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula that harmonises the body when an illness is stuck between the surface and the interior, causing alternating chills and fever, chest and rib-side discomfort, poor appetite, nausea, and irritability. It is one of the most widely used formulas in Chinese medicine, applied to a broad range of conditions involving the Liver, Gallbladder, and digestive system.

Formula Category

Main Actions

  • Harmonizes the Shaoyang
  • Soothes the Liver and Regulates Qi
  • Directs Rebellious Qi Downward and Stops Vomiting
  • Supports the Upright and Dispels Pathogens

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Xiao Chai Hu Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Xiao Chai Hu Tang addresses this pattern

The Shaoyang pattern is the core indication for Xiao Chai Hu Tang. When a pathogenic factor penetrates past the body's surface defences but cannot fully enter the interior, it becomes trapped in the Shaoyang, the 'halfway' zone associated with the Gallbladder and Triple Burner. The pathogen and the body's Qi struggle back and forth, producing the hallmark alternating chills and fever. Gallbladder channel stagnation causes chest and rib-side fullness, and when Gallbladder heat disturbs the Stomach, nausea and loss of appetite follow. Chai Hu vents the exterior aspect, Huang Qin clears the interior heat, while Ban Xia and Sheng Jiang settle the Stomach. Ren Shen, Da Zao, and Zhi Gan Cao strengthen the Spleen so the body can expel the pathogen rather than letting it push deeper.

A practitioner would look for one or more of these signs

Chills

The most characteristic sign, reflecting the struggle between the pathogen and the body's defences

Hypochondriac Fullness

Feeling of fullness, distension, or discomfort along the rib-side and chest

Nausea

Frequent nausea or tendency to vomit, from Gallbladder heat disturbing the Stomach

Poor Appetite

Silent withdrawal and reluctance to eat

Bitter Taste In The Mouth

Bitter taste in the mouth, a key Shaoyang sign indicating Gallbladder heat

Dry Throat
Dizziness

From Gallbladder fire flaring upward

Irritability

Vexation and mental restlessness

How It Addresses the Root Cause

Xiao Chai Hu Tang addresses a situation where a pathogen has moved beyond the body's outermost defences (the Taiyang or 'greater Yang' level) but has not yet penetrated fully into the interior (the Yangming or 'bright Yang' level). It is lodged in between, at the Shaoyang or 'lesser Yang' level, which in TCM theory governs the 'pivot' (枢机) between exterior and interior.

When the body's Qi and Blood are already somewhat weakened (as described in Clause 97: '血弱气尽,腠理开'), the pathogen finds an opening and enters the Shaoyang domain. Here it becomes entangled with the body's defensive forces. Neither side can win outright: when the body's Qi rallies, it pushes the pathogen outward and the patient feels hot; when the pathogen pushes inward, the body loses ground and the patient feels cold. This tug-of-war produces the hallmark symptom of alternating chills and fever. The Shaoyang channel runs along the sides of the torso, so obstruction here causes the characteristic sense of oppressive fullness in the chest and ribcage area. Because the Gallbladder and Liver are closely related, stagnation in this region disrupts the free flow of Qi, leading to irritability, loss of appetite, and a bitter taste in the mouth. When Gallbladder Heat invades the Stomach, it impairs the Stomach's normal downward movement, producing nausea and vomiting.

Crucially, at this half-exterior, half-interior stage, neither sweating (which releases exterior pathogens) nor purging (which clears interior excess) is appropriate. The treatment principle must be 'harmonization' (和解): gently resolving the pathogen from the Shaoyang while simultaneously supporting the body's Qi so it can recover its pivotal function and restore the normal flow between inside and outside.

Formula Properties

Temperature

Slightly Cool

Taste Profile

Predominantly bitter and slightly acrid, with a sweet undertone from the tonifying herbs. The bitter clears Heat and regulates, the acrid disperses and moves Qi, and the sweet supports and harmonizes.

Target Organs
Liver Gallbladder Spleen Stomach San Jiao (Triple Burner)
Channels Entered
Gallbladder Liver Stomach Spleen San Jiao

Formula Origin

Shāng Hán Lùn (傷寒論, Treatise on Cold Damage) by Zhāng Zhòngjǐng

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Xiao Chai Hu Tang

Detailed information about each herb in Xiao Chai Hu Tang and their roles

Kings
Deputies
Assistants
Envoys
Chai Hu
Chai Hu

Bupleurum root

Dosage: 12 - 24g

Temperature Slightly Cool
Taste Acrid / Pungent (辛 xīn), Bitter (苦 kǔ)
Organ Affinity Liver, Gallbladder, Lungs
Parts Used Root (根 gēn)
Role in Xiao Chai Hu Tang

The chief herb that vents pathogenic factors from the Shaoyang level and restores the smooth flow of Qi through the Liver and Gallbladder channels. Its bitter, pungent, and cool nature disperses constraint and clears heat lodged between the exterior and interior.

Huang Qin
Huang Qin

Baical skullcap root

Dosage: 9 - 12g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Parts Used Root (根 gēn)
Role in Xiao Chai Hu Tang

Clears heat from the interior aspect of the Shaoyang. Its bitter, cold nature drains fire and eliminates the irritability and chest heat that develop when the pathogen turns inward. Paired with Chai Hu, it forms the core Chai-Qin combination that addresses both the half-exterior and half-interior aspects of the disease.

Ban Xia
Ban Xia

Pinellia rhizome

Dosage: 9 - 12g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Spleen, Stomach, Lungs
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Xiao Chai Hu Tang

Harmonises the Stomach, descends rebellious Qi, and stops nausea and vomiting. When Gallbladder heat invades the Stomach, it disrupts the downward movement of Stomach Qi. Ban Xia directly addresses this, and also transforms phlegm and dampness that may accumulate.

Ren Shen
Ren Shen

Ginseng root

Dosage: 6 - 9g

Temperature Slightly Warm
Taste Sweet (甘 gān), Bitter (苦 kǔ)
Organ Affinity Spleen, Lungs, Heart, Kidneys
Parts Used Root (根 gēn)
Role in Xiao Chai Hu Tang

Tonifies the Qi of the Spleen and Stomach, supporting the body's righteous Qi (zheng qi) to resist the pathogen. The Shang Han Lun explains that the pathogen enters the Shaoyang because of underlying weakness, so strengthening the middle is essential to prevent further inward transmission.

Sheng Jiang
Sheng Jiang

Fresh ginger rhizome

Dosage: 6 - 9g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Xiao Chai Hu Tang

Warms the middle burner, assists Ban Xia in stopping nausea, and helps harmonise the Stomach. Also moderates the toxicity of Ban Xia.

Da Zao
Da Zao

Jujube fruit

Dosage: 4 - 6 pieces

Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Xiao Chai Hu Tang

Nourishes the Spleen and Stomach, supports the production of Qi and Blood, and works with Sheng Jiang to harmonise the Ying (nutritive) and Wei (defensive) levels. Helps moderate the formula and protect the Stomach.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Xiao Chai Hu Tang

Tonifies the Spleen Qi, assists Ren Shen in supporting the middle burner, and harmonises all the herbs in the formula.

Modern Research (4 studies)

  • Cochrane Systematic Review: Xiao Chai Hu Tang for Chronic Hepatitis B (2019)
  • Systematic Review and Meta-Analysis: Xiao Chai Hu Tang for Peptic Ulcers (2021)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Warm, three times daily between meals (approximately 30-60 minutes before or after eating). Classically taken as '温服一升,日三服' (warm, one dose, three times daily).

Typical Duration

Acute conditions (colds, fevers): 3-7 days. Chronic conditions (hepatobiliary or digestive disorders): 2-4 weeks, then reassessed by a practitioner. Prolonged use beyond several weeks requires monitoring.

Dietary Advice

During treatment, avoid cold and raw foods (such as iced drinks, raw salads, and chilled fruits) as these impair the Stomach Qi that the formula is working to support. Avoid greasy, heavy, and deep-fried foods, which create Dampness and obstruct the Qi mechanism the formula aims to restore. Spicy, hot foods and alcohol should also be avoided, as they may generate Heat and counteract the formula's harmonizing action. Favour light, easily digestible, warm-cooked meals such as congee, steamed vegetables, and simple soups. The classical Shang Han Lun dietary advice for decoction formulas generally emphasizes eating bland and easily digested foods and avoiding overeating during treatment. Emotional agitation (anger in particular) should also be avoided, as it disrupts the Liver Qi that this formula is working to smooth.

Modern Usage

This formula is commonly used for colds, influenza, malaria, chronic hepatitis, liver cirrhosis, acute and chronic cholecystitis, gallstones, acute pancreatitis, pleurisy, otitis media, puerperal fever, acute mastitis, orchitis, bile reflux gastritis, and gastric ulcers, that fall under the category of pathogenic factors residing in the Shao Yang channel and disharmony between the Gallbladder and Stomach.

Special Populations

Pregnancy

Use with caution during pregnancy. Huang Qin (Scutellaria root) is traditionally considered safe and even protective in pregnancy, and has historically been used to calm the fetus. However, Ban Xia (Pinellia) is classically listed among herbs cautioned against during pregnancy due to its acrid, drying, and descending nature. Chai Hu's upward-dispersing quality also raises theoretical concern for destabilizing pregnancy. While some classical texts (including the Shang Han Lun itself) apply this formula to women during menstruation and the postpartum period, pregnancy safety data are insufficient. Pregnant women should avoid this formula unless specifically prescribed and monitored by a qualified practitioner who can make appropriate modifications (such as reducing or substituting Ban Xia).

Breastfeeding

Limited safety data exists for use during breastfeeding. Ban Xia (Pinellia) is acrid and drying, and its alkaloids could theoretically transfer into breast milk. Huang Qin (Scutellaria) contains baicalin and related flavonoids whose effects on nursing infants have not been studied. One Chinese source advises that breastfeeding women should stop nursing during use of this formula to avoid potential effects on the infant. If medically necessary, short-term use under practitioner supervision with careful monitoring of the infant for any digestive upset or unusual behaviour is advisable. Extended use should be avoided.

Pediatric Use

Xiao Chai Hu Tang can be used in children and has a long history of pediatric application. Classical sources note that for children, the adult dose should be divided ('小儿分作二服'). Modern granule preparations (Xiao Chai Hu Ke Li) are commonly used in pediatrics in China. General dosage guidelines: infants under 1 year should only use this formula under direct medical supervision; children aged 1-3 may take approximately one-third to one-half of the adult dose; children aged 3-6 about half the adult dose; and children over 6 approximately two-thirds of the adult dose, adjusted according to body weight and constitution. The formula is commonly used for pediatric fevers at the half-exterior, half-interior stage, particularly when the child shows alternating hot and cold sensations, poor appetite, and nausea. Treatment duration should be kept short (3-5 days for acute conditions) and reassessed if there is no improvement.

Drug Interactions

Interferon (alpha and beta)

The most serious documented interaction. Concurrent use of Xiao Chai Hu Tang with interferon preparations significantly increases the risk of interstitial pneumonia, a potentially fatal condition. This interaction was identified through clinical experience in Japan, where the combination was formally contraindicated in 1994. The mechanism may involve enhanced neutrophil accumulation in lung tissue and overstimulation of inflammatory cytokines (particularly TNF-alpha).

CYP450 Substrate Drugs

Preclinical studies show that Xiao Chai Hu Tang (Sho-saiko-to) can upregulate CYP2B, CYP3A1, and CYP4A1 expression, and may interact with drugs metabolized by CYP2C9. One human study found reduced CYP1A2 activity. Patients taking medications with narrow therapeutic windows that are metabolized by these enzymes should exercise caution.

Glycyrrhiza-containing Preparations and Potassium-depleting Diuretics

Gan Cao (Glycyrrhiza/Licorice) in this formula contains glycyrrhizinic acid, which can cause pseudoaldosteronism (sodium and water retention, potassium loss). Concurrent use with loop diuretics (furosemide, ethacrynic acid) or thiazide diuretics may increase the risk of hypokalemia and associated myopathy. Caution also applies when combining with other glycyrrhiza-containing medicines or glycyrrhizin supplements.

Tolbutamide (Sulfonylurea Antidiabetic)

An animal study showed that Sho-saiko-to reduced the bioavailability of tolbutamide when given concurrently. While clinical significance has not been firmly established, patients on sulfonylurea medications should be monitored.

Anticoagulant and Antiplatelet Drugs

Some components of the formula may theoretically affect platelet aggregation. Caution is warranted when combining with warfarin, heparin, or other blood-thinning medications.

Contraindications

Avoid

Concurrent use with interferon therapy. Japanese clinical experience documented cases of potentially fatal interstitial pneumonia when Xiao Chai Hu Tang (Sho-saiko-to) was used alongside interferon-alpha or interferon-beta. Since 1994, this combination has been formally contraindicated in Japan.

Avoid

Liver cirrhosis or liver cancer (hepatoma). The Japanese prescribing information for Sho-saiko-to formally contraindicates use in these patients due to risk of interstitial pneumonia with serious outcomes including death.

Avoid

Liver dysfunction in chronic hepatitis with platelet count below 100,000/mm³ (suspected cirrhosis). This population carries elevated risk of serious adverse reactions.

Caution

Yin deficiency with Heat (阴虚火旺). Patients with signs such as night sweats, dry mouth and throat, five-centre heat, or a red tongue with little coating should not use this formula, as the warm, dispersing nature of Chai Hu and Ban Xia may further damage Yin fluids.

Caution

Liver Yang rising (肝阳上亢) with headache, dizziness, and irritability. Chai Hu's ascending and dispersing nature may worsen this pattern.

Caution

Interior Cold due to Spleen and Stomach deficiency (脾胃虚寒). As noted in Shang Han Lun clause 98, when the presentation is one of deep cold with a weak, slow pulse and the patient drinks water and vomits, this formula is inappropriate ('柴胡不中与也').

Caution

Pure exterior pattern (Taiyang stage) or pure interior excess (Yangming stage). The Shang Han Lun specifies that Shaoyang disease prohibits the use of sweating, vomiting, and purging methods. Conversely, Xiao Chai Hu Tang is not a substitute for surface-releasing or interior-draining formulas when those are needed.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with pattern of Yin or Blood Deficiency should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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