Formula

Tu Si Zi Wan

菟丝子丸

Also known as:

Da Tu Si Zi Wan (大菟丝子丸, Major Cuscuta Seed Pill)

Properties

Yang-tonifying formulas · Warm

Key Ingredients

Tu Si Zi

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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$24.00 ($0.42/g)
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About This Formula*

Traditional Chinese Medicine background and properties

Formula Description*

A classical warming formula used to strengthen the Kidneys and stop abnormal leakage from the body. It addresses conditions like frequent urination, urinary incontinence, and seminal emissions caused by Kidney Yang weakness, with symptoms including lower back soreness, fatigue, cold limbs, and a frail constitution.

Formula Category*

Main Actions*

  • Tonifies Kidney Yang
  • Secures Essence and Stops Leakage
  • Strengthens the Lower Back and Knees
  • Tonifies the Kidneys
  • Secures Essence and Stops Enuresis

TCM Patterns*

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Tu Si Zi Wan is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Tu Si Zi Wan addresses this pattern

Kidney Yang deficiency is the root pattern this formula treats. When Kidney Yang is insufficient, the body loses its foundational warming power, leading to cold limbs, lower back soreness, fatigue, and a pale tongue. The Yang also governs the Kidney's ability to hold and contain substances, so its weakness leads to frequent urination, incontinence, and seminal emissions. Tu Si Zi Wan addresses this with a strong core of Yang-tonifying herbs (Tu Si Zi, Lu Rong, Rou Cong Rong, Fu Zi) that reignite the Kidney's warming function, while the astringent herbs (Wu Wei Zi, Sang Piao Xiao, Mu Li) restore the containment function once Yang is replenished.

A practitioner would look for one or more of these signs

Frequent Urination

Frequent, scanty urination with continuous dripping after voiding

Lower Back Pain

Lower back soreness and weakness, cold sensation in the lumbar region

Eye Fatigue

Physical exhaustion and mental weariness

Cold Limbs

Aversion to cold with cold extremities

Urinary Incontinence

Inability to control urination, especially at night

How It Addresses the Root Cause*

Tu Si Zi Wan addresses a core pattern of Kidney Qi deficiency and insufficient original Yang (元阳不足). In TCM, the Kidneys are the root of both Yin and Yang for the whole body. They store Essence (Jing) and govern reproductive function, urination, and the structural integrity of the lower back and knees. When Kidney Yang becomes depleted through aging, chronic illness, overwork, or excessive sexual activity, the warming and holding functions of the Kidneys deteriorate.

When Kidney Yang is weak, it can no longer adequately warm the lower body or maintain the Kidneys' grasping and securing functions. This produces two broad categories of symptoms. First, there is cold and weakness: the lower back and knees become sore, weak, and cold because they lack the warming support of Kidney Yang. Second, there is leakage and loss of containment: without sufficient Yang to secure Essence and control the waterways, the body loses its ability to hold things in. This manifests as seminal emission, frequent urination, post-urination dribbling, or in women, excessive thin vaginal discharge. The face may appear dark (黧黑), reflecting the depleted state of Kidney Qi failing to nourish upward, and the person often feels mentally fatigued and physically cold.

The formula works by restoring Kidney Yang and re-establishing the securing function of the lower body, so that Essence is retained, urination normalizes, and the lower back and limbs regain strength and warmth.

Formula Properties*

Temperature

Warm

Taste Profile

Predominantly sweet and acrid (pungent), with warm qualities throughout. The sweet tonifying herbs nourish Essence and Qi, while the acrid herbs warm the Kidney Yang and disperse Cold.

Target Organs
Kidneys Urinary Bladder Liver Spleen
Channels Entered
Kidney Liver Bladder Spleen

Formula Origin

Shi Yi De Xiao Fang (世医得效方, Effective Formulas from Generations of Physicians) by Wei Yilin (危亦林)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Supplier Information

Treasure of the East

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Ingredients in Tu Si Zi Wan

Detailed information about each herb in Tu Si Zi Wan and their roles

Kings
Deputies
Assistants
Tu Si Zi
Tu Si Zi

Chinese Dodder Seed

Dosage: 60g (pill form) / 12 - 20g (decoction)

Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Liver, Kidneys, Spleen
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Tu Si Zi Wan

The chief herb and namesake of the formula. Tu Si Zi tonifies Kidney Yang and nourishes Kidney Essence while also securing the Essence to prevent leakage. It is warm without being drying, making it the ideal lead herb for Kidney deficiency with loss of containment. Its dual capacity to both tonify and astringe the Kidneys directly targets the root cause of the pattern.

Lu Rong
Lu Rong

Deer velvet antler

Dosage: 30g (pill form) / 3 - 6g (decoction)

Temperature Warm
Taste Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Kidneys, Liver
Parts Used Animal — part (动物部分 dòng wù bù fèn)
Role in Tu Si Zi Wan

Powerfully tonifies Kidney Yang, supplements Essence and Blood, and strengthens the Governor Vessel. It reinforces Tu Si Zi's warming and tonifying action while also nourishing the marrow and strengthening the sinews and bones, addressing the weakness and soreness in the lower back and knees.

Rou Cong Rong
Rou Cong Rong

Desert Cistanche

Dosage: 60g (pill form) / 9 - 15g (decoction)

Temperature Warm
Taste Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Kidneys, Large Intestine
Parts Used Stem (茎 jīng)
Role in Tu Si Zi Wan

Warms Kidney Yang and nourishes Essence and Blood. It works alongside Tu Si Zi and Lu Rong to build the foundational Kidney Yang, and its gentle, moistening quality helps to tonify without excessive dryness, supporting the formula's goal of restoring Kidney function from the root.

Lai Fu Zi
Lai Fu Zi

Radish seed

Dosage: 30g (pill form) / 3 - 9g (decoction)

Temperature Neutral
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Spleen, Stomach
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Tu Si Zi Wan

A strongly warming herb that rescues and tonifies Kidney Yang. It fires the gate of vitality (Ming Men), dispersing Cold from the lower body and reinforcing the warming power of the other deputies. Its presence addresses the deep cold and Yang deficiency that underlies the urinary and reproductive symptoms.

Wu Wei Zi
Wu Wei Zi

Schisandra berry

Dosage: 30g (pill form) / 6 - 9g (decoction)

Temperature Warm
Taste Sour (酸 suān), Sweet (甘 gān)
Organ Affinity Lungs, Heart, Kidneys
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Tu Si Zi Wan

Astringes the Kidney Qi and secures the Essence. Its sour, astringent nature helps contain what the body is losing, working with the stabilizing herbs to prevent leakage of urine and seminal fluids. It also calms the spirit, addressing the anxiety and restless sleep often seen in this pattern.

Sang Piao Shao
Sang Piao Shao

Mantis egg-case

Dosage: 30g (pill form) / 6 - 9g (decoction)

Temperature Neutral
Taste Sweet (甘 gān), Salty (咸 xián)
Organ Affinity Liver, Kidneys
Parts Used Animal — secretion (动物分泌物 dòng wù fēn mì wù)
Role in Tu Si Zi Wan

Tonifies the Kidneys, assists Yang, and restrains Essence while reducing urinary frequency. It directly targets the symptom of frequent or uncontrolled urination by strengthening the Kidney's holding function over the Bladder. It works synergistically with Wu Wei Zi and Mu Li to create a strong astringent layer.

Mu Li Ke
Mu Li Ke

Oyster shell

Dosage: 60g (pill form) / 15 - 30g (decoction)

Temperature Slightly Cool
Taste Salty (咸 xián), Astringent (涩 sè)
Organ Affinity Liver, Gallbladder, Kidneys
Parts Used Shell (壳 ké / 甲 jiǎ)
Role in Tu Si Zi Wan

In its calcined form, Mu Li is a powerful astringent that secures Essence and stops abnormal discharge. It also anchors floating Yang and calms the spirit. Together with Sang Piao Xiao and Wu Wei Zi, it forms a stabilizing trio that locks in the body's vital substances once the Kidney Yang has been restored by the King and Deputy herbs.

Ji Nei Jin
Ji Nei Jin

Chicken gizzard lining

Dosage: 15g (pill form) / 3 - 9g (decoction)

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Small Intestine, Urinary Bladder
Parts Used Animal — part (动物部分 dòng wù bù fèn)
Role in Tu Si Zi Wan

Specifically indicated for frequent urination and urinary incontinence. It addresses the primary symptom directly and complements the astringent herbs. Additionally, it supports digestion and helps transform stagnation, ensuring the rich tonifying herbs in the formula are properly absorbed.

Modern Research (1 study)

  • Tu-Si-Zi-Wan reduces D-galactose-induced hepatic and cerebral oxidative damage in aging mice via the Nrf2/ARE pathway (Preclinical study, 2026)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

On an empty stomach, typically in the morning before breakfast and again in the evening before dinner. Classical texts specify taking with warm salted water or warm rice wine.

Typical Duration

Often taken for 4 to 12 weeks as a course of treatment, then reassessed by a practitioner. As a chronic tonifying formula, it may be used intermittently over several months.

Dietary Advice

Avoid cold and raw foods, iced drinks, and excessive consumption of bitter or cold-natured foods (such as raw salads, bitter melon, watermelon, and mung bean soup) while taking this formula, as they can counteract its warming effects and impair its absorption. Foods that support the formula's action include warming, nourishing items such as lamb, venison, walnuts, chestnuts, black sesame seeds, kidney beans, and gently cooked root vegetables. Warm soups and congee are ideal. Traditional advice suggests that salt in small amounts (as in salt-water to send down the pills) helps direct the formula's action downward to the Kidneys. Avoid excessive alcohol consumption. While the classical preparation uses wine-steamed ingredients, heavy drinking damages Kidney Yin and can create Damp-Heat, working against the formula's intent.

Special Populations

Pregnancy

Use with caution during pregnancy. The formula contains Fu Zi (Aconitum, processed), which is classified as a pregnancy-caution herb due to its potency and potential toxicity. Lu Rong (Deer Antler Velvet) is strongly Yang-tonifying and warming, which may be inappropriate during pregnancy when the body's balance tends toward Heat. Several other ingredients (such as Rou Gui/Cinnamon Bark in some versions) are also warming and moving, which could theoretically affect the fetus. This formula was designed primarily for deficiency conditions in non-pregnant patients. Pregnant women should consult a qualified practitioner before use.

Breastfeeding

Caution is advised during breastfeeding. The formula contains Fu Zi (processed Aconitum), which contains trace aconitine alkaloids that could theoretically transfer into breast milk. Lu Rong (Deer Antler Velvet) is a potent Yang tonic whose effects on lactation and nursing infants have not been studied. While the formula's tonifying properties might theoretically support postpartum recovery in Yang-deficient mothers, there is insufficient safety data to recommend routine use during breastfeeding. A qualified practitioner should evaluate the necessity and adjust the formula as needed.

Pediatric Use

Tu Si Zi Wan is generally not appropriate for children. The formula was designed to address Kidney Yang deficiency patterns that are primarily seen in adults, particularly those resulting from aging, chronic illness, or sexual overexertion. In children, Kidney Yang is naturally abundant and these patterns are rare. If a pediatric patient genuinely presents with Kidney deficiency (such as in certain developmental delay or enuresis cases), the formula would need significant modification with reduced dosages under strict practitioner supervision. The presence of Fu Zi (Aconitum) further warrants extreme caution in pediatric use due to its narrow therapeutic window.

Cautions & Warnings

Tu Si Zi Tang is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Tu Si Zi Tang.