Formula

Shuang Huang Lian Tang

双黄连汤

Also known as:

Shuang Huang Lian Kou Fu Ye (双黄连口服液, Shuang Huang Lian Oral Liquid) , Shuang Huang Lian Ke Li (双黄连颗粒, Shuang Huang Lian Granules) , Shuang Huang Lian Tang

Key Ingredients

Jin Yin Hua, Lian Qiao

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula*

Traditional Chinese Medicine background and properties

Formula Description*

A widely used modern Chinese herbal formula for treating the common cold and respiratory infections caused by Wind-Heat. It helps reduce fever, relieve sore throat, and ease cough. The formula combines three cooling, Heat-clearing herbs and is best suited for infections with pronounced Heat signs rather than Cold-type illnesses.

Formula Category*

Main Actions*

  • Disperses Wind-Heat
  • Clears Heat and Resolves Toxicity
  • Benefits the Throat
  • Clears Lung Heat and Stops Cough

TCM Patterns*

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Shuang Huang Lian Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Shuang Huang Lian Tang addresses this pattern

This is the primary pattern Shuang Huang Lian addresses. When Wind-Heat invades from the exterior, it first attacks the Lungs (the organ most exposed to external pathogens) and the defensive Qi layer. The Lungs lose their normal descending and dispersing function, leading to cough. Heat accumulates in the throat, causing pain and swelling. The body's struggle against the invading pathogen produces fever, while the Wind-Heat nature of the pathogen means there is only mild or no aversion to cold. Jin Yin Hua and Lian Qiao directly disperse the Wind-Heat from the exterior while clearing the Heat-Toxin that has lodged in the Lungs and throat. Huang Qin reinforces the clearing of Lung Heat from the interior, ensuring that Heat at both the surface and deeper levels is addressed.

A practitioner would look for one or more of these signs

Fever

Fever with mild or no chills, worse than chills

Sore Throat

Red, swollen, painful throat

Hypochondrial Pain That Is Worse On Coughing And Breathing

Cough with possible yellow sticky phlegm

Headaches

Headache, especially at the front

Thirst

Thirst with desire for cool drinks

Nasal Congestion

Nasal congestion with yellow discharge

How It Addresses the Root Cause*

Shuang Huang Lian addresses the pattern of external Wind-Heat invasion (外感风热). In TCM understanding, when external pathogenic Wind-Heat attacks the body, it first assaults the Lung's exterior-defensive (卫分) layer. The Lungs govern the skin and body surface and are considered the most "delicate" organ, easily overwhelmed by external pathogens. When Wind-Heat lodges in the Lung's exterior, it disrupts the Lungs' descending and dispersing functions, leading to fever, sore throat, and cough.

The Heat component generates inflammation in the upper body, particularly affecting the throat and airways. As Heat accumulates, it can transform into Toxin (热毒), intensifying the sore throat, producing yellow phlegm, and causing higher fever. The body's defensive Qi struggles against the pathogen at the surface, producing the characteristic conflict between Heat (fever) and the body's attempt to expel the invader (mild chills, sweating). The tongue turns red with a thin yellow coating, and the pulse becomes floating and rapid, all signs that the pathogen is still at the surface level but is Hot in nature.

This formula works because all three of its herbs target both aspects of the problem simultaneously: they disperse the external pathogen outward from the surface while also clearing the internal Heat and Toxin that the pathogen has generated. This dual exterior-interior clearing action (表里双清) is what makes the formula effective for Wind-Heat colds and upper respiratory infections where the pathogen has not yet penetrated deeper into the body.

Formula Properties*

Temperature

Cold

Taste Profile

Predominantly bitter with sweet undertones. The bitter taste from Huang Qin and Lian Qiao clears Heat and dries Dampness, while the sweet quality of Jin Yin Hua gently disperses the pathogen from the exterior.

Target Organs
Lungs Heart Stomach
Channels Entered
Lung Heart Stomach Large Intestine Small Intestine Gallbladder

Formula Origin

Modern formula developed in the 1970s at Harbin Medical University, Heilongjiang Province. Derived from Yin Qiao San (银翘散) in Wu Jutong's Wen Bing Tiao Bian (温病条辨, Systematic Differentiation of Warm Diseases). Officially recorded in the Chinese Pharmacopoeia (中华人民共和国药典).

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Supplier Information

Treasure of the East

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Ingredients in Shuang Huang Lian Tang

Detailed information about each herb in Shuang Huang Lian Tang and their roles

Kings
Deputies
Jin Yin Hua
Jin Yin Hua

Honeysuckle flower

Dosage: 15 - 30g

Temperature Cold
Taste Sweet (甘 gān)
Organ Affinity Lungs, Heart, Stomach, Large Intestine
Parts Used Flower bud (花蕾 huā lěi)
Role in Shuang Huang Lian Tang

Jin Yin Hua is sweet and cold, entering the Lung, Heart, and Stomach channels. It is the primary herb in this formula, providing strong Heat-clearing and toxin-resolving action. It both disperses exterior Wind-Heat and clears internal Heat-Toxin, making it especially effective for febrile diseases with sore throat and fever. Its aromatic quality helps release the exterior while its cold nature directly addresses the Heat pathogen.

Lian Qiao
Lian Qiao

Forsythia fruit

Dosage: 30 - 60g

Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Shuang Huang Lian Tang

Lian Qiao is bitter, slightly acrid, and cool, entering the Lung, Heart, and Small Intestine channels. Used at double the dosage of the other two herbs (ratio 2:1:1), it serves as a co-King herb alongside Jin Yin Hua. Known as the 'holy medicine for sores' (疮家圣药), Lian Qiao excels at clearing Heat-Toxin and dissipating clumps. It strongly disperses Wind-Heat from the exterior, vents Heat outward, and works synergistically with Jin Yin Hua to release the exterior while clearing toxins. Its light, ascending nature helps direct the formula's action to the upper body and the exterior.

Huang Qin
Huang Qin

Baical skullcap root

Dosage: 15 - 30g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Parts Used Root (根 gēn)
Role in Shuang Huang Lian Tang

Huang Qin is bitter and cold, entering the Lung, Gallbladder, Spleen, and Large Intestine channels. It serves as the deputy herb, powerfully clearing Heat from the upper burner, especially Lung Heat. Its bitter-cold nature drains Fire downward and dries Dampness, complementing the outward-dispersing action of Jin Yin Hua and Lian Qiao. It adds depth to the formula's Heat-clearing power and helps resolve phlegm-Heat in the Lungs that produces cough.

Modern Research (5 studies)

  • Systematic Review of RCTs: Shuanghuanglian Injection for Acute Upper Respiratory Tract Infection (2013)
  • Metabolomics Analyses of Shuang Huang Lian by UHPLC-QTOF-MS/MS (2022)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

30 minutes before meals or 1 hour after meals, 2-3 times daily. Take with warm water.

Typical Duration

Acute use: 3-7 days. Discontinue once symptoms resolve. Not intended for long-term or preventive use.

Dietary Advice

While taking Shuang Huang Lian, avoid greasy, fried, and rich foods that can generate internal Heat and Dampness, making the pathogen harder to expel. Also avoid spicy-hot foods (chili, ginger, lamb) that could intensify the Heat pattern. Cold and raw foods should be consumed in moderation, as the formula is already very cold in nature and excessive cold foods may upset the Stomach. Favor light, easily digestible meals such as congee, steamed vegetables, and clear soups to support the Spleen and Stomach while the body fights off the pathogen. Stay well hydrated with warm water or mild teas. Avoid alcohol, as it generates Damp-Heat and may worsen symptoms or interact with the formula.

Special Populations

Pregnancy

Use with caution during pregnancy and only under professional medical guidance. While none of the three herbs (Jin Yin Hua, Huang Qin, Lian Qiao) are classified as strongly abortifacient, the formula's overall cold nature may be problematic. Huang Qin (Scutellaria root) is classically noted for calming the fetus (安胎) and is sometimes used during pregnancy, but the formula as a whole delivers a significant cold payload that could disturb Spleen-Stomach function and indirectly affect fetal nourishment. The Chinese Pharmacopoeia drug labels explicitly state that pregnant women should use Shuang Huang Lian under physician supervision. The injectable form should be strictly avoided during pregnancy due to the risk of anaphylactic reactions.

Breastfeeding

Use with caution during breastfeeding and preferably under professional guidance. While there is no strong evidence that the formula's active components (baicalin, chlorogenic acid, forsythoside) transfer into breast milk in clinically significant amounts, the cold nature of all three herbs could theoretically affect the nursing infant's digestion if absorbed through breast milk. The Chinese drug labels explicitly advise that breastfeeding women should take Shuang Huang Lian under physician supervision. Short-term use during acute illness is generally considered lower risk than prolonged use. Monitor the infant for any digestive disturbance such as loose stools.

Pediatric Use

Shuang Huang Lian has a dedicated pediatric oral liquid formulation (双黄连口服液·儿童型) designed for children aged 1 to 7 years, with a sweeter taste to improve compliance. Dosing for children should strictly follow the age-specific guidelines on the product label or a practitioner's instructions. The injectable form is now restricted or prohibited for use in infants and young children due to reports of serious adverse reactions. As with adults, the formula should only be used for confirmed Wind-Heat patterns, not Wind-Cold presentations. Parents should watch for signs of digestive upset (nausea, diarrhea, abdominal pain) due to the cold nature of the formula, and discontinue if symptoms appear. Duration of use should be kept short (typically 3-5 days) and reassessed by a practitioner.

Cautions & Warnings

Shuang Huang Lian Tang is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with this formula.