Formula

Qing Wen Bai Du Yin

清瘟敗毒飲

Also known as:

Qingwen Baidu Decoction , Antipyretic and Antitoxic Decoction , Clear Pestilence and Defeat Toxin Decoction

Properties

Heat-clearing formulas · Cold

Key Ingredients

Shi Gao, Shui Niu Jiao

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A powerful Heat-clearing formula used for severe epidemic febrile diseases where intense Heat and toxic pathogens have invaded both the Qi and Blood levels of the body. It addresses dangerously high fever, delirium, skin rashes, and bleeding by simultaneously cooling the blood and draining fire. This is an emergency formula for critical, life-threatening heat conditions and is not intended for mild or cold-type illnesses.

Formula Category

Main Actions

  • Clears Heat and Resolves Toxicity
  • Cools the Blood
  • Drains Fire
  • Clears both Qi and Blood level Heat
  • Purges Fire from all twelve channels

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Qing Wen Bai Du Yin is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Qing Wen Bai Du Yin addresses this pattern

This is the primary pattern this formula was designed to treat. In the Four-Level (Wei-Qi-Ying-Xue) diagnostic framework used for febrile diseases, Heat that has penetrated to both the Qi level and the Blood level simultaneously creates a dangerous condition called "Qi and Blood both ablaze" (气血两燔). The Qi-level Heat manifests as extreme fever, intense thirst, and profuse sweating, while the Blood-level Heat causes skin rashes (macules), bleeding from multiple sites, and delirium. The formula addresses this by deploying Shi Gao with Zhi Mu and Gan Cao to clear the Qi level, Shui Niu Jiao with Sheng Di Huang, Chi Shao and Mu Dan Pi to cool the Blood level, and Huang Lian, Huang Qin and Zhi Zi to drain toxic fire from all three Burners.

A practitioner would look for one or more of these signs

High Fever

Dangerously high fever unresponsive to ordinary treatment

Excessive Thirst

Extreme thirst with desire to drink large amounts

Delirium

Delirious speech, confusion or loss of consciousness

Skin Rashes

Dark red or purple skin rashes (macules)

Nosebleeds

Nosebleeds or bleeding from multiple sites

Headaches

Splitting headache described as 'head-splitting'

Nausea

Dry heaving and vomiting

Irritability

Extreme agitation and restlessness

How It Addresses the Root Cause

Qing Wen Bai Du Yin addresses what TCM calls "Qi and Blood level burning" (气血两燔, qì xuè liǎng fán), a critical stage of epidemic febrile disease where intense Heat-toxin has penetrated to the deepest levels of the body simultaneously. The word "燔" literally means "to burn" or "to scorch," conveying just how fierce this Heat is.

In normal epidemic febrile disease, Heat enters the body in stages: first the exterior (Wei level), then the Qi level (affecting organ function), then the Ying/Blood levels (affecting the blood and consciousness). In this pattern, however, the toxic Heat is so overwhelming that it blazes through the Qi and Blood levels at the same time. At the Qi level, the pathogenic Heat scorches the Stomach and Lungs, causing extreme fever, raging thirst, drenching sweat, and a forceful pulse. At the Blood level, Heat agitates the blood and disturbs the Heart and Pericardium, causing delirium, loss of consciousness, skin rashes (macules), nosebleeds, vomiting of blood, and a deep crimson tongue. Body fluids are being rapidly consumed, and the Yin is on the verge of collapse.

Because the toxic Heat occupies both levels simultaneously, a treatment that only addresses one level will fail. The formula must simultaneously clear blazing Heat from the Qi level (especially the Yangming/Stomach system), cool and stabilize the Blood to stop hemorrhaging and calm the spirit, and rescue the body's Yin fluids before they are completely consumed. This is why Yu Shi Yu combined three powerful classical strategies into a single prescription.

Formula Properties

Temperature

Cold

Taste Profile

Predominantly bitter and sweet with a pungent quality. Bitter to drain Fire and dry Dampness, sweet to protect fluids and moderate the harsh cold, and pungent (from Shi Gao) to disperse and release trapped Heat outward.

Target Organs
Heart Stomach Liver Lungs Pericardium
Channels Entered
Stomach Heart Lung Liver Pericardium San Jiao

Formula Origin

Yi Zhen Yi De (疫疹一得) by Yu Lin (余霖, courtesy name Shi Yu 師愚)

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Qing Wen Bai Du Yin

Detailed information about each herb in Qing Wen Bai Du Yin and their roles

Kings
Deputies
Assistants
Envoys
Shi Gao
Shi Gao

Gypsum

Dosage: 60 - 240g

Temperature Cold
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Lungs, Stomach
Parts Used Mineral (矿物 kuàng wù)
Role in Qing Wen Bai Du Yin

Used in very large doses to powerfully clear blazing Heat from the Qi level, especially Yangming (Stomach) Heat. As the Stomach is the source of Qi and Blood for all twelve channels, clearing Stomach Heat extinguishes fire across the entire body.

Shui Niu Jiao
Shui Niu Jiao

Water buffalo horn

Dosage: 15 - 30g (Shui Niu Jiao); historically Xi Jiao 6 - 12g

Temperature Cold
Taste Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Heart, Liver, Stomach
Parts Used Animal — part (动物部分 dòng wù bù fèn)
Role in Qing Wen Bai Du Yin

Enters the Blood level to cool Blood, resolve toxins, and clear Heart Heat. Works in tandem with Shi Gao to address both Qi-level and Blood-level Heat simultaneously. Historically Xi Jiao (Rhinoceros Horn) was used; Shui Niu Jiao is the modern ethical substitute at higher dosage.

Shu Di Huang
Shu Di Huang

Prepared Rehmannia root

Dosage: 9 - 30g

Temperature Slightly Warm
Taste Sweet (甘 gān)
Organ Affinity Liver, Kidneys
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Qing Wen Bai Du Yin

Cools the Blood, nourishes Yin, and generates fluids. Supports Shui Niu Jiao in clearing Blood-level Heat while protecting the body fluids that are being consumed by the intense fire.

Huang Lian
Huang Lian

Coptis rhizome

Dosage: 6 - 12g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Liver, Stomach, Large Intestine, Gallbladder, Spleen
Parts Used Rhizome (根茎 gēn jīng)
Role in Qing Wen Bai Du Yin

Drains fire from the Heart and Middle Burner, clears Heat and resolves toxicity. Part of the Huang Lian Jie Du Tang grouping within this formula that purges fire from all three Burners.

Zhi Mu
Zhi Mu

Anemarrhena rhizome

Dosage: 6 - 12g

Temperature Cold
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Lungs, Stomach, Kidneys
Parts Used Rhizome (根茎 gēn jīng)
Role in Qing Wen Bai Du Yin

Assists Shi Gao in clearing Qi-level Heat from the Lung and Stomach, while nourishing Yin and generating fluids to protect against fluid loss from extreme Heat.

Huang Qin
Huang Qin

Chinese skullcap root

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Gallbladder, Spleen, Large Intestine, Small Intestine, Heart, Stomach
Parts Used Root (根 gēn)
Role in Qing Wen Bai Du Yin

Clears Heat from the Upper Burner, particularly Lung Heat. Combines with Huang Lian and Zhi Zi to drain fire across all three Burners.

Zhi Zi
Zhi Zi

Gardenia fruit

Dosage: 6 - 9g

Temperature Cold
Taste Bitter (苦 kǔ)
Organ Affinity Heart, Lungs, San Jiao (Triple Burner)
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Qing Wen Bai Du Yin

Clears Heat from all three Burners and drains it downward through the urine. Particularly effective for clearing Heart fire and resolving irritability and restlessness.

Chi Shao
Chi Shao

Red peony root

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver
Parts Used Root (根 gēn)
Role in Qing Wen Bai Du Yin

Cools the Blood, clears Blood-level Heat, and invigorates Blood circulation to dispel Blood stasis caused by Heat scorching the Blood vessels.

Mu Dan Pi
Mu Dan Pi

Tree peony root bark

Dosage: 6 - 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Qing Wen Bai Du Yin

Cools the Blood and clears deficiency-type Heat. Works alongside Chi Shao in the Xi Jiao Di Huang Tang grouping to cool Blood and dispel stasis.

Xuan Shen
Xuan Shen

Ningpo figwort root

Dosage: 6 - 12g

Temperature Cold
Taste Sweet (甘 gān), Bitter (苦 kǔ), Salty (咸 xián)
Organ Affinity Lungs, Stomach, Kidneys
Parts Used Root (根 gēn)
Role in Qing Wen Bai Du Yin

Nourishes Yin, cools the Blood, drains fire, and resolves toxicity. Particularly effective for sore throat and protecting the fluids of the Kidney and Lung that are damaged by intense Heat.

Lian Qiao
Lian Qiao

Forsythia fruit

Dosage: 6 - 12g

Temperature Slightly Cool
Taste Bitter (苦 kǔ)
Organ Affinity Lungs, Heart, Small Intestine
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Qing Wen Bai Du Yin

Clears Heat and resolves toxicity, disperses clumped Heat, and vents pathogenic Heat outward. Its light, ascending nature helps clear Heat from the Upper Burner.

Dan Zhu Ye
Dan Zhu Ye

Lophatherum herb

Dosage: 3 - 6g

Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Stomach, Small Intestine
Parts Used Whole plant / Aerial parts (全草 quán cǎo)
Role in Qing Wen Bai Du Yin

Clears Heart Heat and promotes urination, guiding Heat downward and out through the urine. Lightens the formula with its gentle, ascending-then-descending nature.

Jie Geng
Jie Geng

Balloon flower root

Dosage: 3 - 6g

Temperature Neutral
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Lungs
Parts Used Root (根 gēn)
Role in Qing Wen Bai Du Yin

Opens the Lung, benefits the throat, and directs the formula's actions upward to the Upper Burner. Also helps expel toxic Heat from the chest and throat area.

Gan Cao
Gan Cao

Licorice root

Dosage: 3 - 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Qing Wen Bai Du Yin

Harmonizes the other herbs in the formula, clears Heat and resolves toxicity, and protects the Stomach from the large dose of cold, bitter herbs. Also works with Shi Gao and Zhi Mu as part of the Bai Hu Tang structure to preserve body fluids.

Modern Research (5 studies)

  • Potential therapeutic effect of Qingwen Baidu Decoction against Corona Virus Disease 2019: a mini review (2020)
  • Anti-inflammatory effect of Qingwen Baidu Decoction in sepsis rats (Animal study, 2014)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Taken in divided doses, typically twice daily (morning and evening), on an empty or near-empty stomach for faster absorption during acute febrile crisis. Shi Gao should be pre-boiled for 15-20 minutes before adding the remaining herbs.

Typical Duration

Acute emergency use: 1 to 5 days, discontinued or modified as soon as the fever breaks and critical symptoms resolve.

Dietary Advice

During treatment, avoid all warming, greasy, and rich foods: no fried foods, lamb, beef, alcohol, spicy dishes (chili, ginger, garlic, pepper), or heavily seasoned meals. These will add Heat and counteract the formula's cooling effect. Also avoid sticky, hard-to-digest foods that burden the Spleen and Stomach, which is already stressed by the formula's cold nature. Light, easily digestible foods are best: thin rice porridge (congee), mung bean soup, fresh fruits like pear and watermelon (which also help clear Heat and generate fluids), and lightly cooked vegetables. Staying well hydrated is critical, as the underlying condition involves severe fluid depletion.

Special Populations

Pregnancy

Contraindicated during pregnancy. This formula contains several herbs of concern: Mu Dan Pi (Moutan bark) and Chi Shao (Red Peony root) both invigorate blood circulation and have the potential to stimulate uterine activity. Zhi Zi (Gardenia) is also considered cautionary in pregnancy. The overall extremely cold nature of the formula poses additional risk of harming fetal development by severely depleting the mother's Yang Qi. This formula should only be considered in a pregnant patient if she is facing a life-threatening epidemic febrile crisis, and only under the direct supervision of an experienced practitioner who can weigh the immediate danger against reproductive risk.

Breastfeeding

Use with significant caution during breastfeeding. The formula's extremely cold nature and potent bitter-cold herbs (Huang Lian, Huang Qin, Zhi Zi) may transfer through breast milk and cause digestive upset or diarrhea in the nursing infant. Sheng Di Huang and Xuan Shen, being rich and cloying, may also affect milk quality. Additionally, prolonged use of such intensely cold herbs can weaken the mother's Spleen and Stomach function, potentially reducing milk production. This formula should only be used in breastfeeding women during acute febrile emergencies, for the shortest possible duration, and ideally with the option to temporarily suspend breastfeeding during treatment.

Pediatric Use

Qing Wen Bai Du Yin has historical and modern clinical use in pediatric patients, particularly for childhood infectious diseases such as infantile pneumonia, hand-foot-mouth disease, and infectious mononucleosis. However, dosing must be carefully adjusted. Children's digestive systems are delicate, and the extremely cold, bitter nature of this formula can easily injure a child's Spleen and Stomach. Dosages should generally be reduced to one-third to one-half of adult doses depending on the child's age and weight, and the treatment course should be as short as possible. For infants and toddlers under 3 years old, use requires particular caution and close monitoring. The formula should be discontinued as soon as the acute Heat crisis resolves. A qualified practitioner experienced in pediatrics should manage the case.

Drug Interactions

Gan Cao (Licorice root) in this formula may interact with several classes of pharmaceuticals. It can cause potassium loss and fluid retention, which may interfere with antihypertensive medications, diuretics (especially potassium-wasting types like furosemide), cardiac glycosides (e.g. digoxin, where hypokalemia increases toxicity risk), and corticosteroids (compounding potassium depletion and fluid retention).

The formula's strong blood-cooling and blood-moving properties (from Sheng Di Huang, Chi Shao, Mu Dan Pi, and water buffalo horn) may potentiate the effects of anticoagulant and antiplatelet medications (e.g. warfarin, heparin, aspirin, clopidogrel), increasing the risk of bleeding. Given that this formula is specifically indicated for conditions where bleeding may already be occurring, concurrent anticoagulant use requires very close monitoring.

Huang Lian (Coptis) contains berberine, which has documented interactions with cyclosporine (increased blood levels) and may affect the metabolism of drugs processed by cytochrome P450 enzymes. Berberine may also lower blood sugar, potentially enhancing the effects of hypoglycemic medications.

Contraindications

Avoid

Yang Deficiency patterns. This is an extremely cold formula that can severely damage Yang Qi. It must never be used in patients with underlying Yang Deficiency, even if they present with some Heat signs.

Avoid

Spleen and Stomach Deficiency. The large doses of bitter-cold and sweet-cold herbs in this formula will further damage an already weakened digestive system, potentially causing severe diarrhea or collapse.

Caution

Exterior-stage febrile disease where Heat has not yet fully entered the Qi and Blood levels. Using this formula prematurely, before the pathogen has penetrated deeply, is excessive and may trap the pathogen or harm the body's Qi.

Caution

Patients with cold or deficiency constitutions who develop mild febrile illness. The formula's powerful cold nature is designed only for extreme Heat-toxin conditions and will cause harm in milder presentations.

Caution

Prolonged use beyond the acute crisis. Once the intense Heat has broken and symptoms are receding, the formula should be discontinued or significantly modified to avoid injuring Yin and Yang through excessive cold purging.

Cautions & Warnings

Qing Wen Bai Du Yin is typically safe for most individuals, but it can lead to side effects in some cases. Pregnant, nursing, or postpartum women, as well as those with liver conditions, should use this formula cautiously and preferably under professional supervision.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified Traditional Chinese Medicine (TCM) practitioner before beginning treatment with Qing Wen Bai Du Yin

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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