Herb

Mu Dan Pi

Mudan peony bark | 牡丹皮

Also known as:

Moutan Bark

Properties

Heat-clearing herbs · Slightly Cool

Parts Used

Bark (皮 pí / 树皮 shù pí)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Herb

Traditional Chinese Medicine background and properties

Herb Description

Tree peony root bark is a cooling herb widely used in Chinese medicine to clear heat from the blood and improve circulation. It is commonly found in formulas for menopausal hot flushes, menstrual problems, skin rashes from febrile illness, and inflammatory conditions. Its unique ability to both cool and move blood makes it one of the most versatile herbs for conditions involving heat and stagnation together.

Herb Category

Main Actions

  • Clears Heat and Cools the Blood
  • Invigorates Blood and Dispels Stasis
  • Clears Deficiency Heat
  • Disperses Swelling and Dissipates Abscesses

How These Actions Work

'Clears Heat and cools Blood' means Mǔ Dān Pí enters the Blood level to clear Heat that has penetrated deep into the body. In warm-febrile diseases (wēn bìng), pathogenic Heat can enter the Blood, causing high fever, a dark-red tongue, skin rashes (macules), and reckless bleeding such as nosebleeds or vomiting blood. Mǔ Dān Pí's bitter and cool nature allows it to clear this kind of intense Blood-level Heat, and its pungent quality gives it the ability to vent and disperse, so it cools the Blood without trapping stasis inside.

'Invigorates Blood and dispels stasis' refers to the herb's ability to get stagnant blood moving again. When blood flow is obstructed, it causes pain, missed periods, or abdominal masses. Because Mǔ Dān Pí is both cooling and blood-moving, it is especially suited for blood stagnation accompanied by Heat. A classical teaching notes that it "cools the Blood without leaving stasis, and moves the Blood without causing reckless bleeding," making it a safe choice for conditions where both Heat and stagnation are present.

'Clears deficiency Heat' is a distinct action from clearing full Heat. In conditions where Yin (the body's cooling, nourishing fluids) is depleted, a low-grade, smoldering heat develops. This shows up as nighttime fevers that subside by morning, a sensation of heat in the bones (bone-steaming), or hot palms and soles. Mǔ Dān Pí has the special quality of being able to penetrate into the Yin level and clear this hidden, lingering heat. This is why it appears in many Yin-nourishing formulas alongside herbs like Shēng Dì Huáng and Zhī Mǔ.

'Reduces swelling and disperses abscesses' relates to the herb's use in treating sores, boils, and especially intestinal abscess (cháng yōng). Its cooling and blood-moving actions work together to break up the stagnation and heat that form the core of abscesses and inflammatory swellings.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Mu Dan Pi is traditionally associated with these specific patterns.

The following describes this herb's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Mu Dan Pi addresses this pattern

When pathogenic Heat invades the Blood level, it can cause reckless bleeding and skin eruptions. Mǔ Dān Pí directly addresses this through its bitter-cold nature, which enters the Heart and Liver channels to clear Heat from the Blood. Its pungent quality allows it to vent trapped Heat outward rather than just suppressing it. Importantly, while cooling the Blood, it simultaneously moves blood, preventing the stasis that often accompanies blood-cooling therapy. This dual action is precisely what Blood Heat requires: cooling without creating new stagnation.

A practitioner would look for one or more of these signs

Nosebleeds

From blood heat forcing blood out of vessels

Skin Rashes

Macules and papules from heat in the blood

Vomiting Blood

Blood heat causing reckless bleeding upward

Blood In Urine

Heat forcing blood into the urine

TCM Properties

Temperature

Slightly Cool

Taste

Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)

Channels Entered
Heart Liver Kidneys
Parts Used

Bark (皮 pí / 树皮 shù pí)

This is partial information on the herb's TCM properties. More detailed information is available on the herb's dedicated page

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Botanical & Sourcing

Quality Indicators

Good quality Mu Dan Pi is thick-walled, in long cylindrical or half-cylindrical pieces, with a distinctly powdery (粉性) cross-section that is pale pink or pinkish-white. The inner surface should show visible sparkling crystals (known as "yin xing" or silver stars, which are paeonol crystals). It should have a strong, distinctive aromatic fragrance and a slightly bitter, astringent taste with a mild numbing sensation on the tongue. The best grade, Feng Dan Pi from Anhui Tongling, is especially prized for its thick bark, abundant powderiness, strong fragrance, and plentiful crystalline deposits. Avoid pieces that are thin, dark, woody, lacking fragrance, or that have been sulfur-fumigated (which bleaches the colour but damages quality).

Primary Growing Regions

The premier source (dao di yao cai) is Anhui province, particularly Tongling's Fenghuang Mountain (铜陵凤凰山), which produces "Feng Dan Pi" (凤丹皮), long considered the finest quality. Anhui Nanling produces "Yao Dan Pi" (瑶丹皮). Other major production regions include Chongqing Dianjiang and Sichuan Guanxian ("Chuan Dan Pi"), Gansu and Shaanxi ("Xi Dan Pi"), Hubei, Hunan (especially Shaodong), Shandong (Heze), and Guizhou. Anhui Bozhou has become one of the largest production areas by volume. Yunnan and Zhejiang also produce smaller quantities.

Harvesting Season

Autumn (late September to early November), after 4-6 years of growth from seed (or 3-5 years from root division), when the above-ground parts have withered.

Supplier Information

Treasure of the East

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Miscellaneous Info

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Usage & Safety

How to use this herb and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This herb is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Traditional Dosage Reference

Standard

6-12g

Maximum

Up to 15-20g in acute Blood Heat conditions with bleeding or high fever, under practitioner supervision. Do not exceed 12g for routine use.

Notes

Use lower doses (6-9g) for cooling Blood Heat and clearing deficiency Heat. Use moderate to higher doses (9-12g) for actively moving Blood stasis, such as in amenorrhea or abscesses. When used in formulas for intestinal abscess (such as Da Huang Mu Dan Pi Tang), it may be used toward the upper end of the range. Raw Mu Dan Pi (sheng dan pi) is preferred for clearing Heat and cooling Blood; charred Mu Dan Pi (dan pi tan) is used specifically for stopping bleeding while retaining some cooling action.

Processing Methods

Processing method

Mǔ Dān Pí slices are stir-fried in a hot, dry wok over moderate heat until they develop slight yellow-brown scorch marks, then removed and cooled.

How it changes properties

Stir-frying moderates the herb's cold nature slightly, reducing its potential to harm the Stomach. The blood-cooling action is somewhat reduced while the blood-moving action is preserved. This form is milder and less likely to cause digestive discomfort.

When to use this form

When blood-moving action is desired but the patient has a somewhat weak Stomach or when the cold nature of the raw herb would be excessive. Also used when the primary goal is activating blood rather than clearing heat.

Toxicity Classification

Non-toxic

Mu Dan Pi is classified as non-toxic in most standard Materia Medica references, though Baidu Baike notes "xiao du" (slightly toxic). At standard dosages (6-12g), no significant toxic effects have been reported. The primary active compound, paeonol, has demonstrated a wide safety margin in animal studies. The main concern is not toxicity per se but rather its pharmacological blood-moving and cooling properties, which can cause problems if used inappropriately (e.g. in pregnancy or with bleeding disorders). Proper dosage adherence and correct pattern differentiation are the key safety measures.

Contraindications

Avoid

Pregnancy: Mu Dan Pi has blood-moving and blood-cooling properties that can disturb the fetus and potentially promote miscarriage. Classical texts consistently list it as a pregnancy caution herb.

Caution

Excessive menstrual bleeding (menorrhagia): The herb's blood-invigorating action can worsen heavy menstrual flow.

Caution

Spleen and Stomach deficiency Cold: The herb's cool to cold nature can further damage already weakened digestive function, worsening diarrhea and poor appetite.

Caution

Blood deficiency with Cold signs: In patients who are already Blood-deficient and Cold, the cooling and blood-moving actions of Mu Dan Pi may further deplete Blood and injure Yang.

Caution

Profuse spontaneous sweating: As noted in the Ben Jing Feng Yuan, Mu Dan Pi can promote the loss of fluids and should be avoided in those already losing fluids through sweating.

Caution

Decline of ministerial fire (xiang huo shuai): When the body's warming function is already weakened, the cooling nature of Mu Dan Pi is inappropriate and may further suppress vital warmth.

Classical Incompatibilities

Mu Dan Pi does not appear on the classical Eighteen Incompatibilities (十八反) or Nineteen Mutual Fears (十九畏) lists. However, several classical sources note individual cautions: the Ben Cao Jing Ji Zhu (《本草经集注》) states it "fears" (畏) Tu Si Zi (Cuscuta seed); the Tang Ben Cao (《唐本草》) states it fears Bei Mu (Fritillaria) and Da Huang (Rhubarb); the Gu Jin Lu Yan Fang (《古今录验方》) advises avoiding Hu Sui (coriander/cilantro); the Ri Hua Zi Ben Cao (《日华子本草》) notes it is incompatible with garlic (suan).

Special Populations

Pregnancy

Contraindicated. Mu Dan Pi has well-documented blood-invigorating (huo xue) and blood-cooling properties that can disturb the fetus and potentially promote uterine contractions or miscarriage. Classical texts consistently list it as a pregnancy caution or prohibition. The Yao Jian (《药鉴》) explicitly states "yun fu suo ji" (孕妇所忌, prohibited for pregnant women). Modern pharmacological research has confirmed anti-early-pregnancy effects in animal models. Avoid use during pregnancy unless there is a specific and urgent clinical indication under expert supervision.

Breastfeeding

No specific classical or modern safety data exists for Mu Dan Pi use during breastfeeding. Given its cool nature and blood-moving properties, caution is advised. It may theoretically affect milk composition or supply through its cooling action. Use only when clinically indicated and under practitioner supervision. If the nursing infant shows signs of digestive upset or loose stools, discontinue.

Pediatric Use

Mu Dan Pi can be used in children when clinically indicated, particularly for Blood Heat conditions. Dosage should be reduced proportionally based on age and body weight, typically one-third to one-half of the adult dose. Its cooling nature means it should be used cautiously in children with weak digestion or a tendency toward loose stools. Avoid prolonged use in children.

Drug Interactions

Anticoagulant and antiplatelet medications (warfarin, heparin, aspirin, clopidogrel): Paeonol, the primary active compound in Mu Dan Pi, has demonstrated antiplatelet and anticoagulant effects in pharmacological studies, including inhibition of platelet aggregation. Concurrent use with blood-thinning medications may increase the risk of bleeding. Close monitoring of INR is advised if used alongside warfarin.

Antihypertensive medications: Mu Dan Pi water decoctions have shown blood pressure-lowering effects in animal studies. Concurrent use with antihypertensive drugs may produce additive hypotensive effects, requiring blood pressure monitoring.

Hypoglycaemic medications: Paeonol and its metabolites have demonstrated hypoglycaemic activity in preclinical studies. Patients taking insulin or oral hypoglycaemic agents should monitor blood sugar levels more frequently when using Mu Dan Pi.

Dietary Advice

Avoid spicy, greasy, and hot-natured foods (such as chilli peppers, fried foods, lamb, and alcohol) while taking Mu Dan Pi for Blood Heat conditions, as these foods can counteract its cooling effect. Classical sources specifically note avoiding garlic and coriander (cilantro) when taking this herb. Cold and raw foods should be limited if the patient already has a weak digestive system, since the herb's cool nature may compound digestive weakness.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.