Formula

Gui Zhi Tang

Cinnamon Twig Decoction | 桂枝汤

Also known as:

Ramulus Cinnamomi Decoction

Properties

Exterior-releasing formulas · Warm

Key Ingredients

Gui Zhi

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

One of the most important classical formulas in all of Chinese medicine, used to gently release the body's exterior when a person catches a wind-cold with symptoms like mild fever, sweating, aversion to wind, headache, and a runny nose. Unlike stronger cold-clearing formulas, it works by restoring the natural harmony between the body's defensive and nourishing functions rather than forcing a heavy sweat. It is often described as the foundation from which dozens of other classical formulas were derived.

Formula Category

Main Actions

  • Releases the Muscle Layer
  • Harmonizes the Nutritive and Defensive Qi
  • Disperses Wind-Cold
  • Warms the Middle and harmonizes the Spleen and Stomach
  • Harmonizes Yin and Yang

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gui Zhi Tang is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Gui Zhi Tang addresses this pattern

This is the primary pattern for Guì Zhī Tāng, specifically the exterior-deficiency (biǎo xū) type of Wind-Cold invasion. When Wind-Cold attacks a person whose exterior defenses are relatively loose, the defensive Qi (Wèi) becomes agitated and floats outward to fight the pathogen, while the nutritive Qi (Yíng) can no longer stay contained and leaks out as spontaneous sweating. This creates the characteristic presentation of simultaneous fever and chills with sweating. Guì Zhī releases the muscle layer and disperses Wind-Cold, Bái Sháo consolidates the nutritive Qi to stop the leakage, and the supporting herbs restore Spleen and Stomach function to replenish the body's defensive resources. The formula resolves the invasion without forcing a harsh sweat, making it suitable for this particular type of Wind-Cold pattern where the body is already sweating.

A practitioner would look for one or more of these signs

Fever

Mild fever that comes and goes, with a warm or flushed feeling

Chills

Aversion to wind and cold, especially with drafts

Excessive Sweating

Spontaneous sweating that does not relieve the condition

Headaches

Headache with stiffness of the head and neck

Nasal Congestion

Nasal congestion with snoring or wheezing sounds from the nose

Nausea

Dry retching or mild nausea

How It Addresses the Root Cause

The core disease mechanism addressed by Gui Zhi Tang is a disruption of the normal working relationship between the body's two surface-level defence systems: the Nutritive Qi (Ying Qi, 营气), which flows within the vessels and nourishes the tissues, and the Defensive Qi (Wei Qi, 卫气), which flows outside the vessels and guards the body surface against external threats.

When Wind-Cold invades a person whose body surface is not firmly consolidated (a condition TCM calls 'exterior deficiency,' or 表虚), the Defensive Qi rushes outward to fight the invader but in doing so loses its ability to properly regulate the pores (腠理). The pores open too much, and the Nutritive Qi, which normally stays contained inside the vessels, leaks outward as sweat. This is described in the Shang Han Lun as 'the Yang floats and the Yin is weak' (阳浮阴弱), or equivalently 'the Defensive is strong while the Nutritive is weak' (卫强营弱). 'Defensive strong' does not mean it is actually powerful; rather, it is hyperactive at the surface in a disorganised way, while the Nutritive Qi is weakened by the ongoing fluid loss through sweating.

This mismatch between the Nutritive and Defensive layers is what sustains the illness: the Wind-Cold pathogen is not fully expelled (because the sweating is not the right kind of therapeutic sweating), yet the body keeps losing fluids and warmth. The result is a characteristic picture of simultaneous fever, aversion to wind, spontaneous sweating, headache, possible nasal congestion and mild nausea, with a floating but soft pulse and a thin white tongue coating. The Spleen and Stomach are also mildly compromised, since they are the source of the Qi and Blood that generate the Nutritive and Defensive systems.

Formula Properties

Temperature

Warm

Taste Profile

Predominantly pungent and sweet with a secondary sour note. The pungent flavor (from Gui Zhi and Sheng Jiang) disperses and opens the exterior, the sweet flavor (from Zhi Gan Cao and Da Zao) tonifies and harmonizes the Middle, and the sour flavor (from Bai Shao) astringes and preserves the Nutritive Qi.

Target Organs
Lungs Spleen Stomach
Channels Entered
Lung Spleen Stomach Heart Bladder

Formula Origin

Shāng Hán Lùn (傷寒論, Treatise on Cold Damage) by Zhāng Zhòngjǐng

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Gui Zhi Tang

Detailed information about each herb in Gui Zhi Tang and their roles

Kings
Deputies
Assistants
Envoys
Gui Zhi
Gui Zhi

Cinnamon twig

Dosage: 9g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder
Parts Used Twig (枝 zhī)
Role in Gui Zhi Tang

The principal herb, acrid and warm, that releases the muscle layer (jiě jī), warms and supports the defensive (Wèi) Qi, and disperses Wind-Cold from the exterior. It targets the core problem of the pattern: the exterior defense is compromised by Wind, and Guì Zhī restores outward-moving Yang Qi to expel the pathogen.

Bai Shao
Bai Shao

White peony root

Dosage: 9g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Gui Zhi Tang

Sour, cool, and astringent, it restrains the nutritive (Yíng) Qi and preserves Yin fluids to prevent excessive sweating. Paired in equal proportion with Guì Zhī, it creates the formula's signature balance: one disperses while the other consolidates, ensuring that the exterior is released without depleting the body's vital substances.

Sheng Jiang
Sheng Jiang

Fresh ginger rhizome

Dosage: 9g

Temperature Slightly Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Lungs, Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Gui Zhi Tang

Acrid and warm, it assists Guì Zhī in dispersing Wind-Cold from the exterior and warms the Stomach to stop nausea and dry retching, a common accompanying symptom in this pattern. Combined with Dà Zǎo, it also supports Spleen and Stomach Qi to help generate the mild perspiration needed to resolve the condition.

Da Zao
Da Zao

Jujube fruit

Dosage: 3 - 4 pieces

Temperature Warm
Taste Sweet (甘 gān)
Organ Affinity Spleen, Stomach, Heart
Parts Used Fruit (果 guǒ / 果实 guǒ shí)
Role in Gui Zhi Tang

Sweet and neutral, it tonifies the middle burner, nourishes the Spleen, and generates fluids to support Bái Sháo in preserving the nutritive Qi. Paired with Shēng Jiāng, it boosts Spleen and Stomach function to provide a source of fluids for the gentle sweating required to expel the pathogen.

Gan Cao
Gan Cao

Licorice root

Dosage: 6g

Temperature Neutral
Taste Sweet (甘 gān)
Organ Affinity Heart, Lungs, Spleen, Stomach
Parts Used Root (根 gēn)
Role in Gui Zhi Tang

Sweet and warming, it harmonizes all the other herbs. It serves a dual role: as an Assistant it tonifies Qi and supports the middle burner; as the Envoy it mediates between the dispersing action of Guì Zhī and the consolidating action of Bái Sháo. Combined with Guì Zhī, the acrid-sweet pairing generates Yang (xīn gān huà yáng); combined with Bái Sháo, the sour-sweet pairing preserves Yin (suān gān huà yīn).

Modern Research (3 studies)

  • Gui-zhi decoction for allergic rhinitis: A protocol for systematic review and meta-analysis (2020)
  • Antipyretic, analgesic, anti-inflammatory and sedative effects of Gui Zhi Tang (Experimental pharmacological study, 1983)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Take warm, followed immediately by sipping hot rice porridge, then cover up warmly to promote a gentle sweat. Classically taken regardless of mealtimes, with doses spaced to allow observation of the sweating response.

Typical Duration

Acute use: 1-3 days for exterior Wind-Cold patterns, with reassessment after each dose (stop immediately once symptoms resolve, per classical instructions).

Dietary Advice

The Shang Han Lun provides explicit dietary prohibitions while taking Gui Zhi Tang: avoid raw and cold foods, sticky or slippery foods, meat and wheat noodles, the five pungent vegetables (garlic, onion, chives, scallions, cilantro), alcohol and fermented dairy, and foul-smelling foods (禁生冷、粘滑、肉面、五辛、酒酪、臭恶等物). These restrictions protect the Spleen and Stomach, which need to generate Qi from food to support the formula's sweating action. Conversely, the classical method specifically calls for sipping hot, thin rice porridge (热稀粥) immediately after taking the decoction to boost the formula's power and provide the body with grain-based Qi to produce a gentle therapeutic sweat. In modern terms: eat light, warm, easily digestible food; avoid greasy, cold, raw, or heavy foods and alcohol during treatment.

Modern Usage

It is commonly used for various types of fever, common cold, influenza, upper respiratory tract infections, and respiratory system diseases, as well as dermatological conditions like urticaria and chronic eczema.

Special Populations

Pregnancy

Generally considered compatible with pregnancy when appropriately prescribed. The Shang Han Lun and later classical sources actually list Gui Zhi Tang among treatments for pregnancy-related morning sickness (妊娠恶阻), and it has been used clinically for pregnancy-associated low-grade fever with the appropriate pattern presentation. None of the five ingredients (Gui Zhi, Bai Shao, Zhi Gan Cao, Sheng Jiang, Da Zao) are classified as prohibited during pregnancy in standard Chinese pharmacopoeia. However, as with any herbal formula during pregnancy, it should only be taken under the guidance of a qualified practitioner, and prolonged use or high doses should be avoided. The sweating action, if excessive, could theoretically deplete fluids, which is undesirable during pregnancy.

Breastfeeding

Gui Zhi Tang is generally considered compatible with breastfeeding. All five ingredients are common food-grade or mild medicinal substances (cinnamon twig, white peony, licorice, ginger, jujube dates), and the formula has historically been used for postpartum conditions including low-grade fever and sweating disorders. Zhi Gan Cao (prepared licorice) in the standard dose is unlikely to cause concerns, though prolonged high-dose licorice use in general can affect electrolyte balance. No specific adverse effects on lactation or the nursing infant have been reported in the traditional or modern literature. As always, use under practitioner guidance is recommended.

Pediatric Use

Gui Zhi Tang has been used in pediatric practice since antiquity. Classical sources from the Song Dynasty era record dosage adjustments for infants aged 100-200 days at approximately half a qian (roughly 1.5g of the raw formula). In modern clinical practice, dosages are typically reduced to one-third to one-half of the adult dose for children aged 3-7 years, and one-quarter for infants, adjusted by age and body weight. The formula's five ingredients are all mild, food-grade substances, making it one of the gentler classical formulas for children. It has been used clinically for pediatric conditions including recurrent colds, bronchial asthma, geographic tongue (地图舌), and spontaneous sweating in constitutionally weak children. As with adults, it should only be used when the pattern fits (exterior deficiency with sweating, aversion to wind) and not for children with high fever, no sweating, or signs of internal Heat.

Drug Interactions

Gan Cao (Licorice root): Zhi Gan Cao in this formula contains glycyrrhizin, which can cause pseudoaldosteronism (sodium retention, potassium loss, elevated blood pressure) with prolonged use. This is clinically relevant for patients taking antihypertensive medications (may reduce their effectiveness), diuretics such as thiazides or loop diuretics (may worsen potassium depletion), cardiac glycosides like digoxin (hypokalemia increases toxicity risk), and corticosteroids (additive mineralocorticoid effects). At the standard dose of 6g in a short course (3-7 days), these interactions are unlikely to be clinically significant, but caution is warranted with prolonged use or in patients already on these medications.

Gui Zhi (Cinnamon twig): Cinnamaldehyde, the primary active compound in Gui Zhi, has mild blood-thinning and vasodilatory properties. Patients taking anticoagulants (warfarin, heparin) or antiplatelet agents (aspirin, clopidogrel) should use the formula with awareness, though the risk at standard doses for short durations is low.

Bai Shao (White Peony root): According to traditional incompatibility rules, Bai Shao is classically listed as incompatible with Li Lu (Veratrum). If a patient is taking any Veratrum-containing preparation, this formula should be avoided.

Contraindications

Avoid

Exterior excess patterns (Wind-Cold with no sweating, tight pulse). The Shang Han Lun explicitly warns against using Gui Zhi Tang when the pulse is floating and tight and there is no sweating, as this is a Ma Huang Tang pattern. Misuse can trap Heat internally and cause serious complications.

Avoid

Interior Heat or blazing Heat patterns. People with intense internal Heat who are given this warm, acrid formula risk worsening the Heat, which can damage the Blood vessels and potentially cause vomiting of blood or pus. The Shang Han Lun (Clause 19) warns: anyone who vomits after taking Gui Zhi Tang will later vomit pus and blood.

Avoid

Damp-Heat constitution or habitual alcohol excess ('wine guests'). The Shang Han Lun specifically cautions that people with internal Damp-Heat from heavy drinking should not take this formula, as its sweet and warm nature will aggravate Dampness and Heat, causing nausea and vomiting.

Avoid

Warm-febrile diseases (Wen Bing). When the pathogen is warm or hot in nature rather than cold, Gui Zhi Tang's warming properties will add fuel to the fire and worsen the condition.

Caution

Yang deficiency with Yin excess, or combined Yin-Yang deficiency with exterior symptoms. The formula's mild tonifying power is insufficient for severe deficiency and may further deplete the body's reserves through sweating.

Caution

Hot summer weather. Use with caution in warm climates or seasons, as the formula's warming nature may be excessive when external Yang is already strong.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Patients with external Heat disease, Yin Deficiency with Excessive Fire, or reckless movement of hot Blood, as well as pregnant women and those with excessive menstrual bleeding should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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