Formula

Gui Zhi Fu Ling Wan

Cinnamon & Poria Formula | 桂枝茯苓丸

Also known as:

Cinnamon and Poria Decoction , Cinnamon Twig and Poria Pill , Cinnamon Twig and Poria Combination , Cinnamon and Hoelen

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula that gently promotes blood circulation and dissolves masses in the lower abdomen. Originally used for gynecological conditions caused by blood stasis, it is now widely applied for conditions like uterine fibroids, ovarian cysts, painful periods, and endometriosis. Its mild but steady action makes it suitable for long-term use.

Formula Category

Main Actions

  • Invigorates Blood and Dispels Stasis
  • Disperses Fixed Masses
  • Warms the Channels and Disperses Cold
  • Harmonizes Qi and Blood
  • Removes Stasis and Generates New Blood

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Gui Zhi Fu Ling Wan is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Gui Zhi Fu Ling Wan addresses this pattern

This is the primary pattern Gui Zhi Fu Ling Wan was designed to treat. When blood stasis lodges in the uterus and lower abdomen, it forms palpable masses (called zheng jia in Chinese medicine). The stagnant blood obstructs normal menstrual flow, causing pain, abnormal bleeding, and the formation of lumps. Gui Zhi warms the channels to restore blood flow, Tao Ren and Mu Dan Pi directly break up the stagnant blood, Shao Yao nourishes healthy blood and relieves cramping, and Fu Ling drains the dampness that often accompanies and contributes to the stasis. The formula's gentle pill form allows it to work steadily over time, gradually dissolving masses without causing sudden, violent purging.

A practitioner would look for one or more of these signs

Amenorrhea

Fixed, stabbing lower abdominal pain that worsens with pressure

Abnormal Uterine Bleeding

Persistent spotting or irregular bleeding with dark, clotted blood

Abdominal Masses

Palpable firm mass in the lower abdomen that is painful to touch

Amenorrhea

Missed periods due to blood stasis blocking normal flow

Dark Complexion

Dull, darkened facial complexion and purplish lips

How It Addresses the Root Cause

This formula addresses a core pattern of Blood stasis obstructing the lower abdomen and Uterus (瘀血内停). In TCM, Blood must flow freely through the vessels to nourish the body. When Blood becomes stuck or stagnant due to Cold congealing the vessels, emotional constraint, trauma, or surgical history, it forms what is called "stasis" (瘀). Over time, this stagnant Blood can accumulate into palpable masses (called 癥瘕, roughly "fixed abdominal lumps"), block normal menstrual flow, or cause persistent abnormal bleeding.

The disease logic works as follows: stasis blocks the free flow of fresh Blood, so the body cannot properly nourish the Uterus or regulate menstruation. The old, stuck Blood occupies space and disrupts function, while the body's attempts to push past the blockage can paradoxically cause bleeding that won't stop. This is Zhang Zhongjing's key insight: the bleeding persists because the mass remains. Additionally, stagnant Blood that lingers generates localized Heat over time (瘀久化热), leading to a mixture of Blood stasis and mild Heat. The Liver, which governs the smooth flow of Blood, becomes tense and constrained when Blood is trapped. The Spleen's ability to hold Blood in the vessels is also compromised.

In modern clinical application, this same mechanism explains its use for conditions like uterine fibroids, ovarian cysts, endometriosis, chronic pelvic inflammatory disease, and painful periods with dark clotted blood. The underlying pattern is always the same: fixed pain (worse with pressure), dark or purplish blood with clots, a purplish tongue or visible sublingual varicosities, and a choppy or wiry pulse, all pointing to Blood that has stopped moving where it should flow.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly pungent, sweet, and slightly bitter, with a mild astringent quality. Pungent to move and disperse stasis, sweet to harmonize and moderate, bitter to clear stagnant Heat from old Blood stasis.

Target Organs
Liver Uterus Spleen Heart
Channels Entered
Liver Spleen Heart Chong Mai (冲脉) Penetrating Vessel

Formula Origin

Jin Gui Yao Lue (金匮要略, Essential Prescriptions from the Golden Cabinet) by Zhang Zhongjing

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Gui Zhi Fu Ling Wan

Detailed information about each herb in Gui Zhi Fu Ling Wan and their roles

Kings
Deputies
Assistants
Gui Zhi
Gui Zhi

Cinnamon twig

Dosage: 9 - 12g

Temperature Warm
Taste Acrid / Pungent (辛 xīn), Sweet (甘 gān)
Organ Affinity Heart, Lungs, Urinary Bladder
Parts Used Twig (枝 zhī)
Role in Gui Zhi Fu Ling Wan

Warms the channels and invigorates blood circulation. Its pungent, warm nature disperses stagnation and drives blood through the vessels, addressing the root cause of blood stasis. It also warms Yang Qi to support the movement of blood in the lower abdomen.

Tao Ren
Tao Ren

Peach kernel

Dosage: 9 - 12g

Temperature Neutral
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Heart, Liver, Large Intestine
Parts Used Seed (种子 zhǒng zǐ / 子 zǐ / 仁 rén)
Role in Gui Zhi Fu Ling Wan

A key blood-moving herb that breaks up blood stasis and dissolves abdominal masses. It directly attacks the accumulation of stagnant blood in the uterus and lower abdomen, powerfully assisting the King herb in resolving the core pathology.

Mu Dan Pi
Mu Dan Pi

Tree peony root bark

Dosage: 9 - 12g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Acrid / Pungent (辛 xīn)
Organ Affinity Heart, Liver, Kidneys
Parts Used Bark (皮 pí / 树皮 shù pí)
Role in Gui Zhi Fu Ling Wan

Clears Blood-level Heat and disperses blood stasis. It works alongside Tao Ren to move stagnant blood while also clearing the Heat that often develops from long-standing blood stasis. This prevents the formula from being overly warming.

Bai Shao
Bai Shao

White peony root

Dosage: 9 - 12g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Gui Zhi Fu Ling Wan

Nourishes and harmonizes blood, preventing the blood-moving herbs from consuming too much healthy blood. Its sour, astringent quality moderates the dispersing actions of the other herbs, relaxes spasm, and alleviates abdominal pain. Paired with Gui Zhi, it harmonizes the Ying (nutritive) and Wei (defensive) levels.

Fu Ling
Fu Ling

Poria

Dosage: 9 - 12g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Gui Zhi Fu Ling Wan

Strengthens the Spleen, calms the spirit, and promotes water metabolism through its bland, seeping nature. It drains dampness and phlegm from the lower body, addressing the phlegm-dampness component that often accompanies blood stasis in forming masses. It also supports healthy Qi to ensure the blood-moving herbs do not weaken the body.

Modern Research (4 studies)

  • Systematic Review of RCTs: Guizhi Fuling Formula for Uterine Fibroids (2014)
  • Randomized Double-Blind Dose-Comparison Trial for Symptomatic Uterine Fibroids (2022)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Before meals (the classical text specifies 食前服, taken before eating), typically 30 minutes before breakfast and dinner, with warm water.

Typical Duration

Commonly prescribed for 4 to 12 weeks, reassessed by a practitioner. For conditions like uterine fibroids or ovarian cysts, longer courses of 3 to 6 months may be used with periodic monitoring.

Dietary Advice

Avoid cold and raw foods (ice water, raw salads, cold fruit) as these can constrict blood vessels and counteract the formula's Blood-moving, channel-warming action. Avoid excessively greasy, rich, or deep-fried foods, which can generate Dampness and Phlegm that impede Blood circulation. Avoid excessively spicy or hot foods, which can aggravate any underlying Heat from chronic Blood stasis. Light, warm, easily digestible meals are ideal. Foods that gently support blood circulation, such as small amounts of hawthorn berry, turmeric in cooking, dark leafy greens, and moderate amounts of vinegar, are compatible with the formula's therapeutic direction. Alcohol should be avoided or minimized as it can unpredictably amplify the formula's Blood-moving effects.

Modern Usage

Gui Zhi Fu Ling Wan is a classical formula in TCM that dates back to the late Han Dynasty, formulated by the renowned physician Zhang Zhong Jing. Historically, it has been employed to address various gynecological concerns, such as menstrual discomfort, fibroids, and endometriosis, by enhancing blood circulation.

The formula is well-regarded in TCM as a Blood-activating formula. It works to alleviate Blood Stagnation in the uterus, promote circulation, and reduce the formation of masses. TCM practitioners frequently recommend Gui Zhi Fu Ling Wan for conditions like dysmenorrhea, ovarian cysts, and other issues linked to Blood Stagnation in the lower abdomen.

Additionally, Gui Zhi Fu Ling Wan is commonly used in Fertility Cycle Therapy, particularly during the ovulation phase (days 12 to 15 of the cycle).

Special Populations

Pregnancy

Contraindicated in pregnancy in standard modern clinical practice. The formula contains Tao Ren (Peach Kernel) and Mu Dan Pi (Moutan Bark), both of which activate Blood circulation and can stimulate uterine contractions, posing a risk of miscarriage. The Chinese Pharmacopoeia labels this formula as "pregnant women should use with caution" (孕妇慎用), and many clinical references upgrade this to "prohibited" (禁用) in pregnancy. Historical note: The original Jin Gui Yao Lue text actually describes using this formula during pregnancy specifically to treat a pre-existing mass that was causing persistent bleeding and threatening the fetus. Zhang Zhongjing's approach was to start with a very small dose (one tiny pill per day) and increase gradually, with the intention of removing the mass without harming the fetus. This was a highly specialized application under careful observation and should not be attempted outside of expert classical prescription.

Breastfeeding

Use with caution during breastfeeding. While no specific toxicity data exists for transfer of this formula's active compounds through breast milk, the Blood-moving nature of its ingredients (particularly Tao Ren and Mu Dan Pi) warrants a cautious approach. In traditional practice, modified versions of this formula have been used postpartum to help clear retained lochia (incomplete discharge after delivery), suggesting short-term use may be acceptable when clinically indicated. However, prolonged use during breastfeeding should be supervised by a qualified practitioner. If the nursing infant develops any unusual symptoms such as loose stools, irritability, or rash, the formula should be discontinued and a practitioner consulted.

Pediatric Use

Gui Zhi Fu Ling Wan is not a standard pediatric formula. Its primary indications (Blood stasis causing menstrual disorders, abdominal masses, pelvic pain) are predominantly adult conditions. There is very limited clinical literature on its use in children. If a qualified practitioner determines it is appropriate for an older adolescent (post-menarche) with clear Blood stasis signs, the dose should be reduced to approximately one-third to one-half of the adult dose, adjusted by age and body weight. It should not be used in young children. As with all Blood-moving formulas, pediatric use requires careful practitioner supervision and a clear diagnostic indication.

Drug Interactions

Anticoagulants and antiplatelet drugs: This formula activates Blood circulation and has pharmacologically demonstrated effects on reducing blood viscosity, lowering fibrinogen levels, and inhibiting platelet aggregation. Concurrent use with warfarin, heparin, rivaroxaban, aspirin, clopidogrel, or similar drugs may potentiate anticoagulant effects and increase the risk of bleeding. Patients on these medications should not take this formula without medical supervision and possible INR monitoring.

Hormonal medications: Research indicates that Gui Zhi Fu Ling Wan can modulate sex hormone levels (estradiol, FSH, LH, progesterone). Patients taking hormonal contraceptives, hormone replacement therapy, or hormonal treatments for conditions like endometriosis or uterine fibroids (e.g. GnRH agonists) should consult their prescribing doctor, as the formula may alter the expected hormonal effects of these medications.

NSAIDs (non-steroidal anti-inflammatory drugs): Both this formula and NSAIDs affect blood clotting and platelet function. Combined use may increase gastrointestinal bleeding risk, particularly with long-term concurrent use.

Contraindications

Avoid

Pregnancy without specialist supervision. The formula contains Tao Ren (Peach Kernel) and Mu Dan Pi (Moutan Bark), both of which activate Blood and can stimulate uterine contractions. Although the original text describes its use in pregnancy with pre-existing masses, this was under very specific conditions with gradual dosing. In modern practice, it should be considered contraindicated in pregnancy unless prescribed by an experienced practitioner for the specific classical indication.

Avoid

Active heavy menstrual bleeding without Blood stasis. The formula's Blood-moving properties can increase menstrual flow. It is generally stopped during the menstrual period unless the practitioner specifically determines that Blood stasis is the cause of the bleeding.

Avoid

Concurrent use of anticoagulant or antiplatelet medications (e.g. warfarin, heparin, aspirin, clopidogrel) without medical supervision. The formula's Blood-activating herbs may potentiate anticoagulant effects and increase bleeding risk.

Caution

Patterns of Qi and Blood deficiency without stasis. This is a Blood-moving formula. If the primary pathology is deficiency rather than stasis (e.g. pale complexion, fatigue, scanty pale menses without clots, pale tongue), the formula can further deplete Qi and Blood.

Caution

Damp-Heat patterns of the Lower Burner. Although the formula contains Mu Dan Pi which can cool Blood, its overall strategy is warming and moving. Pronounced Damp-Heat conditions (yellow foul-smelling discharge, burning sensation, yellow greasy tongue coating) require a different approach.

Avoid

Known allergy or hypersensitivity to any ingredient in the formula. Discontinue immediately if skin rash, itching, or other allergic reactions develop.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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