Herb

E Jiao

Donkey-hide gelatin | 阿胶

Also known as:

Ass-hide Glue

Properties

Blood-tonifying herbs (补血药) · Neutral

Parts Used

Processed / Derived product (加工品 jiā gōng pǐn)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Herb

Traditional Chinese Medicine background and properties

Herb Description

One of the most prized Blood-nourishing substances in Chinese medicine, E Jiao is a gelatin made from donkey hide. It is widely used for blood deficiency conditions such as anemia and dizziness, various types of bleeding, dry cough, and restless insomnia due to Yin depletion. It has been considered a "blood tonic treasure" alongside ginseng and deer antler for over two thousand years.

Herb Category

Main Actions

  • Nourishes Blood
  • Stops Bleeding
  • Nourishes Yin
  • Moistens Dryness
  • Moistens the Lungs
  • Calms the Fetus

How These Actions Work

'Tonifies Blood' means E Jiao directly nourishes and replenishes the Blood. As a 'blood-and-flesh' substance (a product derived from an animal rather than a plant), it has a special affinity for building Blood. This makes it particularly valuable for people with pale complexion, dizziness, heart palpitations, and fatigue caused by Blood deficiency. It is often considered the strongest single Blood-tonifying substance in the materia medica.

'Stops bleeding' refers to E Jiao's ability to help control various forms of abnormal bleeding, including coughing up blood, nosebleeds, blood in the stool or urine, and heavy or prolonged menstrual bleeding. Its sticky, glutinous quality is thought to help seal and consolidate the blood vessels. It is especially suited for bleeding that occurs alongside Blood deficiency or Yin deficiency, since it addresses both the symptom (bleeding) and the underlying weakness simultaneously.

'Nourishes Yin and moistens dryness' means E Jiao replenishes the body's fluids and moisture. This is why it is used for conditions involving internal dryness or depleted Yin, such as restlessness and insomnia after a prolonged fever, or dry cough with little or no phlegm. By restoring Yin fluids, it can also calm internal wind that arises from severe Yin exhaustion, helping to address tremors or spasms in late-stage febrile illness.

'Moistens the Lungs' means E Jiao specifically soothes and nourishes Lung tissue. When the Lungs are too dry or depleted of Yin, a persistent dry cough or coughing of blood can result. E Jiao's rich, moistening nature directly addresses this dryness, which is why classical physicians called it "an essential medicine for the Lung channel."

'Calms the fetus' refers to its traditional use for threatened miscarriage or bleeding during pregnancy. By nourishing Blood and stabilizing the Chong and Ren vessels (the channels closely linked to reproductive function), it helps secure the pregnancy.

Patterns Addressed

In TCM, symptoms cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. E Jiao is traditionally associated with these specific patterns.

The following describes this herb's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why E Jiao addresses this pattern

E Jiao is considered a premier Blood-tonifying substance. Its sweet taste nourishes and supplements, while its neutral temperature makes it suitable for Blood deficiency without generating excess Heat or Cold. As a 'blood-and-flesh' product, it has a particularly strong affinity for building Blood substance. It enters the Liver channel (the organ that stores Blood) and directly replenishes Blood volume and quality, addressing the root cause of this pattern.

A practitioner would look for one or more of these signs

Pallor

Pale or sallow complexion

Dizziness

Dizziness and lightheadedness

Severe Heart Palpitations

Palpitations from insufficient Blood to nourish the Heart

Insomnia

Difficulty sleeping due to Blood failing to anchor the spirit

TCM Properties

Temperature

Neutral

Taste

Sweet (甘 gān)

Channels Entered
Lungs Liver Kidneys
Parts Used

Processed / Derived product (加工品 jiā gōng pǐn)

This is partial information on the herb's TCM properties. More detailed information is available on the herb's dedicated page

Product Details

Manufacturing, supplier, and product specifications

Product Type

Granules

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Botanical & Sourcing

Quality Indicators

Good quality E Jiao comes in neat rectangular blocks, approximately 8.5 cm long, 3.7 cm wide, and 0.7-1.5 cm thick. The surface should be dark brown to jet black (乌黑), smooth, and glossy with a lustrous sheen. When held up to light, authentic E Jiao should be slightly translucent, showing a semi-transparent brownish appearance. The texture should be firm and brittle, snapping cleanly when broken. The fracture surface should be smooth and shiny, matching the exterior color. The taste should be mildly sweet with very little odor and absolutely no fishy or foul smell. Critically, high-quality E Jiao should not soften or become sticky in summer heat (经夏不软). The most prized variety is "Dong'e Jiao" (东阿胶) made with authentic Dong'e well water.

Primary Growing Regions

The finest E Jiao (道地药材) has traditionally come from Dong'e County (东阿县) in Shandong Province, China, where the local well water (阿井水) is rich in minerals such as calcium, magnesium, and potassium. This mineral-rich groundwater has long been considered essential for producing the highest quality product. The name "E Jiao" itself derives from the ancient county name "E" (阿). Shandong Province remains the primary and most famous production region, with Dong-E-E-Jiao Co. Ltd. being the leading manufacturer. Zhejiang Province also produces large quantities. Other production sites include Shanghai, Beijing, Tianjin, and Shenyang.

Harvesting Season

Donkey hides are collected year-round, but traditional production of the highest quality E Jiao occurs from the winter solstice through early March, when the mineral-rich well water is considered at its best quality.

Supplier Information

Treasure of the East

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Miscellaneous Info

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Usage & Safety

How to use this herb and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This herb is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Traditional Dosage Reference

Standard

5-15g

Maximum

Up to 15g in decoction, or 30g in specialized formulas for severe Blood deficiency or hemorrhage, under practitioner supervision.

Notes

Standard clinical dosage is 5-15g. Lower doses (3-6g) may suffice for mild Blood nourishment and Yin supplementation. Higher doses (10-15g) are used for active bleeding conditions or severe Blood deficiency. When used for hemostasis (stopping bleeding), E Jiao is often stir-fried with Pu Huang (cattail pollen), forming "E Jiao Zhu" (阿胶珠). For moistening the Lungs and resolving Phlegm, it is stir-fried with clam shell powder (蛤粉炒阿胶). The raw, unprocessed form is preferred for general Blood and Yin nourishment. E Jiao is cloying, so excessive dosage in patients with weak digestion can cause bloating, nausea, or loose stools. It is often combined with digestive aids like Chen Pi or Sha Ren to offset this tendency.

Processing Methods

Processing method

E Jiao is cut into small cubes, then stir-fried with clam shell powder (Ge Fen) or cattail pollen (Pu Huang) over low heat until the pieces puff up into round beads that are no longer sticky inside.

How it changes properties

The temperature remains neutral but the puffed form is less cloying to the Spleen and Stomach, reducing the tendency to cause nausea or digestive discomfort. When processed with Pu Huang, the hemostatic (bleeding-stopping) action is enhanced. The puffed form dissolves more easily in decoctions and is less likely to stick to the pot.

When to use this form

Use when the patient has a weak Spleen and Stomach and cannot tolerate the raw gelatin's sticky, cloying nature. Also preferred when the primary goal is Lung moistening or stopping bleeding rather than heavy Blood tonification. The Pu Huang-fried form is specifically chosen when stopping bleeding is the priority.

Toxicity Classification

Non-toxic

E Jiao is classified as non-toxic in the Chinese Pharmacopoeia. As a gelatin product composed primarily of collagen-derived amino acids and proteins, it contains no known toxic alkaloids or harmful compounds. Clinical trials and animal studies have confirmed that standard doses do not produce adverse effects. The main concern is not toxicity but rather its rich, sticky nature, which can impair digestion in people with weak Spleen and Stomach function, potentially causing nausea, bloating, or loose stools. Some users report a sensation of internal heat (上火) after taking E Jiao, but controlled studies have not found a statistically significant increase in fire-heat symptoms compared to placebo.

Contraindications

Caution

Spleen and Stomach weakness with poor digestion: E Jiao is sticky and cloying by nature, which can obstruct the Spleen and Stomach, worsening symptoms like bloating, poor appetite, loose stools, or nausea. Classical sources such as the Ben Cao Jing Shu state that those with a weak Stomach prone to vomiting should not take it.

Caution

Phlegm-Damp or Damp-Heat patterns: the rich, sticky nature of E Jiao can trap Dampness and make these conditions worse. It should be avoided in people with heavy feelings in the limbs, thick greasy tongue coating, or signs of Damp accumulation.

Caution

Exterior patterns (colds and flu with active symptoms): using E Jiao during the early stages of an exterior pathogen invasion can trap the pathogen inside the body. Classical teaching warns that when pathogenic factors are dominant at onset, using E Jiao may close the door on the pathogen and create new problems.

Avoid

Known allergy to gelatin or donkey-derived products: individuals with a history of allergic reactions to animal gelatins should avoid E Jiao.

Caution

Uterine fibroids or estrogen-sensitive conditions: pharmacological studies suggest E Jiao may promote endometrial growth and increase estradiol levels. Many TCM practitioners advise caution or avoidance in patients with uterine fibroids, endometrial hyperplasia, or other estrogen-dependent conditions.

Caution

Phlegm with Cold or retained fluid (Han Tan Liu Yin): the Ben Cao Hui Yan specifically warns against using E Jiao when there is Cold Phlegm or retained Yin fluids in the Stomach.

Special Populations

Pregnancy

E Jiao has been traditionally used during pregnancy and is generally considered safe and even beneficial for pregnant women. Classical texts consistently describe it as a medicine that "calms the fetus" (安胎). It appears in famous classical formulas for pregnancy-related bleeding, such as Jiao Ai Tang (胶艾汤) from the Jin Gui Yao Lue, used for threatened miscarriage and uterine bleeding. The Ben Cao Gang Mu records E Jiao combined with Ai Ye (mugwort leaf) for stabilizing pregnancy. However, some pharmacological studies suggest E Jiao may promote endometrial growth and increase estradiol levels, so use during pregnancy should still be under practitioner supervision to ensure appropriate pattern differentiation. Not recommended for self-medication during pregnancy without professional guidance.

Breastfeeding

E Jiao is generally considered compatible with breastfeeding. As a collagen-based gelatin rich in amino acids, it does not contain known harmful compounds that would pose a risk through breast milk. In traditional practice, it is commonly used in the postpartum period to help replenish Blood lost during childbirth and support recovery. Compound E Jiao preparations (such as Fufang E Jiao Jiang) have been used to treat postpartum anemia. However, its rich and cloying nature may cause digestive discomfort in the mother, which could indirectly affect milk quality. As always, use under practitioner guidance is advisable.

Pediatric Use

E Jiao has been used in classical pediatric formulas. For example, Bu Fei E Jiao Tang (补肺阿胶汤) from Qian Yi's Xiao Er Yao Zheng Zhi Jue (《小儿药证直诀》) uses E Jiao for pediatric Lung deficiency with cough. Li Shizhen also noted its use for children's post-convulsion eye disorders. Dosage for children should be significantly reduced from the adult range, typically 2-5g depending on the child's age and weight, and always under practitioner supervision. Its sticky, cloying nature makes it particularly important to assess the child's digestive function before use, as children's Spleen and Stomach function is characteristically immature.

Drug Interactions

No well-documented severe drug interactions have been established for E Jiao in peer-reviewed pharmacological literature. However, theoretical considerations based on its known properties warrant caution in the following situations:

  • Anticoagulant and antiplatelet medications (e.g. warfarin, aspirin, clopidogrel): E Jiao is used traditionally to both stop bleeding and nourish Blood. Its collagen-derived components could theoretically interact with drugs affecting coagulation. Patients on blood-thinning medications should inform their physician before taking E Jiao.
  • Estrogen-related therapies (hormone replacement therapy, oral contraceptives): Pharmacological studies have found that E Jiao may increase estradiol levels and promote endometrial growth. This could potentially have additive effects with exogenous estrogen therapies.
  • Iron supplements: E Jiao is rich in amino acids (particularly glycine) that may enhance calcium and potentially iron absorption. While this is generally beneficial, it may alter the pharmacokinetics of concurrently administered mineral supplements.

Overall, robust clinical data on E Jiao drug interactions is lacking. Patients taking any pharmaceutical medications should consult their healthcare provider before adding E Jiao.

Dietary Advice

While taking E Jiao, avoid excessive consumption of cold and raw foods (such as raw salads, iced drinks, and cold fruit) as these can impair the Spleen's digestive function, compounding E Jiao's naturally cloying quality. Strong tea should be avoided around the time of ingestion, as tannins may interfere with protein absorption. Radish (turnip) is traditionally avoided during E Jiao supplementation, as it is considered to counteract the tonic effect. Warm, easily digestible foods are favored. Pairing E Jiao with a small amount of Chen Pi (tangerine peel) tea or ginger can help offset any digestive heaviness.

Cautions & Warnings

Although this herb is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, and those with liver disease should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.