Formula

Dang Gui Shao Yao San

Dang Gui & Peony Formula | 当归芍药散

Also known as:

Dong Quai and Peony Powder , Tangkuei and Peony Powder , Dang Gui Shao Yao Tang

Properties

Hemostatic formulas · Slightly Warm

Key Ingredients

Bai Shao

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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About This Formula

Traditional Chinese Medicine background and properties

Formula Description

A classical formula originally designed for women experiencing abdominal pain during pregnancy or menstruation, caused by a combination of Blood deficiency and internal Dampness. It nourishes and moves the Blood, supports healthy digestion, and resolves fluid retention, making it helpful for dull abdominal cramping, bloating, dizziness, swelling, and irregular periods.

Formula Category

Main Actions

  • Nourishes Blood and Softens the Liver
  • Strengthens the Spleen and Resolves Dampness
  • Soothes the Liver and Regulates Qi
  • Promotes Urination
  • Relieves Abdominal Pain
  • Calms the Fetus

TCM Patterns

In TCM, symptoms don't appear randomly — they cluster into recognizable patterns of disharmony that reveal what's out of balance in the body. Dang Gui Shao Yao San is traditionally associated with these specific patterns.

The following describes this formula's classification within Traditional Chinese Medicine theory and is provided for educational purposes only.

Why Dang Gui Shao Yao San addresses this pattern

When the Liver lacks sufficient Blood, it loses its ability to maintain smooth flow of Qi and becomes prone to constraint. This manifests as dull, cramping abdominal pain that comes and goes. Bai Shao, as the King herb at high dosage, directly nourishes Liver Blood and relaxes spasms. Dang Gui further supplements the Blood while Chuan Xiong ensures it circulates freely. The Blood-nourishing triad restores the Liver's suppleness, relieving the root cause of the pain and associated symptoms like dizziness, pallor, and irregular menstruation.

A practitioner would look for one or more of these signs

Abdominal Pain

Dull, cramping lower abdominal pain that waxes and wanes

Dizziness

Dizziness and lightheadedness from Blood deficiency

Severe Heart Palpitations

Palpitations due to Blood failing to nourish the Heart

Dull Pale Complexion

Pale or sallow complexion

Irregular Menstruation

Scanty or irregular periods

How It Addresses the Root Cause

This formula addresses a pattern in which two interrelated problems reinforce each other: Blood deficiency in the Liver and Dampness accumulation due to Spleen weakness. In TCM, the Liver stores Blood and governs the smooth flow of Qi, while the Spleen transforms and transports fluids. When Liver Blood becomes insufficient — from menstruation, pregnancy, chronic illness, or constitutional weakness — the Liver loses its softness and flexibility. A Blood-deficient Liver tends toward tension and constraint, which is why the pain it produces is a dull, cramping, continuous ache rather than a sharp or stabbing sensation.

When the constrained Liver "overacts" on the Spleen (a recognized pathological direction in Five Phase theory, where Wood overwhelms Earth), the Spleen's ability to transform and transport fluids deteriorates. Fluids that should be metabolized accumulate as internal Dampness. This Dampness further obstructs the flow of Qi and Blood in the lower abdomen and uterus, worsening the pain and creating symptoms like edema, scanty urination, heaviness, and a white greasy tongue coating. The two problems create a vicious cycle: Blood deficiency makes the Liver tense and overbearing; the overbearing Liver weakens the Spleen; the weakened Spleen generates Dampness; and the Dampness further impedes Blood circulation.

During pregnancy, this mechanism is especially relevant. The body's Blood is directed toward nourishing the fetus, leaving less available for the Liver. The growing uterus and the metabolic demands of pregnancy also tax the Spleen's fluid-processing capacity. This is why Zhang Zhongjing placed this formula in both the pregnancy chapter and the general gynecological chapter of the Jin Gui Yao Lue — the same Liver-Spleen disharmony with Blood deficiency and Dampness accumulation underlies pain in both contexts.

Formula Properties

Temperature

Slightly Warm

Taste Profile

Predominantly sweet and bitter with a sour note — sweet from Bai Zhu and Fu Ling to tonify and harmonize, bitter from Bai Shao and Dang Gui to nourish Blood, and bland from Ze Xie and Fu Ling to drain Dampness through urination.

Target Organs
Liver Spleen Kidneys Uterus
Channels Entered
Liver Spleen Kidney Bladder

Formula Origin

Jin Gui Yao Lue (Essential Prescriptions from the Golden Cabinet) by Zhang Zhongjing

This is just partial information on the formula's TCM properties. More detailed information is available on the formula's dedicated page

Ingredients in Dang Gui Shao Yao San

Detailed information about each herb in Dang Gui Shao Yao San and their roles

Kings
Deputies
Assistants
Bai Shao
Bai Shao

White peony root

Dosage: 15 - 30g

Temperature Slightly Cool
Taste Bitter (苦 kǔ), Sour (酸 suān)
Organ Affinity Liver, Spleen
Parts Used Root (根 gēn)
Role in Dang Gui Shao Yao San

Used in a dominant dose (far exceeding the other herbs), Bai Shao softens the Liver, relieves spasmodic abdominal pain, nourishes Blood, and restrains Liver Qi from overacting on the Spleen. It is the principal herb addressing the core complaint of cramping abdominal pain.

Dang Gui
Dang Gui

Chinese Angelica root

Dosage: 6 - 10g

Temperature Warm
Taste Sweet (甘 gān), Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Heart, Spleen
Parts Used Root (根 gēn)
Role in Dang Gui Shao Yao San

Nourishes and harmonizes the Blood, addressing the underlying Blood deficiency. Works with Bai Shao and Chuan Xiong to form the Blood-regulating core of the formula, supplementing the Liver's Blood stores while gently promoting circulation to relieve pain.

Chuan Xiong
Chuan Xiong

Szechuan lovage rhizome

Dosage: 6 - 15g

Temperature Warm
Taste Acrid / Pungent (辛 xīn)
Organ Affinity Liver, Gallbladder, Pericardium
Parts Used Rhizome (根茎 gēn jīng)
Role in Dang Gui Shao Yao San

Invigorates Blood and promotes the movement of Qi. As a warm, acrid herb, it ensures that the Blood-nourishing action of Dang Gui and Bai Shao does not stagnate, and it facilitates smooth flow of Qi and Blood to resolve pain.

Fu Ling
Fu Ling

Poria

Dosage: 9 - 12g

Temperature Neutral
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Heart, Lungs, Spleen, Kidneys
Parts Used Fungus / Mushroom (菌类 jūn lèi)
Role in Dang Gui Shao Yao San

Strengthens the Spleen and promotes urination to drain Dampness. Supports the Spleen's ability to transform and transport fluids, addressing the internal accumulation of Dampness that contributes to pain and edema.

Bai Zhu
Bai Zhu

White Atractylodes rhizome

Dosage: 9 - 12g

Temperature Warm
Taste Bitter (苦 kǔ), Sweet (甘 gān)
Organ Affinity Spleen, Stomach
Parts Used Rhizome (根茎 gēn jīng)
Role in Dang Gui Shao Yao San

Tonifies the Spleen Qi and dries Dampness. Works together with Fu Ling to restore the Spleen's transportation function, and is classically recognized for its ability to calm a restless fetus when Spleen Qi is deficient.

Ze Xie
Ze Xie

Water plantain rhizome

Dosage: 9 - 15g

Temperature Cold
Taste Sweet (甘 gān), Bland (淡 dàn)
Organ Affinity Kidneys, Urinary Bladder
Parts Used Tuber (块茎 kuài jīng / 块根 kuài gēn)
Role in Dang Gui Shao Yao San

Promotes urination and drains accumulated water and Dampness via the Bladder. Used in relatively large dosage alongside the Spleen-tonifying herbs, Ze Xie provides a direct outlet for fluid stagnation, clearing water retention from the lower body.

Modern Research (4 studies)

  • Systematic Review and Meta-Analysis: Danggui-Shaoyao-San for Dementia (2020)
  • In Vitro Study: Antioxidant and Antiplatelet Effects on Human Blood Cells (2005)
See all research on the formula page

Usage & Safety

How to use this formula and important safety information

Important Medical Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice or to replace consultation with a qualified healthcare professional. This formula is a dietary supplement and has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease.

Always consult with a qualified healthcare provider, particularly if you are pregnant, nursing, have a medical condition, or are taking other medications. Discontinue use and consult your healthcare provider if you experience any adverse reactions.

Recommended Dosage

Instructions for safe storage and consumption

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Best Time to Take

Traditionally taken three times daily with warm rice wine; in modern practice, taken twice daily 30 minutes before meals on a relatively empty stomach to enhance absorption.

Typical Duration

Typically prescribed for 2-8 weeks for menstrual pain or gynecological conditions, reassessed monthly; may be taken throughout pregnancy under practitioner supervision for pregnancy-related abdominal pain.

Dietary Advice

While taking this formula, favor warm, easily digestible, nourishing foods that support both Blood and Spleen function: cooked grains (rice, millet, oats), root vegetables, dark leafy greens, small amounts of lean protein, and warming soups. Foods that traditionally nourish Blood such as red dates, goji berries, and black sesame are beneficial. Avoid cold, raw foods (salads, ice cream, cold drinks, raw sushi) and greasy, heavy, or overly rich foods, as these further burden the Spleen and generate more Dampness — exactly what this formula is trying to resolve. Excessive dairy, sugar, and processed foods should also be minimized. The classical method of administration was with warm wine (酒和服), which helps promote circulation and enhance the formula's Blood-moving function.

Modern Usage

This formula is commonly used to treat women with Liver and Spleen disharmony, Blood Stagnation, and Damp obstruction. Clinically, it is identified by persistent abdominal pain, scanty menstrual flow, irritability, poor appetite, pale tongue with a white greasy coating, and a wiry, thin pulse.

In modern applications, this formula is also used for pregnancy-related abdominal pain, dysmenorrhea, habitual miscarriage, polyhydramnios, malposition of the fetus, infertility, pregnancy-related anemia, functional uterine bleeding, endometritis, pelvic inflammatory disease, uterine fibroids, and menopausal syndrome.

Special Populations

Pregnancy

This formula is classically indicated for use during pregnancy and has been used for abdominal pain in pregnant women for nearly two thousand years. Zhang Zhongjing originally described it specifically for pregnancy-related cramping pain, and it is renowned in the Japanese Kampo tradition for its safety during pregnancy, often prescribed to "stabilize the fetus." However, Chuan Xiong (Ligusticum chuanxiong) is a Blood-invigorating herb with a dispersing nature, and classical commentators advise keeping its dosage conservative during pregnancy to avoid excessive Qi dispersal. In modern clinical practice, this formula is generally considered safe during pregnancy when used at standard doses under professional guidance, but dosage of Chuan Xiong should be moderated (typically 6-10g rather than higher doses). Pregnant women should always consult a qualified practitioner before use.

Breastfeeding

Dang Gui Shao Yao San is generally considered compatible with breastfeeding. All six herbs are commonly used in postpartum recovery formulas to nourish Blood and restore Spleen function after delivery. None of the herbs in this formula are known to be toxic or to produce harmful compounds that transfer through breast milk in clinically significant amounts. Dang Gui has traditionally been used to support postpartum recovery and lactation. However, as with any herbal formula during breastfeeding, use should be supervised by a qualified practitioner, and any changes in the infant's feeding behavior or health should be monitored.

Pediatric Use

Dang Gui Shao Yao San is primarily a gynecological formula and is rarely indicated in pediatric practice. Its main indications (menstrual pain, pregnancy-related conditions, Liver-Spleen disharmony with Blood deficiency and Dampness) are not common presentations in children. If used in adolescents for menstrual-related complaints after menarche, dosages should be reduced to approximately one-half to two-thirds of the standard adult dose, adjusted by body weight and constitution. Use in young children is not standard practice and should only occur under close supervision by a qualified practitioner with specific clinical justification.

Drug Interactions

Anticoagulants and antiplatelet drugs (warfarin, heparin, aspirin, clopidogrel): Dang Gui (Angelica sinensis) contains natural coumarin derivatives and ferulic acid, which can inhibit platelet aggregation and thromboxane formation. Animal studies and case reports have documented that Dang Gui can potentiate the anticoagulant effect of warfarin, increasing INR and bleeding risk. Chuan Xiong (Ligusticum chuanxiong) also possesses antiplatelet properties. Patients on anticoagulant or antiplatelet therapy should inform their physician before using this formula, and INR should be monitored more closely if concurrent use is necessary.

Diuretics: Ze Xie (Alisma orientale), Fu Ling (Poria cocos), and Bai Zhu (Atractylodes macrocephala) all promote urination and fluid metabolism. Combined use with pharmaceutical diuretics (furosemide, hydrochlorothiazide, spironolactone) could theoretically produce additive diuretic effects, potentially contributing to electrolyte imbalance or dehydration, though this has not been formally studied.

Hormone-sensitive conditions and hormonal medications: Dang Gui has demonstrated weak estrogenic activity in some studies. While clinical significance is debated, caution is advised in patients with hormone-sensitive conditions or those taking hormonal medications (oral contraceptives, hormone replacement therapy, tamoxifen).

Contraindications

Caution

Abdominal pain due to excess Heat or true Blood stasis with fixed, stabbing pain and dark clots. This formula is designed for deficiency-type dull pain with Dampness, not for acute excess conditions requiring strong Blood-breaking or Heat-clearing formulas.

Caution

Severe Yin deficiency with empty Heat signs (night sweats, malar flush, dry mouth, red tongue with no coat). The drying and draining herbs (Bai Zhu, Ze Xie, Fu Ling) may further deplete fluids in a genuinely Yin-deficient patient.

Avoid

Active hemorrhage or heavy menstrual bleeding. Dang Gui and Chuan Xiong invigorate Blood circulation, which could worsen active bleeding.

Caution

Concurrent use with anticoagulant or antiplatelet medications (e.g. warfarin, aspirin, clopidogrel) without medical supervision, due to potential additive anticoagulant effects from Dang Gui and Chuan Xiong.

Caution

Cold-type abdominal pain with pronounced cold signs (severe cold limbs, desire for warmth, pale complexion, deep slow pulse) that requires strong warming herbs. This formula is only mildly warm and lacks strong Yang-warming herbs.

Cautions & Warnings

Although this formula is typically safe for most individuals, it may cause side effects in some people. Pregnant women, nursing mothers, postpartum women, should use the formula with caution.

As with any Chinese herbal remedy, it is advisable to seek guidance from a qualified TCM practitioner before beginning treatment.

Product Details

Manufacturing, supplier, and product specifications

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Granules

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Treasure of the East

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